Protein Alignment poe and ubr5

DIOPT Version :9

• Sequence 1: NP_001260222.1
• Gene: poe / 46243
• FlyBaseID: FBgn0011230
• Length: 5322
• Species: Drosophila melanogaster
• Sequence 2: XP_021322301.1
• Gene: ubr5 / 334627
• ZFINID: ZDB-GENE-030131-6559
• Length: 2833
• Species: Danio rerio
• Alignment Length: 1749
• Identity: 343/1749 - (19%)
• Similarity: 568/1749 - (32%)
• Gaps: 628/1749 - (35%)

  Fly   678 GSGNAPAASAGAGTSAGAS----------TKWQTSMIRF-----SGAAGRYIHNLISTSLLSEQL 727
            |.|:.....||.||..|.|          ::.||.:||.     ||..|.....:|..|::.|:|
Zfish   152 GGGSGSGGGAGGGTGGGGSSGRSSTAARDSRRQTRVIRTGRDRGSGLLGSQPQPVIPASVIPEEL 216

  Fly   728 QSN---LLQHLSISPWSTDTNTWPLQVYPSTLSVLVQILLLKPTQEKEAACLSVWHRLINTLV-- 787
            .|.   :||..|                   .||::        :|.:...|.| :..:|.|:
Zfish   217 ISQAQVVLQGKS-------------------RSVII--------RELQRTNLDV-NLAVNNLLSR 253

  Fly   788 ---EGVCSSNTASDSDY-----------EDLNIEHAQLLL-----------------FLFHSLNL 821
               :|....:|||:| |           .|::..|..:::                 |...||:.
Zfish   254 DDEDGDDGDDTASES-YLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSR 317

  Fly   822 MQKKSILLL----------TAGGVIRCAE----------VCRGIS--EDRPVKNSQIMLLSRLLL 864
            :....:|||          ....|:|..|          ..||.:  |..|..:.:.:.|
Zfish   318 LGSSRVLLLPLERDSELLRERESVLRLRERRWLDGASFDAERGSTSREGEPSLDKKSVPL----- 377

  Fly   865 FLEYLMKHLYNAPPELLDQVRWNLFSVSSMPDTQKITDLLNCRTKLNSYCRHDIEENFRKSAGEY 929
                      .:|..|.::::|       .||...:|..:                    |.|..
Zfish   378 ----------QSPVTLGEELQW-------WPDKDYVTKFV--------------------SIGAL 405

  Fly   930 GS-----SIRPTFYSLVMGDPEISYWAQEFKLDGLAWNFILCTPDKLKYPLLVDALTDILSITDM 989
            .|     |.:...|.....:||....||...:......|:..|.:|         :|.:.:.:..
Zfish   406 YSELVAVSTKGELYQWKWNEPEPYRNAQNPSIHHPRVPFLGLTNEK---------ITHLSANSIR 461

  Fly   990 SMYSKEKDKEASMHNLCAIQYCFTIAWKLNLGLPPSTSHVESLKAERSPNLH------------S 1042
            :..:.|.:|.|:..:    :...|:|.||..|    ......|:.||..:||            |
Zfish   462 ATVATENNKVATWVD----ETLSTVAAKLEHG----AQTFPELQGERIVSLHCCALYTCAQLENS 518

  Fly  1043 LMWSIRLPLASSHYLVVSSLIKQGMYTQYAETLWTHVGDIGADIKYSLKQTIL---GVEAFNSQM 1104
            |.|...:|.:....::..:..|.......|..  :.:.:|....:..|:...|   |..||:  :
Zfish   519 LYWWGVVPFSQRKKMLEKARAKNKKPKSSAGI--SSIPNITVGTQVCLRNNPLYHAGAVAFS--V 579

  Fly  1105 NGNGTPRLSDLILFDSLVAHMQAVAWANKEGLKWPRKESEDAAG-EQSAGTSLTSSSNDPEL--- 1165
            |. |.|::.  :|.:|:        |...:..::..:..|.... |::..|..|.:.:.|||
Zfish   580 NA-GIPKVG--VLLESV--------WNMNDSCRFQLRSPESLKNMEKNTKTQETKTESKPELVKT 633

