Protein Alignment MYH7 and myo-1

DIOPT Version :10

• Sequence 1: NP_000248.2
• Gene: MYH7 / 4625
• HGNCID: 7577
• Length: 1935
• Species: Homo sapiens
• Sequence 2: NP_492053.1
• Gene: myo-1 / 172471
• WormBaseID: WBGene00002348
• Length: 1938
• Species: Caenorhabditis elegans
• Alignment Length: 1934
• Identity: 909/1934 - (47%)
• Similarity: 1316/1934 - (68%)
• Gaps: 41/1934 - (2%)

Human    15 YLRKSEKERLEAQTRPFDLKKDVFVPDDKQEFVKAKIVSREGGK-----VTAETEYGKTVTVKED 74
            ||::|.:::|..|:||:|.||:|::||.::.:::. ::...|.|     |||.   ||.||:|:|
 Worm    13 YLKRSREQQLADQSRPYDSKKNVWIPDAEEGYIEG-VIKGPGPKADTVIVTAG---GKDVTLKKD 73

Human    75 QVMQQNPPKFDKIEDMAMLTFLHEPAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVV 139
            .|.:.|||||:|.|||:.||||::.:||:||:.||.:.:||||||||||.:||||.||:||..|.
 Worm    74 IVQEVNPPKFEKTEDMSNLTFLNDASVLWNLRSRYAAMLIYTYSGLFCVVINPYKRLPIYTDSVA 138

Human   140 AAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDR 204
            ..:.||:|:|.|||:|::||.||:|||.|.||||:|||||||||||.|||:||.|||.:.| ..:
 Worm   139 RMFMGKRRTEMPPHLFAVSDQAYRYMLQDHENQSMLITGESGAGKTENTKKVICYFATVGA-SQK 202

Human   205 SKKDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLE 269
            :...:...:.||||||:|.||.||||||||||||:|||||||||||||...|.|||.|||.||||
 Worm   203 AALKEGEKEVTLEDQIVQTNPVLEAFGNAKTVRNNNSSRFGKFIRIHFNKHGTLASCDIEHYLLE 267

Human   270 KSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDN 334
            |||||.|...||.|||||||.|:.||:|.|.||:.:...:|.|::|.|..:..|||.||...||.
 Worm   268 KSRVIRQAPGERCYHIFYQIYSDFKPQLRDELLLNHPISNYWFVAQAELLIDGIDDTEEFQLTDE 332

Human   335 AFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGL 399
            |||||.|:..||...|:|..|.||.||||||.:.|||||||||.:||:::..:.|::....||.|
 Worm   333 AFDVLKFSPTEKMDCYRLMSAHMHMGNMKFKQRPREEQAEPDGQDEAERACNMYGIDVDQFLKAL 397

Human   400 CHPRVKVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQ-PRQYFIGVLDIA 463
            ..||||||.|:|:|||||.||.:|.||:||.:|.|:|:|:|.:.|.||:.|. .|.|||||||||
 Worm   398 VSPRVKVGTEWVSKGQNVDQVHWAIGAMAKGLYARVFHWLVKKCNLTLDQKGIDRDYFIGVLDIA 462

Human   464 GFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPM 528
            |||||||||||||.|||.||||||||||||||||||||.:|||:|||||||:||||||:|||||:
 Worm   463 GFEIFDFNSFEQLWINFVNEKLQQFFNHHMFVLEQEEYAREGIQWTFIDFGLDLQACIELIEKPL 527

Human   529 GIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIKGKP-EAHFSLIHYAGIVDYNIIG 592
            ||:|:|:|||:.|||||||...||.|.||||..||:||:..|||. ||||::.||||.|.||::.
 Worm   528 GIISMLDEECIVPKATDMTLAQKLTDQHLGKHPNFEKPKPPKGKQGEAHFAMRHYAGTVRYNVLN 592

