Protein Alignment MYH6 and Myo61F

DIOPT Version :10

• Sequence 1: NP_002462.2
• Gene: MYH6 / 4624
• HGNCID: 7576
• Length: 1939
• Species: Homo sapiens
• Sequence 2: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Alignment Length: 1102
• Identity: 332/1102 - (30%)
• Similarity: 525/1102 - (47%)
• Gaps: 221/1102 - (20%)

Human    87 IEDMAML-TFLHEPAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEA 150
            ::|..:| .:..|.|.:.|||:|:...:||||.|...::|||||.||:|..:.|.|||.|...|.
  Fly    39 VQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYEM 103

Human   151 PPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFASIAAIGDRGKKDNANANKG 215
            |||||:::|||::.::.:...|.:||:||||:|||..:|:|:|:.|:            .:.|:.
  Fly   104 PPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAA------------CSGNQT 156

Human   216 TLE---DQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQ 277
            |:|   |:::::||.|||||||||.||||||||||::.|.|...|.....:|..||||||||:.|
  Fly   157 TVEGVKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQ 221

Human   278 LKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQG-EVSVASIDDSEELMATDSAFDVLG 341
            :..|||:|||||:|:.....||..|.:......|::::.| ..:|..|:|::.......|..|:.
  Fly   222 MGGERNFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVID 286

Human   342 FTSEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVK 406
            ||.||:..::.:..:|:|.||:.|.:.  |..|:.:..:....:|.|:|:|:::|...|.|..:.
  Fly   287 FTKEEQREIFGIVASILHLGNVGFTEV--EGNAKVNSRDLVVTAARLLGVNASELEAALTHRTID 349

Human   407 VGNEYVTKGQSVQQVYYSIGALAKAVYEKMFNWMVTRINATL---ETKQPRQYFIGVLDIAGFEI 468
            ...:.||...:.:...|:..|||||||:::|:|:|.|:|.:|   ||:..|...:|:|||.||||
  Fly   350 ARGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEI 414

Human   469 FDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMS 533
            |..|||||.||||.||||||.|.......||:||::|||||..:::..:...|..:.||..||:|
  Fly   415 FQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIIS 479

Human   534 ILEEECMFP-KATDMTFKAKLYDNHLGKSNNF----QKPRNIKG---KQEAHFSLIHYAGTVDYN 590
            ||:|||:.| :.||.||..|| ...|.:.:::    :.|.:||.   :.|  |.|:||||.|.|:
  Fly   480 ILDEECLRPGEPTDKTFLEKL-TQKLAQHHHYVCHEKAPAHIKKIMLRDE--FRLVHYAGEVTYS 541

Human   591 ILGWLEKNKDPLNETVVALYQKSSLKLMATLFSSYATADTGDSGKSKGGKKKGSSFQTVSALHRE 655
            :.|:|:||.|.|...:.....|:...::...|..          |.....|:.   :|.....|.
  Fly   542 VNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFPE----------KELRSLKRP---ETAITQFRA 593

Human   656 NLNKLMTNLRTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDF 720
            :||.||..|....|.::|||.||:.:...|.::.||:||::..|::|.:|:.|.||..|..|..|
  Fly   594 SLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELF 658

Human   721 RQRYRILNPVAIPEGQFIDSRK-GTEKLLSSLDIDHNQYKFGHTKVFFK---------------- 768
            .:||:.|:....|..:.....| |.::|:..|..|..:|:.|.||:|.:
  Fly   659 LERYKSLSKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKK 723

Human   769 ---AGLL-----GLLEEMRDERLSRIITRMQAQARGQLMRIEFKKIVERRDALLVIQWNIRAFMG 825
               |.::     ||::..:..:|...:..||:..|.:|.:...||   ||:|...|:..|:.|:.
  Fly   724 HEIAAIIQAHWKGLMQRRKYLKLRAQVIIMQSYCRRKLAQQAAKK---RREAADKIRAFIKGFIT 785

Human   826 VKNWP--------------WMKLYFKIKPLLKSAETEKEMATMKEEFGRIKETLEKS-------- 868
            ..:.|              |         ||:.|   ||:.|         :.|:||
  Fly   786 RNDAPNGFNEEFIANAKRMW---------LLRLA---KELPT---------KVLDKSWPHAPGHC 829

Human   869 -EA-----RRKELEEKMVSLL----QEKNDLQLQVQAEQDNLNDAEERCDQLIKNK--------- 914
             ||     |...|....:..|    |:|...:|:|.||            ::.|.|
  Fly   830 EEASGILHRLHRLHLARIYRLKLTPQQKRQFELKVLAE------------KVFKGKKNNYASSVS 882

Human   915 --IQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV 977
              .|.:...||..:|:.|  .:.:...:::.|.:..|::.                ::|..:::
  Fly   883 TWFQEDRIPKEHIQRVND--FVASTFGSEQLKYQSFCTKF----------------DRHGYKSR- 928

Human   978 KNLTEEMAGLDEIIAKLTK-----EKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLE 1037
                      |..|....|     :.|..::.|:..||             |....|....|||
  Fly   929 ----------DRFILLSNKAIYVLDGKTYKQKHRLPLD-------------KIDFTLTNHNDDL- 969

Human  1038 GSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLEN---------------DKLQLEEKLKK 1084
                  ..:|:.|:..|.|  |||.|....|::...               |:..||..:.|
  Fly   970 ------MVIRIPLDLKKDK--GDLILIIPRIIEFSTYIIDTVGTASIVSIVDRNSLEHNVVK 1023

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH6	NP_002462.2	Myosin_N	32..76	CDD:460670
		MYSc_class_II	99..768	CDD:276951	256/684 (37%)
		Actin-binding	657..679		10/21 (48%)
		Actin-binding	759..773		5/37 (14%)
		Myosin_tail_1	848..1925	CDD:460256	52/286 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1826..1849
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1909..1939
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	256/684 (37%)
		Myosin_TH1	863..1049	CDD:461801	38/224 (17%)