  Fly  1166 -----------------YSSNESIDDQKLKQDDDGKLSSDLQKYNQLVNELMVKLMNSYQLLSVI 1213
                             .:|:.|:..::       :.|:...|..:.|||      ..:.|..|:
Zfish   634 EMGPPPSPASTCSDTSSIASSASLPYKR-------RRSTPAPKEEEKVNE------EQWPLREVV 685

  Fly  1214 ----VR----GQMLK-----------QLSSSTPEKALNLIVPIVSDKPAIMLELHAAFLKLLPNE 1259
                |:    |::||           ..|||...::   ..|..||..:::.:     .:||..:
Zfish   686 FVEDVKNVPVGKVLKVDGAYVAVKFPGTSSSVSSQS---AAPTDSDPSSLLQD-----CRLLRID 742

  Fly  1260 DKQLIA-----------NEWPKCLMVNDFAFNGKQHPVEPYILNV-IDA---HIIELTRGSNYST 1309
            :.|::.           ...||.|.:          |.:..||.| :|:   |.: |..||
Zfish   743 ELQVVKTGGTPKVPDCFQRTPKKLCI----------PEKAEILAVNVDSKGVHAV-LKTGS---- 792

  Fly  1310 LHTLKHCLKSILQLFELLLPHRTANAEVETQLKQLLISSMLDMRTDYLQGHSEHCLREILSGLTQ 1374
              .:::|      :|:|    .|..||.|.......::.:         |.||..:....:|  |
Zfish   793 --WVRYC------VFDL----ATGKAEQENHFPTSNLAFL---------GQSERNVAIFTAG--Q 834

  Fly  1375 EAQKLLLYEHMVGYCYRMLKEFAADLRQPQ----------SAGPSGGAPLDQDRAMFNESMLFAV 1429
            |:..:|...:  |..|.|.|:....:|.|.          ..|....|.|..:..:..::.:
Zfish   835 ESPIILRDGN--GTIYPMAKDCMGGIRDPDWLDLPPIASLGMGVHSLANLPSNSTIKKKAAI--- 894

  Fly  1430 LKTMFKMLEKPVAVQ--------AMRQF--------FKDQRSGSLTTLLLSFTGTSLPVSYARKM 1478
               :...:||...:|        |.||:        ..:|...:|.|||......:..|.:|
Zfish   895 ---IIMAVEKQTLMQHVLRCDYEACRQYLISLEQAMLLEQNPHALDTLLGHRCDGNRNVLHA--- 953

  Fly  1479 LQFVNRLFQLSLQADSQFQHEDLVE--CFSE-LATVD-VARLKQWLGHIIYGPNVS---TDVSTS 1536
              .|:..|.:|.:...:.:..:..|  .|:| |:.|: :|....     :...|.|   |..|:|
Zfish   954 --CVSVCFPVSNKETKEEEEAERSERNTFAERLSAVEAIANAIS-----VVSSNSSGNRTGSSSS 1011

  Fly  1537 EALDTTCRMLTSI------LQPSSSSSSNAQTPTNMATVSAMPSISDQLDPMEIEYDCG---TAA 1592
            ..|.....|..|:      ...|..|||:.|.|  ::...|.||......||:.:.|..   ..|
Zfish  1012 RGLRLREMMRRSLRAAGLGRHESGPSSSDHQDP--VSPPIAPPSWVPDPPPMDPDGDIDFILAPA 1074

  Fly  1593 GGGESNPGTG-GAAANTSQILSLWQAAQPNPSEESSQACDHSDSERNGALLLSFVKSLVKDQSKA 1656
            .|..:...|| ....:||.|        |.||.|.| ..:..|.:.|..|:|..:
Zfish  1075 VGSLTTASTGTSQGPSTSTI--------PGPSSEPS-VVESKDRKANAHLILKLM---------- 1120

