Protein Alignment MYH7 and myo-3

DIOPT Version :9

• Sequence 1: NP_000248.2
• Gene: MYH7 / 4625
• HGNCID: 7577
• Length: 1935
• Species: Homo sapiens
• Sequence 2: NP_506065.2
• Gene: myo-3 / 179676
• WormBaseID: WBGene00003515
• Length: 1969
• Species: Caenorhabditis elegans
• Alignment Length: 1927
• Identity: 957/1927 - (49%)
• Similarity: 1376/1927 - (71%)
• Gaps: 18/1927 - (0%)

Human    14 PYLRKSEKERLEAQTRPFDLKKDVFVPDDKQEFVKAKIVSREGGKVTAETEYGKTVTVKEDQVMQ 78
            |:|..|.:.|.....||||.||:.::||.:..||.|:|.|..|.:||..|..|..:|||:||..:
 Worm    15 PFLGISREARAATAARPFDSKKNCWIPDPEDGFVAAEIQSTTGEQVTVVTVKGNQITVKKDQCQE 79

Human    79 QNPPKFDKIEDMAMLTFLHEPAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYR 143
            .|||||||.||||.||||:|.:||.||||||...|||||||||||.:||||.||:|:..|:..:.
 Worm    80 MNPPKFDKTEDMANLTFLNEASVLGNLKDRYKDLMIYTYSGLFCVVINPYKRLPIYSESVIKHFM 144

Human   144 GKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDRSKKD 208
            ||:|:|.|||:|::||.||:.|:.|:||||:|||||||||||.|||:||.|||::.|....|.|:
 Worm   145 GKRRNEMPPHLFAVSDEAYRNMVQDKENQSMLITGESGAGKTENTKKVISYFAIVGATQAASGKE 209

Human   209 QSPGK--GTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKS 271
            ...||  ||||:||:|.||.||||||||||||:||||||||||.||..:||||..|||.||||||
 Worm   210 AKDGKKGGTLEEQIVQTNPVLEAFGNAKTVRNNNSSRFGKFIRTHFSGSGKLAGGDIEHYLLEKS 274

Human   272 RVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAF 336
            ||:.|...||.|||||||:|...|.|...|.::|:...|.|.||.|.|:..:||.||:..|..||
 Worm   275 RVVRQAPGERCYHIFYQIMSGNDPSLRGKLKLSNDITYYHFCSQAELTIEGMDDKEEMRLTQEAF 339

Human   337 DVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCH 401
            |::||...|...:|:.|..|||.|.||||.:.|||||||||.|:|..:|.::|:.:.:.||.|..
 Worm   340 DIMGFEDNETMDLYRSTAGIMHMGEMKFKQRPREEQAEPDGEEDALNAAAMLGIQAEEFLKALTK 404

Human   402 PRVKVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQ-PRQYFIGVLDIAGF 465
            |||:||.|:|.||||::||.:|...||||:|.|||.|::||.|.||:.|: .|::||||||||||
 Worm   405 PRVRVGTEWVNKGQNLEQVNWAVSGLAKAIYARMFKWIITRCNKTLDAKEIERKHFIGVLDIAGF 469

Human   466 EIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGI 530
            ||||.||||||.|||.||:||||||||||||||||||:|||.|||||||:||||||:|||||:||
 Worm   470 EIFDLNSFEQLWINFVNERLQQFFNHHMFVLEQEEYKREGIAWTFIDFGLDLQACIELIEKPLGI 534

Human   531 MSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIKGKP-EAHFSLIHYAGIVDYNIIGWL 594
            :|||:|||:.|||||||:..||.|.||||..|||||:..|||. :|||:::||||.|.||...:|
 Worm   535 ISILDEECIVPKATDMTYAQKLLDQHLGKHPNFQKPKPPKGKQGDAHFAIVHYAGTVRYNATNFL 599

