DRSC/TRiP Functional Genomics Resources

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Protein Alignment MYH6 and Myo28B1

DIOPT Version :10

Sequence 1:NP_002462.2 Gene:MYH6 / 4624 HGNCID:7576 Length:1939 Species:Homo sapiens
Sequence 2:NP_723294.1 Gene:Myo28B1 / 53515 FlyBaseID:FBgn0040299 Length:2122 Species:Drosophila melanogaster


Alignment Length:2140 Identity:549/2140 - (25%)
Similarity:875/2140 - (40%) Gaps:566/2140 - (26%)


- Green bases have known domain annotations that are detailed below.


Human    17 RKSEKERLEAQTR------PFDIR------TECFVPDD--KEEFVKAKILSREGGKVIAETENGK 67
            ||.|...::.|..      ||..|      |:..|.||  |:.:|.|       |.|:    ...
  Fly     8 RKGEYVWVKPQNTTSEFAVPFGARIVRTEKTQTLVCDDRNKQFWVPA-------GDVL----KAM 61

Human    68 TVTVKEDQVLQQNPPKFDKIEDMAMLTFLHEPAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLP 132
            .:|.:||            :|||..|..|.|..:|.||:.|||..:||||:|...|.:|||:.||
  Fly    62 HITSQED------------VEDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILP 114

Human   133 VYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAS 197
            :|....:..||.|..:|.|||||:|||||:|.:...:|||.::|:||||||||.:||.::||.|:
  Fly   115 IYTNREIQLYRNKSLAELPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAA 179

Human   198 IAAIGDRGKKDNANANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASA 262
            |:     ||       ...:|.|||:|||.:|||||||||||||||||||:|.|.|...|.:..|
  Fly   180 IS-----GK-------HSWIEQQIIEANPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGA 232

Human   263 DIETYLLEKSRVIFQLKAERNYHIFYQILSN-KKPELLDMLLVTNNPYDYAFVSQGE-VSVASID 325
            .|:.|||||||::||.:.||||||||.:|:. ...|...:.|...:|..|.:::||. .::....
  Fly   233 RIQQYLLEKSRIVFQSRDERNYHIFYCMLAGLSTAERERLKLQEQSPSQYHYLAQGGCFTLPGRG 297

Human   326 DSEELMATDSAFDVLGFTSEEKAGVYKLTGAIMHYGNMKFKQKQ--REEQAEPDGTEDADKSAYL 388
            |:::.....:|..||.|..||...:..|..||:|.||::|...:  ....||.|.|.:..:.|.|
  Fly   298 DAKDFADIRAAMKVLSFKPEEVWSILSLLAAILHLGNLRFTATEVANLATAEIDDTPNLQRVAQL 362

Human   389 MGLNSADLLKGLCHPRVKVGNEYVTKGQSVQQVYYSIGALAKAVYEKMFNWMVTRINATL--ETK 451
            :|:..:.|...|....:.|..|:||...|.:.......|..|::|:.:|..:|.|||.|:  :..
  Fly   363 LGIPISALNAALTQRTIFVHGEHVTTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETINKQVD 427

Human   452 QPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGM 516
            ||.. .||||||.|||.||.|||||||||:.||.|||||..|:|.:||:||:.|.|.|..|:| .
  Fly   428 QPMN-SIGVLDIFGFENFDNNSFEQLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEF-Q 490

Human   517 DLQACIDLI-EKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNIKGK--QEAHF 578
            |.|..:||| .|||.:||:::||..|||.||.|...||:..|..:|      ..:|||  |.:.|
  Fly   491 DNQQILDLIGMKPMNLMSLIDEESKFPKGTDQTLLEKLHVQHGNRS------IYVKGKTTQTSLF 549

Human   579 SLIHYAGTVDYNILGWLEKNKDPLNETVVALYQKSSLKLMATLFSSYATADTGDSGKSKGGKKKG 643
            .:.||||.|.||.||:||||:|..:..:..|.|:|:.|.:..:|......||        .||: 
  Fly   550 GIRHYAGVVMYNPLGFLEKNRDSFSGDLRTLVQRSTNKYLVDIFPHEMPMDT--------AKKQ- 605

Human   644 SSFQTVSALHRENLNKLMTNLRTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICR 708
               .|:....|.:|:.||..|...||:|:|||.|||.|.|...|..|.:.|||.:|::|..||.|
  Fly   606 ---PTLCVKFRNSLDMLMRTLSQAHPYFIRCIKPNEYKEPKNFDKELCVRQLRYSGMMETARIRR 667