  Fly  1657 SQIAPPLFQALLQLGQTLISPPQEGCDFADVLQIMITLADASPARGHVAL--------FNTTLLW 1713
                                     ||...:...:..|..|..|||....        :...:..
Zfish  1121 -------------------------CDSIVLRPHLRELLSAKDARGMTPFMLAVSGRAYPAAITV 1160

  Fly  1714 LELA-KLQLPDKHLKHAENVSAQLRYLSELLQSIGFRGSRQHNPPWDDELQTDIDELYDELAEEG 1777
            ||.| |:...:..|...|:.:      |..::.|...|:   ||
Zfish  1161 LEAAQKIAKGEPGLGEKEDTA------SVFMEMICPSGT---NP--------------------- 1195

  Fly  1778 EQDSLLDDSDEDTL-NNKLCTFSQTQKEFMNQHWYHCHTCNMINTVGVCSVCARVCHKGHDVSYA 1841
                  |||....| .|..|:|:.|..|.:||..:.|.||.::.::..|:.||||||||||....
Zfish  1196 ------DDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDCKLK 1254

  Fly  1842 KYG-NFFCDCGAKEDGSCQALSRRIGSNEVRDSAGIGSYLPSHMSLLAGKKRSSLPVGQPVLTRK 1905
            :.. ..:|||..|    |:.                       .:|:||:|.:.|.:...:||..
Zfish  1255 RTSPTAYCDCWEK----CKC-----------------------KTLIAGQKAARLDLLYRLLTTT 1292

  Fly  1906 DSLT--NER-IAVLTKLLEPYRETLQHQDQWLLVVRCILEYFDLLLPSINENCMLYSIVGCHKRA 1967
            :.:|  |.| ..:|..|::             .|.|..:|:.....|.|.|:       ...|.|
Zfish  1293 NLVTTPNSRGEHILLFLVQ-------------TVARQSVEHCQYRPPRIRED-------RNRKAA 1337

  Fly  1968 TA------------------ALERLHLLEQSFQVTDQLMFATLGSQEGAFENVRMNYSGD---QG 2011
            :|                  ||||  :|:....:...:||   ||||          :.|   ..
Zfish  1338 SAEDSDMPDHDLEPPRFAQLALER--VLQDWNALKSMIMF---GSQE----------NKDPLSAS 1387

  Fly  2012 QTIKHLL---------SSGVVRRVAFC-CL---SSPH---------------------GRRQQLA 2042
            ..|.|||         .||.:|...|. ||   .:|.                     |||::..
Zfish  1388 SRIAHLLPEEQMYLNQQSGTIRLDCFTHCLIVKCAPDITFIDTLLGTLVKELQNKYTPGRREEAI 1452

  Fly  2043 VSHEKGKVTILQLSALLKQADASKRKLTLTQLSSAPIA-CTVISLAANP------CN--EDCL-- 2096
            ....:...::.::..:|....||.:|  .......||. |..:..|..|      ||  |..:
Zfish  1453 NVTRRFLRSVARVFVILSVEMASSKK--KNNFIPQPIGKCRRVFQALLPYAVEELCNVAESLIVP 1515

  Fly  2097 --------------------AVCGLKECHIL-----------TFSSSGSTNEHIVVNPQ 2124
                                ||.|.:|...:           :.|||.|.:.:|:.|||
Zfish  1516 VRMGIARPTAPFTLASTSIDAVQGSEELFSVEPLPPRPSPDQSSSSSQSASSYIIRNPQ 1574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
poe	NP_001260222.1	ZnF_UBR1	1794..1862	CDD:197698	25/68 (37%)
		DZR	3793..3837	CDD:289539
		E3_UbLigase_R4	4493..5296	CDD:290481
ubr5	XP_021322301.1	E3_UbLigase_EDD	206..253	CDD:288409	15/74 (20%)
		ZnF_UBR1	1207..1274	CDD:197698	25/93 (27%)
		PolyA	2423..2486	CDD:197769
		HECTc	2505..2830	CDD:214523

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010