DRSC/TRiP Functional Genomics Resources

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Protein Alignment MYH9 and ck

DIOPT Version :9

Sequence 1:NP_002464.1 Gene:MYH9 / 4627 HGNCID:7579 Length:1960 Species:Homo sapiens
Sequence 2:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster


Alignment Length:2128 Identity:550/2128 - (25%)
Similarity:905/2128 - (42%) Gaps:443/2128 - (20%)


- Green bases have known domain annotations that are detailed below.


Human    32 VWVPSDKSGFEPASLKE-EVGEEAIVELVENGKKVKVNKDD-----------IQKMNPPKFSKVE 84
            :|:       ||||.:| :|...|.|...| |::::|..||           |:.|:......||
  Fly    10 IWI-------EPASGREFDVAIGARVVSAE-GRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVE 66

Human    85 DMAELTCLNEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEMYKGKKRHEMPPH 149
            ||..|..|:||.:|.||..||...|||||:|...|.:|||:.||||:.:.:::||.:|..|:|||
  Fly    67 DMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPH 131

Human   150 IYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAYVASSHKSKKDQGELERQLLQA 214
            |:||.|.||..|.:.|:||.|:.:|||||||||:||.::||||.::..|      ..:|:|:|:|
  Fly   132 IFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKH------SWIEQQILEA 190

Human   215 NPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKEERTFHIFYY 279
            ||||||||||||::|||||||||:|.|:|..||.|.||.||.|||||||.:.|...||.:|:||.
  Fly   191 NPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYC 255

Human   280 LLSGAGEHLKTDLLLEPYNKYRFLSNGH-VTIPGQQDKDMFQETMEAMRIMGIPEEEQMGLLRVI 343
            :|:|.....|:.|.|.....|::|:.|: :|..|:.|...|.:...||:::...::|...:::::
  Fly   256 ILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLL 320

Human   344 SGVLQLGNIVFKKE--RNTDQASMPDNTAAQKVSHLLGINVTDFTRGILTPRIKVGRDYVQKAQT 406
            :.:|..|||.:|..  .|.|...:|::...::|:.|||:.:......:....:....:.|....:
  Fly   321 AALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTLS 385

Human   407 KEQADFAIEALAKATYERMFRWLVLRINKALDKTKRQGASFIGILDIAGFEIFDLNSFEQLCINY 471
            ::|:....:|..|..|.|||..:|.:||.|:.|.:....:.||:|||.|||.||.|||||.||||
  Fly   386 RDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENFDQNSFEQFCINY 450

Human   472 TNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIEKPAGPPGILALLDEECWFPK 536
            .||.|||.|...:|.||||||..|.|.|..|:| :|.|..:|||  ......|:||:|||..|||
  Fly   451 ANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDALDLI--AIKQLNIMALIDEEARFPK 512

Human   537 ATDKSFVEKVMQEQGTHPKFQKPKQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNIATLLH 601
            .||::.:.|:.:..|:|..:.|||. .....|.:.|:||.|.|....:|.||.|..:.::..|:.
  Fly   513 GTDQTMLAKLHKTHGSHKNYLKPKS-DINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVS 576

Human   602 QSSDKFVSELW-KDVDRIIGLDQVAGMSETALPGAFKTRKGMFRTVGQLYKEQLAKLMATLRNTN 665
            ||::||:.::: :|::.                || :||| ...|:...:::.|..||.||.:..
  Fly   577 QSTNKFLRQIFAQDIEM----------------GA-ETRK-RTPTLSTQFRKSLDALMKTLSSCQ 623

Human   666 PNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQRYEILTPNSIP 730
            |.|:|||.||..||....|..|...|||.:|::|.|||.|.|:|.|..|:||.:||..|.| .:|
  Fly   624 PFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIP-GVP 687

Human   731 KGFMDGKQACVLMIKALELDSNLYRIGQSKVFFRAGVLAHLEEERDLKITDVIIGFQACCRGYLA 795
            .......||....|.|:.|..:.|::|.:|||.:......||:|||..:|..|:..|...||::.
  Fly   688 PAHRTDCQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVY 752

Human   796 RKAFAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRL-FTKVKPLLQ-------------------- 839
            |:.|.:.:   .|...:||....|.:.:.::..|: :.:::.|::                    
  Fly   753 RRRFLRLR---AAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQA 814

