|
Fly 3 AHSGGTD----WNSVVKALILNRTGALNKNEVVNLLKAITRCEHDFFEEESNFTQFYTAFAALAA 63
|.:.|.| |...|:.|:.....|....|:..|:.::...|.:....|..:..||::|.||:.
Rat 18 APATGQDTTPGWEVAVRPLLSASYSAFEMKELPQLVASVIESESEILHHEKQYEPFYSSFVALST 82
Fly 64 DKLMQIKTIC----QTQICQLHDATAVLIRFIIYRL---PRVSVYETKWLLGALKMLCEGRECPA 121
. .|.|:| :.|:..:..|..|||.|.:.|| ........|.|:..:|.||.| |..
Rat 83 H---YITTVCSLIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTG--CSR 142
Fly 122 SASSSMFDYNAVANVLKSCKHPESTTKSIMPSSSSSGSGASNDKE--SPKS-EIKRSRSDLSSVI 183
...:.:..:.| ::||.|.|: |.|:: |...:.|| ||.| |:::....:: .
Rat 143 LDRTEIITFTA---MMKSAKLPQ-TVKTL--------SDVEDQKELASPVSPELRQKEVQMN--F 193
Fly 184 LQQLIAPLEPGKMTWVPLSEEV--------TDCTEQ---------ILAANVEYFQEQNGVDTLLD 231
|.||.:...|..:...|:|.:. ...||| .:|.||...||..|.:.||.
Rat 194 LNQLTSVFNPRTVPSPPISPQALVEGENDEQSSTEQASAVKTKNVFIAQNVASLQELGGSEKLLR 258
Fly 232 VCVSLPILNRYRSKYMETINGGKSLYLPLTQVEATAVKSSMNHMLTDLTILSQAQALIEMQPLTP 296
||::||...||.:::.:.:.......:|.|..:||||::..:.::.|:|:.....:|..::||.|
Rat 259 VCLNLPYFLRYINRFQDAVVANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNP 323
Fly 297 SRIERLSMCGIAALYNAVLTSIATSVLGMSQASSSQKQTASTSQGSGVGGSSGGQSNKDHDDFED 361
||::.:::..::.||..| |:||.:..:...|:.|.:|.||| ...:|:|.
Rat 324 SRLQDVTVLSLSCLYAGV--SVATCMAILHVGSAQQVRTGSTS--------------SKEEDYES 372
Fly 362 QACSIVNKALEIYSNIGHMFKTSARI---HVYQNHLCYGSWLLISGIQGAMGASGSG----GSSS 419
.|.:||.|.||||..||....:|.|. | :||....|:|.|::.:...:..|.:. |...
Rat 373 DAATIVQKCLEIYDMIGQAISSSRRAGGEH-FQNFQLLGAWCLLNSLFLILHLSPTALADKGKEK 436
Fly 420 DSAS----KSASKATKSGSEAGTAPTTPIARVNLFKVQQGFGELNAAIANHSIKLLSELIEDLKV 480
|..: :.....||.| .|:....| .|..||||.|:..:|||:||||:.|.:||:|
Rat 437 DPLAALRVRDILSRTKEG--VGSPKLGP------GKGHQGFGVLSVILANHAIKLLTSLFQDLQV 493
Fly 481 EAACGQSLESTELPEPAQFDILQNYSSLERIVRVLNTATLHQLFTFLATVAYRKACTLKRASAKD 545
||. .....|:.| ||...|:...:|.:|:.|::::..|..|...|.:.:|||||.|:| ..|.
Rat 494 EAL--HKGWETDGP-PAVLSIMAQSTSTQRVQRLIDSVPLTNLLLTLLSTSYRKACVLQR-QRKG 554
Fly 546 RTECEPISYSDSTTYFNDSLSCS--DNSEEDDSESYLGHWFKETLSP----------------ET 592
....:..:.:||.||:.|..|.: |:|::||||..||.||:||:|| |:
Rat 555 SMSSDASASTDSNTYYEDDFSSTEEDSSQDDDSEPILGQWFEETISPSKEKAAPPPPPPPPPLES 619
Fly 593 HDDNANTSTQERAEQKSALVPKLDEPHEYLDLAADIFCFLDQFLAN-RHAYMQRYVKAGVSDQQM 656
.....:.|.|...|:.:.|..:.| |..:|.||::|..|:...:.| |:.:::.|:...:|:|.|
Rat 620 SPRVKSPSKQASGEKGNILASRKD-PELFLGLASNILNFITSSMLNSRNNFIRNYLSVSLSEQHM 683
Fly 657 LLMANIIKDFDRDVMRNESDQGSGNAPAASAGAGTSAGASTKWQTSMIRFSGAAGRYIHNLISTS 721
..:|:|||:.|:|.::..||:. |:.|...:.|:|:::.
