DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment poe and ubr5

DIOPT Version :9

Sequence 1:NP_001260222.1 Gene:poe / 46243 FlyBaseID:FBgn0011230 Length:5322 Species:Drosophila melanogaster
Sequence 2:XP_004915163.2 Gene:ubr5 / 100490232 XenbaseID:XB-GENE-939896 Length:2794 Species:Xenopus tropicalis


Alignment Length:2800 Identity:482/2800 - (17%)
Similarity:840/2800 - (30%) Gaps:1108/2800 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   239 LNRYRSKYMETINGGKSLYLPLTQVEATAVKSSM---NHMLTDLTILSQAQALIEMQPLTPSRIE 300
            ||:|          ..|.:.||..:|.|.:|..:   ||          |..|:|     ..||.
 Frog    29 LNKY----------NLSSHPPLNVLEQTTIKQCVVGPNH----------AAFLLE-----DGRIC 68

  Fly   301 RLSMCGIAALYNAVLTSIATSVLGMSQASSSQKQTASTSQGSGVGGSSGGQSNKDHDDFEDQACS 365
            |:..            |:....|.:|:..::  ..:..|.|||.|.:|......|...|      
 Frog    69 RIGF------------SVQPDRLELSKPENN--DGSKLSSGSGAGRTSRPGRTSDSPWF------ 113

  Fly   366 IVNKALEIYSNIGHMFKTSARIHVYQNHLCYGSWLLISGIQGAMGASGSGGSSSDSASKSA---- 426
                 |.....:|.:               .|:.|   |.:.:.|..||||.||..:|..|    
 Frog   114 -----LSGSETLGRL---------------AGNTL---GSRWSSGVGGSGGGSSGRSSAGARDSR 155

  Fly   427 --SKATKSGSEAGTA-------PTTPIARVNLFKVQQGFGELNAAIANHSIKLLSELIEDLKVEA 482
              ::..::|.:.|:.       |..|.:.:.                       .|||...:|  
 Frog   156 RQTRVIRTGRDRGSGLLGSQPQPVIPASVIP-----------------------EELISQAQV-- 195

  Fly   483 ACGQSLESTELPEPAQFDILQNYSSLERIVRVLNTATLHQLFTFLATVAYRKACTLKRASAKDRT 547
                              :||. .|...|:|.|....|                           
 Frog   196 ------------------VLQG-KSRSVIIRELQRTNL--------------------------- 214

  Fly   548 ECEPISYSDSTTYFNDSLSCSDNSEEDDSESYLGHWFKETLSPETHDDNANTSTQERAEQKSALV 612
                    |.....|:.|| .|:.:.||.                 ||.|:.|.....:..|.|.
 Frog   215 --------DVNLAVNNLLS-RDDEDGDDG-----------------DDTASESYLPGEDLMSLLD 253

  Fly   613 PKLDEPHEYLDLAADIFCFLDQFLANRHAYMQRYVKAGVSDQQMLLMANIIKDFDRDVMRN---- 673
            ..:...|..:.:.||.. |.:......:...:|...:.:...::||:.   .:.|.:::|.    
 Frog   254 ADIHSAHPSVIIDADAM-FSEDISYFGYPSFRRSSLSRIGSSRVLLLP---LERDSELLRERESV 314

  Fly   674 --------------ESDQGS-----------GNAPAASAGAGTSAGASTKW-----QTSMIRFSG 708
                          ::::||           .|.|..|.   .|.|...:|     .|..|    
 Frog   315 LRLRERRWLDGASFDNERGSTSKEGEPALDKKNTPIQSP---VSLGEDLQWWPEKDGTKFI---- 372

  Fly   709 AAGRYIHNLISTSLLSEQLQSNLLQHLSISPWSTDTNTWPLQVYPSTLSVL----VQILLL---- 765
            :.|.....|::.|...|..|...::.   .|:   .||..|.::....|.|    .:|:||    
 Frog   373 SIGALYSELVAVSSKGELYQWKWMES---EPY---RNTQNLSLHHPRASFLGLTNEKIVLLSANS 431

  Fly   766 -KPTQEKEAACLSVWHRLINTLVEGVCSSNTASDSDYEDLNIEH-AQLLLFLFHSLNLMQKKSIL 828
             :.|...|:..::.|   ::..:..|.|            .:|| ||    :|..|   |...|:
 Frog   432 IRATVATESNKVATW---VDETLSSVAS------------KLEHTAQ----IFPEL---QGDKIV 474