Human   709 KGFPNRILYGDFRQRYRILNPVAIPEGQFIDSRKGTEKLLS-SLDIDHNQYKFGHTKVFFKAGLL 772
            .|:|.|..|..|.:|||:|.|...|..| .|.||...::.. :|..|.:: ::|.||:|.:....
  Fly   668 AGYPIRHAYRAFVERYRLLVPPVGPLEQ-CDCRKLARQICEVALPADSDR-QYGKTKLFLRDEDD 730

Human   773 GLLEEMRDERLSRIITRMQAQARGQLMRIEFKKIVER-RDALLVIQWNIRAFMGVKNWPWMKLYF 836
            ..||..|.:.:.:.|..:|   || :.|:.|::.::| |:|::.:|...|..:..:.:..|:..|
  Fly   731 ASLELQRSQLMLKSIVTIQ---RG-IRRVLFRRYMKRYREAIITVQRYWRGRLQRRKYQVMRQGF 791

Human   837 KIKPLLKSAETEKEMATMKEEFGRIK------ETLEKSEARRKELEEKMVSLLQEKNDLQLQVQA 895
            .   .|.:....:::.|   :|..::      :.|.:....||:.::|::. .:::|.|:.:...
  Fly   792 H---RLGACIAAQQLTT---KFTMVRCRTIKLQALSRGYLVRKDFQKKLLE-RRKQNQLKKEELL 849

Human   896 EQDNLNDAEE--RCDQLIKNKIQLEAKVKEMNE-RLEDEEEMNAELTAKKRKLEDECSELKKDID 957
            :...:.:|||  |..||   |.|.|.:.:|..| ||::|:.:.||..|:.               
  Fly   850 KLAKMKEAEELLRLQQL---KEQKEREQREQQEKRLQEEQRLKAEAAARN--------------- 896

Human   958 DLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQ----QALDDLQVEE-- 1016
              .|.:|.|::::                         :.|...|||.:    ||.:.|....  
  Fly   897 --ALAMAAVQQKR-------------------------RTKPVKQEAPKAPTLQARNSLPPPPTT 934

Human  1017 ---------------DKVNSLSKSKVKLE-----QQVDDLEGSLEQEKKVRMDLERAKRKL---- 1057
                           .::|::.:|...::     |.|||:...|..|.      :.|.|||    
  Fly   935 LIVAAPLPTRPASAVTRINTIPESPGTIDVESSKQMVDDVFRFLNDEP------DAALRKLNNIS 993

Human  1058 EGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEE 1122
            .||                                          .::|.|.:..|   |:    
  Fly   994 SGD------------------------------------------TIRLPKSVPNN---ID---- 1009

Human  1123 ELEAERTARAKVEKLRSDLSRELEEISERLEEA-----GGATSVQIEMNKKREAEFQKMRRDLEE 1182
                           .||.|        .|:.|     ||||:             |..|:.|::
  Fly  1010 ---------------TSDFS--------YLKYAATYFGGGATA-------------QHERKPLKK 1038

Human  1183 ATLQHEATAAALRKKH-ADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKAN 1246
            :.|:||         | .|.:|.....:..|:            |..:|.||.|:....:....|
  Fly  1039 SLLKHE---------HPIDEMASKAIWLTILR------------FMGDLPDVVSSPTLHVFDNEN 1082

Human  1247 LEKVSRTLEDQANEYRVKL-----------------EEAQRS----LNDFTTQRAKLQTENGELA 1290
            |.....:|.:.::.|:.:|                 :|||..    ||..|:...|:....|...
  Fly  1083 LMSDLASLLNTSDSYKPRLFVRQSQRRIPKPLASGEKEAQEFYQHWLNVPTSHLEKIHFIIGHGI 1147

Human  1291 RQLEEKEALISQLTR------GKLSY----------------TQQMEDLKRQLEEEGKAKNALAH 1333
            .:...::.:::|:.:      .:.||                :::.|...|...::|.|:.....
  Fly  1148 IKNSLRDEILAQICKQLYLNPSRSSYSRGWLLLSLCLSCFPPSKEFEPHLRSFMKQGTAQLQATP 1212

Human  1334 ALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1398
            :||                     .|:|.|  .|....|..:.:|..||:....|     :|...
  Fly  1213 SLQ---------------------RLERTL--VNGPRCQPPSLFELHAIRGRHPL-----RLDIH 1249

Human  1399 LQDAEE----------AVEAVNAKCSSLEKTK-------HRLQNEIEDLMVDVERSNAAAAALDK 1446
            |.|.::          |.||||..|..:..|.       ..|..::..|....|  :...|..:.
  Fly  1250 LMDGQQRRLQVDAASTAREAVNQLCQGMGLTDTFGFGLVMSLNGKLMPLGAGQE--HVLDAISEC 1312