Human   593 WLQKNKDPLNETVVGLYQKSSLK--LLSTLFANYA---GADAPIEKGKG-KAKKGSSFQTVSALH 651
            ||:|||||||:|||.: .|:|.|  ||..::.:|.   .|.|..:.|.| |..|..||.|||.::
 Worm   593 WLEKNKDPLNDTVVSV-MKASKKNDLLVEIWQDYTTQEEAAAAAKAGGGRKGGKSGSFMTVSMMY 656

Human   652 RENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYG 716
            ||:||||||.|..|||||:|||||||.|..|::|..||::||.||||||||||||||||||..:.
 Worm   657 RESLNKLMTMLHKTHPHFIRCIIPNEKKQSGMIDAALVLNQLTCNGVLEGIRICRKGFPNRTQHP 721

Human   717 DFRQRYRILNPAAIPEGQFIDSRK---GA--EKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEM 776
            ||.|||.||   |..|.:..|..|   ||  :.|::...::..|::.||||||||||::..:|::
 Worm   722 DFVQRYAIL---AAKEAKSSDDMKTCAGAILQALINQKQLNDEQFRIGHTKVFFKAGVVAHIEDL 783

Human   777 RDERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMGVKNWPWMKLYFKIKPLLK 841
            ||::|::|||..|:..|...|..:.....::.:|.:::|.|||::..::.|.|..|:.|::|.||
 Worm   784 RDDKLNQIITGFQSAIRWYTATADAGARRKQLNSYIILQRNIRSWCVLRTWDWFLLFGKLRPQLK 848

Human   842 SAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCD 906
            ..:..:||..|.||...|:...:|:|:.||..||....|..|::.|...::..|...|..||:..
 Worm   849 CGKMAEEMIKMAEEQKVLEAEAKKAESARKSQEEAYAKLSAERSKLLEALELTQGGSAAIEEKLT 913

Human   907 QLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHAT 971
            :|...:.::|..:.:.|:||.:.||.||:|..::||.:.|...||:.|:.::..|||..:||.|.
 Worm   914 RLNSARQEVEKSLNDANDRLSEHEEKNADLEKQRRKAQQEVENLKKSIEAVDGNLAKSLEEKAAK 978

Human   972 ENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEG 1036
            ||::.:|.:||...||.|.|:.||||.|:|.::|.:|||||||.|.....:.:.||||.:|::|.
 Worm   979 ENQIHSLQDEMNSQDETIGKINKEKKLLEENNRQLVDDLQAEEAKQAQANRLRGKLEQTLDEMEE 1043

Human  1037 SLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALG 1101
            ::|:||::|.:.|::|||:||:||..||:|.:|...|.:.|..||||:.:::||..||||||||.
 Worm  1044 AVEREKRIRAETEKSKRKVEGELKGAQETIDELSAIKLETDASLKKKEADIHALGVRIEDEQALA 1108

Human  1102 SQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKK 1166
            ::|.::.||...||.|:|:|||.||.:|:|.::.|::|.|||:|::|||:|......:|.:.|||
 Worm  1109 NRLTRQSKENAQRIIEIEDELEHERQSRSKADRARAELQRELDELNERLDEQNKQLEIQQDNNKK 1173

Human  1167 REAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDV 1231
            :::|..|.||||:|..:.:|...|.:|:|:.|.::.|...:|.||:.|.|:||||...:.||||:
 Worm  1174 KDSEIIKFRRDLDEKNMANEDQMAMIRRKNNDQISALTNTLDALQKSKAKIEKEKGVLQKELDDI 1238

Human  1232 TSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEA 1296
            .:.::|..|::...|::.:..|.|:.|.:.|.:|..|.:.:.||.:.:|..:|.:|:||::|.|.
 Worm  1239 NAQVDQETKSRVEQERLAKQYEIQVAELQQKVDEQSRQIGEYTSTKGRLSNDNSDLARQVEELEI 1303

