DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYH7 and myh7

DIOPT Version :9

Sequence 1:	NP_000248.2	Gene:	MYH7 / 4625	HGNCID:	7577	Length:	1935	Species:	Homo sapiens
Sequence 2:	NP_001106204.1	Gene:	myh7 / 30616	ZFINID:	ZDB-GENE-991123-5	Length:	1938	Species:	Danio rerio

Alignment Length:	1939	Identity:	1667/1939 - (85%)
Similarity:	1812/1939 - (93%)	Gaps:	5/1939 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MGDSEMAVFGAAAPYLRKSEKERLEAQTRPFDLKKDVFVPDDKQEFVKAKIVSREGGKVTAETEY 65
            |||::||.|||||.|||||::|||||||||||:||:.||||..:|:|||.||||||.|||.:||.
Zfish     1 MGDAQMAEFGAAASYLRKSDRERLEAQTRPFDMKKECFVPDPDEEYVKASIVSREGDKVTVQTEK 65

Human    66 GKTVTVKEDQVMQQNPPKFDKIEDMAMLTFLHEPAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKW 130
            .|||||||..:..||||||||||||||.|||||||||:|||:||.:|||||||||||||||||||
Zfish    66 RKTVTVKEADIHPQNPPKFDKIEDMAMFTFLHEPAVLFNLKERYAAWMIYTYSGLFCVTVNPYKW 130

Human   131 LPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYF 195
            ||||..|||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   131 LPVYNQEVVVAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYF 195

Human   196 AVIAAIGDRSKKDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLAS 260
            |.||| |..:||:.:..|||||||||||||||||||||||:||||||||||||||||||:|||||
Zfish   196 ASIAA-GGSAKKEGAEKKGTLEDQIIQANPALEAFGNAKTIRNDNSSRFGKFIRIHFGASGKLAS 259

Human   261 ADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDD 325
            |||||||||||||.|||||||||||||||||.:|||||:||||||||||||:|||||||||||:|
Zfish   260 ADIETYLLEKSRVTFQLKAERDYHIFYQILSQRKPELLEMLLITNNPYDYAYISQGETTVASIND 324

Human   326 AEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGL 390
            .|||:|||.||||||||.||||.:|||.||||||||||||.||||||||.||||:.||.||||||
Zfish   325 GEELLATDEAFDVLGFTQEEKNGIYKLIGAIMHFGNMKFKQKQREEQAEADGTEDGDKVAYLMGL 389

Human   391 NSADLLKGLCHPRVKVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQY 455
            |||||:|||||||||||||:||||||||||.||.|||||:|||:||.|||.|||.:|:|||||||
Zfish   390 NSADLIKGLCHPRVKVGNEWVTKGQNVQQVYYAIGALAKSVYEKMFLWMVVRINQSLDTKQPRQY 454

Human   456 FIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQAC 520
            ||||||||||||||||:||||||||||||||||||||||||||||||||||||.|||||||||||
Zfish   455 FIGVLDIAGFEIFDFNTFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLQAC 519

Human   521 IDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIKGKPEAHFSLIHYAGI 585
            |||||||||||||||||||||||:|.||||||:|||||||.||||||.||||||:||||:||||.
Zfish   520 IDLIEKPMGIMSILEEECMFPKASDSTFKAKLYDNHLGKSNNFQKPRAIKGKPESHFSLVHYAGT 584

Human   586 VDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPI---EKGKGKAKKGSSFQTV 647
            |||||..||.|||||||||||||:|||::||||.|||||||.::..   .||.|..|||||||||
Zfish   585 VDYNINNWLVKNKDPLNETVVGLFQKSTVKLLSMLFANYAGTESDNGKGGKGGGSKKKGSSFQTV 649

Human   648 SALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNR 712
            ||||||||||||||||||||||||||||||||:||.|:|||||||||||||||||||||||||||
Zfish   650 SALHRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMENPLVMHQLRCNGVLEGIRICRKGFPNR 714

Human   713 ILYGDFRQRYRILNPAAIPEGQFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMR 777
            ||||||:|||||||||||||||||||||||||||.||||||||||||||||||||||||.|||||
Zfish   715 ILYGDFKQRYRILNPAAIPEGQFIDSRKGAEKLLGSLDIDHNQYKFGHTKVFFKAGLLGQLEEMR 779

Human   778 DERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKS 842
            |:|||.||:.|||:|||:|||:|::|::||||:|||||||:||||||||||||||:|||||||||
Zfish   780 DDRLSLIISGIQARSRGLLARVEFQKIVERRDALLVIQWNVRAFMGVKNWPWMKLFFKIKPLLKS 844

Human   843 AEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQ 907
            ||.|||||:||:||.:||||..||||||||||||||||||||||||||||||||||.||||||||
Zfish   845 AEAEKEMANMKDEFAKLKEAYAKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLCDAEERCDQ 909

Human   908 LIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATE 972
            |||||||||||.||:.||||||||||||||||||||||||||||:||||||||||||||||||||
Zfish   910 LIKNKIQLEAKAKELTERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATE 974

Human   973 NKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGS 1037
            |||||||||||.||:||||||||||||||||||.|||||:||||||||||||.||||||||||||
Zfish   975 NKVKNLTEEMAALDDIIAKLTKEKKALQEAHQQTLDDLQSEEDKVNTLTKAKAKLEQQVDDLEGS 1039

