DRSC/TRiP Functional Genomics Resources

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Protein Alignment MYH8 and ck

DIOPT Version :9

Sequence 1:NP_002463.2 Gene:MYH8 / 4626 HGNCID:7578 Length:1937 Species:Homo sapiens
Sequence 2:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster


Alignment Length:2086 Identity:529/2086 - (25%)
Similarity:882/2086 - (42%) Gaps:422/2086 - (20%)


- Green bases have known domain annotations that are detailed below.


Human    29 AQNKPFDAKTSVFVAEPKESYVKSTIQSKEGGKVTVKTEGGATLTVR-EDQVFPMNPPKYDKIED 92
            |..:.||..            :.:.:.|.||.::.|:.:.|..:.:. |.::..|:......:||
  Fly    15 ASGREFDVA------------IGARVVSAEGRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVED 67

Human    93 MAMMTHLHEPGVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYKPEVVAAYRGKKRQEAPPHI 157
            |..:..|||.|:|.||..||...:||||:|...|.||||:.||:|..:.:..|:.:|..|.||||
  Fly    68 MISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHI 132

Human   158 FSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEKKKDESGKMQGTLEDQ 222
            |:|.||||..|...|::|.|:|:||||||||.:||.::||.|.|          ||| ...:|.|
  Fly   133 FAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAI----------SGK-HSWIEQQ 186

Human   223 IISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYH 287
            |:.|||:|||||||||:||||||||||:|.|||...|.:..|.||.|||||||:..|..:||:||
  Fly   187 ILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYH 251

Human   288 IFYQITSNKKPDLIEMLLITTNPYDYAFVSQG-EITVPSIDDQEELMATDSAIDILGFTPEEKVS 351
            :||.|.:....|....|.:.. ..||.:::.| .||....||..|.....||:.:|.|:.:|...
  Fly   252 VFYCILAGLSADEKSRLDLGM-AADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWE 315

Human   352 IYKLTGAVMHYGNMKFKQKQREEQAEPDGTEV-----ADKAAYLQSLNSADLLKALCYPRVKVGN 411
            |.||..|::|.||:|:|....:..   |.||:     .::.|.|..|....|:.||....:....
  Fly   316 IIKLLAALLHCGNIKYKATVVDNL---DATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHG 377

Human   412 EYVTKGQTVQQVYNAVGALAKAVYEKMFLWMVTRINQQLDTKQPR---QYFIGVLDIAGFEIFDF 473
            |.|....:..|..:...|..|.:|.:||:.:|.:||..:  .:||   :..||||||.|||.||.
  Fly   378 ETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAI--FKPRGTSRNAIGVLDIFGFENFDQ 440

Human   474 NSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIE-KPLGIFSIL 537
            ||.||.|||:.||.|||||..|:|.||||||..|.|.|..|:| :|....::||. |.|.|.:::
  Fly   441 NSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDALDLIAIKQLNIMALI 504

Human   538 EEECMFPKATDTSFKNKLYDQHLGKSANFQKPKVVKGKAEAHFSLIHYAGTVDYNITGWLDKNKD 602
            :||..|||.||.:...||:..| |...|:.||   |......|.|.|:||.|.|:..|:||||:|
  Fly   505 DEEARFPKGTDQTMLAKLHKTH-GSHKNYLKP---KSDINTSFGLNHFAGVVFYDTRGFLDKNRD 565

Human   603 PLNDTVVGLYQKSAMKTLASLFSTYASAEADSSAKKGAKKKGSSFQTVSALFRENLNKLMTNLRS 667
            ..:..::.|..:|..|.|..:|:        ...:.||:.:..: .|:|..||::|:.||..|.|
  Fly   566 TFSPDLLHLVSQSTNKFLRQIFA--------QDIEMGAETRKRT-PTLSTQFRKSLDALMKTLSS 621

Human   668 THPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASA 732
            ..|.|:|||.|||.|.|...:..|...|||.:|::|.|||.|.|:|.|..:.:|.:||:.| ...
  Fly   622 CQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFL-IPG 685

Human   733 IPEGQFIDSKKASEKLLASIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDEKLAQIITRTQAVCRG 797
            :|.....|.:.|:.::.|.: :..:.|:.||||||.|......||:.||..|.:.|...|...||
  Fly   686 VPPAHRTDCQAATSRICAVV-LGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRG 749

