Protein Alignment MYH9 and Myo31DF

DIOPT Version :10

• Sequence 1: NP_002464.1
• Gene: MYH9 / 4627
• HGNCID: 7579
• Length: 1960
• Species: Homo sapiens
• Sequence 2: NP_523538.1
• Gene: Myo31DF / 34445
• FlyBaseID: FBgn0086347
• Length: 1011
• Species: Drosophila melanogaster
• Alignment Length: 787
• Identity: 291/787 - (36%)
• Similarity: 438/787 - (55%)
• Gaps: 69/787 - (8%)

Human    83 VEDMAELTCLNEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEMYKGKKRHEMP 147
            |:|...|..::....:.||::|:.:|.||||.|..||.:|||:.:.||..|.:..|||::..|..
  Fly     9 VQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRELFENA 73

Human   148 PHIYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAYVASSHKSKKDQGELER--- 209
            ||::||.|:|||.:.|.::|..||.:|||||||||.:|.:::|:|.|.::    :.|.|:||
  Fly    74 PHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNA----QGQNEIERVKN 134

Human   210 QLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKEERTF 274
            .|:|:|.|||.||||||.:|||||||||::.|.||.....||..|..|||||||.::|...||.|
  Fly   135 VLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNF 199

Human   275 HIFYYLLSGAGEH-LKTDLLLEPYNKYRFLSNGHVTIPGQQDKDMFQETMEAMRIMGIPEEEQMG 338
            |.||.||.||.:: |:...|.:...||.:|:.|.:.|  ..:|..::.|..|.:.:|...:|...
  Fly   200 HSFYQLLRGANDNELRQYELQKETGKYHYLNQGSMDI--LTEKSDYKGTCNAFKTLGFSTDEVQT 262

Human   339 LLRVISGVLQLGNIVFKKERNTDQASMPDNTAAQKVSHLLGINVTDFTRGILTPRIKVGRDYVQK 403
            :.|.|:.||.|||:.|  :...|:..:.:....:..:.||.:..|:.:..:....|..|.:.:||
  Fly   263 IWRTIAAVLHLGNVEF--QTIEDELVISNKQHLKSTAKLLQVTETELSTALTKRVIAAGGNVMQK 325

Human   404 AQTKEQADFAIEALAKATYERMFRWLVLRINKAL----DKTKRQGASFIGILDIAGFEIFDLNSF 464
            .....||::..:|||||.|:|:|.|::.|||:|:    .||:.:..|.||:|||.||||||.|||
  Fly   326 DHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIYGFEIFDSNSF 390

Human   465 EQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIEKPAGPPGILALLD 529
            ||.||||.||||||||...:...||||||||||||..|::..:...| ||:|:|  ..||:|::|
  Fly   391 EQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIIC-DLVEQP--HKGIIAIMD 452

Human   530 EECW-FPKATDKSFVEKVMQEQGTHPKFQ----KP--KQLKDKADFCIIHYAGKVDYKADEWLMK 587
            |.|. ..|.||.:.:..:.:....||.:.    ||  |:||.:.||.|.||||.|.|..:.::.|
  Fly   453 EACLSVGKVTDDTLLGAMDKNLSKHPHYTSRQLKPTDKELKHREDFRITHYAGDVIYNINGFIEK 517

Human   588 NMDPLNDNIATLLHQSSDKFVSELWKDVDRIIGLDQVAGMSETALPGAFKTRKGMFR--TVGQLY 650
            |.|.|..:...|||.|.|..:||:|.:                   ||...:|...|  |.|.|:
  Fly   518 NKDTLYQDFKRLLHNSKDANLSEMWPE-------------------GAQDIKKTTKRPLTAGTLF 563

Human   651 KEQLAKLMATLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQ 715
            :..:|.|:.||....|.:||||.||..|.:...|...|..|:|..|:||.:|:.|.||.:|..:.
  Fly   564 QRSMADLVVTLLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYD 628

Human   716 EFRQRYEILT----PNSIPKGFMDGKQACVLMIKALELDSNLYRIGQSKVFFRA-GVLAHLEEER 775
            :|..||::::    ||.......||.:   ::|:..:...:: :.|.:|:|.|: ..|..||.:|
  Fly   629 KFLLRYKMISQYTWPNFRAGSDRDGVR---VLIEEKKFAQDV-KYGHTKIFIRSPRTLFALEHQR 689

Human   776 DLKITDVIIGFQACCRGYLARKAFAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQV 840
            :..|..::...|...||::.|:.|.|.:..:|.::..:    || |||::        |:.|...
  Fly   690 NEMIPHIVTLLQKRVRGWIVRRNFKKMKAAITIVRAYK----AY-KLRSY--------VQELANR 741

Human   841 SRQEEEM 847
            .|:.::|
  Fly   742 LRKAKQM 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH9	NP_002464.1	Mediates interaction with LIMCH1. /evidence=ECO:0000269|PubMed:28228547	2..838		288/776 (37%)
		Myosin_N	27..72	CDD:460670
		Motor_domain	95..764	CDD:473979	266/689 (39%)
		Actin-binding	654..676		10/21 (48%)
		Myosin_tail_1	841..1921	CDD:460256	2/7 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1035..1057
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1118..1137
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1877..1960
Myo31DF	NP_523538.1	MYSc_Myo1	21..677	CDD:276829	266/689 (39%)
		Myosin_TH1	801..977	CDD:461801