Protein Alignment MYH6 and MYO1

DIOPT Version :10

• Sequence 1: NP_002462.2
• Gene: MYH6 / 4624
• HGNCID: 7576
• Length: 1939
• Species: Homo sapiens
• Sequence 2: NP_011888.1
• Gene: MYO1 / 856418
• SGDID: S000001065
• Length: 1928
• Species: Saccharomyces cerevisiae
• Alignment Length: 2097
• Identity: 619/2097 - (29%)
• Similarity: 1001/2097 - (47%)
• Gaps: 397/2097 - (18%)

Human    38 FVPDDKEEFVKAKILSREGGK--------------VIAETENGKTVTVKEDQVLQQNPPKFDKIE 88
            ::||:||.|||.:::|.:..|              .:..||....|.|:...|...||..|||:|
Yeast    14 WIPDEKEVFVKGELMSTDINKNKFTGQEEQIGIVHPLDSTEVSNLVQVRISDVFPVNPSTFDKVE 78

Human    89 DMAMLTFLHEPAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGK-------- 145
            :|:.||.|:||:||:||::||...:||||||||.|.:|||..|.:|:.:.:..|..|
Yeast    79 NMSELTHLNEPSVLYNLEKRYDCDLIYTYSGLFLVAINPYHNLNLYSEDHINLYHNKHNRLSKSR 143

Human   146 ----KRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFASIAAIGDRGK 206
                ...:.|||||:|::.||:.:|::.::||||:|||||||||.|||:::||.|||.:    |.
Yeast   144 LDENSHEKLPPHIFAIAEEAYENLLSEGKDQSILVTGESGAGKTENTKKILQYLASITS----GS 204

Human   207 KDNANANKG-----TLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIET 266
            ..|.....|     :.|.:|:|:||.||:||||:||||:|||||||||:|.|...|.:..|.||.
Yeast   205 PSNIAPVSGSSIVESFEMKILQSNPILESFGNAQTVRNNNSSRFGKFIKIEFNEHGMINGAHIEW 269

Human   267 YLLEKSRVIFQLKAERNYHIFYQILSN-KKPELLDMLLVTNNPYDYAFVSQGEVS-VASIDDSEE 329
            |||||||::.|...|||||||||:||. ...||.::.|.:.|..||..:|..... :..|:|.|.
Yeast   270 YLLEKSRIVHQNSKERNYHIFYQLLSGLDDSELKNLRLKSRNVKDYKILSNSNQDIIPGINDVEN 334

Human   330 LMATDSAFDVLGFTSEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSA 394
            .....||.:::||:.::...::::...|:..||::| ...|.|||  ....|.......:|::..
Yeast   335 FKELLSALNIIGFSKDQIRWIFQVVAIILLIGNIEF-VSDRAEQA--SFKNDVSAICSNLGVDEK 396

Human   395 DLLKGLCHPRVKVGNEYVTKGQSVQQVYYSIGALAKAVYEKMFNWMVTRINATLETKQPRQYFIG 459
            |....:..||.|.|.|:|::.::.||..:.:.||::.:||::|.::|..||..|:.......:||
Yeast   397 DFQTAILRPRSKAGKEWVSQSKNSQQAKFILNALSRNLYERLFGYIVDMINKNLDHGSATLNYIG 461

Human   460 VLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDL 524
            :|||||||||:.|||||||||:||||||||||:|||||||.||.||.|:|.:||:|.|||..|||
Yeast   462 LLDIAGFEIFENNSFEQLCINYTNEKLQQFFNNHMFVLEQSEYLKENIQWDYIDYGKDLQLTIDL 526

Human   525 IEK---PMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNIKGKQEAHFSLIHYAGT 586
            ||.   |.|::.:|:||.:.||:||.:|.:||.......|:.|::.|...|     |.|.||||.
Yeast   527 IESKGPPTGVLPLLDEEAVLPKSTDESFYSKLISTWDQNSSKFKRSRLKNG-----FILKHYAGD 586

Human   587 VDYNILGWLEKNKDPLNETVVALYQKSSLKLMATLF------SSYATADTGDSGKSKGGKKKGSS 645
            |:|.:.|||.|||||||:.:::|...|...:::.||      ||.|..:...|.:......:.|:
Yeast   587 VEYTVEGWLSKNKDPLNDNLLSLLSSSQNDIISKLFQPEGEKSSSAGVEANISNQEVKKSARTST 651

