DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MYH7 and ck

DIOPT Version :9

Sequence 1:NP_000248.2 Gene:MYH7 / 4625 HGNCID:7577 Length:1935 Species:Homo sapiens
Sequence 2:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster


Alignment Length:2080 Identity:549/2080 - (26%)
Similarity:882/2080 - (42%) Gaps:411/2080 - (19%)


- Green bases have known domain annotations that are detailed below.


Human    40 PDDKQEF---VKAKIVSREGGKVTAETEYGKTV-TVKEDQVMQQNPPKFDKIEDMAMLTFLHEPA 100
            |...:||   :.|::||.||.::....:.|..| ...|.::...:......:|||..|..|||..
  Fly    14 PASGREFDVAIGARVVSAEGRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVEDMISLGDLHEAG 78

Human   101 VLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYM 165
            :|.||..||...:||||:|...|.||||:.||:||.:.:..|:.:|..|.|||||:|.||||.:|
  Fly    79 ILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHIFAIGDNAYAHM 143

Human   166 LTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGKGT-LEDQIIQANPALEA 229
            ...|::|.|:|:||||||||.:||.::||.|.|:            ||.: :|.||::|||.|||
  Fly   144 KRYRQDQCIVISGESGAGKTESTKLILQYLAAIS------------GKHSWIEQQILEANPILEA 196

Human   230 FGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQI---LS 291
            ||||||:||||||||||:|.|||.|.|.:..|.||.|||||||::.|..:||:||:||.|   ||
  Fly   197 FGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCILAGLS 261

Human   292 NKKPELLDMLLITNNPYDYAFISQGET-TVASIDDAEELMATDNAFDVLGFTSEEKNSMYKLTGA 355
            ..:...||:.:..    ||.:::.|.: |....|||.|.....:|..||.|:.:|...:.||..|
  Fly   262 ADEKSRLDLGMAA----DYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLLAA 322

Human   356 IMHFGNMKFKLKQREEQAEPDGTE-----EADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQ 415
            ::|.||:|:|....:..   |.||     ..::.|.|:||....|:..|....:....|.|....
  Fly   323 LLHCGNIKYKATVVDNL---DATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTL 384

Human   416 NVQQVIYATGALAKAVYERMFNWMVTRIN-ATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCIN 479
            :..|.:....|..|.:|.|||..:|.:|| |..:.:...:..||||||.|||.||.|||||.|||
  Fly   385 SRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENFDQNSFEQFCIN 449

Human   480 FTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIE-KPMGIMSILEEECMFPKA 543
            :.||.|||||..|:|.||||||..|.|.|..|:| :|.|..:|||. |.:.||::::||..|||.
  Fly   450 YANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDALDLIAIKQLNIMALIDEEARFPKG 513

Human   544 TDMTFKAKLFDNHLGKSANFQKPRNIKGKPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGL 608
            ||.|..|||...| |...|:.||   |......|.|.|:||:|.|:..|:|.||:|..:..::.|
  Fly   514 TDQTMLAKLHKTH-GSHKNYLKP---KSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHL 574

Human   609 YQKSSLKLLSTLFANYAGADAPIEKGKGKAKKGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCI 673
            ..:|:.|.|..:||.      .||.|....|:   ..|:|...|::|:.||..|.|..|.|:|||
  Fly   575 VSQSTNKFLRQIFAQ------DIEMGAETRKR---TPTLSTQFRKSLDALMKTLSSCQPFFIRCI 630

Human   674 IPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDS 738
            .|||.|.|.:.|..|...|||.:|::|.|||.|.|:|.|..:.:|.:|||.|.| .:|.....|.
  Fly   631 KPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIP-GVPPAHRTDC 694

Human   739 RKGAEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQSRGVLARMEYKK 803
            :....::.:.: :..:.|:.||||||.|......||:.||..|:|.|..:|...||.:.|   ::
  Fly   695 QAATSRICAVV-LGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYR---RR 755

