DRSC/TRiP Functional Genomics Resources

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Protein Alignment MYH6 and ck

DIOPT Version :9

Sequence 1:NP_002462.2 Gene:MYH6 / 4624 HGNCID:7576 Length:1939 Species:Homo sapiens
Sequence 2:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster


Alignment Length:2134 Identity:549/2134 - (25%)
Similarity:877/2134 - (41%) Gaps:504/2134 - (23%)


- Green bases have known domain annotations that are detailed below.


Human    26 AQTRPFDIRTECFVPDDKEEFVKAKILSREGGKVIAETENGKTV-TVKEDQVLQQNPPKFDKIED 89
            |..|.||:.            :.|:::|.||.::....::|..| ...|.::...:......:||
  Fly    15 ASGREFDVA------------IGARVVSAEGRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVED 67

Human    90 MAMLTFLHEPAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHI 154
            |..|..|||..:|.||..||...:||||:|...|.||||:.||:|..:.:..|:.:|..|.||||
  Fly    68 MISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHI 132

Human   155 FSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFASIAAIGDRGKKDNANANKGTLED 219
            |:|.||||.:|...|::|.|:|:||||||||.:||.::||.|:|:     ||       ...:|.
  Fly   133 FAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAIS-----GK-------HSWIEQ 185

Human   220 QIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERNY 284
            ||::|||.|||||||||:||||||||||:|.|||.|.|.:..|.||.|||||||::.|..:||||
  Fly   186 QILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNY 250

Human   285 HIFYQI---LSNKKPELLDMLLVTNNPYDYAFVSQG-EVSVASIDDSEELMATDSAFDVLGFTSE 345
            |:||.|   ||..:...||:.:..    ||.:::.| .::....||:.|.....||..||.|:.:
  Fly   251 HVFYCILAGLSADEKSRLDLGMAA----DYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQ 311

Human   346 EKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTE-----DADKSAYLMGLNSADLLKGLCHPRV 405
            |...:.||..|::|.||:|:|....:..   |.||     :.::.|.|:||....|:..|....:
  Fly   312 EIWEIIKLLAALLHCGNIKYKATVVDNL---DATEIPEHINVERVAGLLGLPIQPLIDALTRRTL 373

Human   406 KVGNEYVTKGQSVQQVYYSIGALAKAVYEKMFNWMVTRIN-ATLETKQPRQYFIGVLDIAGFEIF 469
            ....|.|....|..|......|..|.:|.:||..:|.:|| |..:.:...:..||||||.|||.|
  Fly   374 FAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENF 438

Human   470 DFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIE-KPMGIMS 533
            |.|||||.|||:.||.|||||..|:|.||||||..|.|.|..|:| :|.|..:|||. |.:.||:
  Fly   439 DQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDALDLIAIKQLNIMA 502

Human   534 ILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNIKGKQEAHFSLIHYAGTVDYNILGWLEKN 598
            :::||..|||.||.|..|||:..| |...|:.||   |......|.|.|:||.|.|:..|:|:||
  Fly   503 LIDEEARFPKGTDQTMLAKLHKTH-GSHKNYLKP---KSDINTSFGLNHFAGVVFYDTRGFLDKN 563

Human   599 KDPLNETVVALYQKSSLKLMATLFSSYATADTGDSGKSKGGKKKGSSFQTVSALHRENLNKLMTN 663
            :|..:..::.|..:|:.|.:..:|:.          ..:.|.:......|:|...|::|:.||..
  Fly   564 RDTFSPDLLHLVSQSTNKFLRQIFAQ----------DIEMGAETRKRTPTLSTQFRKSLDALMKT 618

Human   664 LRTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILN 728
            |.:..|.|:|||.|||.|.|.:.|..|...|||.:|::|.|||.|.|:|.|..:.:|.:|||.|.
  Fly   619 LSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLI 683

Human   729 PVAIPEGQFIDSRKGTEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRMQAQ 793
            | .:|.....|.:..|.::.:.: :..:.|:.||||||.|......||:.||..|:|.|..:|..
  Fly   684 P-GVPPAHRTDCQAATSRICAVV-LGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRS 746

