Protein Alignment MYH6 and Mhc

DIOPT Version :10

• Sequence 1: NP_002462.2
• Gene: MYH6 / 4624
• HGNCID: 7576
• Length: 1939
• Species: Homo sapiens
• Sequence 2: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Alignment Length: 1917
• Identity: 1090/1917 - (56%)
• Similarity: 1444/1917 - (75%)
• Gaps: 12/1917 - (0%)

Human    15 YLRKSEKERLEAQTRPFDIRTECFVPDDKEEFVKAKILSREGGKVIAETENGKTVTVKEDQVLQQ 79
            ||..|.::|...|::|:|.:..|::||:||.::..:|.:.:|..|....:.|:|..:|:|.:.|.
  Fly    16 YLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGETRDLKKDLLQQV 80

Human    80 NPPKFDKIEDMAMLTFLHEPAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRG 144
            ||||::|.|||:.||:|::.:||.||::||...:||||||||||.:||||..|||.......|||
  Fly    81 NPPKYEKAEDMSNLTYLNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRG 145

Human   145 KKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFASIAAIGDRGKKDN 209
            |:|:|.|||||:|||.||..|||:..|||:|||||||||||.|||:||.|||:   :|...|.|.
  Fly   146 KRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFAT---VGASKKTDE 207

Human   210 ANANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRV 274
            |..:||:||||::|.||.|||||||||||||||||||||||||||.|||||.||||||||||:||
  Fly   208 AAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARV 272

Human   275 IFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELMATDSAFDV 339
            |.|...||:|||||||:|...|.:.|:.|:|:|.|||..||||:|:||||||:||...||.|||:
  Fly   273 ISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDI 337

Human   340 LGFTSEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPR 404
            ||||.:||..||::|.|:||.|.|||||:.||||||.||.|:..:.:.|.|.::|:|.|.|..||
  Fly   338 LGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPR 402

Human   405 VKVGNEYVTKGQSVQQVYYSIGALAKAVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIF 469
            :|||||:||:|::||||..|||||.|.|::::|.|:|.:.|.||:|:|.||:|||||||||||||
  Fly   403 IKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIF 467

Human   470 DFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSI 534
            ::|.|||||||||||||||||||||||||||||::|||||||||||||||.|||||||||||:||
  Fly   468 EYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLIEKPMGILSI 532

Human   535 LEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNIK-GKQEAHFSLIHYAGTVDYNILGWLEKN 598
            ||||.|||||||.||..||.:.|||||..||||:..| |:|.|||::.||||.|.|||.||||||
  Fly   533 LEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKN 597

Human   599 KDPLNETVVALYQKSSLKLMATLFSSYATADTGDSGKSKGGK-KKGSSFQTVSALHRENLNKLMT 662
            |||||:|||..::||..||:..:|:.:| ..:|...::|||: |||..|.|||:.::|.||.|||
  Fly   598 KDPLNDTVVDQFKKSQNKLLIEIFADHA-GQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMT 661

Human   663 NLRTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRIL 727
            .||:|.|||||||||||.|.|||:|..||||||.||||||||||||||||||::|.||:.||:|:
  Fly   662 TLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIM 726

Human   728 NPVAIPEGQFID-SRKGTEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRMQ 791
            .|..:   |.:: .:|.||.::..:|:..:||:.|:|||||:||:||.:||.|||||.:|::.||
  Fly   727 CPKLL---QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQ 788

Human   792 AQARGQLMRIEFKKIVERRDALLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAETEKEMATMKE 856
            |.|||.|.|..|||:.|:|.||.|:|.|:|.::.::.|||.||:.|:||||..:..|.|:|.::|
  Fly   789 AWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEE 853

Human   857 EFGRIKETLEKSEAR-RKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAK 920
            :..:.:| |..:|.: |||||.....||.||..|...:..|:..|.|.:||..:|...|..||.:
  Fly   854 KAKKAEE-LHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQ 917