Rat 684 ATLASIIKEVDKDGLKGSSDED---------------------------FAAALYHFNHSLVTSD 721
Fly 722 LLSEQLQSNLLQHLSISPWSTDTNTWPLQVYPSTLSVLVQILLLKPTQEKEAA--------CLSV 778
|.|..||:.|||.|.::|.| :..|||.::|..||||.::||: .|.|..| ||.|
Rat 722 LQSPNLQNTLLQQLGVAPLS--SGPWPLYIHPQGLSVLSRLLLI--WQHKAGAQGDPDVPECLKV 782
Fly 779 WHRLINTL----VEGVCSSNTASDSDYEDLNIEHAQLLLFLFHSLNLMQKKSILLLTAGGVIRCA 839
|.|.:.|: ::||..|.| |||||||.||||.:|||.:...:::||......:
Rat 783 WDRFLTTMKQSALQGVVPSET------EDLNIEHLQLLLLIFHSFSEKGRRAILTTLVQSI---- 837
Fly 840 EVCRGISEDRPVK-NSQIMLLSRLLLFLEYLMKHLYNAPPELLDQVRWNLFS-----VSSMPDTQ 898
:.:|.:..|: .|..::|:||||..:||:.....||..|.:||:.||.| .|...|:.
Rat 838 ---QELSVNMEVQMRSAPLILARLLLIFDYLLHQYSKAPVYLFEQVQHNLLSPPFGWASGSQDSS 899
Fly 899 KITDLLNCRTKLNSYCRH---DIEENFRKSAGEYGSSIRPTFYSLVMGDPEISYWAQE---FKLD 957
..:. |..:..| | ::|||:.|.... .::.:|.||.: :|..|.| .:||
Rat 900 SSSR----RANIPLY--HGFKEVEENWSKHFSS-DAAPQPRFYCV------LSTEASEEDLNRLD 951
Fly 958 GLAWNFILCTPDKL-KYPLLVDALTDILSI-TDMSMYSKEKDKEASMHNLCAIQYCFTIAWKLNL 1020
..|...:. .|| ||..|..:||.:|:. :.:....::::|..:....||:||.|.|.|:: |
Rat 952 SEACEVLF---SKLVKYDELYSSLTALLAAGSQLDTVKRKENKNMTALEACALQYYFLILWRI-L 1012
Fly 1021 G-LPPSTSHVESLKAERSPN------LHSLMWSIRLPLASSHYLVVSSLIKQGMYTQYAETLWTH 1078
| ||||.:::..| |..||. ||:|.||.||.::|....:...||:|||..::|.:|...
Rat 1013 GILPPSKTYMNQL-AMNSPEMSECDILHTLRWSSRLRISSYVSWIKDHLIRQGMRPEHAGSLVEL 1076
Fly 1079 VGDIGADIKYSLKQTILGVEAFNSQMNG------------NGTPRLSDLILFDSLVAHMQAVAWA 1131
.....:.:||.:: :..|.|..|::. :..|.|..:...|:.|:.:|.
Rat 1077 AASKCSSVKYDVE---IVEEYFARQISSFCSIDCTTVLQLHEIPSLQSIYTLDAAVSKVQV---- 1134
Fly 1132 NKEGLKWPRKESEDAAGEQSAGTSLTSSSNDPELYSSNESIDD--QKLKQDDDGKLSSDLQKYNQ 1194
|:|: .|:..:.|...||::.| |.