Human   840 -----VSRQE--EEMMAKEEELVKVRE--KQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETEL 895
                 :.|:|  .:|.|    ::|::.  :::.|..|..::. |:.:..||.|||::        
  Fly   815 HARGYLVRREYGHKMWA----VIKIQSHVRRMIAMRRYRKLR-LEHKQFAEVLQLRK-------- 866

Human   896 CAEAEELRARLTAKKQELEE-----ICHDLEAR-VEEEEERCQHLQAEKKKMQQNIQELEEQLEE 954
             .|.:||..|.....:|:.|     ..|:||.| ::|:.|..:.::.....:....::.||.:::
  Fly   867 -LEEQELLHRGNKHAREIAEQHYRDRLHELERREIQEQLENRRRVEVNMNIINDAARKQEEPVDD 930

Human   955 EESARQKLQ-LEKVTTEAKLKKLEEEQIILED----QNCKLAKEKKLLEDRIAEFTTNLTEEEEK 1014
            .:....... |...:::|.......|..:..|    ||..       .:|.||..  :::|:||.
  Fly   931 GKLVEAMFDFLPDSSSDAPTPHGGRETSVFNDLPHAQNVN-------QDDIIAPI--HISEDEED 986

Human  1015 ------------------SKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGD----- 1056
                              :...||...||..    |....:.::...|.|..|..:..||     
  Fly   987 LSEFKFQKFAATYFQGNVNHQYAKKALKHPL----LPLHTQGDQLAAQALWITILRFTGDMPEPK 1047

Human  1057 --STDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQK-----------NMALKKIRE 1108
              :.|..|..:.:....|.|.....:.:|..:|.|..::.:|..|           ::.||:..:
  Fly  1048 YHTMDRMDTTSVMSKVTATLGRNFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKNK 1112

Human  1109 LESQI-SELQED----------LESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQ--- 1159
            |...: ..||:|          |:|...|  ..||....:|..:  |:.||.|.:.....:|   
  Fly  1113 LGEDVRRRLQDDEYTADSYQSWLQSRPTS--NLEKLHFIIGHGI--LRAELRDEIYCQICKQLTN 1173

Human  1160 -ELRSKR-----------------EQEVNILKKTLEEEAKTHEAQIQEMRQK------HSQAVEE 1200
             .|:|..                 |:.||.|:..:.|....:....:|..::      .:|....
  Fly  1174 NPLKSSHARGWILLSLCVGCFAPSEKFVNYLRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSW 1238

Human  1201 LAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQE-LQVKFNEG 1264
            |  :|:.|        |:|:.:......:....|.||   .||....:::..||.: :.:|...|
  Fly  1239 L--ELQAT--------KSKKPIMLPITFMDGNTKTLL---ADSATTARELCNQLSDKISLKDQFG 1290

Human  1265 ERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALES----QLQDTQELL---QEENR 1322
            ..:...|.|||:.|....|:|...:||.:    :..|:..|.|.    :|...:|:.   .|...
  Fly  1291 FSLYIALFDKVSSLGSGGDHVMDAISQCE----QYAKEQGAQERNAPWRLFFRKEIFAPWHEPTH 1351

Human  1323 QKLSLSTKLKQVEDEKNSFREQLEEEEE---------------------------------AKHN 1354
            .:::.:...:||.........:.::||:                                 ....
  Fly  1352 DQVATNLIYQQVVRGVKFGEYRCDKEEDLAMIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSG 1416

Human  1355 LEKQIATLHAQVADMKKK---MEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAY----DKLE 1412
            ::|.|....|.|....||   ::|.:..|:..|::....:.....|..|..|   ||    ..|.
  Fly  1417 VDKAIERWAALVLQAYKKSYYVKDKIAPLKIKEDIVSYAKYKWPLLFSRFYE---AYRNSGPNLP 1478

Human  1413 K---------TKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLA------EEKTISAKYAE 1462
            |         |...:..:.:.:|::|.....:|.:.:|..|.|.|..:      ||.|..:..||
  Fly  1479 KNDVIIAVNWTGVYVVDDQEQVLLELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEFTFQSPNAE 1543