Human  1038 LEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGS 1102
            ||||||:|||||||||||||||||||||:||||||||||:|||||||||::.||.:|||||.:..
Zfish  1040 LEQEKKLRMDLERAKRKLEGDLKLTQESLMDLENDKQQLEERLKKKDFEISQLNGKIEDEQTICI 1104

Human  1103 QLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKR 1167
            ||||||||||||||||||||||||.|||||||.|:||:|||||||||||||||||:.||||||||
Zfish  1105 QLQKKLKELQARIEELEEELEAERAARAKVEKQRADLARELEEISERLEEAGGATAAQIEMNKKR 1169

Human  1168 EAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVT 1232
            ||||||:||||||||||||||||.||||.|||||||||||||||||||||||||||.:||||||.
Zfish  1170 EAEFQKLRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELRLELDDVV 1234

Human  1233 SNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEAL 1297
            ||||.::|.|||||||.|:|||||||:::|.||.||.:||.|.|::|||:|||||||||:||::|
Zfish  1235 SNMEHVVKTKANLEKMTRSLEDQMNEYKTKYEEGQRCINDFTMQKSKLQSENGELSRQLEEKDSL 1299

Human  1298 ISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLS 1362
            :|||||.|::||||:||||||||||.|||:|||||:||||||.||||||||||.||||||||.:|
Zfish  1300 VSQLTRSKMSYTQQIEDLKRQLEEETKAKSALAHAVQSARHDTDLLREQYEEEQEAKAELQRGMS 1364

Human  1363 KANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIED 1427
            |||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||
Zfish  1365 KANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQETEEAVEAVNAKCSSLEKTKHRLQNEIED 1429

Human  1428 LMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESL 1492
            ||||:|||||||||||||||||||:|:|||||:||||:||||||||||.||||||||||:|||:|
Zfish  1430 LMVDLERSNAAAAALDKKQRNFDKVLSEWKQKFEESQAELESSQKEARCLSTELFKLKNSYEEAL 1494

Human  1493 EHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGK 1557
            :||||.|||||||||||||||||||..||:||||||:|||||.||.|:|||||||||||||||||
Zfish  1495 DHLETMKRENKNLQEEISDLTEQLGEGGKSIHELEKMRKQLEQEKSEIQSALEEAEASLEHEEGK 1559

Human  1558 ILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDL 1622
            ||||||||:||||:||||||||||||||:|||..|.:|:||:||::||||||||||:||||||||
Zfish  1560 ILRAQLEFSQIKADIERKLAEKDEEMEQSKRNLQRTIDTLQSSLESETRSRNEALRIKKKMEGDL 1624

Human  1623 NEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEE 1687
            ||||||||.|||.|||||||:||:.:.:||.|:||||::|.|:|||||.||||||||||||||||
Zfish  1625 NEMEIQLSQANRQAAEAQKQLKSVHAHMKDAQLQLDDSLRTNEDLKENTAIVERRNNLLQAELEE 1689

Human  1688 LRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAE 1752
            |||.:|||||.||||||||::|||||||||||||||:|||||::.|:||||||||||||||||||
Zfish  1690 LRAALEQTERGRKLAEQELLDTSERVQLLHSQNTSLLNQKKKLETDISQLQTEVEEAVQECRNAE 1754

Human  1753 EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEA 1817
            ||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||:|||||
Zfish  1755 EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIAMKGGKKQVQKLEA 1819

Human  1818 RVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQA 1882
            ||||||:|:|:|||:::|:|||:||.||||||||||||||||||.||||||||||||||||||.|
Zfish  1820 RVRELESEVESEQKKSSEAVKGIRKYERRIKELTYQTEEDRKNLARLQDLVDKLQLKVKAYKRAA 1884

Human  1883 EEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGT-KGLNEE 1935
            ||||||||||||||||:|||||||||||||||||||||||||||:.: ||.::|
Zfish  1885 EEAEEQANTNLSKFRKIQHELDEAEERADIAESQVNKLRAKSRDVSSKKGHDQE 1938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYH7	NP_000248.2	COG5022	37..1432	CDD:227355	1208/1397 (86%)
		MYSc_Myh7	99..766	CDD:276881	587/669 (88%)
		Actin-binding	655..677		21/21 (100%)
		Actin-binding	757..771		13/13 (100%)
		SMC_prok_B	1173..1930	CDD:274008	646/757 (85%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1907..1935		22/28 (79%)
myh7	NP_001106204.1	Myosin_N	35..72	CDD:280832	24/36 (67%)
		Myosin_head	87..768	CDD:278492	598/681 (88%)
		MYSc_class_II	99..768	CDD:276951	587/669 (88%)
		MIT_CorA-like	780..>991	CDD:294313	182/210 (87%)
		Myosin_tail_1	848..1925	CDD:279860	934/1076 (87%)
		RILP-like	963..1096	CDD:304877	120/132 (91%)
		MIT_CorA-like	<1297..>1409	CDD:294313	96/111 (86%)
		COG6	1374..>1536	CDD:303003	146/161 (91%)
		GBP_C	1563..1825	CDD:303769	222/261 (85%)
		TMPIT	1742..>1832	CDD:285135	84/89 (94%)
		coiled coil	1795..1805	CDD:293879	9/9 (100%)
		coiled coil	1814..1825	CDD:293879	9/10 (90%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1819	1.000	Domainoid score	I77
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68044
Inparanoid	1	1.050	3295	1.000	Inparanoid score	I120
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D13275at7742
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		mtm6669
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	LDO	PTHR45615
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2660
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	15	15.360