Rat 1135 ---------------------------------------SLDEHFSKMAAETDPHKSSEITK-NL 1159
Fly 1195 LVNELMVKLMNSYQLLSVIVRGQMLKQLSSSTPEKALNLIVPIVSDKPAIMLELH--AAFLKL-- 1255
|...| :|:::| :...|..:|:.|:.... ::||: ..:|| ||.|.:
Rat 1160 LPATL--QLIDTY---ASFTRAYLLQNLNEEGS-----------TEKPS-QEKLHGFAAVLAIGS 1207
Fly 1256 ---------------LPNEDKQLIANEWPKCLMVNDF--------AFNGKQHPVEPYILNVIDAH 1297
||: ..|.:...|.. :..|:| ||.....|.|.||..|..||
Rat 1208 SRCKANTLGPTLVQNLPS-SVQSVCESWNN-INTNEFPNIGSWRNAFANDTIPSESYISAVQAAH 1270
Fly 1298 IIELTRGSNYSTLHTLKHCLKSILQLF-ELLLPHRTANAEVETQLKQLLISSMLDMRTDYLQGHS 1361
:..|. |.:.....:|||.|.|:::|. :|::.....| ..|:.:.|:..:|:..|:.....|
Rat 1271 LGTLC-GQSLPLAASLKHALLSLVRLTGDLIVWSDEMN---PAQVIRALLPLLLESSTESAAEIS 1331
Fly 1362 EHCLREILSGLTQEAQKLLLYEHMVGYCYRMLKEFAADLRQPQSAGPSGGAPLDQDRAMFNESML 1426
.:.|..||.....:.....:||.::..||.:| ...|.||.| .:||:|
Rat 1332 SNSLERILGPAESDEFLARVYEKLITGCYNIL---------ANHADPSSG---------LDESVL 1378
Fly 1427 FAVLKTMFKMLEKPVAVQAMRQFFKDQRSGSLTTLLLSFTGTSLPVSYARKMLQFVNRLFQLSLQ 1491
...|:.:.|.||...|.:||.:||.| .|.|..::::.....|...:..::|:|..:||||:.:
Rat 1379 EECLQYLEKQLESSQARKAMEEFFSD--GGELVQIMMATANEDLSAKFCNRVLKFFTKLFQLTEK 1441
Fly 1492 A-DSQFQHEDLVECFSELATVDVARLKQWLGHIIYGPNVSTDVSTSEALDTTCRMLTSILQPSSS 1555
: :....| |....::||.|:..||:.|| .||.||
Rat 1442 SPNPSLLH--LCGSLAQLACVEPVRLQAWL----------------------TRMTTS------- 1475
Fly 1556 SSSNAQTPTNMATVSAMPSISDQLDPMEIEYDCGTAAGGGESNPGTGGAAANTSQILSLWQAAQP 1620
.|..||||:.:
Rat 1476 ----------------PPKDSDQLEVI-------------------------------------- 1486
Fly 1621 NPSEESSQACDHSDSERNGALLLSFVKSLVKDQSKASQ-IAPPLFQALLQLGQTLISPPQEGCDF 1684
:.|..||......:|::.|:..: :...|...|..:...::: ..:|..|
Rat 1487 ---------------QENRQLLQLLTTYIVRENSQVGEGVCAVLLGTLTPMATDMLA-NGDGTGF 1535
Fly 1685 ADVLQIMITLADASPARGHVALFNTTLLWLELAKLQLPDK-----------HLKHA---ENVSAQ 1735
.:::.:|.|||.|....||:.|.|..:.||...|..|..| |.||. |.....
Rat 1536 PELMVVMATLASAGQGAGHLQLHNAAVDWLGRCKKYLSQKNVVEKLNANVMHGKHVMVLECTCHI 1600
Fly 1736 LRYLSELLQSIGFRGSRQHNPPWDDELQTDIDE--------LYDELAEEGEQDSLLDDSDEDTLN 1792
:.||:::..::. |.|......|..|.:| ..:|||.| |:||..:|||||:|.
Rat 1601 MSYLADVTNALS-----QSNGQGPSHLSVDGEERAIEVDSDWVEELAVE-EEDSQAEDSDEDSLC 1659
Fly 1793 NKLCTFSQTQKEFMNQHWYHCHTCNMINTVGVCSVCARVCHKGHDVSYAKYGNFFCDCGAKEDGS 1857
||||||:.||||||||||||||||.|::.||||:|||:||||.|::||||||:||||||||||||
Rat 1660 NKLCTFTITQKEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHEISYAKYGSFFCDCGAKEDGS 1724
Fly 1858 CQALSRRIG----SNEVRDSA-----GIGSYLPSHMSLL-AGKKRSSLPVGQPVLTRKDSLTNER 1912
|.||.:|.. |:.:::|| .:...|..|.|.. |.|.:.::..|:.....|...::
Rat 1725 CLALVKRTPSSGMSSTMKESAFQSEPRVSESLVRHASTSPADKAKVTISDGKVADEEKPKKSS-- 1787
Fly 1913 IAVLTKLLEPYRETLQHQDQWLLVVRCILEYFDLLLPSINENCMLYSIVGCHKRATAALERLHLL 1977
|.:.:|..||.||:|..:.. ...:|:..:.|:.:|..|....|.||...||..||..||.:
Rat 1788 ---LCRTVEGCREELQNQANFSF-APLVLDMLNFLMDAIQTNFQQASAVGSSSRAQQALSELHTV 1848
Fly 1978 EQSFQVTDQLMFATLGSQEGAFENVRMNYSGDQGQTIKHLLSSGVVRRVAFCCLSSPHGRRQQLA 2042
::..::|||||..||||||||||||||||||||||||:.|:|:.|:||||.|.|||||||||.||
Rat 1849 DKVVEMTDQLMVPTLGSQEGAFENVRMNYSGDQGQTIRQLISAHVLRRVAMCVLSSPHGRRQHLA 1913
Fly 2043 VSHEKGKVTILQLSALLKQADASKRKLTLTQLSSAPIACTVISLAANPCNEDCLAVCGLKECHIL 2107
|||||||:|:|||||||||||:||||||||:|:|||:..||:||..|||.||.|||||||:||:|
Rat 1914 VSHEKGKITVLQLSALLKQADSSKRKLTLTRLASAPVPFTVLSLTGNPCKEDYLAVCGLKDCHVL 1978
Fly 2108 TFSSSGSTNEHIVVNPQLENGNYIKKAVWLPGSQTLLAVVTSDYVKIYDLAVDTYSPKYYYLVAV 2172
|||||||.::|:|::|||..||:|.||||||||||.||:||:|:||||||:||..||.:|:|:..
