DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MYH6 and didum

DIOPT Version :9

Sequence 1:NP_002462.2 Gene:MYH6 / 4624 HGNCID:7576 Length:1939 Species:Homo sapiens
Sequence 2:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster


Alignment Length:1885 Identity:512/1885 - (27%)
Similarity:854/1885 - (45%) Gaps:429/1885 - (22%)


- Green bases have known domain annotations that are detailed below.


Human    63 TENGKTVTVK-----EDQVLQQNPPKFDKIEDMAMLTFLHEPAVLFNLKERYA-AWMIYTYSGLF 121
            |::||...||     .|....:||.......|:..|::||||.||.||:.|:. ..:||||.|:.
  Fly    43 TDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGII 107

Human   122 CVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTV 186
            .|.:|||..:|:|...::.||||....:..||||::::.||..:..:..|.||:::|||||||||
  Fly   108 LVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTV 172

Human   187 NTKRVIQYFASIAAIGDRGKKDNANANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRI 251
            :.|..::|||::          ..:.::..:|.:::.::|.:||||||||.|||||||||||.::
  Fly   173 SAKYAMRYFAAV----------GGSESETQVERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKL 227

Human   252 HF-GATGK--LASADIETYLLEKSRVIFQLKAERNYHIFYQILS--NKKPELLDMLLVTNNPYDY 311
            .| ...|.  |..|.:.|||||||||::|.:.|||||||||:.:  :|.||     ||.::...:
  Fly   228 LFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQLCAARSKYPE-----LVLDHQDKF 287

Human   312 AFVSQGEV-SVASIDDSEELMATDSAFDVLGFTSEEKAGVYKLTGAIMHYGNMKFKQKQREEQAE 375
            .|::.|.. .:..:.|:|:...|..|..||||:.::.|.:.|:...|:|.||::..:|..|...|
  Fly   288 QFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEE 352

Human   376 PDGTEDADK------------SAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSVQQVYYSIGAL 428
                ||:|.            :|.|:.:::.||.:.|...:::..||||....|::....:..||
  Fly   353 ----EDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDAL 413

Human   429 AKAVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHH 493
            ||.:|.|:|.::|..:|.:|.....:..|||||||.|||.|:.|||||.|||:.||||||.||.|
  Fly   414 AKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQH 478

Human   494 MFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHL 558
            :|.||||||.||||.||.||| .|.|.||||||..:|::.:|:|||..||.:|.::..||    :
  Fly   479 VFKLEQEEYLKEGITWTMIDF-YDNQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKL----I 538

Human   559 GKSN---NFQKPRNIKGKQEAHFSLIHYAGTVDYNILGWLEKNKDPLNETVVALYQKSSLKLMAT 620
            ||.|   :|:|||    .....|.:.|::.||:|::.|:||||:|.:::.:..:..:|::.| |.
  Fly   539 GKCNKFPHFEKPR----FGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSL-AK 598

Human   621 LFSSYATADT--GDSGKSK----------GGKKKGSSF-----------QTVSALHRENLNKLMT 662
            ...:....||  .||.||.          |.|::|:..           :||.:..:|:|..|::
  Fly   599 QVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLIS 663

Human   663 NLRTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRIL 727
            .|..|.||:||||.||:.|.....:...::.|||..||||.:||...|||:|.||.||..||::|
  Fly   664 TLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLL 728

Human   728 NPVAIPEGQFIDSRKGTEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDE----------- 781
              |...:....|.:.....::.....|.::|:||:|::||:||.:..||::|..           
  Fly   729 --VYRSKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQS 791

Human   782 ------------RLSRIITRMQAQARGQLMRIEFKKIVERRDALLVIQWNIRAFMGVKNWPWMKL 834
                        |:.::|..:|..|||.|.|...:|:.|.|..|::.::       .:.|...:.
  Fly   792 VVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILSKY-------ARGWLCRRR 849

Human   835 YFKIKPLLKSAET------------------------------------EKEMATM--------- 854
            |.:::..:...:|                                    :|....:         
  Fly   850 YLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRR 914

Human   855 ---KEEFGRIK---ETLEKSEARRKELEEKMVSL-----------------------LQEKNDLQ 890
               :.:|.|:|   :|:...|.:...||.|::|:                       |:.|.:|:
  Fly   915 FLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKLELK 979

Human   891 LQVQAEQDNLNDAEERCDQLIK--NKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELK 953
            ..::||..|:..|.:..|:||:  || ||||:..|..:.||:......|..::|:....|..||:
  Fly   980 KTLEAEFKNVKAACQDKDKLIEALNK-QLEAERDEKMQLLEENGHAQEEWISQKQTWRQENEELR 1043

Human   954 KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDK 1018
            :.||::      ::..|:|..|: :|..:.|  |.||      :.:.|.||:|:|:.|.:|.|::
  Fly  1044 RQIDEI------IDMAKNAEVNQ-RNQEDRM--LAEI------DNRELNEAYQRAIKDKEVIENE 1093

Human  1019 VNSLSKSKVKL----------------EQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQES 1067
            ...|.:...:|                .|..||:..:   ..|..:|:.|....|..:...    
  Fly  1094 NFMLKEELSRLTAGSFSLHARKASNASSQNEDDVGYA---SAKNTLDINRPPDLLSKNYSY---- 1151

