Protein Alignment MYH6 and zip

DIOPT Version :10

• Sequence 1: NP_002462.2
• Gene: MYH6 / 4624
• HGNCID: 7576
• Length: 1939
• Species: Homo sapiens
• Sequence 2: NP_523860.2
• Gene: zip / 38001
• FlyBaseID: FBgn0287873
• Length: 2056
• Species: Drosophila melanogaster
• Alignment Length: 1949
• Identity: 761/1949 - (39%)
• Similarity: 1180/1949 - (60%)
• Gaps: 72/1949 - (3%)

Human    38 FVPDDKEEFVKAKILSREGGKVIAE-TENGKTVTVKEDQVLQQNPPKFDKIEDMAMLTFLHEPAV 101
            :||.:.:.||.|.|....|.:|..| .|.||.|.:..|.:.:.|||||||:||||.||.|:|.:|
  Fly    83 WVPHENQGFVAASIKREHGDEVEVELAETGKRVMILRDDIQKMNPPKFDKVEDMAELTCLNEASV 147

Human   102 LFNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYML 166
            |.|:|:||.:.:||||||||||.|||||.||:|..:::..|:|.||.|.|||:|:|:|:||:.||
  Fly   148 LHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPPHVFAITDSAYRNML 212

Human   167 TDRENQSILITGESGAGKTVNTKRVIQYFASIAAIGDRGK------------------------- 206
            .|||:||||.|||||||||.|||:|||:.|.:||...:|.
  Fly   213 GDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLINFSVNTNKYIKVKIM 277

Human   207 -----------------KDNANANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFG 254
                             :.|:|..:|.||.|::||||.||||||||||:|||||||||||||:|.
  Fly   278 AQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFD 342

Human   255 ATGKLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEV 319
            |:|.::.|:||||||||||.|.|.|.||.:|||||:|:...||..:..:: ::...|||:|.|.:
  Fly   343 ASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFIL-DDVKSYAFLSNGSL 406

Human   320 SVASIDDSEELMATDSAFDVLGFTSEEKAGVYKLTGAIMHYGNMKFKQKQREEQAE-PDGTEDAD 383
            .|..:||..|..||..:.:::|.|||:...::::..|::.:|:|||:|::..:||. ||.|. |.
  Fly   407 PVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNNDQATLPDNTV-AQ 470

Human   384 KSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSVQQVYYSIGALAKAVYEKMFNWMVTRINATL 448
            |.|:|:||:..|:.:....||:|||.::|||.|:.:||.:::.|:|||.||:||.|:|.|||.:|
  Fly   471 KIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAIAKACYERMFKWLVNRINRSL 535

Human   449 E-TKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFI 512
            : ||:....|||:||:||||||:.|||||||||:|||||||.|||.||:||||||::|||||.||
  Fly   536 DRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWKFI 600

Human   513 DFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNIKGKQEAH 577
            |||:|||..||||:||.|||::|:|||.||||||.||..||...| .....|.| .:.:|  .|.
  Fly   601 DFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVDKLVSAH-SMHPKFMK-TDFRG--VAD 661

Human   578 FSLIHYAGTVDYNILGWLEKNKDPLNETVVALYQKSSLKLMATLF--------SSYATADTGDSG 634
            |:::||||.|||:...||.||.|||||.:|:|.|.|....:..::        :..|..||
  Fly   662 FAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAEIVGMAQQALTDT---- 722

Human   635 KSKGGKKKGSSFQTVSALHRENLNKLMTNLRTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNG 699
             ..|.:.:...|:|||.|::|.|.|||..||.|:|:||||||||..|..|.:|.|||:.||||||
  Fly   723 -QFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCNG 786

Human   700 VLEGIRICRKGFPNRILYGDFRQRYRILNPVAIPEGQFIDSRKGTEKLLSSLDIDHNQYKFGHTK 764
            |||||||||:||||||.:.:|||||.:|.|..||:| |:|.:|..||::.:|::|.|.|:.|.:|
  Fly   787 VLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKG-FMDGKKACEKMIQALELDSNLYRVGQSK 850

Human   765 VFFKAGLLGLLEEMRDERLSRIITRMQAQARGQLMRIEFKKIVERRDALLVIQWNIRAFMGVKNW 829
            :||:||:|..|||.||.::|.:|...||..||.|.|..::|.:::.:|:.:||.|..|::.::||
  Fly   851 IFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQRNCAAYLKLRNW 915

Human   830 PWMKLYFKIKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQ 894
            .|.:||.|:||||:..:.|:::...::|..:::|.|:......:|.|.|....|.||..|..|:|
  Fly   916 QWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTLAKNTQEYERKYQQALVEKTTLAEQLQ 980