Human   921 VKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMA 985
            ::::.|||..||:...:|..:|:|.:.|.|.|||||:||||.:.|.|::|...:::::||.:|:|
  Fly   918 LRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIA 982

Human   986 GLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDL 1050
            ..||:|.||.||||...|.:|:..::||..|||:|.|:|.|.||||.:|:||.|||:|||||.|:
  Fly   983 HQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDV 1047

Human  1051 ERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQA 1115
            |::|||:|||||||||::.|||.:|.:||:.:::|:.:::...:|:|||||:.|:.|:::||.||
  Fly  1048 EKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQA 1112

Human  1116 RIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDL 1180
            ||||||||:||||.||||.||.|:||:|||||:.|||||||||||.|||:|||||||..|:||||
  Fly  1113 RIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDL 1177

Human  1181 EEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKA 1245
            |||.:|||:|.|.|||||.|:|||:.||:|.|.::|.|.||||:|:..:|:|:.:.::.|...||
  Fly  1178 EEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKA 1242

Human  1246 NLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSY 1310
            ..||:::.|:...||.:.||:|..|:||||...:.||..||.:|.|||||.|:.:|||::.|:|.
  Fly  1243 AQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISL 1307

Human  1311 TQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRT 1375
            |.|:||.||..:||.:.:..|....::..||.|.||||.|||.|.||:|||.|||||:|...||:
  Fly  1308 TTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRS 1372

Human  1376 KYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAA 1440
            |||:|.:.|:|||||||:||..||.:|||.:|::|.||..|||||.||..|:|||.::|:|:||.
  Fly  1373 KYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAI 1437

Human  1441 AAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENK 1505
            |.|.:|||:.||||:.|||.|.::..:||::||||.|:.|||||:||.||||..|.||..:||||
  Fly  1438 ANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENK 1502

Human  1506 NLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQI 1570
            ||.:|:.||.:|:||||:|:||:||.||:||.||.|||:|||||||:||.||.|:||||||.:|:
  Fly  1503 NLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQV 1567

Human  1571 KAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHAN 1635
            :.||:|::.||:||.|..::||||.:||:|.||:||.:.:.|.||:|||:|.|:||:||.|.|||
  Fly  1568 RQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHAN 1632

Human  1636 RMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERS 1700
            :..|||||.:|..|..|||.|..|::..||.||.:|.:.|.|||.|.||.||||.|.::||.:|.
  Fly  1633 KANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRG 1697

Human  1701 RKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAA 1765
            |:.|||||.:..|::..:.:||.|:...|:|:||:|..|.|:::|.:.|.:|:|||||||:.|||
  Fly  1698 RRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDAA 1762

Human  1766 MMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEA 1830
            .:|:||:.|||.:...|:::|.:||.||:||.||||||..|||||||.:||||.||||||.||:.
  Fly  1763 RLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDG 1827

Human  1831 EQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNL 1895
            ||:|:|::.|.:||||||:|||::|:|||:||..|:||||||||.|:|.||||.|||||.|..||
  Fly  1828 EQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNL 1892

Human  1896 SKFRKVQHELDEAEERADIAESQVNKLRAKSR 1927
            :||||.|.||:|||||||:||..::|.|||.|
  Fly  1893 AKFRKAQQELEEAEERADLAEQAISKFRAKGR 1924

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH6	NP_002462.2	Myosin_N	32..76	CDD:460670	13/43 (30%)
		MYSc_class_II	99..768	CDD:276951	431/671 (64%)
		Actin-binding	657..679		17/21 (81%)
		Actin-binding	759..773		8/13 (62%)
		Myosin_tail_1	848..1925	CDD:460256	583/1077 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1826..1849		12/22 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1909..1939		12/19 (63%)
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670	12/41 (29%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	431/671 (64%)
		Myosin_tail_1	842..1922	CDD:460256	583/1080 (54%)