Protein Alignment MYH9 and nmy-1

DIOPT Version :10

• Sequence 1: NP_002464.1
• Gene: MYH9 / 4627
• HGNCID: 7579
• Length: 1960
• Species: Homo sapiens
• Sequence 2: NP_508504.2
• Gene: nmy-1 / 180581
• WormBaseID: WBGene00003776
• Length: 1963
• Species: Caenorhabditis elegans
• Alignment Length: 1972
• Identity: 991/1972 - (50%)
• Similarity: 1398/1972 - (70%)
• Gaps: 43/1972 - (2%)

Human     8 KYLYVDKNFINNPLAQADWAAKKLVWVPSDKSGFEPASLKEEVGEEAIVELVENGKKVKVNKDDI 72
            :||.|.:..:.:|...|.||.:||.|||....||...|:|.|..:|.:||||:..::|.:::||:
 Worm     5 QYLQVQRAAVADPATLAAWAQRKLCWVPDQNEGFLIGSIKRETNDEVLVELVDTSRQVTISRDDV 69

Human    73 QKMNPPKFSKVEDMAELTCLNEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEM 137
            ||.|||||.|:|||:|||.|||||||||||:||||.|||||||||||||||||.||||||:::|.
 Worm    70 QKANPPKFDKIEDMSELTYLNEASVLHNLKDRYYSSLIYTYSGLFCVVINPYKKLPIYSEDLIEE 134

Human   138 YKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAYVASSHKSK- 201
            :||||||||||||:||.|||||||:|:||||||||||||||||||||||||||||:||.:.::|
 Worm   135 FKGKKRHEMPPHIFAIADTAYRSMLQEREDQSILCTGESGAGKTENTKKVIQYLAHVAGATRNKS 199

Human   202 ----------------KDQGELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIV 250
                            ...||||.||||||||||||||:||||||||||||||||||||::|||.
 Worm   200 LNAAAQQNIVQKPDVRNPIGELEHQLLQANPILEAFGNSKTVKNDNSSRFGKFIRINFDMSGYIS 264

Human   251 GANIETYLLEKSRAIRQAKEERTFHIFYYLLSGAGEHLKTDLLLEPYNKYRFLSNGHVTIPGQQD 315
            |||||.|||||||.:|||::||:|||||.:|.|.....|::.|||..:.||||.|..:|:|...|
 Worm   265 GANIEFYLLEKSRVLRQAQDERSFHIFYQILRGCSAKEKSEYLLEGVDNYRFLVNRGITLPNVDD 329

Human   316 KDMFQETMEAMRIMGIPEEEQMGLLRVISGVLQLGNIVFKKERNTDQASMPDNTAAQKVSHLLGI 380
            ...|..|:.:|||||..::|...::||:|.||.|||:.|.:|:.:|||.:.|:...|||.||||:
 Worm   330 VQEFHSTINSMRIMGFADDEISSIMRVVSAVLLLGNLEFTQEKKSDQAMLQDDRVIQKVCHLLGL 394

Human   381 NVTDFTRGILTPRIKVGRDYVQKAQTKEQADFAIEALAKATYERMFRWLVLRINKALDKTKRQGA 445
            .|.:..:..|.|||||||::|.|||.:|||:||:||:|||:|||:|:|||.||||:||:|.||||
 Worm   395 PVIELQKAFLRPRIKVGREFVNKAQNQEQAEFAVEAIAKASYERLFKWLVTRINKSLDRTHRQGA 459

Human   446 SFIGILDIAGFEIFDLNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQP 510
            |||||||||||||||:|||||:||||||||||||||:|||||||||||||||||:||||||||||
 Worm   460 SFIGILDIAGFEIFDINSFEQICINYTNEKLQQLFNNTMFILEQEEYQREGIEWDFIDFGLDLQP 524

Human   511 CIDLIEKPAGPPGILALLDEECWFPKATDKSFVEKVMQEQGTHPKFQKPKQLKDKADFCIIHYAG 575
            .|||||||.   |:||||||||.||||.|||||||:.:....||||..| .::.|:.|.::||||
 Worm   525 TIDLIEKPM---GVLALLDEECLFPKANDKSFVEKLQKTHNKHPKFIVP-DMRSKSHFAVVHYAG 585