  Fly   829 LLTAGGVIRCAEVCRGISEDRPVKNSQIMLLSRLLLFLEYLMKHLY-------NAPPELLDQVR- 885
            .|....:..||:                            |..:||       :...::|::.| 
 Frog   475 SLHCCALYTCAQ----------------------------LENNLYWWGVVPFSQRKKMLEKARA 511

  Fly   886 -----WNLFSVSSMPDTQKITDLLNCRTKLNSYCRHDIEENFRKSAGEYGSSIRPTFYSLVMGDP 945
                 .:...:||||:....|.:          |   :..|....||...       :|:..|.|
 Frog   512 KNKKPKSSAGISSMPNITVGTQV----------C---LRNNPLYHAGAVA-------FSISAGIP 556

  Fly   946 EISYWAQEFKLDGLAWN------FILCTPDKLKYPLLVDALTDILSITDMSMYSKEKDKEASMHN 1004
            ::....:.      .||      |.|.:|:.||.          |..|:.:..:|.:.|:..:  
 Frog   557 KVGVLMES------VWNMNDSCRFQLRSPESLKN----------LEKTNKTTEAKPESKQEPV-- 603

  Fly  1005 LCAIQYCFTIAWKLNLGLPPSTSHVESLKAERSPNLHSLMWSIRLPLASSHYLVVSSLIKQGMYT 1069
                        |..:|.|||       .|....:..|:..|..:|                 |.
 Frog   604 ------------KTEMGPPPS-------PASTCSDASSIASSASMP-----------------YK 632

  Fly  1070 QYAETLWTHVGDIGADIKYSLKQTILGVEAFNSQMNGNGTPRLSDLILFDSLVAHMQAVAWANKE 1134
            :...|......:...:.::||::.:...:..|       .|....|.:..:.||           
 Frog   633 RRRSTPAPKEEEKVNEEQWSLREVVFVEDVKN-------VPVGKVLKVDGAYVA----------- 679

  Fly  1135 GLKWPRKESEDAAGEQSAGTSLTSSSN-----DPELYSSNESIDDQKLKQDDDGKLSSDLQKYNQ 1194
             :|:|             |||..|::.     ||:   .:..:.|.:|.:.|:            
 Frog   680 -VKFP-------------GTSNNSNNQCTPGCDPD---PSSLLQDCRLLRIDE------------ 715

  Fly  1195 LVNELMVKLMNSYQLLSVIVRGQMLK--QLSSSTPEKALNLIVPIVSDKPAIMLE---LHA---- 1250
                           |.|:..|...|  .....||:|   |.:|..::..|:.::   :||    
 Frog   716 ---------------LQVVKTGGTPKVPDCFQRTPKK---LCIPEKTEILAVNVDSKGVHAVLKT 762

  Fly  1251 ------AFLKLLPNEDKQLIANEWPKCLMVNDFAFNGKQH---------PVEPYILNVIDAHIIE 1300
                  ....|...:.:|  .|.:|    .:..||.|:..         ...|.||         
 Frog   763 GTWVRYCIFDLATGKAEQ--ENNFP----TSSIAFLGQNERNVAIFTAGQESPIIL--------- 812

  Fly  1301 LTRGSNYSTLHTLKHCLKSILQLFELLLP---------HRTANAEVETQLKQ---LLISSMLDMR 1353
              |..|.:.....|.|:..|.....|.||         |...|....:.:|:   ::|.::    
 Frog   813 --RDGNGTIYPMAKDCMGGIRDPDWLDLPPISSLGMGVHSLTNLPANSTIKKKAAIIIMAV---- 871

  Fly  1354 TDYLQGHSEHCLREILSGLTQEAQKLLLYEHMVGYCYRMLKEFAADLRQPQSAGPSGGAPLDQDR 1418
                    |.|:::            .|.:|::...|...:::..:|.|        |..||.:.
 Frog   872 --------EVCIKQ------------TLMQHILRCDYEACRQYLMNLEQ--------GVVLDPNT 908

  Fly  1419 AMF----------NESMLFAVLKTMFKMLEKPVAVQAMRQFFKDQRSGSLTTLLLSFTGTSLPVS 1473
            .|.          |.::|.|.:...|     |.:.:..::..:.:||...|              
 Frog   909 QMLQTFLSHRCDGNRNILHACVSVCF-----PTSNKETKEEEEAERSERNT-------------- 954

