DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYH8 and LOC100495212

DIOPT Version :9

Sequence 1:	NP_002463.2	Gene:	MYH8 / 4626	HGNCID:	7578	Length:	1937	Species:	Homo sapiens
Sequence 2:	XP_031750436.1	Gene:	LOC100495212 / 100495212	-ID:	-	Length:	1936	Species:	Xenopus tropicalis

Alignment Length:	1932	Identity:	1653/1932 - (85%)
Similarity:	1809/1932 - (93%)	Gaps:	2/1932 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     4 SSDAEMAVFGEAAPYLRKSEKERIEAQNKPFDAKTSVFVAEPKESYVKSTIQSKEGGKVTVKTEG 68
            ||||||||||.||.:|||:|||||||||:||||||||||.:||:.|||..:|||||||.|||.|.
Frog     2 SSDAEMAVFGVAAQFLRKNEKERIEAQNRPFDAKTSVFVIDPKQMYVKGIVQSKEGGKATVKKED 66

Human    69 GATLTVREDQVFPMNPPKYDKIEDMAMMTHLHEPGVLYNLKERYAAWMIYTYSGLFCVTVNPYKW 133
            .:|.||::|::|||||||:||||||||:|||:||.||||||||||||||||||||||||||||||
Frog    67 MSTATVKDDEIFPMNPPKFDKIEDMAMLTHLNEPSVLYNLKERYAAWMIYTYSGLFCVTVNPYKW 131

Human   134 LPVYKPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYF 198
            ||||.||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   132 LPVYNPEVVNAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYF 196

Human   199 ATIAVTGEKKKDES--GKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKL 261
            ||||..|:|||:|:  ||:|||||||||.||||||||||||||||||||||||||||||||||||
Frog   197 ATIAAIGDKKKEEAAPGKIQGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKL 261

Human   262 ASADIETYLLEKSRVTFQLKAERSYHIFYQITSNKKPDLIEMLLITTNPYDYAFVSQGEITVPSI 326
            :||||||||||||||||||.|||||||||||.|||:|:||:||||||||:|:.|||||||:|.||
Frog   262 SSADIETYLLEKSRVTFQLSAERSYHIFYQIMSNKRPELIDMLLITTNPFDFPFVSQGEISVASI 326

Human   327 DDQEELMATDSAIDILGFTPEEKVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQ 391
            ||||||||||||||||||..:|||.|||:|||||||||||||||||||||||||||||||||||.
Frog   327 DDQEELMATDSAIDILGFNADEKVGIYKMTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLM 391

Human   392 SLNSADLLKALCYPRVKVGNEYVTKGQTVQQVYNAVGALAKAVYEKMFLWMVTRINQQLDTKQPR 456
            .|||||||||||:||||||||:||||||||||||:||||.|:||||||||||.||||||||||||
Frog   392 GLNSADLLKALCFPRVKVGNEFVTKGQTVQQVYNSVGALGKSVYEKMFLWMVIRINQQLDTKQPR 456

Human   457 QYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLA 521
            |:|||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||
Frog   457 QHFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLA 521

Human   522 ACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKSANFQKPKVVKGKAEAHFSLIHYA 586
            |||||||||:||||||||||||||||||||||||||||||||.||||||..||||||||||:|||
Frog   522 ACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKPGKGKAEAHFSLVHYA 586

Human   587 GTVDYNITGWLDKNKDPLNDTVVGLYQKSAMKTLASLFSTYASAEADSSAKKGAKKKGSSFQTVS 651
            |||||||:|||||||||||:||:||||||::|.|:.|:|.||.::||:..|||.|||||||||||
Frog   587 GTVDYNISGWLDKNKDPLNETVIGLYQKSSVKLLSFLYSAYAGSDADTGGKKGGKKKGSSFQTVS 651

Human   652 ALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRI 716
            |||||||||||:||||||||||||:|||||||||||:|.||:|||||||||||||||||||||||
Frog   652 ALFRENLNKLMSNLRSTHPHFVRCLIPNETKTPGAMDHYLVMHQLRCNGVLEGIRICRKGFPSRI 716

Human   717 LYGDFKQRYKVLNASAIPEGQFIDSKKASEKLLASIDIDHTQYKFGHTKVFFKAGLLGLLEEMRD 781
            ||||||||||:||||||||||||||||||||||.|||:||||||||||||||||||||.||||||
Frog   717 LYGDFKQRYKILNASAIPEGQFIDSKKASEKLLGSIDVDHTQYKFGHTKVFFKAGLLGTLEEMRD 781

Human   782 EKLAQIITRTQAVCRGFLMRVEYQKMLQRREALFCIQYNVRAFMNVKHWPWMKLFFKIKPLLKSA 846
            ::|||:||||||:|||||||||::||::|||::||||||:|:||||||||||||:||||||||||
Frog   782 DRLAQLITRTQAMCRGFLMRVEFRKMMERRESVFCIQYNIRSFMNVKHWPWMKLYFKIKPLLKSA 846

Human   847 ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQL 911
            |:||||..|||||:|||:.||||||||||||||||.:|:|||||||||.||::.|||||||||.|
Frog   847 ESEKEMQNMKEEFEKTKEALAKSEAKRKELEEKMVAILQEKNDLQLQVTSESEGLADAEERCEGL 911

Human   912 IKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN 976
            ||.||||||||||..||.|:|||.|||||||||||||||||||||||||||||||||||||||||
Frog   912 IKAKIQLEAKIKEANERLEDEEESNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN 976

