Protein Alignment MYH9 and myp2

DIOPT Version :10

• Sequence 1: NP_002464.1
• Gene: MYH9 / 4627
• HGNCID: 7579
• Length: 1960
• Species: Homo sapiens
• Sequence 2: NP_593816.1
• Gene: myp2 / 2543576
• PomBaseID: SPAC4A8.05C
• Length: 2104
• Species: Schizosaccharomyces pombe
• Alignment Length: 2193
• Identity: 672/2193 - (30%)
• Similarity: 1057/2193 - (48%)
• Gaps: 397/2193 - (18%)

Human    11 YVDKNFIN----------------NPLAQADWAAKKLVWVPSDKSGFEPASLKEEVGEEAIVELV 59
            |:.||..|                |.:..|.:..:..:|:|..|..|..|.:.|::||:..|:|.
pombe     3 YLSKNGSNDNNNIIKKLVDAEKHCNAVKDASFDERTWIWIPDSKESFVKAWIVEDLGEKYRVKLE 67

Human    60 ENGKKVKVNKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLKERYYSGLIYTYSGLFCVVINPY 124
            .:|.:..|:..|.:|:|||||..|:|||.||||||.||::||.:||...|||||||||.|.:|||
pombe    68 RDGSERIVDGFDAEKVNPPKFDMVDDMAALTCLNEPSVVNNLTQRYEKDLIYTYSGLFLVAVNPY 132

Human   125 KNLPIYSEEIVEMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQ 189
            .:||||.:::|..|:.|:..|..|||:...|.||||:::.|.:||||.||||||||||.||||||
pombe   133 CHLPIYGDDVVRKYQSKQFKETKPHIFGTADAAYRSLLERRINQSILVTGESGAGKTETTKKVIQ 197

Human   190 YLAYVASSHKSKKDQGELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANI 254
            ||..|..:  |..|..:||:::|:.||:|||||||:||:|:|||||||||||.|..||.|||||:
pombe   198 YLTSVTDA--STSDSQQLEKKILETNPVLEAFGNAQTVRNNNSSRFGKFIRIEFSNNGSIVGANL 260

Human   255 ETYLLEKSRAIRQAKEERTFHIFYYLLSGAGEHLKTDLLLEPY-NKYRFLSNGHVTIPGQQDKDM 318
            :.|||||||.|..:..||.:|:||.||.||...|...|.|:.| :.|.:|.||...|.|..|...
pombe   261 DWYLLEKSRVIHPSSNERNYHVFYQLLRGADGSLLESLFLDRYVDHYSYLKNGLKHINGVDDGKE 325

Human   319 FQETMEAMRIMGIPEEEQMGLLRVISGVLQLGNIVFKKERNTDQASMPDNTAAQKVSHLLGINVT 383
            ||:....:|.:|....|...|..:|:.:|.:|||....:| :.||..|..|...::.|||.|.|.
pombe   326 FQKLCFGLRTLGFDNNEIHSLFLIIASILHIGNIEVASDR-SGQARFPSLTQIDQLCHLLEIPVD 389

Human   384 DFTRGILTPRIKVGRDYVQKAQTKEQADFAIEALAKATYERMFRWLVLRINKALDKTKRQGASFI 448
            .|....|.|:.|.||:::..|:|:||....:::|||..|||.|..||.|:|:.:..::.:...||
pombe   390 GFVNAALHPKSKAGREWIVTARTREQVVHTLQSLAKGLYERNFAHLVKRLNQTMYYSQSEHDGFI 454

Human   449 GILDIAGFEIFDLNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCID 513
            |:|||||||||..|||||||||:|||||||.|||.||:||||||.:|.|||:|||:|.||||.||
pombe   455 GVLDIAGFEIFTFNSFEQLCINFTNEKLQQFFNHYMFVLEQEEYTQERIEWDFIDYGNDLQPTID 519

Human   514 LIEKPAGPPGILALLDEECWFPKATDKSFVEKVMQEQGTHPKFQ------KPKQLKDKADFCIIH 572
            .||| :.|.||.:.|||:|..|.|||.:|.||:      |..|:      :||:...:. |.:.|
pombe   520 AIEK-SEPIGIFSCLDEDCVMPMATDATFTEKL------HLLFKGKSDIYRPKKFSSEG-FVLKH 576

Human   573 YAGKVDYKADEWLMKNMDPLNDNIATLLHQSSDKFVSELWKDV-DRIIGLDQVAGMSETALPGAF 636
            |||.|:|...:||.||.||||..:|.|:.:|::..||.|:.|. ....|.|.:
pombe   577 YAGDVEYDTKDWLEKNKDPLNACLAALMFKSTNSHVSSLFDDYSSNASGRDNI------------ 629

