Protein Alignment MYH7 and ck

DIOPT Version :10

• Sequence 1: NP_000248.2
• Gene: MYH7 / 4625
• HGNCID: 7577
• Length: 1935
• Species: Homo sapiens
• Sequence 2: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Alignment Length: 2076
• Identity: 549/2076 - (26%)
• Similarity: 883/2076 - (42%)
• Gaps: 403/2076 - (19%)

Human    40 PDDKQEF---VKAKIVSREGGKVTAETEYGKTV-TVKEDQVMQQNPPKFDKIEDMAMLTFLHEPA 100
            |...:||   :.|::||.||.::....:.|..| ...|.::...:......:|||..|..|||..
  Fly    14 PASGREFDVAIGARVVSAEGRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVEDMISLGDLHEAG 78

Human   101 VLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYM 165
            :|.||..||...:||||:|...|.||||:.||:||.:.:..|:.:|..|.|||||:|.||||.:|
  Fly    79 ILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHIFAIGDNAYAHM 143

Human   166 LTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGKGT-LEDQIIQANPALEA 229
            ...|::|.|:|:||||||||.:||.::||.|.|:            ||.: :|.||::|||.|||
  Fly   144 KRYRQDQCIVISGESGAGKTESTKLILQYLAAIS------------GKHSWIEQQILEANPILEA 196

Human   230 FGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQI---LS 291
            ||||||:||||||||||:|.|||.|.|.:..|.||.|||||||::.|..:||:||:||.|   ||
  Fly   197 FGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCILAGLS 261

Human   292 NKKPELLDMLLITNNPYDYAFISQGET-TVASIDDAEELMATDNAFDVLGFTSEEKNSMYKLTGA 355
            ..:...||:.:..    ||.:::.|.: |....|||.|.....:|..||.|:.:|...:.||..|
  Fly   262 ADEKSRLDLGMAA----DYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLLAA 322

Human   356 IMHFGNMKFKLKQREEQAEPDGTE-----EADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQ 415
            ::|.||:|:|....:..   |.||     ..::.|.|:||....|:..|....:....|.|....
  Fly   323 LLHCGNIKYKATVVDNL---DATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTL 384

Human   416 NVQQVIYATGALAKAVYERMFNWMVTRIN-ATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCIN 479
            :..|.:....|..|.:|.|||..:|.:|| |..:.:...:..||||||.|||.||.|||||.|||
  Fly   385 SRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENFDQNSFEQFCIN 449

Human   480 FTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIE-KPMGIMSILEEECMFPKA 543
            :.||.|||||..|:|.||||||..|.|.|..|:| :|.|..:|||. |.:.||::::||..|||.
  Fly   450 YANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDALDLIAIKQLNIMALIDEEARFPKG 513

Human   544 TDMTFKAKLFDNHLGKSANFQKPRNIKGKPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGL 608
            ||.|..|||...| |...|:.||   |......|.|.|:||:|.|:..|:|.||:|..:..::.|
  Fly   514 TDQTMLAKLHKTH-GSHKNYLKP---KSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHL 574

Human   609 YQKSSLKLLSTLFANYAGADAPIEKGKGKAKKGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCI 673
            ..:|:.|.|..:||.      .||.|....|:   ..|:|...|::|:.||..|.|..|.|:|||
  Fly   575 VSQSTNKFLRQIFAQ------DIEMGAETRKR---TPTLSTQFRKSLDALMKTLSSCQPFFIRCI 630

Human   674 IPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDS 738
            .|||.|.|.:.|..|...|||.:|::|.|||.|.|:|.|..:.:|.:|||.|.| .:|.....|.
  Fly   631 KPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIP-GVPPAHRTDC 694

Human   739 RKGAEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQSRGVLARMEYKK 803
            :....::.:.: :..:.|:.||||||.|......||:.||..|:|.|..:|...||.:.|   ::
  Fly   695 QAATSRICAVV-LGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYR---RR 755

Human   804 LLERRDSLLVIQWNIRAFMGVKNWPWMKL-YFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSE 867
            .|..|.:.:.:|...:.:...|.:..|:: |.:::.|::|.........::.....| :|..:..
  Fly   756 FLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGL-QAHARGY 819

Human   868 ARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEM 932
            ..|:|...||.::::.::.::..:...:              ..|::||.  |:..|.|:
  Fly   820 LVRREYGHKMWAVIKIQSHVRRMIAMRR--------------YRKLRLEH--KQFAEVLQ----- 863

Human   933 NAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKK 997
                   .||||::  ||..            ...|||.|...::..:.:..|         |::
  Fly   864 -------LRKLEEQ--ELLH------------RGNKHAREIAEQHYRDRLHEL---------ERR 898

Human   998 ALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDD---LEGSLE---------------QEKKV 1044
            .:||    .|::.:..|..:|.:..|..|.|:.|||   :|...:               :|..|
  Fly   899 EIQE----QLENRRRVEVNMNIINDAARKQEEPVDDGKLVEAMFDFLPDSSSDAPTPHGGRETSV 959

Human  1045 RMDLERAKRKLEGDLKLTQESI---MDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQK 1106
            ..||..|:       .:.|:.|   :.:..|::.|.| .|.:.|........:..:.|     :|
  Fly   960 FNDLPHAQ-------NVNQDDIIAPIHISEDEEDLSE-FKFQKFAATYFQGNVNHQYA-----KK 1011

Human  1107 KLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKK--REA 1169
            .||.....:....::|.|: .....:.:...|:........:|::.....:.|...:.:.  |..
  Fly  1012 ALKHPLLPLHTQGDQLAAQ-ALWITILRFTGDMPEPKYHTMDRMDTTSVMSKVTATLGRNFIRSK 1075

