|
Human 37 VFVPDDKQEFVKAKIVSRE--GGKVTAE------------TEYGKTVTVKEDQVMQQNPPKFDKI 87
|::||:|:.|||.:::|.: ..|.|.: ||....|.|:...|...||..|||:
Yeast 13 VWIPDEKEVFVKGELMSTDINKNKFTGQEEQIGIVHPLDSTEVSNLVQVRISDVFPVNPSTFDKV 77
Human 88 EDMAMLTFLHEPAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGK------- 145
|:|:.||.|:||:|||||:.||...:||||||||.|.:|||..|.:|:.:.:..|..|
Yeast 78 ENMSELTHLNEPSVLYNLEKRYDCDLIYTYSGLFLVAINPYHNLNLYSEDHINLYHNKHNRLSKS 142
Human 146 -----KRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDRS 205
...:.|||||:|::.||:.:|::.::||||:|||||||||.|||:::|| :|:|...|
Yeast 143 RLDENSHEKLPPHIFAIAEEAYENLLSEGKDQSILVTGESGAGKTENTKKILQY---LASITSGS 204
Human 206 KKDQSPGKG-----TLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIET 265
..:.:|..| :.|.:|:|:||.||:||||:||||:|||||||||:|.|...|.:..|.||.
Yeast 205 PSNIAPVSGSSIVESFEMKILQSNPILESFGNAQTVRNNNSSRFGKFIKIEFNEHGMINGAHIEW 269
Human 266 YLLEKSRVIFQLKAERDYHIFYQILSN-KKPELLDMLLITNNPYDYAFIS-QGETTVASIDDAEE 328
|||||||::.|...||:||||||:||. ...||.::.|.:.|..||..:| ..:..:..|:|.|.
Yeast 270 YLLEKSRIVHQNSKERNYHIFYQLLSGLDDSELKNLRLKSRNVKDYKILSNSNQDIIPGINDVEN 334
Human 329 LMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYL--MGLN 391
.....:|.:::||:.::...::::...|:..||::| :..|.||| :.:.|.||.. :|::
Yeast 335 FKELLSALNIIGFSKDQIRWIFQVVAIILLIGNIEF-VSDRAEQA----SFKNDVSAICSNLGVD 394
Human 392 SADLLKGLCHPRVKVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYF 456
..|....:..||.|.|.|:|::.:|.||..:...||::.:|||:|.::|..||..|:.......:
Yeast 395 EKDFQTAILRPRSKAGKEWVSQSKNSQQAKFILNALSRNLYERLFGYIVDMINKNLDHGSATLNY 459
Human 457 IGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACI 521
||:|||||||||:.|||||||||:||||||||||:|||||||.||.||.|:|.:||:|.|||..|
Yeast 460 IGLLDIAGFEIFENNSFEQLCINYTNEKLQQFFNNHMFVLEQSEYLKENIQWDYIDYGKDLQLTI 524
Human 522 DLIEK---PMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIKGKPEAHFSLIHYA 583
||||. |.|::.:|:||.:.||:||.:|.:||.......|:.|::.|...| |.|.|||
Yeast 525 DLIESKGPPTGVLPLLDEEAVLPKSTDESFYSKLISTWDQNSSKFKRSRLKNG-----FILKHYA 584
Human 584 GIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLF------ANYAGADAPIEKGK-GKAKKG 641
|.|:|.:.|||.|||||||:.::.|...|...::|.|| ::.||.:|.|...: .|:.:.
Yeast 585 GDVEYTVEGWLSKNKDPLNDNLLSLLSSSQNDIISKLFQPEGEKSSSAGVEANISNQEVKKSART 649
Human 642 SSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICR 706
|:|:|.|:.|||....|:..|.|||||||||||||..|.....:..|::.||||||||||||:.|
Yeast 650 STFKTTSSRHREQQITLLNQLASTHPHFVRCIIPNNVKKVKTFNRRLILDQLRCNGVLEGIRLAR 714
Human 707 KGFPNRILYGDFRQRYRILNPAAIPEGQFIDSRKGAEK-----LLSSLDIDHNQYKFGHTKVFFK 766
:|:||||.:.:|.||||||.|.......|....|.:.| ||:||.:|...||.|:||:|||
Yeast 715 EGYPNRIAFQEFFQRYRILYPENSTTTTFSSKLKASTKQNCEFLLTSLQLDTKVYKIGNTKLFFK 779
Human 767 AGLLGLLEEMRDERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMG-VKNWPWM 830
||:|..||:.:|.:|:.|:.::.|..||...|.|....|::.....||....|.:.. ||..||.
Yeast 780 AGVLADLEKQKDVKLNNIMIKLTATIRGYTVRKEITYHLQKLKKTRVIGNTFRLYNRLVKEDPWF 844
Human 831 KLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQ 895
.|:.:|||||.|:..........|:..:||..|::.|:::|.||||....:.|..:.|..:..|:
Yeast 845 NLFIRIKPLLTSSNDMTRTKKFNEQINKLKNDLQEMESKKKFLEEKNQKTVNELENTQDLLNQEK 909
Human 896 DNLA---------------------DAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAK 939
:||. |.....|::.:.|:::...::|.:::::..:|...|..|.
Yeast 910 ENLRKNESLLNRVKTSSETLQKQFDDLVSEKDEISREKLEVAQNLEEAHQKIQGLQETIREREAT 974
Human 940 KRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQ 1004
..||..:.:||.:.|.||...::|.:..:...:.....|..|:..|.::|....:|.|:..:...