  Fly  1474 YARKMLQFVNRLFQLSLQADSQFQHEDLVECFSELATVDVARLKQWLGHIIYGPNVSTDVSTSEA 1538
                   |..||              ..||..:...:|..:.          ||......|:|.:
 Frog   955 -------FAERL--------------SAVEAIANAISVVSSN----------GPGNRAGSSSSRS 988

  Fly  1539 LDTTCRMLTSIL-----QPSSSSSSNAQTPTN--MATVSAMPSISDQLDP-MEIEYDCGTAAGGG 1595
            |.....|..|:.     :..:.:||:.|.|.:  :|..|.:|. ...:|| .:|::....|.|..
 Frog   989 LRLREMMRRSLRAAGLGRHEAGASSDHQDPVSPPIAPPSWVPD-PPAMDPDGDIDFILAPAVGSL 1052

  Fly  1596 ESNPGTGGAAANTSQILSLWQAAQPNPSEESSQACDHSDSERNGALLLSFVKSLVKDQSKASQIA 1660
            .:.....|...:||.|        |.||.|.| ..:..|.:.|...:|..:              
 Frog  1053 TTASTVPGQGPSTSTI--------PGPSSEPS-VVESKDRKANAHFILKLL-------------- 1094

  Fly  1661 PPLFQALLQLGQTLISPPQEGCDFADVLQIMITLADASPARGHVALFNTTLLWLELAKLQLPDKH 1725
                                 ||...:...:..|..|..|||.....:........|.:.:    
 Frog  1095 ---------------------CDSIVLQPYLRDLLSAKDARGMTPFMSAVSGRAYPAAITI---- 1134

  Fly  1726 LKHAENVSAQLRYLSELLQSIGFRGSRQHNPPWDDELQTDIDELYDELAEEGEQDSLLDDSDEDT 1790
            |:.|:.::......||..:.: |:|  ...||..:                      .|||....
 Frog  1135 LETAQKIAKAEANSSEKEEDV-FKG--MICPPGTN----------------------ADDSPLYV 1174

  Fly  1791 L-NNKLCTFSQTQKEFMNQHWYHCHTCNMINTVGVCSVCARVCHKGHDVSYAKYG-NFFCDCGAK 1853
            | .|..|:|:.|..|.:||..:.|.||.::.::..|:.||||||||||....:.. ..:|||..|
 Frog  1175 LCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEK 1239

  Fly  1854 EDGSCQALSRRIGSNEVRDSAGIGSYLPSHMSLLAGKKRSSLPVGQPVLTRKDSLTNERIAVLTK 1918
                |:.                       .:|:||:|.:.|.:...:||            :|.
 Frog  1240 ----CKC-----------------------KTLIAGQKSARLDLLYRLLT------------ITN 1265

  Fly  1919 LLEPYRETLQHQDQWLL--VVRCILEYFDLLLPSINENCMLYSIVGCHKRATA------------ 1969
            |:.......:|...:|:  |.|..:|:.....|.|.|:         ..|..|            
 Frog  1266 LVTMPNSRGEHILLFLVQTVARQTVEHCQYRPPRIRED---------RNRKAANPEDSDMPDHDL 1321

  Fly  1970 --------ALERLHLLEQSFQVTDQLMFATLGSQEGAFENVRMNYSGD---QGQTIKHLL----- 2018
                    ||||  :|:....:...:||   ||||          :.|   ....|.|||     
 Frog  1322 EPPRFAQLALER--VLQDWNALKSMIMF---GSQE----------NKDPLSASSRIGHLLPEEQV 1371

  Fly  2019 ----SSGVVRRVAFC-CL-------------------------SSPHGRRQQLAVSHEKGKVTIL 2053
                .||.:|...|. ||                         .:| |||::......:...::.
 Frog  1372 YLNQQSGTIRLDCFTHCLIVKCTADILLLDTLLGTLVKELQNKYTP-GRREEAVAVTMRFLRSVA 1435

  Fly  2054 QLSALLKQADASKRK---------------------LTLTQL-----------------SSAPIA 2080
            ::..:|....||.:|                     ..:.:|                 .:||..
 Frog  1436 RVFVILSVEMASSKKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFT 1500

  Fly  2081 CTVISLAANPCNEDCLAVCGL--KECHILTFSSSGSTNEHIVVNPQLENGNYIKKAVWLPGSQTL 2143
            ....|:.|...:|:..:|..|  :.....:.||:.|.:.:|:.|||...         :..||.:
 Frog  1501 LASTSIDAMQGSEELFSVEPLPPRPSSDQSNSSNQSQSSYIIRNPQQRR---------ISQSQPV 1556