Human  1170 EFQK---MRRD------LEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFK 1225
            |||:   |..|      .:..:::|:..:..|::|:     :|||.:   :|..|..|.....::
  Fly  1076 EFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKN-----KLGEDV---RRRLQDDEYTADSYQ 1132

Human  1226 LELDD-VTSNMEQ--------IIKAKANLEKMCRTLEDQMNEHRSKAEE---------------- 1265
            ..|.. .|||:|:        |::|:...|..|:..: |:..:..|:..
  Fly  1133 SWLQSRPTSNLEKLHFIIGHGILRAELRDEIYCQICK-QLTNNPLKSSHARGWILLSLCVGCFAP 1196

Human  1266 TQRSVNDLTS--------------QRAKLQTENGELSRQLDEKEALISQLTRGK------LTY-- 1308
            :::.||.|.:              :|.|....||..::.....|.   |.|:.|      :|:
  Fly  1197 SEKFVNYLRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLEL---QATKSKKPIMLPITFMD 1258

Human  1309 --TQQL--------EDLKRQLEEEVKAKNALAHALQSA------------RHDCDLLR--EQYEE 1349
              |:.|        .:|..||.:::..|:....:|..|            .|..|.:.  |||.:
  Fly  1259 GNTKTLLADSATTARELCNQLSDKISLKDQFGFSLYIALFDKVSSLGSGGDHVMDAISQCEQYAK 1323

Human  1350 ETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL--QEAEEAVEAVNAKCS 1412
            |           ..|....|.||..:..:......  |....::|..|  |:....|:....:|.
  Fly  1324 E-----------QGAQERNAPWRLFFRKEIFAPWH--EPTHDQVATNLIYQQVVRGVKFGEYRCD 1375

Human  1413 ---------------------SLEKTKHRLQNEIEDLM---VDVERSNAAAAALDKKQRNF---D 1450
                                 |:|:....|.|.|.|..   ||......||..|...::::   |
  Fly  1376 KEEDLAMIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSGVDKAIERWAALVLQAYKKSYYVKD 1440

Human  1451 KILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQ 1515
            || |..|.|     .::.|..|....|....|            .|.::....||.:  :|:...
  Fly  1441 KI-APLKIK-----EDIVSYAKYKWPLLFSRF------------YEAYRNSGPNLPK--NDVIIA 1485

Human  1516 LGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAE---IERKLA 1577
            :..:|..:.:        :.|::.|:.:..|..|....:..|:.......:.::.|   .:...|
  Fly  1486 VNWTGVYVVD--------DQEQVLLELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEFTFQSPNA 1542

Human  1578 EKDEEME----QAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQ---------- 1628
            |...::.    ...:...:.|.:||     :.|:.::........:|||..:|.:
  Fly  1543 EDIRDLVVYFLDGLKKRSKYVIALQ-----DYRAPSDGTSFLSFFKGDLIILEDESCGESVLNNG 1602

Human  1629 --LSHANRMAAEAQ---KQVKSLQSLLKDTQ-----IQLDDAVRAND-DLKENIAIVE---RRNN 1679
              :...:|......   :.|..|.:|.|..|     ..:::|..... .:..|...||   |.:.
  Fly  1603 WCIGRCDRSQERGDFPAETVYVLPTLSKPPQDILALFNIEEAHHGRRLSMASNGGAVEPRDRPHT 1667

Human  1680 LLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEA 1744
            |::..|:..|...::|      ..:.|..:|:|.:.|...:...|....     |.:||::.|.|
  Fly  1668 LMEYALDHFRLPPKRT------MSKTLTLSSKRSEELWRYSRDPIKAPL-----LRKLQSKEEFA 1721

Human  1745 VQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKD--LQHRLDEAEQIALKG 1807
            .:.|              ...|..||...|..:...||...:...|.|  |:|.:...|...
  Fly  1722 EEAC--------------FAFAAILKYMGDLPSKRPRMGNEITDHIFDGPLKHEILRDEIYC--- 1769

Human  1808 GKKQLQKLEARVRELENELEAEQKRNAESV---KGM-RKSERRIKELTYQTEEDRKNLLRLQDLV 1868
               ||.|     :..:|.....::|..|.:   .|: ..|:..:|||.......|..:  .||.:
  Fly  1770 ---QLMK-----QLTDNRNRMSEERGWELMWLATGLFACSQGLLKELLLFLRTRRHPI--SQDSM 1824

Human  1869 DKLQLKVKAYKR-----QAE-EAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAK 1923
            .:||..::..:|     |.| ||.:...|.:  |.||... |:.:|..::..|    .|||
  Fly  1825 HRLQKTIRHGQRKYPPHQVEVEAIQHKTTQI--FHKVYFP-DDTDEAFEVDSS----TRAK 1878

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH7	NP_000248.2	COG5022	37..1432	CDD:227355	446/1537 (29%)
		MYSc_Myh7	99..766	CDD:276881	282/678 (42%)
		Actin-binding	655..677		11/21 (52%)
		Actin-binding	757..771		7/13 (54%)
		SMC_prok_B	1173..1930	CDD:274008	168/903 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1907..1935		5/17 (29%)
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832	282/678 (42%)
		MyTH4	<1138..1245	CDD:214535	19/110 (17%)
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612	19/108 (18%)
		B41	1251..1467	CDD:214604	46/246 (19%)
		FERM_C1_MyoVII	1461..1559	CDD:270019	15/119 (13%)
		SH3	1560..1624	CDD:473055	10/68 (15%)
		MyTH4	1701..1849	CDD:214535	39/179 (22%)
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613	9/32 (28%)
		B41	1856..2068	CDD:214604	9/28 (32%)
		FERM_C2_MyoVII	2064..2159	CDD:270020