Human  1447 KQRNFD---------KILAEWKQK----------YEESQSELESSQKEARSLST----------- 1481
            :||..|         ::.|.|...          |::..:.|:..:...||...           
  Fly  1313 EQRQLDAPWKLYIRKEMFATWYDPSMDPKATQLIYKQILNGLKCGEYRCRSEKDIAMVCALACFV 1377

Human  1482 -----ELFKLK----NAY---------EESLEH-----LETFKRENKNLQEEISDLTEQLGEGGK 1523
                 |:.:||    .|:         |.::|:     ..|::: :..::||.:||   |.|..|
  Fly  1378 EYGPGEILRLKPSEITAFVPSDLLAPGERAIENWSRLIAATYEK-SSYVKEEQNDL---LLEAQK 1438

Human  1524 NVHE-----------------LEKVRKQ-LEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQI 1570
            ...|                 .|.|||: .:::..||...:..|...|..|..::|.:......:
  Fly  1439 RAKEDICLFAHLSWPMRHSRLFEVVRKEGPKLQSDELMLGINSAGLFLIDETEQVLASCCFSEVL 1503

Human  1571 KAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLR-------------------V 1616
            |..:     |.|:::......|...|....::.||     |||:.                   |
  Fly  1504 KVHV-----ESDDKLHVMTFQHVNFVLQCSSAQDA-----NEVINYMLDNLRQRSSYGVALDPVV 1558

Human  1617 KKKME-------GDLNEMEIQLSHANRMAAEAQ--------------------------KQVKSL 1648
            :..:|       |||.|.|..::.|..||..||                          |..:.|
  Fly  1559 EGDLEDCLVLNPGDLIEFEAGVTGAQLMAGNAQDCYRGCVNGQWGQFLAGNVRVLATLTKPSEKL 1623

Human  1649 QSLLKDTQIQ--LDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQ-----TERSRKLAEQ 1706
            |.:|::.:.|  .....|||...:       |::|:.|......|..::.     ::.|.:..:.
  Fly  1624 QDILREGRFQEPPKPTPRANYSRR-------RQHNISQLAESHFREPLDSDKAPLSKFSPEPLKA 1681

Human  1707 ELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAE-- 1769
            .|::...:|..|..|...:.:...|...|:.:....|        |.:...:.|:....:..|  
  Fly  1682 PLLKAVVKVPPLFQQALVMHHHILKYMGDIARSNLPV--------NTDLIFQPALQHPLLCDELY 1738

Human  1770 -ELKKEQDTSAHLERMKKN-----------------MEQTIKDLQHRLDEAEQIALKGGKKQLQK 1816
             :|.|:...:...|..|:.                 |.:.|..|:.|.|......||..|:.|.:
  Fly  1739 CQLMKQLSDNPSSESEKRGWDLLYLATGLVAPSVLVMRELIILLRMRADALADACLKRLKRSLAQ 1803

Human  1817 LEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLK 1876
            .:.:......|:|..|:|.......:...:..::  .::.|...:....:.|:..:|:||
  Fly  1804 GQRKKAPHLIEVEGIQQRCLHIYHKIYFPDDTVE--AFEIESHTRGAELIADIAQRLELK 1861

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYH6NP_002462.2 Myosin_N 32..76 CDD:460670 13/51 (25%)
MYSc_class_II 99..768 CDD:276951 284/678 (42%)
Actin-binding 657..679 11/21 (52%)
Actin-binding 759..773 4/13 (31%)
Myosin_tail_1 848..1925 CDD:460256 223/1284 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1826..1849 4/22 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1909..1939
Myo28B1NP_723294.1 MYSc_Myo7 81..726 CDD:276832 284/678 (42%)
IQ 765..785 CDD:197470 4/19 (21%)
Atrophin-1 <820..>946 CDD:460830 33/171 (19%)
MyTH4 1031..1239 CDD:470587 43/251 (17%)
FERM1_F1_Myosin-VII 1243..1334 CDD:340612 19/97 (20%)
B41 1248..1429 CDD:214604 30/183 (16%)
PH-like 1454..1547 CDD:473070 20/102 (20%)
MyTH4 1674..1819 CDD:214535 26/152 (17%)
FERM2_F1_Myosin-VII 1825..1919 CDD:340613 5/39 (13%)
B41 1827..2032 CDD:214604 5/37 (14%)
FERM_C2_MyoVII 2028..2121 CDD:270020
Blue background indicates that the domain is not in the aligned region.

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