Human   646 FQTVSALHRENLNKLMTNLRTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKG 710
            |:|.|:.|||....|:..|.:||||||||||||..|.....:..|::.||||||||||||:.|:|
Yeast   652 FKTTSSRHREQQITLLNQLASTHPHFVRCIIPNNVKKVKTFNRRLILDQLRCNGVLEGIRLAREG 716

Human   711 FPNRILYGDFRQRYRILNPVAIPEGQFIDSRKGTEK-----LLSSLDIDHNQYKFGHTKVFFKAG 770
            :||||.:.:|.||||||.|.......|....|.:.|     ||:||.:|...||.|:||:|||||
Yeast   717 YPNRIAFQEFFQRYRILYPENSTTTTFSSKLKASTKQNCEFLLTSLQLDTKVYKIGNTKLFFKAG 781

Human   771 LLGLLEEMRDERLSRIITRMQAQARGQLMRIEFKKIVERRDALLVIQWNIRAFMG-VKNWPWMKL 834
            :|..||:.:|.:|:.|:.::.|..||..:|.|....:::.....||....|.:.. ||..||..|
Yeast   782 VLADLEKQKDVKLNNIMIKLTATIRGYTVRKEITYHLQKLKKTRVIGNTFRLYNRLVKEDPWFNL 846

Human   835 YFKIKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDN 899
            :.:|||||.|:..........|:..::|..|::.|:::|.||||....:.|..:.|..:..|::|
Yeast   847 FIRIKPLLTSSNDMTRTKKFNEQINKLKNDLQEMESKKKFLEEKNQKTVNELENTQDLLNQEKEN 911

Human   900 LNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLA 964
            |.          ||:..|. :||..:|.|:                        |..|||.....
Yeast   912 LR----------KNESLLN-RVKTSSETLQ------------------------KQFDDLVSEKD 941

Human   965 KVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKA-LQEAHQQALDDLQVEEDKVNSLSKSKVK 1028
            ::.:||......::...:::.||.|.|    :|::| |::.|           .|.|.|.|
Yeast   942 EISREKLEVAQNLEEAHQKIQGLQETI----REREATLEKLH-----------SKNNELIK---- 987

Human  1029 LEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQN 1093
               |:.||...:.:|:..:..::.:|.|||.::|              :|::.:..||.:|...|
Yeast   988 ---QISDLNCDISKEQSSQSLIKESKLKLENEIK--------------RLKDVINSKEEEIKSFN 1035

Human  1094 SKI----EDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEE 1154
            .|:    ||..:..:.|:|......:|::.|..|....|:.....:|.::.|:.:|
Yeast  1036 DKLSSSEEDLDIKLVTLEKNCNIAMSRLQSLVTENSDLRSKNENFKKEKAALNNQL--------- 1091

Human  1155 AGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKL 1219
                        |.:|:|..||:..::    .|:...|...|:..|:|:|.|           |:
Yeast  1092 ------------KNKESELLKMKEKID----NHKKELATFSKQRDDAVSEHG-----------KI 1129

Human  1220 EKEKSEFKLELDDVTSNMEQIIKAKANLEKVSR--------TLEDQANEYRVKLEEA----QRSL 1272
            ..|..|.:::|.:..||.::|.:..:|.::.::        :|.:..|:.::|..||    :.||
Yeast  1130 TAELKETRIQLTEYKSNYQKIKEEYSNFQRETKEQEQKKRNSLVESLNDSKIKELEARLSQEISL 1194

Human  1273 NDFTTQRAK---------------------------------LQTENGELAR----QLEEKEALI 1300
            |.:..:|..                                 ||....|:.|    ::|||:.||
Yeast  1195 NQYLNKRISGNSVETNISSTRRSTSYSDDPLDKEDIIKKYYDLQLAFTEITRNLENEIEEKKNLI 1259

Human  1301 SQL--TRGKLSYTQ--------QMEDLKRQLEEEGKAKNALAHALQSARHDC------------- 1342
            |:|  |..:|:.:.        ||:.||:.:::...: ..|...|.....:|
Yeast  1260 SRLRFTETRLASSSFEDQKIKAQMKKLKKLIQDMDPS-IPLDSILNEPLDNCPDKESDINKLMLE 1323