Human   576 KVDYKADEWLMKNMDPLNDNIATLLHQSSDKFVSELWKDVDRIIGLDQVAGMSETALPGAFKTRK 640
            :|||.||:||||||||||:|:..|:..|:|.||:.:|||.: ..|: ..|.|:|||.  ..::||
 Worm   586 RVDYSADQWLMKNMDPLNENVVGLMQNSTDPFVAGIWKDAE-FAGI-CAAEMNETAF--GMRSRK 646

Human   641 GMFRTVGQLYKEQLAKLMATLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICR 705
            ||||||.||:||||.|||.|||||:|:||||||||||||:||::.:|||:|||||||||||||||
 Worm   647 GMFRTVSQLHKEQLTKLMTTLRNTSPHFVRCIIPNHEKKSGKINSNLVLEQLRCNGVLEGIRICR 711

Human   706 QGFPNRVVFQEFRQRYEILTPNSIPKGFMDGKQACVLMIKALELDSNLYRIGQSKVFFRAGVLAH 770
            |||||||.|||||.|||||||:.|||.|:|||::...||.||::|:|||||||||||||.|||||
 Worm   712 QGFPNRVPFQEFRHRYEILTPDVIPKNFIDGKESVRKMITALDIDTNLYRIGQSKVFFRTGVLAH 776

Human   771 LEEERDLKITDVIIGFQACCRGYLARKAFAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVK 835
            ||||||||:|.:|:.|||.|||:|:|:.:.:||||.:|::::|||..||||||||||||||||||
 Worm   777 LEEERDLKLTALIMNFQAQCRGFLSRRLYTRRQQQSSAIRIIQRNGLAYLKLRNWQWWRLFTKVK 841

Human   836 PLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAE 900
            |||||:|.::|:.||::||...:|:.|..|:...|.|....|::.|:..:|||||.|:|..||.:
 Worm   842 PLLQVTRTDDEIRAKDDELRATKERLLKMEHDFRENEKKLDQVIVERAVIQEQLQQESENSAELD 906

Human   901 ELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLE 965
            ::|.||..:.||||.|.:|:..|:.|||::.:....|::|..:.:::||||||:||.|||||.|:
 Worm   907 DIRGRLQTRNQELEYIVNDMRDRLSEEEQQNEKNNDERRKQMETVRDLEEQLEQEEQARQKLLLD 971

Human   966 KVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMIT 1030
            |...:.:|:.|||..:.|:|...||.|||:|||:::...||.|.:.||::|...|.|.:.|..:.
 Worm   972 KTNVDQRLRNLEERLVELQDAYDKLLKEKRLLEEKVEGLTTQLLDHEERAKHGVKAKGRLENQLH 1036

Human  1031 DLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEE 1095
            :||:.|.||.:.:.|||:.:|||..:..|..|.:||...::.||..||.|::||||..|.|.:||
 Worm  1037 ELEQDLNRERQYKSELEQHKRKLLAELEDSKDHLAEKMGKVEELNNQLMKRDEELQHQLTRYDEE 1101

Human  1096 AAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQE 1160
            :|...:..|::|::::.|.||:||:|:||.:|||||..:|::..:||.:|.::.|.:|.....|:
 Worm  1102 SANVTLMQKQMRDMQTTIDELREDMETERNARNKAEMTRREVVAQLEKVKGDVLDKVDEATMLQD 1166

Human  1161 LRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENE 1225
            |.|::::|||..|:.:|:...|.|.:|:|.:.|.|:.||||.:|:||.|:.::.|||.:...:.|
 Worm  1167 LMSRKDEEVNATKRAIEQIQHTMEGKIEEQKAKFSRQVEELHDQIEQHKKQRSQLEKQQNQADQE 1231

Human  1226 RGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLS 1290
            |.::|.|:.:|...:.|.:.|||..||.|.|:|....|.:..:..|.|::.:.:.|||::..:..
 Worm  1232 RADMAQEIALLQASRADIDKKRKIHEAHLMEIQANLAESDEHKRTLIDQLERSRDELDHLNRVRE 1296