Human   794 ARGQLMRIEFKKIVERRDALLVIQWNIRAFMGVKNWPWMKL-YFKIKPLLKSAETEKEMATMKEE 857
            .||.:.|..|.::   |.|.:.:|...:.:...|.:..|:: |.:::.|::|       ..:...
  Fly   747 IRGWVYRRRFLRL---RAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRS-------RVLSHR 801

Human   858 FGRIKETLEKSEAR------RKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQ 916
            |..::..:...:|.      |:|...||.::::.::.::..:...:              ..|::
  Fly   802 FRHLRGHIVGLQAHARGYLVRREYGHKMWAVIKIQSHVRRMIAMRR--------------YRKLR 852

Human   917 LEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLT 981
            ||.  |:..|.|:            .||||::  ||..            ...|||.|...::..
  Fly   853 LEH--KQFAEVLQ------------LRKLEEQ--ELLH------------RGNKHAREIAEQHYR 889

Human   982 EEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDD---LEGSLE-- 1041
            :.:..|         |::.:||    .|::.:..|..:|.::.:..|.|:.|||   :|...:  
  Fly   890 DRLHEL---------ERREIQE----QLENRRRVEVNMNIINDAARKQEEPVDDGKLVEAMFDFL 941

Human  1042 -------------QEKKVRMDLERAKRKLEGDLKLTQESI---MDLENDKLQLEEKLKKKEF--- 1087
                         :|..|..||..|:       .:.|:.|   :.:..|:..|.| .|.::|   
  Fly   942 PDSSSDAPTPHGGRETSVFNDLPHAQ-------NVNQDDIIAPIHISEDEEDLSE-FKFQKFAAT 998

Human  1088 ----DINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEI 1148
                ::|.|.:|            |.||.....:....::|.|: .....:.:...|:.......
  Fly   999 YFQGNVNHQYAK------------KALKHPLLPLHTQGDQLAAQ-ALWITILRFTGDMPEPKYHT 1050

Human  1149 SERLEEAGGATSVQIEMNKK--REAEFQK---MRRD------LEEATLQHEATAAALRKKHADSV 1202
            .:|::.....:.|...:.:.  |..|||:   |..|      .:..:::|:..:..|::|:    
  Fly  1051 MDRMDTTSVMSKVTATLGRNFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKN---- 1111

Human  1203 AELGEQIDNLQRVKQKLEKEKSEFKLELDD-VTSNMEQ--------IIKAKANLE---KVSRTL- 1254
             :|||.:   :|..|..|.....::..|.. .|||:|:        |::|:...|   ::.:.| 
  Fly  1112 -KLGEDV---RRRLQDDEYTADSYQSWLQSRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLT 1172

Human  1255 -------------------------EDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLE 1294
                                     |...|..|..:.|.......:..:|.|....||   .:.:
  Fly  1173 NNPLKSSHARGWILLSLCVGCFAPSEKFVNYLRAFIREGPPGYAPYCEERLKRTFNNG---TRNQ 1234

Human  1295 EKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCD------LLREQY---- 1349
            ....|..|.|:.|......:..:      :|..|..||.:..:||..|:      .|::|:    
  Fly  1235 PPSWLELQATKSKKPIMLPITFM------DGNTKTLLADSATTARELCNQLSDKISLKDQFGFSL 1293

Human  1350 ---------------EEETEAKAELQRVLSK--ANSEVAQWRTKYETDAIQRTEE---------- 1387
                           :...:|.::.::...:  |....|.||..:..:......|          
  Fly  1294 YIALFDKVSSLGSGGDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEIFAPWHEPTHDQVATNL 1358

Human  1388 -LEEAKK--KLAQRLQDAEEAVEAVNAK--------CSSLEKTKHRLQNEIEDLM---VDVERSN 1438
             .::..:  |..:...|.||.:..:.|:        ..|:|:....|.|.|.|..   ||.....
  Fly  1359 IYQQVVRGVKFGEYRCDKEEDLAMIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSGVDKAIER 1423

Human  1439 AAAAALDKKQRNF---DK------------------------------------------ILAEW 1458
            .||..|...::::   ||                                          |...|
  Fly  1424 WAALVLQAYKKSYYVKDKIAPLKIKEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPKNDVIIAVNW 1488