Human   895 AEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDL 959
            ||.:...:|||...:|:..|.:||..::|:..|:|:|||....|..:|:|||....:|::.:::.
  Fly   981 AEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEERVLALGGEKKKLELNIQDLEEQLEEE 1045

Human   960 ELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSK 1024
            |....|::.||...:.|:|...|::|..|:...||.||||.|:|........|..||:|...|:|
  Fly  1046 EAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLAK 1110

Human  1025 SKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDI 1089
            .|.|.|..:.:||..|.::::.|.:.:|:|||:|.::...:|.:.:......:::.:|.|:|.::
  Fly  1111 LKAKHEATISELEERLHKDQQQRQESDRSKRKIETEVADLKEQLNERRVQVDEMQAQLAKREEEL 1175

Human  1090 NQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEE 1154
            .|...:|::|.......||..:|.::::.|::|:||||:.||||.||:|.|||.|||.:...|.:
  Fly  1176 TQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEALKNELLD 1240

Human  1155 AGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKL 1219
            :...|:.|.|:..|||.|...:::.|||.|:.||...|.:|.||:..:..:.:|::||::.|..|
  Fly  1241 SLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQLENLRKAKTVL 1305

Human  1220 EKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQT 1284
            ||.|...:.|..|:.:.:..:..::...::..:..|.|..|.:|||.|.:|:.::...:..|||.
  Fly  1306 EKAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQIAELQVKLAEIERARSELQEKCTKLQQ 1370

Human  1285 ENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQY 1349
            |...:..||||.|...|...:...:...|:.:.::.||||.:.|..|:..|:....:.:.|:||.
  Fly  1371 EAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEETRQKLGLSSKLRQIESEKEALQEQL 1435

Human  1350 EEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCS 1414
            ||:.|||...:|.|::..:::.:.:.|.|.|| ...:||||.||:|.:.::..|..|:.:.|:..
  Fly  1436 EEDDEAKRNYERKLAEVTTQMQEIKKKAEEDA-DLAKELEEGKKRLNKDIEALERQVKELIAQND 1499

Human  1415 SLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSL 1479
            .|:|:|.::|:|:||..:::|........|:|||:||||||||.|...|:...|.:::::|||..
  Fly  1500 RLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNFDKILAEEKAISEQIAQERDTAEREAREK 1564

Human  1480 STELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQS 1544
            .|::..:....:|:.:.:|..:.:.|.||.|:.||....|...||||||||.::.||.:..||::
  Fly  1565 ETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLANTQGTADKNVHELEKAKRALESQLAELKA 1629

Human  1545 ALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRS 1609
            ..||.|..|:..|...||.::....::::.||.|..|:|..|:.:|...:.:..|:|.||.|.:.
  Fly  1630 QNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAKEEGAEEKRRGLVKQLRDLETELDEERKQ 1694

Human  1610 RNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIA 1674
            |...:..|||:||||.|:|..:...|::..:|.|..|.||:.:||.....::|..|.::|:....
  Fly  1695 RTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAKKLQAQVKDALRDAEEAKAAKEELQALSK 1759

Human  1675 IVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQL 1739
            ..||:...|:||:.:|...:..:||:|:.||.|..|.:|.:....::.:.:|::|:::|:.:..|
  Fly  1760 EAERKVKALEAEVLQLTEDLASSERARRAAETERDELAEEIANNANKGSLMIDEKRRLEARIATL 1824

Human  1740 QSEVEEAVQECRNAE---EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE 1801
            :.|:||   |..|:|   ::::||......:..||..|:..|...|..:..:|:..|:|:.:|.|
  Fly  1825 EEELEE---EQSNSEVLLDRSRKAQLQIEQLTTELANEKSNSQKNENGRALLERQNKELKAKLAE 1886

Human  1802 AEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRL 1866
            .|.......|..:..|||::..||.:||.|.|......|..||.:::|||||...|::::::.:.
  Fly  1887 IETAQRTKVKATIATLEAKIANLEEQLENEGKERLLQQKANRKMDKKIKELTMNIEDERRHVDQH 1951

Human  1867 QDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIG 1930
            ::.:|||..::|..||..:|.||:.....::.||.|.|.::..|..:....::|.|:.|.|..|
  Fly  1952 KEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQRECEDMIESQEAMNREINSLKTKLRRTG 2015

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH6	NP_002462.2	Myosin_N	32..76	CDD:460670	14/38 (37%)
		MYSc_class_II	99..768	CDD:276951	360/720 (50%)
		Actin-binding	657..679		15/21 (71%)
		Actin-binding	759..773		6/13 (46%)
		Myosin_tail_1	848..1925	CDD:460256	336/1079 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1826..1849		7/22 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1909..1939		6/22 (27%)
zip	NP_523860.2	Myosin_N	79..122	CDD:460670	14/38 (37%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	360/720 (50%)
		Myosin_tail_1	931..2011	CDD:460256	336/1083 (31%)