Human  1463 E-RDRA-----EAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEME-DLMSSKDD-VGKS 1519
            : ||..     ..:.|.|...||...||..:           ...|.:..: ||:..:|: .|:|
  Fly  1544 DIRDLVVYFLDGLKKRSKYVIALQDYRAPSD-----------GTSFLSFFKGDLIILEDESCGES 1597

Human  1520 VHE----LEKSKRALE------QQVEEMKTQLEELEDEL------QATEDAKLRLEVNLQAM--- 1565
            |..    :.:..|:.|      :.|..:.|..:..:|.|      :|....:|.:..|..|:   
  Fly  1598 VLNNGWCIGRCDRSQERGDFPAETVYVLPTLSKPPQDILALFNIEEAHHGRRLSMASNGGAVEPR 1662

Human  1566 ------------------KAQFERDLQGRDEQSEEK--------KKQLVRQVREMEAELEDERKQ 1604
                              |....:.|....::|||.        |..|:|:::..|...|    :
  Fly  1663 DRPHTLMEYALDHFRLPPKRTMSKTLTLSSKRSEELWRYSRDPIKAPLLRKLQSKEEFAE----E 1723

Human  1605 RSMAVAARKKLEMDL--------KDLEAHI-DSANKN---RDEAIKQLRKLQAQMKDCMRELDDT 1657
            ...|.||..|...||        .::..|| |...|:   |||...||.|   |:.|....:.:.
  Fly  1724 ACFAFAAILKYMGDLPSKRPRMGNEITDHIFDGPLKHEILRDEIYCQLMK---QLTDNRNRMSEE 1785

Human  1658 RA--------------------------SREEILAQ---------AKENEKKLKSMEAEMIQLQE 1687
            |.                          :|...::|         .:..::|....:.|:..:|.
  Fly  1786 RGWELMWLATGLFACSQGLLKELLLFLRTRRHPISQDSMHRLQKTIRHGQRKYPPHQVEVEAIQH 1850

Human  1688 -------------------ELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQ 1733
                               |:.::.|||           |...|.|.:.:|...|...|..:|| 
  Fly  1851 KTTQIFHKVYFPDDTDEAFEVDSSTRAK-----------DFCNNISQRLSLRTSEGFSLFVKIA- 1903

Human  1734 LEEELEEEQGN-----TELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVK 1793
             ::.:...:|:     ...:.|.:|||....|..|.....:....:|........:.:|.:|...
  Fly  1904 -DKVISVPEGDFFFDFVRHLTDWIKKARPIRDGANPQFTYQVFFMKKLWTNTVPGKDRNADLIFH 1967

Human  1794 L-QEMEGTVKSKYKASITALEAKIAQLEEQLD-NETKERQAACKQVRR 1839
            . ||:...::..:|.| ....||:|.|..::. .|.|:...|..|:.|
  Fly  1968 YHQELPKLLRGYHKCS-REEAAKLAALVFRVRFGENKQELQAIPQMLR 2014

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYH9NP_002464.1 Mediates interaction with LIMCH1. /evidence=ECO:0000269|PubMed:28228547 2..838 309/822 (38%)
Myosin_N 29..68 CDD:367160 11/36 (31%)
Motor_domain 95..764 CDD:354959 269/672 (40%)
Actin-binding 654..676 11/21 (52%)
Myosin_tail_1 841..1921 CDD:366712 240/1277 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1035..1057 5/28 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1118..1137 6/28 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1877..1960
ckNP_001285949.1 MYSc 64..733 CDD:214580 279/697 (40%)
MYSc_Myo7 77..721 CDD:276832 269/672 (40%)
MyTH4 <1138..1245 CDD:214535 21/120 (18%)
B41 1251..1467 CDD:214604 39/222 (18%)
FERM_B-lobe 1355..1439 CDD:271216 10/83 (12%)
FERM_C1_MyoVII 1461..1559 CDD:270019 22/100 (22%)
SH3 1560..1624 CDD:302595 15/74 (20%)
MyTH4 1701..1849 CDD:214535 28/154 (18%)
B41 1856..2068 CDD:214604 35/173 (20%)
FERM_M 1966..2068 CDD:278785 13/50 (26%)
FERM_C2_MyoVII 2064..2159 CDD:270020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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