Human  1297 LISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVL 1361
            .::.:.|.|..::.||.:.|:..|:|:..:.....|.::..|:.|...|..||:...|.::||.|
 Worm  1304 HLATINRAKTAFSSQLVEAKKAAEDELHERQEFHAACKNLEHELDQCHELLEEQINGKDDIQRQL 1368

Human  1362 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIE 1426
            |:.|||::||:.:||.:.:..:|||||.|:|...|:.:.:||:.|...|..||||.|.:|..|.|
 Worm  1369 SRINSEISQWKARYEGEGLVGSEELEELKRKQMNRVMDLQEALSAAQNKVISLEKAKGKLLAETE 1433

Human  1427 DLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEES 1491
            |...||:|.....|:|:||||.||||:.:||:|.::.|.|::::.:::|:.|||:|||:::.:..
 Worm  1434 DARSDVDRHLTVIASLEKKQRAFDKIVDDWKRKVDDIQKEIDATTRDSRNTSTEVFKLRSSMDNL 1498

Human  1492 LEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEG 1556
            .|.:||.:||||...:||.|:.||:...|:|..|:.|..::||.||.|||.||:||||:||.||.
 Worm  1499 SEQIETLRRENKIFSQEIRDINEQITQGGRTYQEVHKSVRRLEQEKDELQHALDEAEAALEAEES 1563

Human  1557 KILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGD 1621
            |:||.|:|..||::|||:::.||:||.|..::||.|.::|:|.||:.|.:|:.|..|.|||:|.|
 Worm  1564 KVLRLQIEVQQIRSEIEKRIQEKEEEFENTRKNHQRALESIQASLETEAKSKAELARAKKKLETD 1628

Human  1622 LNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELE 1686
            :|::||.|.|||:...:|||.:|.|...:|:.|.|:||..|..::::||....|:|..:..:|.|
 Worm  1629 INQLEIALDHANKANVDAQKNLKKLFDQVKELQGQVDDEQRRREEIRENYLAAEKRLAIALSESE 1693

Human  1687 ELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLIN-------QKKKMDADLSQLQTEVEEA 1744
            :|...:|.:::.:|..|   ||.:|    |.|.||.||.       .|:|::.::...:.|::|.
 Worm  1694 DLAHRIEASDKHKKQLE---IEQAE----LKSSNTELIGNNAALSAMKRKVENEVQIARNELDEY 1751

Human  1745 VQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGK 1809
            :.|.:.:||:|:||..||..:|||:::||:.:.|::|.:|::|...|:||.::|:||:..::.|.
 Worm  1752 LNELKASEERARKAAADADRLAEEVRQEQEHAVHVDRQRKSLELNAKELQAKIDDAERAMIQFGA 1816

Human  1810 KQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLK 1874
            |.|.|:|.|||.||.||.:||:|:.||:||..|.|||.:||.:|.|||:|...|||:.|:|||.|
 Worm  1817 KALAKVEDRVRSLEAELHSEQRRHQESIKGYTKQERRARELQFQVEEDKKAFDRLQENVEKLQQK 1881

Human  1875 VKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAK 1923
            ::..|||.|||||.|..||||||::|..|:.|||||::||:.:.::|.:
 Worm  1882 IRVQKRQIEEAEEVATQNLSKFRQIQLALENAEERAEVAENSLVRMRGQ 1930

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH7	NP_000248.2	COG5022	37..1432	CDD:227355	683/1412 (48%)
		MYSc_Myh7	99..766	CDD:276881	408/679 (60%)
		Actin-binding	655..677		17/21 (81%)
		Actin-binding	757..771		10/13 (77%)
		SMC_prok_B	1173..1930	CDD:274008	305/758 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1907..1935		7/17 (41%)
myo-1	NP_492053.1	Myosin_N	30..73	CDD:460670	16/46 (35%)
		MYSc_class_II	98..773	CDD:276951	408/679 (60%)
		Myosin_tail_1	854..1919	CDD:460256	434/1071 (41%)