Rat 1979 TFSSSGSVSDHLVLHPQLATGNFIIKAVWLPGSQTELAIVTADFVKIYDLSVDALSPTFYFLLPS 2043
Fly 2173 GKIRDCTFVYQDGNYNMLTFASS-GYIYTQQLDQQSLAVHGDFYVTNTLELSHQHIKDIAGHIGG 2236
.||||.||::.:...|::...|| ||:|||.:::.|.|..|.|||||.||::|:.:||....:.|
Rat 2044 SKIRDVTFLFNEEGKNIIVIMSSAGYMYTQLMEEASSAQQGPFYVTNVLEINHEDLKDSNSQVAG 2108
Fly 2237 GGVSIYYSHTLQLLFYSYSCGRSFFSPLTNVSEGVKGIYHLDTNSASKSASKGPLQPLVQWTEVT 2301
||||:||||.||:||:|||.|:||.:.::..:..|..::.::..|::..:...| .|.||:||.
Rat 2109 GGVSVYYSHVLQMLFFSYSQGKSFAATVSRSTLEVLQLFPINIKSSNGGSKTSP--ALCQWSEVM 2171
Fly 2302 GHPGLVYASMQTSNNPIILMITPERIYLQEIKAQSAKSRIMDVVGIRHAVAG-VEKTTLLLLCED 2365
.|||||....||:..|:::|:.|:...:||||...||::|.|:|.|||.... .::||::|||||
Rat 2172 NHPGLVCCVQQTTGVPLVVMVKPDTFLIQEIKTLPAKAKIQDMVAIRHTACNEQQRTTMILLCED 2236
Fly 2366 GSLRIFSAQPEYTSFWLSPQVQPFGNQLYSSTLMAKGGGSGSTSKSKSNTASGKMTSRKASQQQK 2430
|||||:.|..|.||:||.|.:|| ||.: |..|......:..:|:|.:|
Rat 2237 GSLRIYMANVENTSYWLQPSLQP------SSVI--------SIMKPVRKRKTATITARTSS---- 2283
Fly 2431 QPTAGGQPVFPIDFFEHCNMLADVEFGGNDLLQIYNKQKLKTRLFSTGMFVASTRSNGFTLEVIN 2495
|..||||||||...|.|||||||||||:||.|::|.||.||||:||:|:..|||:|:.|
Rat 2284 ------QVTFPIDFFEHNQQLTDVEFGGNDLLQVYNAQQIKHRLNSTGMYVANTKPGGFTMEISN 2342
Fly 2496 NDPNVVIVGIRVLIGTQDVQRAPQSVTILGRTIPTPVRRARWFDIPLTREEMLQSDKLLKVVFAK 2560
|...:|:.|:|:.||||.::|||..:.|.|||:...:.|:||||.|.||||.||:|:.|.:....
Rat 2343 NSSTMVMTGMRIQIGTQAIERAPSYIEIFGRTMQLNLSRSRWFDFPFTREEALQADRKLNLFIGA 2407
Fly 2561 APDPEHVTLLDCIEVYGKSKELVGWPDE-SED--------VTVPG-----------SSAPAVSSS 2605
:.||..||::|.:::|||:||..||||| .|| |..|. |:|||.:|.
Rat 2408 SVDPAGVTMIDAVKIYGKTKEQFGWPDEPPEDFPSASVSSVCPPNLNQSNSTGDSDSAAPATTSG 2472
Fly 2606 QASSANFGEGFNCITQLDRMANHLLEVMDCALHLLGSGVPASMRQKAVKTASALLL-LPTPNPVQ 2669
....::..|. :|:|||:....||.:: :...:|..:.....:.|.:..:.||| ||.|..||
Rat 2473 TVLESSETES---LTKLDRLVVSSLEALE-SCFAVGPIIEKERNKHAAQELATLLLSLPAPASVQ 2533
Fly 2670 TQARYVLATLYGTRALYHNYKDGVLLQFVNRELQSMQPKLEKLETLREIDPEAFYRLVLMVRGIA 2734
.|::.:||:|:.:|:.||::||..|| ::.:|.:....:: .:::|||.|.|||:..|.||
Rat 2534 QQSKSLLASLHSSRSAYHSHKDQALL---SKAVQCLNTSSKE---GKDLDPEVFQRLVITARSIA 2592
Fly 2735 NARPQSLAKI----------------CVENNYDIVPTLMGIVLELHKVTPTLD------------ 2771
..||.:|... |...|..||..|:|..|| ||:.:
Rat 2593 VTRPNNLVHFTESKLPQMETDCFSPRCACWNLGIVGILIGAPLE----TPSAEGAEEGKEPQKQV 2653
Fly 2772 ---------------------EPVNIVKRGLCQP-----ETIVHCLVEIMYGFALADPGQVGRMT 2810
:|.|......|.| |..|:.||:|::|:...:...:...:
Rat 2654 EGDGCSFITQLVNHFWKLHASKPKNAFLAPACLPGLTHIEATVNALVDIIHGYCTCELDCINTAS 2718
Fly 2811 KYFIDLLKHDASVISHSAKEALILLLSPRMKRRKVAIVTPPACSTP---------TPSTSTMQAL 2866
|.::.:|......:|.|.|:|||.:|.||.|||.|.:.:.|..:|| ..:...||:.