Human   637 KTRKGMFRTVGQLYKEQLAKLMATLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGI 701
             .:||:||||.|.::.||:.||..|..|.|:||||||||:.|:...||..|||.|||||||||||
pombe   630 -EKKGIFRTVSQRHRRQLSSLMHQLEATQPHFVRCIIPNNLKQPHNLDKSLVLHQLRCNGVLEGI 693

Human   702 RICRQGFPNRVVFQEFRQRYEILTPNSIPKGFMDGKQACVLMIKALELDSNLYRIGQSKVFFRAG 766
            ||.:.||||::.:.|||.||.||: .|:.:|:::.|:|.:.:|..|:|.|.:||:|::||||:|.
pombe   694 RIAQTGFPNKLFYTEFRARYGILS-QSLKRGYVEAKKATITIINELKLPSTVYRLGETKVFFKAS 757

Human   767 VLAHLEEERDLKITDVIIGFQACCRGYLARKAFAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLF 831
            ||..||:.|:..:..:...|.|..||:|.|:...:...:..|..:||.|......|:...||.||
pombe   758 VLGSLEDRRNALLRVIFNSFSARIRGFLTRRRLYRFNHRQDAAILLQHNLRQLKLLKPHPWWNLF 822

Human   832 TKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELC 896
            ..:||||..: |.:|.:.:::.|:...:.||.:...:....|:..:.:   |||...||.|..|.
pombe   823 LHLKPLLGTT-QTDEYLRRKDALINNLQNQLESTKEVANELTITKERV---LQLTNDLQEEQALA 883

Human   897 AEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQK 961
            .|.:.|..|..::.:.:.|....||.:|...:|:.:.|.|||       |.:||.|..:::....
pombe   884 HEKDILVERANSRVEVVHERLSSLENQVTIADEKYEFLYAEK-------QSIEEDLANKQTEISY 941

Human   962 LQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLK---N 1023
            |.....|.|.||..::      :|:....:|.|:|.:|    :...:.:.:..|:.|:.|:   |
pombe   942 LSDLSSTLEKKLSSIK------KDEQTISSKYKELEKD----YLNIMADYQHSSQHLSNLEKAIN 996

Human  1024 KHEAMITDLEERLRREE-----KQR------QELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQ 1077
            :....|.:|.|:|.|.:     |||      |||.:....|:........|:|.|.::.:|.:.:
pombe   997 EKNLNIRELNEKLMRLDDELLLKQRSYDTKVQELREENASLKDQCRTYESQLASLVSKYSETESE 1061

Human  1078 LAKKEEELQAALARVEEEAAQKNMA----------------------------------LKKIRE 1108
            |.|||.||......:.|...|.:.|                                  ||.::|
pombe  1062 LNKKEAELVIFQKEITEYRDQLHKAFQNPEKTHNINDVKSGPLNSDENIYSTSSTTLSILKDVQE 1126

Human  1109 LES-----------QISELQEDLESERASRNKAEKQKRDLGEELEALKTELED------------ 1150
            |:|           :|.|:.|.||...|:..|..::..:|.:.:||||.:::|
pombe  1127 LKSLHTKEANQLSERIKEISEMLEQSIATEEKLRRKNSELCDIIEALKYQIQDQETEIISLNADN 1191

Human  1151 --------TLDSTAAQ----QELRSKREQEVNILKKTLEEE--------AKTHEAQIQE------ 1189
                    .|:..|:.    |.::|:.|.:::.|...|::|        .||....:.:
pombe  1192 LDLKDTNGVLEKNASDFIDFQGIKSRYEHKISDLLNQLQKERCKVGLLKQKTENRSVTQHTLDGN 1256

Human  1190 -----MRQKHSQAVEELAEQLEQ--------------TKRVKANLEKAKQTLENE---------- 1225
                 ..:|||      .:.|::              .|.:..:|:..:.|:|.|
pombe  1257 SPHPSFEEKHS------GDPLKRIDGNNDDRKIDNKLLKTISKSLDALQLTVEEELSNLYSLSKD 1315

Human  1226 ------RGELANEVKVLLQGKGDSEHKRKKVEAQ---------LQELQVKFNEGERVRTELADK- 1274
                  .|.:.|.::.|.:|.......::::.|.         .::.|...|..:.:....:|.
pombe  1316 LSFTDISGHIPNSIRKLEKGLSTLSELKERLNASNSDRPSPDIFKDTQAIMNSRKLLSNPNSDAQ 1380

Human  1275 ---VTKLQVELDN------VTGLLSQSDSKSSKL--------TKDFSALESQLQDTQE------- 1315
               ::.||.:|.|      .|||...|.||.|.|        :|....:|:.:::..:
pombe  1381 SGLISSLQKKLYNPESNMEFTGLKPLSPSKISNLPSSQPGSPSKRSGKMEALIRNFDQNSSIPDP 1445