Human   804 LLERRDSLLVIQWNIRAFMGVKNWPWMKL-YFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSE 867
            .|..|.:.:.:|...:.:...|.:..|:: |.:::.|::|.........::.....| :|..:..
  Fly   756 FLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGL-QAHARGY 819

Human   868 ARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEM 932
            ..|:|...||.::::.::.::..:...:              ..|::||.  |:..|.|:     
  Fly   820 LVRREYGHKMWAVIKIQSHVRRMIAMRR--------------YRKLRLEH--KQFAEVLQ----- 863

Human   933 NAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKK 997
                   .||||::  ||..            ...|||.|...::..:.:..|         |::
  Fly   864 -------LRKLEEQ--ELLH------------RGNKHAREIAEQHYRDRLHEL---------ERR 898

Human   998 ALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDD---LEGSLE---------------QEKKV 1044
            .:||    .|::.:..|..:|.:..|..|.|:.|||   :|...:               :|..|
  Fly   899 EIQE----QLENRRRVEVNMNIINDAARKQEEPVDDGKLVEAMFDFLPDSSSDAPTPHGGRETSV 959

Human  1045 RMDLERAKRKLEGDLKLTQESI---MDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQK 1106
            ..||..|:       .:.|:.|   :.:..|::.|.| .|.:.|........:..:.|     :|
  Fly   960 FNDLPHAQ-------NVNQDDIIAPIHISEDEEDLSE-FKFQKFAATYFQGNVNHQYA-----KK 1011

Human  1107 KLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKK--REA 1169
            .||.....:....::|.|: .....:.:...|:........:|::.....:.|...:.:.  |..
  Fly  1012 ALKHPLLPLHTQGDQLAAQ-ALWITILRFTGDMPEPKYHTMDRMDTTSVMSKVTATLGRNFIRSK 1075

Human  1170 EFQK---MRRD------LEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFK 1225
            |||:   |..|      .:..:::|:..:..|::|:     :|||.:   :|..|..|.....::
  Fly  1076 EFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKN-----KLGEDV---RRRLQDDEYTADSYQ 1132

Human  1226 LELDD-VTSNMEQ--------IIKAKANLEKMCRTLEDQMNEHRSKAEE---------------- 1265
            ..|.. .|||:|:        |::|:...|..|:..: |:..:..|:..                
  Fly  1133 SWLQSRPTSNLEKLHFIIGHGILRAELRDEIYCQICK-QLTNNPLKSSHARGWILLSLCVGCFAP 1196

Human  1266 TQRSVNDLTS--------------QRAKLQTENGELSRQLDEKEALISQLTRGK------LTY-- 1308
            :::.||.|.:              :|.|....||..::.....|.   |.|:.|      :|:  
  Fly  1197 SEKFVNYLRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLEL---QATKSKKPIMLPITFMD 1258

Human  1309 --TQQL--------EDLKRQLEEEVKAKNALAHALQSARHD------------------CDLLRE 1345
              |:.|        .:|..||.:::..|:....:|..|..|                  |    |
  Fly  1259 GNTKTLLADSATTARELCNQLSDKISLKDQFGFSLYIALFDKVSSLGSGGDHVMDAISQC----E 1319

Human  1346 QYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL--QEAEEAVEAVN 1408
            ||.:|           ..|....|.||..:..:......  |....::|..|  |:....|:...
  Fly  1320 QYAKE-----------QGAQERNAPWRLFFRKEIFAPWH--EPTHDQVATNLIYQQVVRGVKFGE 1371

Human  1409 AKCS---------------------SLEKTKHRLQNEIEDLM---VDVERSNAAAAALDKKQRNF 1449
            .:|.                     |:|:....|.|.|.|..   ||......||..|...::::
  Fly  1372 YRCDKEEDLAMIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSGVDKAIERWAALVLQAYKKSY 1436