Rat 2719 KIYMQMLLCPDPAVSFSCKQALIRVLRPRNKRRHVTLPSSPRSNTPMGDKDDDDDDDADEKMQSS 2783
Fly 2867 --------------QAAASSAASDIIEEAAGVVVDGSVGGGGLPEPNADAEGAAVGVGGVGQQQM 2917
|:.......:::.|:..:....:|..|. |.|
Rat 2784 GIPDGGHIRQESQEQSEVDHGDFEMVSESMVLETAENVNNGN-PSP------------------- 2828
Fly 2918 LNLEAFMGG--GFPRLLGLPEDADDEAIMDIAIALSLQ--QHGGDANA--LQSLQQGLANLQGIR 2976
|||.:.| |||.:|.:|.|||||.::::||||||| |.|..::| |||| .|.|..
Rat 2829 --LEALLAGAEGFPPMLDIPPDADDETMVELAIALSLQQDQQGSSSSALGLQSL-----GLSGQA 2886
Fly 2977 QATAMAAAVNAAANVSLGGSDDDEGSNVATDGSTLRTSPAEPAGSGGSESGGSGVESIGG---TS 3038
.:::...|...:...:...:.|||||..||||||||||||:..||.|||||||.|:|:.| .|
Rat 2887 PSSSSLDAGTLSDTTASAPASDDEGSTAATDGSTLRTSPADHGGSVGSESGGSAVDSVAGEHSVS 2951
Fly 3039 ARSSNFGDHANASPPRQGSTKDDQEQPGPSGVAGSGGVAVLSAMSSSEDNEANEDD--------- 3094
.|||.:||......| .||..|:.|.| .:|..:..::.:.:|.:
Rat 2952 GRSSAYGDATAEGHP-----------AGPGSVSSSTG--AISTTTGHQEGDGSEGEGEGEAEGDV 3003
Fly 3095 -KLSKLHDLRIAVLESIIQHLGTFDLCNGLQAIPLIQVILMLTTDLNGNNERDQQVLHDLLTALV 3158
..::||.:|:.:||.::|.|.......|::|||.:||||||||||:|.:|:|:..|.:||..|:
Rat 3004 HTSNRLHMVRLMLLERLLQTLPQLRNVGGVRAIPYMQVILMLTTDLDGEDEKDKGALDNLLAQLI 3068
Fly 3159 DYVEIGKRGAAARMETKCPGNEVRLALLSLFGVLMGKTKSKQTGTTSPPHQFKDNSSFVASTTAN 3223
..:.:.|:..:.:.| :...|||.|.::.|..|.|.:||| |:.| ...::||.::|.||.