Human   798 FLMRVEYQKMLQRREALFCIQYNVRAFMNVKHWPWMKL-FFKIKPLLKSAETEKEMATMKEEFQK 861
            ::.|   ::.|:.|.|...:|...:.:...|.:..|:: :.:::.|::|       ..:...|:.
  Fly   750 WVYR---RRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRS-------RVLSHRFRH 804

Human   862 TKDEL------AKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEA 920
            .:..:      |:....|:|...||..::|.::.::..:         |..|     ..|::||.
  Fly   805 LRGHIVGLQAHARGYLVRREYGHKMWAVIKIQSHVRRMI---------AMRR-----YRKLRLEH 855

Human   921 KIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEM 985
            |     :.||         ..:.||||::  ||..            ...|||.|...::..:.:
  Fly   856 K-----QFAE---------VLQLRKLEEQ--ELLH------------RGNKHAREIAEQHYRDRL 892

Human   986 AGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDD---LEGSLE----- 1042
            ..|         |::.:||    .|::.:..|..:||:..|..|.|:.|||   :|...:     
  Fly   893 HEL---------ERREIQE----QLENRRRVEVNMNIINDAARKQEEPVDDGKLVEAMFDFLPDS 944

Human  1043 ----------QEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDE-KLEKKEFEISNLISK 1096
                      :|..:..||..|:...:.|:    .:.:.:..|::.|.| |.:|  |..:.....
  Fly   945 SSDAPTPHGGRETSVFNDLPHAQNVNQDDI----IAPIHISEDEEDLSEFKFQK--FAATYFQGN 1003

Human  1097 IEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS 1161
            :..:.|     :|.:|.....:...|:::.|: |......:...|:........:|::.....:.
  Fly  1004 VNHQYA-----KKALKHPLLPLHTQGDQLAAQ-ALWITILRFTGDMPEPKYHTMDRMDTTSVMSK 1062

Human  1162 AQVELNKK--REAEFQK-----------LRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNL 1213
            ....|.:.  |..|||:           |::  :..:::|:.:...|::|:     :|||.    
  Fly  1063 VTATLGRNFIRSKEFQEAQLMGLDPDAFLKQ--KPRSIRHKLVSLTLKRKN-----KLGED---- 1116

Human  1214 QRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKM---------------------CRSLED 1257
              |:::|:.:    :...|...|..:  |:...||||:                     |:.|.:
  Fly  1117 --VRRRLQDD----EYTADSYQSWLQ--SRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTN 1173

Human  1258 QVSELKTKEEE--------------QQRLINDLTAQRARLQTEAGEYSRQLDEK----------- 1297
              :.||:....              .::.:|.|   ||.::.....|:...:|:           
  Fly  1174 --NPLKSSHARGWILLSLCVGCFAPSEKFVNYL---RAFIREGPPGYAPYCEERLKRTFNNGTRN 1233

Human  1298 ---DALVSQLSRSKQA------------------STQQIEELKHQLEEETKAKNALAHAL----- 1336
               ..|..|.::||:.                  |.....||.:||.::...|:....:|     
  Fly  1234 QPPSWLELQATKSKKPIMLPITFMDGNTKTLLADSATTARELCNQLSDKISLKDQFGFSLYIALF 1298

Human  1337 -------QSSRHDCDLLR--EQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEA 1392
                   ....|..|.:.  |||.:||           .|....|.||..:..:......  |..
  Fly  1299 DKVSSLGSGGDHVMDAISQCEQYAKEQ-----------GAQERNAPWRLFFRKEIFAPWH--EPT 1350

Human  1393 KKKLAQRL--QEAEEHVEAVNAKC---------------------ASLEKTKQRLQNEVEDLMLD 1434
            ..::|..|  |:....|:....:|                     .|:|:....|.|.:.|..|.
  Fly  1351 HDQVATNLIYQQVVRGVKFGEYRCDKEEDLAMIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLS 1415

Human  1435 -VERSNAACAALDKKQRNFDKVLSEWKQKY--EETQAELEASQKESRSLSTELFKVKNVYEESLD 1496
             |:::....|||         ||..:|:.|  ::..|.|:..:.   .:|...:|...::...  
  Fly  1416 GVDKAIERWAAL---------VLQAYKKSYYVKDKIAPLKIKED---IVSYAKYKWPLLFSRF-- 1466