Human  1343 -DLLREQYEEETEAKAELQRVLSKANSEVAQ------------WRTKYETDAIQRTEELEEAKKK 1394
             |.|:.|.:.||.|..:.:..:|..:|:..:            ::.|:|... :|.:.||:..|.
Yeast  1324 VDYLKRQLDIETRAHYDAENAISALHSKFRKIQGESSLSSSDIYKLKFEASE-ERVKSLEDKLKT 1387

Human  1395 LAQR----------------LQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAA 1443
            :..|                :...||.:.....:...|::..:....::..|.:|:.:|.:..|.
Yeast  1388 MPLRDRTNLPVGDIIKNRDSISKYEEEIRYYKLENYKLQEILNESNGKLSQLTLDLRQSKSKEAL 1452

Human  1444 LDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQ 1508
            |.::   .|::           |.:|||::::...||:.:.:.|..:|..::.|:   .....|:
Yeast  1453 LSEQ---LDRL-----------QKDLESTERQKELLSSTIKQQKQQFENCMDDLQ---GNELRLR 1500

Human  1509 EEISDLTEQLGEGGKNVHE-LEKVRKQ-LEVEKLELQSALEEAEASLEHEEG--KILRAQLEFNQ 1569
            |.|..| :|..|..||:.. :||::.| .:.|||..:..:|..::.::.:|.  ::.|.|    .
Yeast  1501 EHIHAL-KQAEEDVKNMASIIEKLKTQNKQKEKLIWEREMERNDSDMQLQETLLELKRVQ----D 1560

Human  1570 IKAEIERKLAEKDEEMEQAKRNHQ------RVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEME 1628
            :|..:...||...|.:...:...|      |:.:.|..||.|||..:.|...:|.|:|...|:.|
Yeast  1561 VKKILSDDLAHLKERLSAVEDRSQYTDEINRLKEELNCSLKAETNLKKEFATLKYKLETSTNDSE 1625

Human  1629 IQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDL---KENIAIVER----RNNLLQAE 1686
            .::|                 .|||    |||...:..:.|   |:.|::.|:    :...|..|
Yeast  1626 AKIS-----------------DLLK----QLDHYTKVVEMLNNEKDAISLAEKELYQKYEALNTE 1669

Human  1687 LEELRAVVEQTERSRKLAEQELIETSERVQLLH------SQNTSLINQKKKMESDLTQLQSEVEE 1745
            .|.|:..:....:.::..|.:|.:.::.:|:.:      :|....|.:|.|...:..|||.|
Yeast  1670 CESLKGKIVSLTKIKQELESDLNQKTDALQISNAALSSSTQKNKEITEKIKYLEETLQLQME--- 1731

Human  1746 AVQECRNAE---------EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRL-D 1800
              |..||.|         ...|....|......:|.:|..|   |:::..:::..:|:|..|| |
Yeast  1732 --QNSRNGELVKTLQASCNGYKDKFDDEKQKNIDLYEENQT---LQKLNTDLQLQLKNLHERLSD 1791

Human  1801 EAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLR 1865
            ..|:.|..          :::.|||..:..|.....|.:|..:..||.::||  ||:..::
Yeast  1792 TTEKNAWL----------SKIHELENMVSLETDLKYEEMKKNKSLERAVEEL--QTKNSQQ---- 1840

Human  1866 LQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKV--QHEL-------------DEAEERADIA 1915
                .|.::|..| .:.:.|||..:....:|...|.  |.||             |:.:|.|.
Yeast  1841 ----TDVIELANK-NRSEFEEATLKYEAQISDLEKYISQQELEMKKSIRDNSSYRDKVQEMAQ-- 1898

Human  1916 ESQVNKLRAKSRDIGAK 1932
            |.:..|.|.:|..||:|
Yeast  1899 EIEFWKSRYESTMIGSK 1915

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH6	NP_002462.2	Myosin_N	32..76	CDD:460670	13/51 (25%)
		MYSc_class_II	99..768	CDD:276951	306/701 (44%)
		Actin-binding	657..679		13/21 (62%)
		Actin-binding	759..773		9/13 (69%)
		Myosin_tail_1	848..1925	CDD:460256	255/1230 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1826..1849		5/22 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1909..1939		9/24 (38%)
MYO1	NP_011888.1	COG5022	2..1691	CDD:227355	559/1840 (30%)
		Smc	1607..>1901	CDD:440809	76/345 (22%)