Rat 3069 AELGMDKKDVSKKNE-RSALNEVHLVVMRLLSVFMSRTKS---GSKS---SICESSSLISSATAA 3126
Fly 3224 VLSKSGAFVYALEALNTLLVHWKNVLGDPYAAGGGLASQSAQASGGASGPGVQLLKPIKHGPKPD 3288
.|..|||..|.|..|.:||.:|| ..||.:.....| |||||......||
Rat 3127 ALLSSGAVDYCLHVLKSLLEYWK-------------GQQSEEEPVTTS----QLLKPHTTSSPPD 3174
Fly 3289 ISILIPHNYLKNY-PDIFESYDGLLTEIIVRLPYQILRLSSAHPDNYDSGFCEAMTFTLCEYMML 3352
:|......|:|.: .|:||:|..||||:::||||||.:::..........|..:..:.|.||:|:
Rat 3175 MSPFFLRQYVKGHAADVFEAYTQLLTEMVLRLPYQIKKIADTSSRIPPPVFDHSWFYFLSEYLMI 3239
Fly 3353 NLNTLLRRQVRKLLMYICGSKEKFRMYRDGHSLDAHFRVVKRV---------CNIVSSKTGAPYN 3408
.....:||||||||::|||||||:|..||.|:||:|.|.:|:: .::|::.:|:
Rat 3240 QQTPFVRRQVRKLLLFICGSKEKYRQLRDLHTLDSHVRGIKKLLEEQGIFLRASVVTASSGS--- 3301
Fly 3409 ANPPMLSYDALVELTEHLRTCQEISQMRTGNWQKFCVVHEDALAMLMEIACYQLDDGVSPIIIQL 3473
.|.||.|:.|.|||:.|.||:..||.||||||:..:..|..|:::: :.:|:||||:::||
Rat 3302 ----ALQYDTLISLMEHLKACAEIAAQRTINWQKFCIKDDSVLYFLLQVS-FLVDEGVSPVLLQL 3361
Fly 3474 LQAAVC-------------------NLPPPSGSKQAQPQPSTSSASGKLRTDREKSEDTDAYYSK 3519
|..|:| :.||.:.|.|...|..:|:...| :.::||.::.::..|:
Rat 3362 LSCALCGSKVLAALAASTGSSSVASSAPPAASSGQTTTQSKSSTKKSK-KEEKEKEKEGESSGSQ 3425
Fly 3520 FDPAQCGTFVHQIFRYACDALIIRFVRIFLLENNITQLRWQAHSFMTGLFEHANERQREKLLNIF 3584
.|.. |...|:|:.|:|....:|:|:|.||||:|.:.:|||||.....::.::|:.|:|.||::.
Rat 3426 EDQL-CTALVNQLNRFADKETLIQFLRCFLLESNSSSVRWQAHCLTLHIYRNSNKAQQELLLDLM 3489
Fly 3585 WNLWPLVPTYGRRTAQFVDLLGYLTLSTRSITERLPEFVSRAVDVLRQQNELLCKHPNAPIYTTL 3649
|::||.:|.|||:.|||||||||.:|.|....::|.|:..:||::||.||.:|..|||:.||.||
Rat 3490 WSIWPELPAYGRKAAQFVDLLGYFSLKTAQTEKKLKEYSQKAVEILRTQNHILTNHPNSNIYNTL 3554
Fly 3650 ESILQVNGYYLESEPCLVCNNPEVPMANIKLPSVKSDSKYTTTTMIYKLVQCHTISKLIVRIADL 3714
..:::.:||||||:|||||||||||...|||.|:|.|::||||..:.||:..|||||:.|:|.||
Rat 3555 SGLVEFDGYYLESDPCLVCNNPEVPFCYIKLSSIKVDTRYTTTQQVVKLIGSHTISKVTVKIGDL 3619
Fly 3715 KRTKMVRTINVYYNNRSVQAVVELKNRPALWHKARSVSLQSAQTELKIDFPLPITACNLMIEFAD 3779
||||||||||:|||||:|||:|||||:||.||||:.|.|...|||:|||.||||.|.||||||||
Rat 3620 KRTKMVRTINLYYNNRTVQAIVELKNKPARWHKAKKVQLTPGQTEVKIDLPLPIVASNLMIEFAD 3684
Fly 3780 FFETVSGSSENLQCPRCSAAVPAYPGVCGNCGENVFQCHKCRAINYDEKDPFLCHSCGFCKYAKF 3844
|:|....|:|.||||||||:|||.|||||||||||:||||||:|||||||||||::|||||||:|
Rat 3685 FYENYQASTETLQCPRCSASVPANPGVCGNCGENVYQCHKCRSINYDEKDPFLCNACGFCKYARF 3749
Fly 3845 DFSMYARVCCAVDPIESAEDRVKTVSLIHSSLERADRNYRQLLTNKQMLELLIQKVAEHRSSDRM 3909
||.:||:.||||||||:.|||.|.||.|::.|::|||.|.||:.::..||.|:.||.| .:.::.
Rat 3750 DFMLYAKPCCAVDPIENEEDRKKAVSNINTLLDKADRVYHQLMGHRPQLENLLCKVNE-AAPEKP 3813
Fly 3910 VEDN--MASVHSTS-QVNKIIQLLAQKYCVESRTSFEELSKIVQKVKACRSELVAYDRQQQD--- 3968
.||: ...:.||| .||:.|..|||:||.:.:.||:|||||:|||.|.|.||:.||.||::
Rat 3814 QEDSGTAGGISSTSASVNRYILQLAQEYCGDCKNSFDELSKIIQKVFASRKELLEYDLQQREAAT 3878
Fly 3969 -------QPPVNPG-----STTGAENPTTNRCYGCALASTEQCLTLLRAMAYNYDCRVCLYSQGL 4021
||..... |..|..:.::.:|||||.|.||.|:|||||:|.|...|..|.||||
Rat 3879 KSSRTSVQPTFTASQYRALSVLGCGHTSSTKCYGCASAVTEHCITLLRALATNPALRHILVSQGL 3943
Fly 4022 VSELAEHNLRRGTPLIQEEVRNLLVVLTKDNAEACMHLLQLVTTRVKNALMGSIPLISLEAAVHQ 4086
:.||.::|||||...|:||||.|:.:||:||.||...:..|:..:|..||.|......|.:::..