Human  1450 ---DKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISD 1511
               ||| |..|.|     .::.|..|....|....|            .|.::....||.:  :|
  Fly  1437 YVKDKI-APLKIK-----EDIVSYAKYKWPLLFSRF------------YEAYRNSGPNLPK--ND 1481

Human  1512 LTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAE---IE 1573
            :...:..:|..:.:        :.|::.|:.:..|..|....:..|:.......:.::.|   .:
  Fly  1482 VIIAVNWTGVYVVD--------DQEQVLLELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEFTFQ 1538

Human  1574 RKLAEKDEEME----QAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQ------ 1628
            ...||...::.    ...:...:.|.:||     :.|:.::........:|||..:|.:      
  Fly  1539 SPNAEDIRDLVVYFLDGLKKRSKYVIALQ-----DYRAPSDGTSFLSFFKGDLIILEDESCGESV 1598

Human  1629 ------LSHANRMAAEAQ---KQVKSLQSLLKDTQ-----IQLDDAVRAND-DLKENIAIVE--- 1675
                  :...:|......   :.|..|.:|.|..|     ..:::|..... .:..|...||   
  Fly  1599 LNNGWCIGRCDRSQERGDFPAETVYVLPTLSKPPQDILALFNIEEAHHGRRLSMASNGGAVEPRD 1663

Human  1676 RRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTE 1740
            |.:.|::..|:..|...::|      ..:.|..:|:|.:.|...:...|....     |.:||::
  Fly  1664 RPHTLMEYALDHFRLPPKRT------MSKTLTLSSKRSEELWRYSRDPIKAPL-----LRKLQSK 1717

Human  1741 VEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKD--LQHRLDEAEQI 1803
            .|.|.:.|              ...|..||...|..:...||...:...|.|  |:|.:...|..
  Fly  1718 EEFAEEAC--------------FAFAAILKYMGDLPSKRPRMGNEITDHIFDGPLKHEILRDEIY 1768

Human  1804 ALKGGKKQLQKLEARVRELENELEAEQKRNAESV---KGM-RKSERRIKELTYQTEEDRKNLLRL 1864
            .      ||.|     :..:|.....::|..|.:   .|: ..|:..:|||.......|..:  .
  Fly  1769 C------QLMK-----QLTDNRNRMSEERGWELMWLATGLFACSQGLLKELLLFLRTRRHPI--S 1820

Human  1865 QDLVDKLQLKVKAYKR-----QAE-EAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAK 1923
            ||.:.:||..::..:|     |.| ||.:...|.:  |.||... |:.:|..::..|    .|||
  Fly  1821 QDSMHRLQKTIRHGQRKYPPHQVEVEAIQHKTTQI--FHKVYFP-DDTDEAFEVDSS----TRAK 1878

Human  1924  1923
              Fly  1879  1878

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYH7NP_000248.2 COG5022 37..1432 CDD:227355 446/1541 (29%)
MYSc_Myh7 99..766 CDD:276881 282/678 (42%)
Actin-binding 655..677 11/21 (52%)
Actin-binding 757..771 7/13 (54%)
SMC_prok_B 1173..1930 CDD:274008 168/907 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1907..1935 5/17 (29%)
ckNP_001285949.1 MYSc 64..733 CDD:214580 292/703 (42%)
MYSc_Myo7 77..721 CDD:276832 282/678 (42%)
MyTH4 <1138..1245 CDD:214535 19/110 (17%)
B41 1251..1467 CDD:214604 46/250 (18%)
FERM_B-lobe 1355..1439 CDD:271216 16/83 (19%)
FERM_C1_MyoVII 1461..1559 CDD:270019 15/119 (13%)
SH3 1560..1624 CDD:302595 10/68 (15%)
MyTH4 1701..1849 CDD:214535 39/179 (22%)
B41 1856..2068 CDD:214604 9/28 (32%)
FERM_M 1966..2068 CDD:278785
FERM_C2_MyoVII 2064..2159 CDD:270020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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