DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MYH9 and ninaC

DIOPT Version :10

Sequence 1:NP_002464.1 Gene:MYH9 / 4627 HGNCID:7579 Length:1960 Species:Homo sapiens
Sequence 2:NP_523503.2 Gene:ninaC / 34012 FlyBaseID:FBgn0002938 Length:1501 Species:Drosophila melanogaster


Alignment Length:863 Identity:211/863 - (24%)
Similarity:377/863 - (43%) Gaps:128/863 - (14%)


- Green bases have known domain annotations that are detailed below.


Human    17 INNP----LAQADWAAK--KLVWVPSDKSGFEPASLKEEVGEEAIVELVENGKKVKVNKDDIQKM 75
            |.||    :...:|:.:  ..:....:|:......:.|.|....:.||:||..::   :.||.:|
  Fly   238 IRNPPPTLMRPTNWSQQINDFISESLEKNAENRPMMVEMVEHPFLTELIENEDEM---RSDIAEM 299

Human    76 ---------------------------NPPKFSKVEDMAELTCLNEASVLHNLKERYYSGLIYTY 113
                                       ..|:....||:|.|....:.:::.:|:.|...|..|::
  Fly   300 LELSRDVKTLYKEPELFVDRGYVKRFDEKPEKMYPEDLAALENPVDENIIESLRHRILMGESYSF 364

Human   114 SGLFCVVINPYKNLPIYSEEIVEMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTGESGA 178
            .|...:.:|..:....:.:|....|:.|.|.|..|||:::.|.||:.|:..:|.|.|:.:|||.:
  Fly   365 IGDILLSLNSNEIKQEFPQEFHAKYRFKSRSENQPHIFSVADIAYQDMLHHKEPQHIVLSGESYS 429

Human   179 GKTENTKKVIQYLAYVASSHKSKKDQGELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINF 243
            ||:.|.:.:|::|.|:...::..  .|.:|..:.....::    ||.|..|::|:|......:.|
  Fly   430 GKSTNARLLIKHLCYLGDGNRGA--TGRVESSIKAILMLV----NAGTPVNNDSTRCVLQYCLTF 488

Human   244 DVNGYIVGANIETYLLEKSRAIRQAKEERTFHIFYYLLSGAGEHLKTDLLLEPYN-----KYRFL 303
            ...|.:.||....|:|||.|.......:..||||||..    :.:.....|:.||     .||:|
  Fly   489 GKTGKMSGAVFNMYMLEKLRVATTDGTQHNFHIFYYFY----DFINQQNQLKEYNLKADRNYRYL 549

Human   304 SNGHVTIPG---------QQDKDMFQETMEAMRIMGIPEEEQMGLLRVISGVLQLGNIVFKKERN 359
            .......|.         :.:.:.::|....:|.:....::...:.:|::.:|.:|||.|:  :|
  Fly   550 RVPPEVPPSKLKYRRDDPEGNVERYREFENILRDIDFNHKQLETVRKVLAAILNIGNIRFR--QN 612

Human   360 TDQASMPDNTAAQKVSHLLGINVTDFTRGILTPRIKVGRDYVQKAQ-TKEQADFAIEALAKATYE 423
            ...|.:.:.....:::.||.::...|... ||..|.|.....::.| |.|:|..|.:|:|...|.
  Fly   613 GKYAEVENTDIVSRIAELLRVDEKKFMWS-LTNFIMVKGGIAERRQYTTEEARDARDAVASTLYS 676

Human   424 RMFRWLVLRINKALDKTKRQGASF-----IGILDIAGFEIFDLNSFEQLCINYTNEKLQQLFNHT 483
            |:..:::.|||..:...:   |.|     |.|.|:.|||.|:.|..|||.||..||::|..:|..
  Fly   677 RLVDFIINRINMNMSFPR---AVFGDTNAIIIHDMFGFECFNRNGLEQLMINTLNEQMQYHYNQR 738

Human   484 MFILEQEEYQREGIEWNFIDFGLDLQPCID-LIEKPAGPPGILALLDE---ECWFPKATDKSFVE 544
            :||.|..|.:.|.|:...::| .|.:..:| |:.|   |.|:..::|:   .|     .|:..:.
  Fly   739 IFISEMLEMEAEDIDTINLNF-YDNKTALDNLLTK---PDGLFYIIDDASRSC-----QDQDLIM 794

Human   545 KVMQEQGTHPKFQKPKQLKDKA-DFCIIHYAGKVDYKADEWLMKNMDPLNDNIATLLHQSSDK-- 606
            ..:.|:  |.:|.|    |..| :..:.||.|::.|....:...|.|.:...:......|.|:  
  Fly   795 DRVSEK--HSQFVK----KHTATEISVAHYTGRIIYDTRAFTDINRDFVPPEMIETFRSSLDESI 853

Human   607 ---FVSELWKDVDRIIGLDQVAGMSET--------ALPGAFKTRKGMFRTVGQLYK---EQLAKL 657
               |.::|.|..:..:..:.|....|:        .|.....::....||:...::   ..|.|:
  Fly   854 MLMFTNQLTKAGNLTMPFEAVQHKDESERKSYALNTLSAGCISQVNNLRTLAANFRFTCLTLLKM 918

Human   658 MATLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQRYE 722
            ::...|...:|||||..:.|.|.......:|..|::..|||:.:...::||.:|:.|.||.:||:
  Fly   919 LSQNANLGVHFVRCIRADLEYKPRSFHSDVVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQ 983

Human   723 ILT-----PNSIPKGFMDGKQACVLMIKALELDSNLYRIGQSKVFFR---AGVLAHLEEERDLKI 779
            .|.     |..:.      |..|.|:...|:::.  :.:|::|||.|   ...||.|.|.:..|:
  Fly   984 FLAFDFDEPVEMT------KDNCRLLFLRLKMEG--WALGKTKVFLRYYNDEFLARLYELQVKKV 1040

Human   780 TDVIIGFQACCRGYLARK 797
            ..|    |:..|..||||
  Fly  1041 IKV----QSMMRALLARK 1054

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYH9NP_002464.1 Mediates interaction with LIMCH1. /evidence=ECO:0000269|PubMed:28228547 2..838 211/863 (24%)
Myosin_N 27..72 CDD:460670 7/46 (15%)
Motor_domain 95..764 CDD:473979 179/714 (25%)
Actin-binding 654..676 8/21 (38%)
Myosin_tail_1 841..1921 CDD:460256
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1035..1057
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1118..1137
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1877..1960
ninaCNP_523503.2 STKc_myosinIII_N_like 9..282 CDD:270785 7/43 (16%)
MYSc_Myo21 346..1022 CDD:276848 179/714 (25%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.