Human  1497 QLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKI 1561
             .|..|....||.:  :|:.  ||.....::.::      :||:..::.:..|..|....:..|:
  Fly  1467 -YEAYRNSGPNLPK--NDVI--IAVNWTGVYVVD------DQEQVLLELSFPEITAVSSQKTNKV 1520

Human  1562 LRIQLELNQVKSEVDRKIAEKDEEI--------DQLKRNHTRVVETMQSTLDAEIRSRNDALRVK 1618
            ......|:.|:.|.....:...|:|        |.||:....|:...      :.|:.:|.....
  Fly  1521 FTQTFSLSTVRGEEFTFQSPNAEDIRDLVVYFLDGLKKRSKYVIALQ------DYRAPSDGTSFL 1579

Human  1619 KKMEGDLNEMEIQLNHANRLAAESLRN----------YRNTQGILKETQLHLDDALRGQEDLKEQ 1673
            ...:|||..:|      :....||:.|          .:.......||...|....:..:|:   
  Fly  1580 SFFKGDLIILE------DESCGESVLNNGWCIGRCDRSQERGDFPAETVYVLPTLSKPPQDI--- 1635

Human  1674 LAI--VERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLEND 1736
            ||:  :|...:..:..:......:|..:|...:.|..|  ...|:....|.:.:|..:.|:.|..
  Fly  1636 LALFNIEEAHHGRRLSMASNGGAVEPRDRPHTLMEYAL--DHFRLPPKRTMSKTLTLSSKRSEEL 1698

Human  1737 VSQLQSEVE-EVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKD--LQH 1798
            ....:..:: .::::.::.||.|::|   ....|..||...|..:...||...:...:.|  |:|
  Fly  1699 WRYSRDPIKAPLLRKLQSKEEFAEEA---CFAFAAILKYMGDLPSKRPRMGNEITDHIFDGPLKH 1760

Human  1799 RLDEAE---QLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAV----------KGLRKHERRV 1850
            .:...|   ||     .||:.....|:.|         :|..|.:          :||      :
  Fly  1761 EILRDEIYCQL-----MKQLTDNRNRMSE---------ERGWELMWLATGLFACSQGL------L 1805

Human  1851 KELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHEL---EEAEER 1912
            |||.......|..:  .||.:.:||..::..:|:....:.:..|...|..::.|::   ::.:|.
  Fly  1806 KELLLFLRTRRHPI--SQDSMHRLQKTIRHGQRKYPPHQVEVEAIQHKTTQIFHKVYFPDDTDEA 1868

Human  1913 ADIAES 1918
            .::..|
  Fly  1869 FEVDSS 1874

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYH8NP_002463.2 Myosin_N 38..75 CDD:280832 5/36 (14%)
Myosin_head 90..769 CDD:278492 280/688 (41%)
MYSc_Myh8 102..769 CDD:276882 274/676 (41%)
Actin-binding 658..680 11/21 (52%)
Actin-binding 760..774 7/13 (54%)
Myosin_tail_1 849..1926 CDD:279860 220/1254 (18%)
eIF-4B <1042..1099 CDD:283846 11/72 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1126..1146 3/19 (16%)
COG6 1375..>1510 CDD:303003 29/160 (18%)
DUF342 <1505..1581 CDD:302792 13/75 (17%)
TMPIT 1741..>1828 CDD:285135 20/92 (22%)
ckNP_001285949.1 MYSc 64..733 CDD:214580 283/701 (40%)
MYSc_Myo7 77..721 CDD:276832 274/676 (41%)
MyTH4 <1138..1245 CDD:214535 16/111 (14%)
B41 1251..1467 CDD:214604 42/243 (17%)
FERM_B-lobe 1355..1439 CDD:271216 19/92 (21%)
FERM_C1_MyoVII 1461..1559 CDD:270019 20/110 (18%)
SH3 1560..1624 CDD:302595 12/75 (16%)
MyTH4 1701..1849 CDD:214535 34/172 (20%)
B41 1856..2068 CDD:214604 3/19 (16%)
FERM_M 1966..2068 CDD:278785
FERM_C2_MyoVII 2064..2159 CDD:270020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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