Rat 3944 IRELFDYNLRRGAAAIREEVRQLMCLLTRDNPEATQQMNDLIIGKVSTALKGHWANPDLASSLQY 4008
Fly 4087 EMTLLEVLLGQDDICWEYKLKVIFELFISNCRLPRGPVTA--VLHPCLRIMQNLICPVLPGSKPN 4149
||.||...:.::|.|||.:|:....||:....: :.||.. :...||||:|.||.|..|.||.|
Rat 4009 EMLLLTDSISKEDSCWELRLRCALSLFLMAVNI-KTPVVVENITLMCLRILQKLIKPPAPTSKKN 4072
Fly 4150 QKVATTDLCSMKMFEGNTVDYRA--WLNSDRNHEYAAWSKRMPSNNQAKLKNAKDQNVAASGGSD 4212
:.|....|.::|.: .|.:..:| ||..|....|.||.|.:|.. ...|...
Rat 4073 KDVPVEALTTVKPY-CNEIHAQAQLWLKRDPKASYEAWKKCLPIR-------------GVDGNGK 4123
Fly 4213 APPKSRREVRVAFLSEKYGKRWRERVLDKQRVIKPL---VFNAKWIQPLLFNANSRFGRQLACSL 4274
:|.|| |:...:|:|||..||::.:..:.:...|| :.:..|::.:||...::..||.||::
Rat 4124 SPSKS--ELHRLYLTEKYVWRWKQFLSRRGKRTTPLDLKLGHNNWLRQVLFTPATQAARQAACTI 4186
Fly 4275 LSSLSRTNERRQQALNMLTSFLKHVGEAGEASAEYLMLYKNMATEQPWLQYLVLKGVLSQISQLL 4339
:.:|:....|:||.|::|||:|..:..|||.:||||.||:.:.....|..||..:|||..:..|:
Rat 4187 VEALATVPSRKQQVLDLLTSYLDELSVAGECAAEYLALYQKLIASCHWKVYLAARGVLPYVGNLI 4251
Fly 4340 AIEISKVHRMEEYSLSSDLSLGYALRQYVELLWLLLECPNIRRTYKTRMLGPVLESYLALRSLVV 4404
..||:::..:||.:||:||..||||:....||...:|..:|:|.:|:|::|.||..||.||.||:
Rat 4252 TKEIARLLALEEATLSTDLQQGYALKSLTGLLSSFVEVESIKRHFKSRLVGTVLNGYLCLRKLVL 4316
Fly 4405 QRTRLIDDAQEKLLEMLEDMTSGTEEETRAFMEILIDTVEKTRMNDIKTPVFVFERLYSIIHPEE 4469
|||:|||:.|:.|||||||||:|||.||:|||.:.|:|.::..::|.:||||:||||.|||:|||
Rat 4317 QRTKLIDETQDMLLEMLEDMTTGTESETKAFMAVCIETAKRYNLDDYRTPVFIFERLCSIIYPEE 4381
Fly 4470 HDESEFYMTLEKDPQQEDFLQGRMLGNPYPSSEMGLGPLMRDVKNKICTDCELIALLEDDNGMEL 4534
::.:||::||||||||||||||||.||||.|:|.|:||||||:|||||.||:|:||||||:||||
Rat 4382 NEVTEFFVTLEKDPQQEDFLQGRMPGNPYSSNEPGIGPLMRDIKNKICQDCDLVALLEDDSGMEL 4446
Fly 4535 LVNNKIISLDLPVKDVYKKVWLA--EGGDRDAMRIVYRMRGLLGDATEEFVETLNNKSQEQVDTE 4597
|||||||||||||.:||||||.. || :.||||||||||||||||||:|:|::.:.|:.|.|
Rat 4447 LVNNKIISLDLPVAEVYKKVWCTTNEG---EPMRIVYRMRGLLGDATEEFIESLDSTTDEEEDEE 4508
Fly 4598 QLYRMANVLADCNGLRVMLERIGSLQRISRNRELIQVLLKLFLICVKVRRCQEVLCQPEIGAINT 4662
::||||.|:|.|.||:.||.|:..::...:.|.|:.||||||..||||:..::.|.:.|:..:|.
Rat 4509 EVYRMAGVMAQCGGLQCMLNRLAGVKDFKQGRHLLTVLLKLFSYCVKVKVNRQQLVKLEMNTLNV 4573
Fly 4663 LLKVLQMCLQSENDSIQS---AVTEQLLEIMETILSKAASDTLDSFLQFSLTFGGPEYVSALISC 4724
:|..|.:.|.:|.:|..| ||.||:|.|||.||.::.::.|.......|..|..:.:..|:..