Human  1291 QSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNL 1355
            :.:...:.:.:..:..|.|:|:..|.:|||.|.|::...:.:|:|||||:..::.||.|..:.:|
 Worm  1297 EEEHAFANMQRRLATAEGQIQELNEQIQEETRLKIANINRARQLEDEKNALLDEKEEAEGLRAHL 1361

Human  1356 EKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQ 1420
            ||:|........:.::|.|:||.  :..||:::|..:|:|.|.::.||...|.:::.::|.::||
 Worm  1362 EKEIHAARQGAGEARRKAEESVN--QQLEELRKKNLRDVEHLQKQLEESEVAKERILQSKKKIQQ 1424

Human  1421 ELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARAL 1485
            ||:|..::|::.|.|..:.||:||||:..:|||:....|...:||....|.|::||:.|||...:
 Worm  1425 ELEDSSMELENVRASHRDSEKRQKKFESQMAEERVAVQKALLDRDAMSQELRDRETRVLSLLNEV 1489

Human  1486 EEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQA 1550
            :...|...|.:|:.:..:.|::|.:|:|||.||:||||||:||:||.::.:|:.|:|||||.||.
 Worm  1490 DIMKEHLEESDRVRRSLQQELQDSISNKDDFGKNVHELEKAKRSLEAELNDMRVQMEELEDNLQI 1554

Human  1551 TEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKL 1615
            .|||:|||||..||:|::.:|.:..:|.::|||::.|::|:|::|.|||:|::.:|.||:.|||:
 Worm  1555 AEDARLRLEVTNQALKSESDRAISNKDVEAEEKRRGLLKQIRDLENELENEKRGKSGAVSHRKKI 1619

Human  1616 EMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEA 1680
            |..:.:||..::.||:.::|..|||:|.|..:|:...|.::.|.::|:|.|..:|.::|.:::||
 Worm  1620 ENQIGELEQQLEVANRLKEEYNKQLKKNQQIIKEYQIECEEARQAKEDIAALLREADRKFRAVEA 1684

Human  1681 EMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNT 1745
            |..||:|......:|::|.:.|.|||.:..|..   |.::.||||||||:||||||||||||.|.
 Worm  1685 EREQLREANEGLMQARKQLELENDELEELRAKG---GGISSEEKRRLEAKIAQLEEELEEEQSNC 1746

Human  1746 ELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASIT 1810
            ||..|:.:||.:|::||.|||::||:..||.|..:|.|||.|::.|.|:.|:|...:|:.:|.:.
 Worm  1747 ELAIDKQRKAQVQLEQITTDLSMERTLNQKTEAEKQSLERSNRDYKAKITELESGAQSRARAQMA 1811

Human  1811 ALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQL 1875
            |||||:..||:||:.|.:|:.||.:..||.||:|.|...|.:||:|..||.|:..:|::.:.:.|
 Worm  1812 ALEAKVQYLEDQLNVEGQEKTAANRAARRLEKRLNDTTQQFEDEKRANEQAKELLEKSNLKNRNL 1876

Human  1876 KRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLK-NKLRRGDL----PFVVPRRMA 1935
            :|||:|||:|..|.....|.:|||.:|..:..:.:.||:.:|: |..||.|:    .|.||
 Worm  1877 RRQLDEAEDEMSRERTKHRNVQREADDLLDANEQLTRELMNLRGNNRRRADMRLRRGFDVP---- 1937

Human  1936 RKGAGD--GSDEEVDGKADGAE 1955
              |:.|  ..:||.:....|:|
 Worm  1938 --GSSDNLAREEENESNVSGSE 1957

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH9	NP_002464.1	Mediates interaction with LIMCH1. /evidence=ECO:0000269|PubMed:28228547	2..838		556/846 (66%)
		Myosin_N	27..72	CDD:460670	18/44 (41%)
		Motor_domain	95..764	CDD:473979	462/685 (67%)
		Actin-binding	654..676		17/21 (81%)
		Myosin_tail_1	841..1921	CDD:460256	419/1080 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1035..1057		9/21 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1118..1137		11/18 (61%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1877..1960		29/86 (34%)
nmy-1	NP_508504.2	Myosin_N	26..69	CDD:460670	17/42 (40%)
		MYSc_class_II	92..770	CDD:276951	462/685 (67%)
		Myosin_tail_1	847..1919	CDD:460256	417/1076 (39%)