DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MYH8 and didum

DIOPT Version :9

Sequence 1:NP_002463.2 Gene:MYH8 / 4626 HGNCID:7578 Length:1937 Species:Homo sapiens
Sequence 2:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster


Alignment Length:2098 Identity:532/2098 - (25%)
Similarity:897/2098 - (42%) Gaps:523/2098 - (24%)


- Green bases have known domain annotations that are detailed below.


Human    22 SEKERIEAQNKPFDAKTSVFVAEP---KESYVKSTIQSK---EGGK---VTVKTEGGATLTVRED 77
            |.:|.:.||........:..|.|.   :|||.|.....|   :.||   |.:|.:|.....:|  
  Fly     2 SSEEMLYAQGAKIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLR-- 64

Human    78 QVFPMNPPKYDKIEDMAMMTHLHEPGVLYNLKERYA-AWMIYTYSGLFCVTVNPYKWLPVYKPEV 141
                 ||.......|:..:::|||||||:||:.|:. ..:||||.|:..|.:|||..:|:|.|.:
  Fly    65 -----NPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSI 124

Human   142 VAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGE 206
            :.||||....:..||||::::.||..:..:..|.||:::|||||||||:.|..::|||  ||.|.
  Fly   125 IRAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFA--AVGGS 187

Human   207 KKKDESGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHF-GTTGK--LASADIET 268
            :.:.:       :|.::::::|::||||||||.|||||||||||.::.| ...|.  |..|.:.|
  Fly   188 ESETQ-------VERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHT 245

Human   269 YLLEKSRVTFQLKAERSYHIFYQITS--NKKPDLIEMLLITTNPYDYAFVSQGEI-TVPSIDDQE 330
            ||||||||.:|.:.||:||||||:.:  :|.|:     |:..:...:.|::.|.. .:..:.|.|
  Fly   246 YLLEKSRVVYQAQGERNYHIFYQLCAARSKYPE-----LVLDHQDKFQFLNMGGAPEIERVSDAE 305

Human   331 ELMATDSAIDILGFTPEEKVSIYKLTGAVMHYGNMKFKQKQRE--EQAEPDGTEVADKAAYLQSL 393
            :...|..|:.:|||:.::...|.|:...::|.||::..:|..|  |:.:.|..::.....:||. 
  Fly   306 QFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQI- 369

Human   394 NSADLLKA--------LCYPRVKVGNEYVTKGQTVQQVYNAVGALAKAVYEKMFLWMVTRINQQL 450
             :||||:.        |...:::..||||....:::....|..||||.:|.|:|.::|..:|:.|
  Fly   370 -TADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSL 433

Human   451 DTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFID 515
            :....:..|||||||.|||.|:.||.||.|||:.||||||.||.|:|.||||||.||||.||.||
  Fly   434 NNGSKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMID 498

Human   516 FGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKSANFQKPKVVKGKAEAHF 580
            | .|...||:|||..||:..:|:|||..||.:|.|:..||..: ..|..:|:||:.    ....|
  Fly   499 F-YDNQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKLIGK-CNKFPHFEKPRF----GTTSF 557

Human   581 SLIHYAGTVDYNITGWLDKNKDPLNDTVVGLYQKSAMKTLASLFSTYASAEADS----SAKK--- 638
            .:.|::.||:|::.|:|:||:|.::..:..:..:|.| :||....|.  .|.|:    |||.   
  Fly   558 FIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNM-SLAKQVMTL--EEIDTLCVDSAKSSTL 619

Human   639 --------GAKKKGSSF-----------QTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTP 684
                    |.|::|:..           :||.:.|:|:|..|::.|.:|.||:||||.||:.|..
  Fly   620 GGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVA 684

Human   685 GAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVL-NASAIPEGQFIDSKKASEKL 748
            ...|...::.|||..||||.:||...|||||.||.||..||::| ..|.:.:.   |.|.:...:
  Fly   685 FKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN---DMKLSCRNI 746

Human   749 LASIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDEKLAQIITRTQAV------------------- 794
            :.....|..:|:||:|::||:||.:..||::|.....:.||..|:|                   
  Fly   747 VMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVING 811

Human   795 ----CRGFLMRVEYQKMLQRREALFCIQYNVRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATM 855
                .||:|.|...|||.:.|..|...:|       .:.|...:.:.:::..:...:|.......
  Fly   812 IQKHARGYLARERTQKMREARAGLILSKY-------ARGWLCRRRYLRLRHSISGIQTYARGMLA 869

Human   856 KEEFQKTKDELAKSEAKR-------KELEEKMVTLLKEKNDLQLQ--------------VQSEAD 899
            :.:|...:|.....:.:|       :...:|     :.:|.:..|              :::||.
  Fly   870 RNKFHAMRDHYRAVQIQRFVRGALARRAYQK-----RRRNIIICQAAIRRFLARRKFKRMKAEAK 929

Human   900 SLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTL 964
            :::..|.:...|....|.::.:|.|:.......:...:|::..|.||     ||||.::      
  Fly   930 TISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKL-----ELKKTLE------ 983

Human   965 AKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTK 1029
            |:.:..|.|.::|           |:.|..|:|:              |:||.|:...|      
  Fly   984 AEFKNVKAACQDK-----------DKLIEALNKQ--------------LEAERDEKMQL------ 1017

Human  1030 LEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLA---------QESTMDMENDKQQLDEKLEK 1085
            ||:.....|..:.|::..|.:.|..:|:::..:.:|         ||..|..|.|.::|:|..::
  Fly  1018 LEENGHAQEEWISQKQTWRQENEELRRQIDEIIDMAKNAEVNQRNQEDRMLAEIDNRELNEAYQR 1082