Yeast 975 LEKLHSKNNELIKQISDLNCDISKEQSSQSLIKESKLKLENEIKRLKDVINSKEEEIKSFNDKLS 1039
Human 1005 QALDDLQAEEDKVNTLTK----AKVKLEQQV---DDLEGSLEQEKKVRMDLERAKRKLEGDLKLT 1062
.:.:|| :.|:.||.| |..:|:..| .||....|..||.:..|....:..|.:|...
Yeast 1040 SSEEDL---DIKLVTLEKNCNIAMSRLQSLVTENSDLRSKNENFKKEKAALNNQLKNKESELLKM 1101
Human 1063 QESIMDLENDKQQLDERLKKKD---FELNALNARIEDEQALGSQLQKKLKELQARIEELEEEL-E 1123
:|.| :|.|::|....|::| .|...:.|.:::.:. :|.|.::..::::||. .
Yeast 1102 KEKI---DNHKKELATFSKQRDDAVSEHGKITAELKETRI-------QLTEYKSNYQKIKEEYSN 1156
Human 1124 AERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEAT 1188
.:|..:.:.:|.|:.|...|.: .:::|.....|.:|.:| |.:.:.:...:::...:
Yeast 1157 FQRETKEQEQKKRNSLVESLND--SKIKELEARLSQEISLN-------QYLNKRISGNSVETNIS 1212
Human 1189 AAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLE 1253
:......::| :.:| |:.:.|:..:.:|...::|.|:|..|:.|.||....|..|
Yeast 1213 STRRSTSYSD------DPLD-----KEDIIKKYYDLQLAFTEITRNLENEIEEKKNLISRLRFTE 1266
Human 1254 DQMNEHRSKAEETQRSVNDLTSQRAKLQ----------TENGELSRQLD---EKEALISQLTRGK 1305
.:: .|.:.|.|: :.:|..||: ..:..|:..|| :||:.|::|
Yeast 1267 TRL---ASSSFEDQK----IKAQMKKLKKLIQDMDPSIPLDSILNEPLDNCPDKESDINKL---- 1320
Human 1306 LTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQ 1370
..:::.|||||:.|.:|.....:|: ||.| ....::|...|.::|::
Yeast 1321 ---MLEVDYLKRQLDIETRAHYDAENAI-SALH-------------SKFRKIQGESSLSSSDI-- 1366
Human 1371 WRTKYETDAIQRTEELEEAKKKLAQR----------------LQEAEEAVEAVNAKCSSLEKTKH 1419
::.|:|... :|.:.||:..|.:..| :.:.||.:.....:...|::..:
Yeast 1367 YKLKFEASE-ERVKSLEDKLKTMPLRDRTNLPVGDIIKNRDSISKYEEEIRYYKLENYKLQEILN 1430
Human 1420 RLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKL 1484
....::..|.:|:.:|.:..|.|.:: .|:: |.:|||::::...||:.:.:.
Yeast 1431 ESNGKLSQLTLDLRQSKSKEALLSEQ---LDRL-----------QKDLESTERQKELLSSTIKQQ 1481
Human 1485 KNAYEESL-----------EHLETFKR---ENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEA 1535
|..:|..: ||:...|: :.||:...|..|..|.....|.|.|.|..|...:
Yeast 1482 KQQFENCMDDLQGNELRLREHIHALKQAEEDVKNMASIIEKLKTQNKQKEKLIWEREMERNDSD- 1545
Human 1536 EKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTS 1600
|:||..| .|.....:..|||...|. .:| ||..|.:|......:.|.|: :.|..|
Yeast 1546 --MQLQETL--LELKRVQDVKKILSDDLA--HLK---ERLSAVEDRSQYTDEINRLK--EELNCS 1599
Human 1601 LDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRAND 1665
|.|||..:.|...:|.|:|...|:.|.::| .||| |||...:..:
Yeast 1600 LKAETNLKKEFATLKYKLETSTNDSEAKIS-----------------DLLK----QLDHYTKVVE 1643
Human 1666 DL---KENIAIVER----RNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLH------ 1717
.| |:.|::.|: :...|..|.|.|:..:....:.::..|.:|.:.::.:|:.:
Yeast 1644 MLNNEKDAISLAEKELYQKYEALNTECESLKGKIVSLTKIKQELESDLNQKTDALQISNAALSSS 1708
Human 1718 SQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAE---------EKAKKAITDAAMMAEELKKEQ 1773
:|....|.:|.|...:..|||.| |..||.| ...|....|......:|.:|.
Yeast 1709 TQKNKEITEKIKYLEETLQLQME-----QNSRNGELVKTLQASCNGYKDKFDDEKQKNIDLYEEN 1768
Human 1774 DTSAHLERMKKNMEQTIKDLQHRL-DEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESV 1837
.| |:::..:::..:|:|..|| |..|:.|.. :::.||||.:..|.....|.:
Yeast 1769 QT---LQKLNTDLQLQLKNLHERLSDTTEKNAWL----------SKIHELENMVSLETDLKYEEM 1820
Human 1838 KGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKV--Q 1900
|..:..||.::|| ||:..:: .|.::|..| .:.:.|||..:....:|...|. |
Yeast 1821 KKNKSLERAVEEL--QTKNSQQ--------TDVIELANK-NRSEFEEATLKYEAQISDLEKYISQ 1874
Human 1901 HEL-------------DEAEERADIAESQVNKLRAKSRDIGTKGLN 1933
.|| |:.:|.|. |.:..|.|.:|..||:|.::
Yeast 1875 QELEMKKSIRDNSSYRDKVQEMAQ--EIEFWKSRYESTMIGSKNID 1918
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