Human  1459 KQKY---EESQSELESSQKEARSLS--------TELFKLKNAYEESLEHLETFKRENKNLQEEIS 1512
            ...|   ::.|..||.|..|..::|        |:.|.|.....|..    ||:..|   .|:|.
  Fly  1489 TGVYVVDDQEQVLLELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEF----TFQSPN---AEDIR 1546

Human  1513 DLTEQLGEGGKNVHELEKVRKQLE-VEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIER 1576
            ||.         |:.|:.::|:.: |..|:...|..:..:.|...:|.::..:            
  Fly  1547 DLV---------VYFLDGLKKRSKYVIALQDYRAPSDGTSFLSFFKGDLIILE------------ 1590

Human  1577 KLAEKDEEMEQAKRNHQRVVDSLQTSLD-----AETRSRNEVLRVKKKMEGDLNEM-EIQLSHAN 1635
                 ||...::..|:...:.....|.:     |||   ..||....|...|:..: .|:.:|..
  Fly  1591 -----DESCGESVLNNGWCIGRCDRSQERGDFPAET---VYVLPTLSKPPQDILALFNIEEAHHG 1647

Human  1636 RMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERS 1700
            |..:.|..                ..||...|          |.:.|::..|:..|...::|   
  Fly  1648 RRLSMASN----------------GGAVEPRD----------RPHTLMEYALDHFRLPPKRT--- 1683

Human  1701 RKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAA 1765
               ..:.|..:|:|.:.|...:...|....     |.:|||:.|.|.:.|              .
  Fly  1684 ---MSKTLTLSSKRSEELWRYSRDPIKAPL-----LRKLQSKEEFAEEAC--------------F 1726

Human  1766 MMAEELKKEQDTSAHLERMKKNMEQTIKD--LQHRLDEAEQIALKGGKKQLQKLEARVRELEGEL 1828
            ..|..||...|..:...||...:...|.|  |:|.:...|...      ||.|            
  Fly  1727 AFAAILKYMGDLPSKRPRMGNEITDHIFDGPLKHEILRDEIYC------QLMK------------ 1773

Human  1829 EAEQKRNAESVKGMRKSERRIKELTYQ-------TEEDKKNLLRL---------QDLVDKLQLKV 1877
            :....||       |.||.|..||.:.       ::...|.||..         ||.:.:||..:
  Fly  1774 QLTDNRN-------RMSEERGWELMWLATGLFACSQGLLKELLLFLRTRRHPISQDSMHRLQKTI 1831

Human  1878 KAYKR-----QAE-EAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAK 1925
            :..:|     |.| ||.:...|.:  |.||... |:.:|..::..|    .|||
  Fly  1832 RHGQRKYPPHQVEVEAIQHKTTQI--FHKVYFP-DDTDEAFEVDSS----TRAK 1878

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYH6NP_002462.2 Myosin_N 35..72 CDD:280832 6/37 (16%)
Myosin_head 87..768 CDD:278492 283/691 (41%)
MYSc_class_II 99..768 CDD:276951 276/679 (41%)
Actin-binding 657..679 10/21 (48%)
Actin-binding 759..773 7/13 (54%)
Myosin_tail_1 848..1925 CDD:279860 232/1297 (18%)
SPEC 881..1043 CDD:295325 29/179 (16%)
MM_CoA_mutase <1134..1295 CDD:294532 35/209 (17%)
MIT_CorA-like <1297..>1409 CDD:294313 23/151 (15%)
TMPIT 1740..>1832 CDD:285135 19/93 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1826..1849 5/22 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1909..1939 5/17 (29%)
ckNP_001285949.1 MYSc 64..733 CDD:214580 286/704 (41%)
MYSc_Myo7 77..721 CDD:276832 276/679 (41%)
MyTH4 <1138..1245 CDD:214535 18/109 (17%)
B41 1251..1467 CDD:214604 33/221 (15%)
FERM_B-lobe 1355..1439 CDD:271216 16/83 (19%)
FERM_C1_MyoVII 1461..1559 CDD:270019 22/113 (19%)
SH3 1560..1624 CDD:302595 12/83 (14%)
MyTH4 1701..1849 CDD:214535 42/191 (22%)
B41 1856..2068 CDD:214604 9/28 (32%)
FERM_M 1966..2068 CDD:278785
FERM_C2_MyoVII 2064..2159 CDD:270020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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