Human   977 KVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSL 1041
            ||||||||||.||||||||:||||||||.||||||||||||||||.|||||||||||||||||||
Frog   977 KVKNLTEEMAVLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKTKLEQQVDDLEGSL 1041

Human  1042 EQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQ 1106
            |||||||||:||||||||||||||||||||:|||:||||||::|||||||.|.||||||||:..|
Frog  1042 EQEKKLRMDMERAKRKLEGDLKLAQESTMDLENDRQQLDEKVKKKEFEISQLQSKIEDEQALAAQ 1106

Human  1107 LQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKRE 1171
            |||||||||||||||.||||||||:||||||||||||||||||||||||||||||||:|:|||||
Frog  1107 LQKKIKELQARIEELEEEIEAERAARAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKRE 1171

Human  1172 AEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSS 1236
            |||||:|||||||||||||..||||||.|||:|||||||||||||||||||||||||||.|||:|
Frog  1172 AEFQKMRRDLEEATLQHEATAAALRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDLAS 1236

Human  1237 NAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALV 1301
            |.|::||||.|||||||:||||.||:||||||..|:|||:.||||||.||.|||:|||:||::|:
Frog  1237 NMESVSKAKSNLEKMCRTLEDQFSEVKTKEEEHLRVINDINAQRARLHTENGEYARQLEEKESLI 1301

Human  1302 SQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSK 1366
            |||||:|||.|||.||||.||||||||||||||.|||:||||||||||||||||.|.||||:|||
Frog  1302 SQLSRAKQAFTQQTEELKRQLEEETKAKNALAHGLQSARHDCDLLREQYEEEQEAKGELQRSLSK 1366

Human  1367 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDL 1431
            ||.||||||||||||||||||||||||||||||||||||.:||||:|||||||||||||||||||
Frog  1367 ANGEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQNEVEDL 1431

Human  1432 MLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLD 1496
            |:||||||:|||||||||:||||||::||||:||:|||||||||||||||||:||:||.|||:||
Frog  1432 MVDVERSNSACAALDKKQKNFDKVLADWKQKFEESQAELEASQKESRSLSTEVFKMKNSYEEALD 1496

Human  1497 QLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKI 1561
            |||||:||||||||||||||||:||.||.|||:||.|||:|.||.::|||||||||||||||.||
Frog  1497 QLETLKRENKNLQQEISDLTEQVAEAGKSIHEIEKAKKQIESEKSDLQAALEEAEASLEHEEAKI 1561

Human  1562 LRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLN 1626
            |||||||||||.|:|||||||||||:|:|||..|.:|:|||||||||||||||||:|||||||||
Frog  1562 LRIQLELNQVKGEIDRKIAEKDEEIEQIKRNSQRALESMQSTLDAEIRSRNDALRLKKKMEGDLN 1626

Human  1627 EMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEEL 1691
            ||||||:||||.||||.:..||.|.:.|:|||||||||||.:||||||||||||.||:.|||||:
Frog  1627 EMEIQLSHANRQAAESQKQLRNVQSLYKDTQLHLDDALRGNDDLKEQLAIVERRNNLMTAEIEEM 1691

Human  1692 WATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEE 1756
            .:.||||||.||:|||||:|.:|||||||:|||||||||||||.|||||||||||.:||:|||:|
Frog  1692 RSALEQTERGRKVAEQELIDVTERVQLLHSQNTSLINTKKKLEADVSQLQSEVEEAVQEARNADE 1756

Human  1757 KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEAR 1821
            |||||||||||||||||||||||||||||||||||||||||||||||||||:||||||:||||||
Frog  1757 KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLAMKGGKKQLQKLEAR 1821

Human  1822 VRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAE 1886
            |||||.|::.||||.::|:||:||.|||||||:||:|||:|||.||||||||||.|||:||||:|
Frog  1822 VRELENELDAEQKRGSDAIKGVRKFERRVKELSYQSEEDKKNVFRLQDLVDKLQLKVKAYKRQSE 1886

Human  1887 EAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTK 1933
            :.|||:|.:||:|||.||||||||||||||||||||||.|||::..|
Frog  1887 DVEEQANVHLSRFRKAQHELEEAEERADIAESQVNKLRAKSRDIGKK 1933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYH8	NP_002463.2	Myosin_N	38..75	CDD:280832	23/36 (64%)
		Myosin_head	90..769	CDD:278492	610/680 (90%)
		MYSc_Myh8	102..769	CDD:276882	600/668 (90%)
		Actin-binding	658..680		19/21 (90%)
		Actin-binding	760..774		13/13 (100%)
		Myosin_tail_1	849..1926	CDD:279860	910/1076 (85%)
		eIF-4B	<1042..1099	CDD:283846	49/56 (88%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1126..1146		18/19 (95%)
		COG6	1375..>1510	CDD:303003	119/134 (89%)
		DUF342	<1505..1581	CDD:302792	62/75 (83%)
		TMPIT	1741..>1828	CDD:285135	80/86 (93%)
LOC100495212	XP_031750436.1	Myosin_N	35..73	CDD:397036	24/37 (65%)
		Motor_domain	100..769	CDD:419868	600/668 (90%)
		Myosin_tail_1	849..1926	CDD:396244	910/1076 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1779	1.000	Domainoid score	I142
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	3326	1.000	Inparanoid score	I187
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D12270at7742
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		mtm10347
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.060