Human   595 QKNKDPLNETVVGLYQKSS-LKLLSTLFANYAGADAPIEKGK------GKAKKGSSFQTVSALHR 652
            :|||||||:|.|.|.:.|: ..|:..::.:|...:...|..|      ||..|.|||.|||.::|
 Worm   600 EKNKDPLNDTAVALLKHSTDNSLMLDIWQDYQTQEEAAEAAKAGQTAGGKRGKSSSFATVSMIYR 664

Human   653 ENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGD 717
            |:||.||..|..|||||:|||||||.|:.||:|:.||::||.||||||||||||||||||:||.|
 Worm   665 ESLNNLMNMLYQTHPHFIRCIIPNEKKASGVIDSALVLNQLTCNGVLEGIRICRKGFPNRMLYPD 729

Human   718 FRQRYRILNPAAIPEGQFIDSRKGAEKLLSSLDIDHN----QYKFGHTKVFFKAGLLGLLEEMRD 778
            |:.||.||...|..|.   |.:|.:..:|..:.:|.|    ::|.|.||:|||||:|..||::||
 Worm   730 FKHRYAILAADAAKES---DPKKASVGILDKISVDGNLTDEEFKVGETKIFFKAGVLAKLEDLRD 791

Human   779 ERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSA 843
            |.||||:|..|::.|..||:.|.::..|::..|||:|.|:||:..::.|.|.||:.|:||:||:.
 Worm   792 EILSRIVTMFQSRIRSYLAKAEVRRRYEQQTGLLVVQRNVRAWCTLRTWEWFKLFGKVKPMLKAG 856

Human   844 EREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQL 908
            :.::.|..:..:..:|:||:::.|..|.:||.::..|::|||.|.|.::.|:.||||||||.::|
 Worm   857 KEQEAMGELAVKIQKLEEAVQRGEIARSQLESQVADLVEEKNALFLSLETEKANLADAEERNEKL 921

Human   909 IKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATEN 973
            .:.|..||:|:.::..:|||.:|.|.:|..:|:|.:.|.|:.|:.:.||||:|.|.|:||.:.::
 Worm   922 NQLKATLESKLSDITGQLEDMQERNEDLARQKKKTDQELSDTKKHVQDLELSLRKAEQEKQSRDH 986

Human   974 KVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSL 1038
            .:::|.:|||..||.:|||.||||..:|::::..:|||:||||||.|.|.:.|||||:|:||.::
 Worm   987 NIRSLQDEMANQDEAVAKLNKEKKHQEESNRKLNEDLQSEEDKVNHLEKIRNKLEQQMDELEENI 1051

Human  1039 EQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQ 1103
            ::||:.|.|:|:||||:|||||:.||:|.::...|..::..||:|:.:|:..||::.:..::.::
 Worm  1052 DREKRSRGDIEKAKRKVEGDLKVAQENIDEITKQKHDVETTLKRKEEDLHHTNAKLAENNSIIAK 1116

Human  1104 LQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKRE 1168
            ||:.:|||.||..||||||||||.:|.|.::.||:..|||||::||||:.||||:.|:|.|||||
 Worm  1117 LQRLIKELTARNAELEEELEAERNSRQKSDRSRSEAERELEELTERLEQQGGATAAQLEANKKRE 1181

Human  1169 AEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTS 1233
            ||..|:||:.||.:|.||...::|||:|.||||||.||::.||::|.|.|.|||:.:.:|::...
 Worm  1182 AEIAKLRREKEEDSLNHETAISSLRKRHGDSVAELTEQLETLQKLKAKSEAEKSKLQRDLEESQH 1246

Human  1234 NMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALI 1298
            ..:..::::.:|||..:|:|.|.:|.::||:|..|.:.|..:.:.:|..||.:|:|.|:|.:..:
 Worm  1247 ATDSEVRSRQDLEKALKTIEVQYSELQTKADEQSRQLQDFAALKNRLNNENSDLNRSLEEMDNQL 1311

Human  1299 SQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSK 1363
            :.|.|.|.|...||::.:|..:||.:.:.|||...::..|:..:|||..:||.|:||:|.|.:||
 Worm  1312 NSLHRLKSTLQSQLDETRRNYDEESRERQALAATAKNLEHENTILREHLDEEAESKADLTRQISK 1376