Human  1068 IMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARA 1132
                 ||...|..|| :...:..:|..|:..||.:.|..:.|..|:..|:.|||.|.|   ..|:
  Fly  1152 -----NDSTSLVVKL-RSILEEEKQKHKVLQEQYIKLSSRHKPTEDSFRVSELEVENE---KLRS 1207

Human  1133 KVEKLRSDLS-----REL--------EEISERLEEAGGATSVQIEMN---KKREAEFQKMR---- 1177
            :.::||:.:.     .||        ||:..|.||.....:|.::.:   :..|.|..:||    
  Fly  1208 EYDQLRTSIKHGVEINELNAQHAALQEEVRRRREECIQLKAVLLQQSQSMRSLEPESLQMRGNDV 1272

Human  1178 RDLEEA-------TLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTS 1235
            .:|.||       ..|.|:...|:.::|...:.|:.::|:.|...|.:|:|...|...|.:|  |
  Fly  1273 NELMEAFHSQKLINRQLESELKAITEEHNSKLVEMTQEIERLNNEKDELQKVMFESIDEFED--S 1335

Human  1236 NMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQT---ENGELARQLEEKE 1297
            |::.:   :.|...:.|.|:....::.:..||.:.:       .|||:.   :.|:|..::||: 
  Fly  1336 NVDTL---RQNDRYLRRELQKAVAQFLLVQEELKLA-------NAKLKAYRQDGGQLEHKIEEE- 1389

Human  1298 ALISQLTRGK-----LSYTQQMED-----LKRQLEEEGKAKNALAHALQSARHDCDLLRE----- 1347
             :|...:.|.     .:.|:|...     :|....:..|....|..|| :.|....||..     
  Fly  1390 -MIRNKSNGTSADVGANVTKQKSQNPQGLMKFHSSDLDKILQRLLSAL-TPRTVVGLLPGFPAYL 1452

Human  1348 -----QYEEETEAKAELQRVLSKANSEVAQW-RTKY--ETDAIQRTEELEEAKKKLAQRLQDAEE 1404
                 :|.:.|.|..:::.:|||...::.:. ||.:  |...|.....:  ....|.::..|.:|
  Fly  1453 IFMCIRYTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSI--TLLNLMKQYGDVDE 1515

Human  1405 AVEAVNAKCSSLEKTKHRLQN--------EIEDLMVDVERS--NAAAAALDKK----QRNFDKIL 1455
            .|     |.::.::.:.:|:|        .|.||:|::.::  ......||.|    ..|.|:|.
  Fly  1516 YV-----KFNTEKQNQQQLKNFNLFEYRRVILDLIVNLYQALIMQIQGLLDPKIVPAILNNDEIQ 1575

Human  1456 --------------------------AEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESL 1494
                                      ..|||..    .:||...|:.:.     |.|.|.|.|.:
  Fly  1576 RGRQAHGMRSRATSIGASSSPEHGGGPAWKQLI----GQLEHFYKQFQH-----FGLDNCYAEQI 1631

Human  1495 EH----------LETFKRENKNLQEEISDLTEQLGEGGKNV-HELEKVRKQLEVEKLELQSALEE 1548
            .|          |....     |:.:|.     :.|.|..: :.:..:...:..:|:        
  Fly  1632 FHQLLYFICAVALNCLM-----LRGDIC-----MWETGMIIRYNIGCIEDWVRSKKM-------- 1678

Human  1549 AEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEV 1613
                    ...:|.|....||:...::.:.:|:|.         |.:.| |.|||     |..:|
  Fly  1679 --------SNDVLTALAPLNQVSQLLQSRKSEQDV---------QTICD-LCTSL-----STAQV 1720

Human  1614 LRVKK-----------------KMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDD 1661
            |:|.|                 |:...||..::|.|:::....: ||.::..:.:.:.:.|:|:|
  Fly  1721 LKVMKSYKLDDYESEITNVFLEKLTEKLNARQMQKSNSDEFTID-QKFIQPFKVVFRYSDIKLED 1784

Human  1662  1661
              Fly  1785  1784

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYH6NP_002462.2 Myosin_N 35..72 CDD:280832 3/8 (38%)
Myosin_head 87..768 CDD:278492 275/725 (38%)
MYSc_class_II 99..768 CDD:276951 270/713 (38%)
Actin-binding 657..679 11/21 (52%)
Actin-binding 759..773 7/13 (54%)
Myosin_tail_1 848..1925 CDD:279860 208/991 (21%)
SPEC 881..1043 CDD:295325 48/202 (24%)
MM_CoA_mutase <1134..1295 CDD:294532 42/190 (22%)
MIT_CorA-like <1297..>1409 CDD:294313 26/134 (19%)
TMPIT 1740..>1832 CDD:285135
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1826..1849
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1909..1939
didumNP_724569.1 MYSc 65..778 CDD:214580 282/743 (38%)
MYSc_Myo5 84..767 CDD:276831 270/713 (38%)
IQ 900..922 CDD:197470 1/21 (5%)
GBP_C <971..1086 CDD:303769 39/130 (30%)
coiled coil 1049..1068 CDD:293879 5/27 (19%)
coiled coil 1077..1086 CDD:293879 4/8 (50%)
JAKMIP_CC3 <1190..1299 CDD:292653 28/111 (25%)
Myo5_CBD 1424..1792 CDD:271254 79/420 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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