Human  1316 --------LLQEENRQKLSLSTKLKQ-----VEDEK--NSFRE----QLEEEEEAKHNLEKQIAT 1361
                    :||.| .:|::|  |||:     :.|.|  :.|.|    .|:|.||.| ||......
pombe  1446 FIVNQRNSVLQTE-FEKINL--KLKEATKSGILDNKDLSKFSELIQSLLKENEELK-NLTTSNLG 1506

Human  1362 LHAQVADMKKKMED--------SVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRL 1418
            ...::.|....:||        ..|.:|.|...||.:.|    |....|||:.:   .||....:
pombe  1507 SDDKMLDFAPLLEDVPNNTRNQIKGFVEKAISSKRAIAK----LYSASEEKLFS---TEKALREI 1564

Human  1419 QQELDDLLVDLDHQRQSACNLEKKQKKFDQLL------------AEEKT------ISAKYAEERD 1465
            .:|.|.||..|  |..|......|.....||:            .||:|      ::....:|..
pombe  1565 TKERDRLLHGL--QGPSVPTSPLKAPTASQLIIPNFDGSITNYSGEEETEWLQEEVNIMKIKELT 1627

Human  1466 RAEAEAREKETKALSLARALEEAME---QKA------------ELERLNKQFRTEMEDLMSSKDD 1515
            ....:.||:    |::.::|.|..|   .||            |:|.|.:.|:|...||.:...|
pombe  1628 STVNKYREQ----LAMVQSLNEHAESSLSKAERSKNYLTGRLQEVEELARGFQTTNADLQNELAD 1688

Human  1516 --VGKSVHE---LEKS---------KRALEQQVEEMKT-QLEELEDELQATEDAKLRLEVNLQAM 1565
              |.:..:|   :|||         |..|.:|::|... ::::||:..:..:....|.:..|...
pombe  1689 AVVKQKEYEVLYVEKSNDYNTLLLQKEKLMKQIDEFHVIRVQDLEEREKKDQLLFQRYQKELNGF 1753

Human  1566 KAQFERDLQGRDEQSEEKKKQL-VRQ-VREMEAELEDERK-------QRSMAVAARKKLEMDLKD 1621
            |.|.|          ||::|.| :|| .|.|.||:.|.|.       :::..:.....|:.||:.
pombe  1754 KVQLE----------EEREKNLRIRQDNRHMHAEIGDIRTKFDELVLEKTNLLKENSILQADLQS 1808

Human  1622 LEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDT-RASREEILAQAKENEKKLKSMEAEMIQL 1685
            |....:|::..:..|..||..|.||::: :||.:.| |..::.:|.:.:..|:||..:..   ||
pombe  1809 LSRVNNSSSTAQQNAQSQLLSLTAQLQE-VREANQTLRKDQDTLLRENRNLERKLHEVSE---QL 1869

Human  1686 QEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELIND 1750
            .::..::.|...:.:.|::.|.                   |::.:||.::.|..       :.:
pombe  1870 NKKFDSSARPFDEIEMEKEVLT-------------------LKSNLAQKDDLLSS-------LVE 1908

Human  1751 RLKKANLQIDQINTDLNLERSHAQKNENARQQ---LERQNKELKVKLQEME-GTVKSKYKASITA 1811
            |:|:..:...:...|.|   :|.::|....:|   |:::.|:|::||.::: .|........:..
pombe  1909 RIKQIEMFALKTQKDSN---NHREENLQLHRQLGVLQKEKKDLELKLFDLDLKTYPISTSKDVRM 1970

Human  1812 LEAKIAQLEEQLDNETKERQAA---CKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLK 1873
            |:.:|:.||........||...   |:...||.::|:..:.:.||:::   :.:....:...|..
pombe  1971 LQKQISDLEASFAASDIERIKGIDECRNRDRTIRQLEAQISKFDDDKK---RIQSSVSRLEERNA 2032

Human  1874 QLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKL 1921
            ||:.|||:.:....:...:.|:.:..|::..|...::..:....::.|
pombe  2033 QLRNQLEDVQASETQWKFALRRTEHALQEERERVKSLETDFDKYRSLL 2080

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH9	NP_002464.1	Mediates interaction with LIMCH1. /evidence=ECO:0000269|PubMed:28228547	2..838		388/850 (46%)
		Myosin_N	27..72	CDD:460670	12/44 (27%)
		Motor_domain	95..764	CDD:473979	329/676 (49%)
		Actin-binding	654..676		13/21 (62%)
		Myosin_tail_1	841..1921	CDD:460256	281/1337 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1035..1057		9/32 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1118..1137		5/18 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1877..1960		7/45 (16%)
myp2	NP_593816.1	COG5022	17..1607	CDD:227355	557/1654 (34%)
		CCDC158	<1622..>2070	CDD:464943	107/497 (22%)