Human  1364 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDL 1428
            .|:|:.||:.:::::.:.:.||:|.|||.|..::||..:..|.:.||.:|.||.:.:|..:::|.
 Worm  1377 LNAEIQQWKARFDSEGLNKLEEIEAAKKALQLKVQELTDTNEGLFAKIASQEKVRFKLMQDLDDA 1441

Human  1429 MVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE 1493
            ..|||::.|..|..:|.:|.|:.|:||||:|.::..|||:::|::.|.|||:|||.|.|.:|..|
 Worm  1442 QSDVEKAAAQVAFYEKHRRQFESIIAEWKKKTDDLSSELDAAQRDNRQLSTDLFKAKTANDELAE 1506

Human  1494 HLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKI 1558
            :|::.:||||:|.:|:.|||:|||..|:::.||:|:.::||.||.|||.||:||||:||.||.|:
 Worm  1507 YLDSTRRENKSLAQEVKDLTDQLGEGGRSVAELQKIVRKLEVEKEELQKALDEAEAALEAEEAKV 1571

Human  1559 LRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLN 1623
            ||||:|.:||::|||:::.||:||.|..:|||.|.::|:|.:|:|||:.:.||||:|||:|.|:|
 Worm  1572 LRAQIEVSQIRSEIEKRIQEKEEEFENTRRNHQRALESMQATLEAETKQKEEALRIKKKLESDIN 1636

Human  1624 EMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEEL 1688
            ::||.|.||||..|:|||.:|.....:::.|.|:::..|..|:::|.....|:||.:||:|.:||
 Worm  1637 DLEIALDHANRAYADAQKTIKKYMETVQELQFQIEEEQRQKDEIREQFLASEKRNAILQSEKDEL 1701

Human  1689 RAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEE 1753
            ....|..||:|:.||.|.||..|:...|::..::|..|::|::.:|.....|:||...|.:||.|
 Worm  1702 AQQAEAAERARRNAEAECIELREQNNDLNAHVSALTGQRRKLEGELLAAHAELEEIANELKNAVE 1766

Human  1754 KAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEAR 1818
            :.:||..|||.:||||::||:.|.|:||::|.:|..||::|.|||:||..|||||||.:.:||||
 Worm  1767 QGQKASADAARLAEELRQEQEHSMHIERIRKGLELQIKEMQIRLDDAENAALKGGKKIIAQLEAR 1831

Human  1819 VRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAE 1883
            :|.:|.||:.||:|:.::.|..||:|||:||:.:|..|::||..||.:||||||.|:|.:|||.|
 Worm  1832 IRAIEQELDGEQRRHQDTEKNWRKAERRVKEVEFQVVEEKKNEERLTELVDKLQCKLKIFKRQVE 1896

Human  1884 EAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSR 1925
            ||||.|.:||:|::.:..:.::|||||||||:.::|:|.|.|
 Worm  1897 EAEEVAASNLNKYKVLTAQFEQAEERADIAENALSKMRNKIR 1938

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH7	NP_000248.2	COG5022	37..1432	CDD:227355	711/1409 (50%)
		MYSc_Myh7	99..766	CDD:276881	399/681 (59%)
		Actin-binding	655..677		15/21 (71%)
		Actin-binding	757..771		9/13 (69%)
		SMC_prok_B	1173..1930	CDD:274008	330/753 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1907..1935		12/19 (63%)
myo-3	NP_506065.2	Myosin_N	36..73	CDD:280832	14/36 (39%)
		Myosin_head	88..779	CDD:278492	408/693 (59%)
		MYSc_class_II	100..779	CDD:276951	399/681 (59%)
		Myosin_tail_1	857..1937	CDD:279860	476/1079 (44%)
		DUF4795	932..1090	CDD:292662	71/157 (45%)
		SPEC	1186..1391	CDD:295325	77/204 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	998	1.000	Domainoid score	I8
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1945	1.000	Inparanoid score	I16
Isobase	1	0.950	-	0	Normalized mean entropy	S2139
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41153at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		mtm5042
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.780