Human  1086 KEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAE----------KQRS 1140
                      .|:|::.:|.: ...:||..:|:......:.|.:||.|.::          |...
  Fly  1083 ----------AIKDKEVIENE-NFMLKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTL 1136

Human  1141 DLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAE 1205
            |::|..:.:|:.. ....:||..|:|....|.|.||      ...||.:.:..:.|.|..:....
  Fly  1137 DINRPPDLLSKNY-SYNDSTSLVVKLRSILEEEKQK------HKVLQEQYIKLSSRHKPTEDSFR 1194

Human  1206 LGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQ 1270
            :.|           ||.|..:|:.|.|.|.::      .|..:|                     
  Fly  1195 VSE-----------LEVENEKLRSEYDQLRTS------IKHGVE--------------------- 1221

Human  1271 RLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHA 1335
              ||:|.||.|.||.|......:..:..|::.|.|:|.::           ||.|         :
  Fly  1222 --INELNAQHAALQEEVRRRREECIQLKAVLLQQSQSMRS-----------LEPE---------S 1264

Human  1336 LQSSRHDCDLLREQYEEE----QEGKAELQRALSKANSEVAQW-----RTKYETDAIQRT----- 1386
            ||...:|.:.|.|.:..:    ::.::||:....:.||::.:.     |...|.|.:|:.     
  Fly  1265 LQMRGNDVNELMEAFHSQKLINRQLESELKAITEEHNSKLVEMTQEIERLNNEKDELQKVMFESI 1329

Human  1387 EELEEAK--------KKLAQRLQEA-------EEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVE 1436
            :|.|::.        :.|.:.||:|       :|.::..|||..:..:...:|::::|:.|:. .
  Fly  1330 DEFEDSNVDTLRQNDRYLRRELQKAVAQFLLVQEELKLANAKLKAYRQDGGQLEHKIEEEMIR-N 1393

Human  1437 RSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKE-----SRSLS--------------- 1481
            :||...|         |...:..|||.:..|..::....:     .|.||               
  Fly  1394 KSNGTSA---------DVGANVTKQKSQNPQGLMKFHSSDLDKILQRLLSALTPRTVVGLLPGFP 1449

Human  1482 ----------TELFK----VKNVYEESLDQLETLRR-----ENK-----------NLQQEISDLT 1516
                      |:|..    |:.:..:.:.|::.:.|     ||:           ||.::..|:.
  Fly  1450 AYLIFMCIRYTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNLMKQYGDVD 1514

Human  1517 EQIAEGGKQIHELEKIKKQVEQEK----CEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDR 1577
            |.:        :....|:..:|.|    .|.:..:.:...:|         .|..:.|::..:|.
  Fly  1515 EYV--------KFNTEKQNQQQLKNFNLFEYRRVILDLIVNL---------YQALIMQIQGLLDP 1562

Human  1578 KIAE---KDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLA 1639
            ||..   .::||.:.::.|.  :.:..:::.|.....:......|::.|.|.....|..|     
  Fly  1563 KIVPAILNNDEIQRGRQAHG--MRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQH----- 1620

Human  1640 AESLRNYRNTQGILKETQLHLDDALRGQ--EDLKEQLAIVERRANLLQAEIEELWAT-------- 1694
                              ..||:....|  ..|...:..|.....:|:.:| .:|.|        
  Fly  1621 ------------------FGLDNCYAEQIFHQLLYFICAVALNCLMLRGDI-CMWETGMIIRYNI 1666

Human  1695 --LEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEK 1757
              :|...||                             ||:.|||....:.:.:|.|        
  Fly  1667 GCIEDWVRS-----------------------------KKMSNDVLTALAPLNQVSQ-------- 1694

Human  1758 AKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARV 1822
                      :.:..|.|||.            ||:.||...|..|:.|.:....|        :
  Fly  1695 ----------LLQSRKSEQDV------------QTICDLCTSLSTAQVLKVMKSYK--------L 1729

Human  1823 RELEGEVEN------EQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSY 1881
            .:.|.|:.|      .:|.||..::.....|..:.:...|   ..|.|.|..|:           
  Fly  1730 DDYESEITNVFLEKLTEKLNARQMQKSNSDEFTIDQKFIQ---PFKVVFRYSDI----------- 1780

Human  1882 KRQAEEAEEQSNANLSKF 1899
              :.|:.|..|:.||.:|
  Fly  1781 --KLEDIELPSHLNLDEF 1796

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYH8NP_002463.2 Myosin_N 38..75 CDD:280832 12/45 (27%)
Myosin_head 90..769 CDD:278492 274/722 (38%)
MYSc_Myh8 102..769 CDD:276882 270/710 (38%)
Actin-binding 658..680 11/21 (52%)
Actin-binding 760..774 7/13 (54%)
Myosin_tail_1 849..1926 CDD:279860 217/1195 (18%)
eIF-4B <1042..1099 CDD:283846 13/65 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1126..1146 7/29 (24%)
COG6 1375..>1510 CDD:303003 37/204 (18%)
DUF342 <1505..1581 CDD:302792 15/90 (17%)
TMPIT 1741..>1828 CDD:285135 15/86 (17%)
didumNP_724569.1 MYSc 65..778 CDD:214580 281/740 (38%)
MYSc_Myo5 84..767 CDD:276831 270/710 (38%)
IQ 900..922 CDD:197470 3/26 (12%)
GBP_C <971..1086 CDD:303769 36/166 (22%)
coiled coil 1049..1068 CDD:293879 3/18 (17%)
coiled coil 1077..1086 CDD:293879 2/18 (11%)
JAKMIP_CC3 <1190..1299 CDD:292653 33/168 (20%)
Myo5_CBD 1424..1792 CDD:271254 79/493 (16%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.910

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