Rat 4574 MLGTLNLALVAEQESKDSGGAAVAEQVLSIMEIILDESNAEPLSEDKGNLLLTGDKDQLVMLLDQ 4638
Fly 4725 TDCPNVRNNPSVLRHLIRVLAALVYGNEVKMALLCEHFKDTLNFNRFDNERTPEEEFKLELFCVL 4789
.:...||:|||||:.|:|::..|.:|...||.:|.|.||...:|:::|.:.:.:::..|:.||.:
Rat 4639 INSTFVRSNPSVLQGLLRIIPYLSFGEVEKMQILVERFKPYCSFDKYDEDHSGDDKVFLDCFCKI 4703
Fly 4790 TNQIEHNCIGGTLKDYIVSLGIVERSLAYITEHAPCVKPTLLRTDSDELKEFISRPSLKYILRFL 4854
...|::|..|..|||.|:..||.:.:|.|:.:|.|..| ..|:|..|:|:|||:|.:|||.|
Rat 4704 AAGIKNNSNGHQLKDLILQKGITQSALDYMKKHIPSAK----NLDADIWKKFLSRPALPFILRLL 4764
Fly 4855 TGLSNHHEATQVAISKDIIPIIHRLEQVSSDEHVGSLAENLLEALSTDSATAARVQQVRDFTRAE 4919
.||:..|.||||.|..|.|..:|:||||||||.:|:|||||||||........::...|..||||
Rat 4765 RGLAMQHPATQVLIGTDSITSLHKLEQVSSDEGIGTLAENLLEALREHPDVNKKIDAARRETRAE 4829
Fly 4920 KKRLAMATREKQLDALGMRTNEKGQVTAKGSILQKIEKLRDETGLTCFICREGYACQPDKVLGIY 4984
|||:|||.|:|.|..|||.|||||||..|.::|:::|:|.:|.||||.||||||..||.||||||
Rat 4830 KKRMAMAMRQKALGTLGMTTNEKGQVVTKTALLKQMEELIEEPGLTCCICREGYKFQPTKVLGIY 4894
Fly 4985 TFTKRCNVEEFELKSRKTIGYTTVTHFNVVHVDCHTSAI------------RLTRGRDEWERASL 5037
|||||..:||.|.|.||..||:||:|||:||.|||.:|: ||.|||:|||.|:|
Rat 4895 TFTKRVALEEMENKPRKQQGYSTVSHFNIVHYDCHLAAVSCLSLLSSLSPSRLARGREEWESAAL 4959
Fly 5038 QNANTRCNGLLPLWGPAVGEAAFSACMTRHSSYMQESTQRCDISYTSSVHDLKLLLVRFAWERSF 5102
|||||:||||||:|||.|.|:||:.|:.||::|:||.|.:.:.:|..::||:|||.:|||.|:||
Rat 4960 QNANTKCNGLLPVWGPHVPESAFATCLARHNTYLQECTGQREPTYQLNIHDIKLLFLRFAMEQSF 5024
Fly 5103 HDDAGGGGPQSNMHFVPYLLFYSVYLLLSSRSAARDSKTLLTYLQAPPSEKWLECGYEVDGPLFM 5167
..|.||||.:||:|.:||::...:|:|.::|:.:|:.|.|..:|: .|.|||.|..::||||.:.
Rat 5025 SADTGGGGRESNIHLIPYIIHTVLYVLNTTRATSREEKNLQGFLE-QPREKWTESAFDVDGPHYF 5088
Fly 5168 ATISLSLHSRELWNKHKLAHLKRMIAVAQGRHVSPAVLCKALLAPADRQVKDYTVYKPFLMMWAL 5232
..::|.:...|.|...::..|:|::..:..|.|:|....:. .|:.||||:.|:..|:.|||
Rat 5089 TILALHVLPPEQWKATRVEILRRLLVASHARAVAPGGATRL----TDKAVKDYSAYRSSLLFWAL 5149
Fly 5233 VDLIYDNLFKTVSTPKEE-DWPISLFDYLRKNDEALLKSTDSILQTLTEEFLPCTSFVEFCDVAG 5296
||||| |:||.|.|...| .|..||.:|:|.||..:.::.|..|:|..|||:|..:|.||.|.||
Rat 5150 VDLIY-NMFKKVPTSNTEGGWSCSLAEYIRHNDMPIYEAADKALKTFQEEFMPVETFSEFLDAAG 5213
Fly 5297 LLHLIEHPDNFIEEILAALP 5316
||..|..|::|::::|.::|
Rat 5214 LLSEITDPESFLKDLLNSVP 5233
| 