  Fly  2144 LA-------VVTSDYVKI-------------------------------------YDLAVDTYSP 2164
            ..       :|::|..::                                     .|:.:|    
 Frog  1557 RGRDEEQDDIVSADVEEVEVVEGVAGEEDHHDEQEEHGEENTEAEGQHDEHDEDGSDMELD---- 1617

  Fly  2165 KYYYLVAVGKIR---DCTFVYQD---GNYNMLTFASSG--------------------------- 2196
                |:|..:..   :.....||   |..:::|.|::|                           
 Frog  1618 ----LLAAAETESDSESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSDS 1678

  Fly  2197 -YIYTQQLDQQSLAVHGDFYVTNTLELSHQHIKDIAGHIGGGGVSIYYSHTLQLLFYSYSCGRSF 2260
             ...:..|||::      |.:...||.|..     :.|..|...:   ..::|   ::....:|.
 Frog  1679 SSSQSDDLDQET------FMIDEPLERSSN-----SNHANGAAQA---PRSMQ---WAVRNTQSQ 1726

  Fly  2261 FSPLTNVSEGVKGIYHLDTNSASKSASKGPL---QPLVQWTEVTGHPGLVYASMQTSNNPIILMI 2322
            .:|.|..|           |:::.:||.|.|   :|...............|:::.||:...|..
 Frog  1727 RAPNTTPS-----------NTSTPAASSGALIYIEPSSLRRSGNMSSSAAAAALEASNSSSYLTS 1780

  Fly  2323 TPE--RIYLQEIKAQSAKSRIMDVVGI----RHAVAGVEKTTLLLLCEDG-SLRIFSAQ---PEY 2377
            ...  |.|...|:      :|.|::|:    .|.|.......:.|..:|. :|:.:..:   |.:
 Frog  1781 ASSLARAYSIVIR------QISDLMGLIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTW 1839

  Fly  2378 TSFWLSPQVQPFGNQLYSSTLMAKGGGSGSTS----KSKSNTASGKMTSRK-------------- 2424
            .  |:...:.....||...:.:|..|..|..:    .|:::....:||:|:              
 Frog  1840 N--WMVSIMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSNRRERMTAREEASLRTLEGRRRAT 1902

  Fly  2425 -ASQQQKQPTAGGQPVFPIDFFEHC-NMLADVEFGGNDLLQIYNKQKLK--TRLFSTGMFVASTR 2485
             .|.:|.....|       ||..:. :::.......:|:|.:.:...||  ..:|...::.....
 Frog  1903 LLSARQGMSARG-------DFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAM 1960

  Fly  2486 SNGFTLEV---------------INN---------DPNVVIVGIRVLIGTQDVQRAP-------- 2518
            :...||:.               ::|         |.|..:.     :..:|....|        
 Frog  1961 NQQTTLDTPQLERKRTRELLELGLDNEDSEHENDDDTNQSLT-----LNDKDDDTLPSETGPNHP 2020

  Fly  2519 -----QSVTILGRTIPTPVRRARWFDIPLT-------REEMLQSDKLLKVVFAKAPDPEH----- 2566
                 .|:|.||...|.|      |::||.       :..:||.:...:.:|.:.....:     
 Frog  2021 FFRRSDSMTFLGCIPPNP------FEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSTAN 2079

  Fly  2567 -------VTL-LDCIEV------YG-------------KSKELVGWPDESEDVTVPGSSAPAVSS 2604
                   ||: .:|:||      |.             |..|....|.|..|.:.||.||..:::
 Frog  2080 TGKCLLEVTVDRNCLEVLPTKMSYASNLKNVMNMQSRQKEAEEQNVPAEENDTSKPGPSAHDLAA 2144

  Fly  2605 SQASS 2609
            ...||
 Frog  2145 QLKSS 2149

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
poeNP_001260222.1 ZnF_UBR1 1794..1862 CDD:197698 25/68 (37%)
DZR 3793..3837 CDD:289539
E3_UbLigase_R4 4493..5296 CDD:290481
ubr5XP_004915163.2 CUE_UBR5 184..230 CDD:270606 16/125 (13%)
ZnF_UBR1 1179..1246 CDD:197698 25/93 (27%)
PolyA 2385..2448 CDD:197769
HECTc 2469..2791 CDD:214523
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D717at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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