Protein Alignment MYH6 and Myo31DF

DIOPT Version :10

• Sequence 1: NP_002462.2
• Gene: MYH6 / 4624
• HGNCID: 7576
• Length: 1939
• Species: Homo sapiens
• Sequence 2: NP_523538.1
• Gene: Myo31DF / 34445
• FlyBaseID: FBgn0086347
• Length: 1011
• Species: Drosophila melanogaster
• Alignment Length: 1060
• Identity: 315/1060 - (29%)
• Similarity: 509/1060 - (48%)
• Gaps: 152/1060 - (14%)

Human    87 IEDMAMLTFLHEPAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAP 151
            ::|..:|..:.....:.||::|:....||||.|..||::|||:.:.:|..|.:..|:|::..|..
  Fly     9 VQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRELFENA 73

Human   152 PHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFASIAAIGDRGKKDNANANK-- 214
            ||:|:|:|:||:.:...:::..|||:||||||||..:|.:::|.|::.         ||....
  Fly    74 PHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVT---------NAQGQNEI 129

Human   215 GTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLK 279
            ..:::.:||:|..||.||||||.||||||||||::.|.|..........|..||||||||:.|..
  Fly   130 ERVKNVLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQP 194

Human   280 AERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELMATDSAFDVLGFTS 344
            .|||:|.|||:|.......|....:......|.:::||.:.:  :.:..:...|.:||..|||::
  Fly   195 GERNFHSFYQLLRGANDNELRQYELQKETGKYHYLNQGSMDI--LTEKSDYKGTCNAFKTLGFST 257

Human   345 EEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGN 409
            :|...:::...|::|.||::|  :..|::......:....:|.|:.:...:|...|....:..|.
  Fly   258 DEVQTIWRTIAAVLHLGNVEF--QTIEDELVISNKQHLKSTAKLLQVTETELSTALTKRVIAAGG 320

Human   410 EYVTKGQSVQQVYYSIGALAKAVYEKMFNWMVTRINATL-----ETKQPRQYFIGVLDIAGFEIF 469
            ..:.|..:..|..|...|||||:|:::|.|:::|||..:     :|:......||||||.|||||
  Fly   321 NVMQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIYGFEIF 385

Human   470 DFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKP-MGIMS 533
            |.|||||.|||:.||||||.|...:...|||||::||||||.|::..:...| ||:|:| .||::
  Fly   386 DSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIIC-DLVEQPHKGIIA 449

Human   534 ILEEECM-FPKATDMTFKAKLYDNHLGKSNNFQ----KPRNIKGKQEAHFSLIHYAGTVDYNILG 593
            |::|.|: ..|.||.|....: |.:|.|..::.    ||.:.:.|....|.:.||||.|.|||.|
  Fly   450 IMDEACLSVGKVTDDTLLGAM-DKNLSKHPHYTSRQLKPTDKELKHREDFRITHYAGDVIYNING 513

Human   594 WLEKNKDPLNETVVALYQKSSLKLMATLFSSYATADTGDSGKSKGGKKKGSSFQTVSALHRENLN 658
            ::|||||.|.:....|...|....::.::...|          :..||......|...|.:.::.
  Fly   514 FIEKNKDTLYQDFKRLLHNSKDANLSEMWPEGA----------QDIKKTTKRPLTAGTLFQRSMA 568

Human   659 KLMTNLRTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQR 723
            .|:..|....|.:||||.||:.|:..|.|...|.||:|..|:||.:|:.|.||.:|..|..|..|
  Fly   569 DLVVTLLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLLR 633

Human   724 YRILNPVAIPEGQFIDSRKGTEKLLSSLDIDHNQYKFGHTKVFFKA-GLLGLLEEMRDERLSRII 787
            |::::....|..:....|.|...|:.......: .|:||||:|.:: ..|..||..|:|.:..|:
  Fly   634 YKMISQYTWPNFRAGSDRDGVRVLIEEKKFAQD-VKYGHTKIFIRSPRTLFALEHQRNEMIPHIV 697

Human   788 TRMQAQARGQLMRIEFKKIVERRDALLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAETEKEMA 852
            |.:|.:.||.::|..|||:    .|.:.|   :||:..          :|::..::........|
  Fly   698 TLLQKRVRGWIVRRNFKKM----KAAITI---VRAYKA----------YKLRSYVQELANRLRKA 745

Human   853 TMKEEFGRIKETLEKSEARRKELEEKMVSLL--------------QEKNDLQLQV---------- 893
            ....::|:..:..:...|.|| :|.|:..:.              .|...|:||:
  Fly   746 KQMRDYGKSIQWPQPPLAGRK-VEAKLHRMFDFWRANMILHKYPRSEWPQLRLQIIAATALAGRR 809

Human   894 ----QAEQ---DNL-----NDAEERCDQLIKN------------KIQLEAKVKEMNERLEDEEEM 934
                ||.:   |.|     |...|..:..|||            ::...:.||:.|   ...::.
  Fly   810 PYWGQARRWVGDYLANSQENSGYEAYNGSIKNIRNHPADGETFQQVLFSSFVKKFN---HFNKQA 871

Human   935 NA----------ELTAKKRKLEDECSELKKDIDDLELTLAKVEKEK------HATENK--VKNLT 981
            |.          :|...|.|.:|    :|:.|...|||...|...:      |:::||  |.:|.
  Fly   872 NRAFIVSDSTIHKLDGIKNKFKD----MKRTIKIRELTSISVSPGRDQLIVFHSSKNKDLVFSLE 932

Human   982 EEMAGL-----DEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLE 1041
            .|...|     .|::..:.|:           ..||...|.:||..:....:|:.:...:  ::|
  Fly   933 SEYTPLKEDRIGEVVGIVCKK-----------YHDLTGTELRVNVTTNISCRLDGKARII--TVE 984

Human  1042 QEKKVRMDLERAKRKLEGDL 1061
            ....|.:...|.|   ||::
  Fly   985 AASNVEVPNFRPK---EGNI 1001

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH6	NP_002462.2	Myosin_N	32..76	CDD:460670
		MYSc_class_II	99..768	CDD:276951	239/681 (35%)
		Actin-binding	657..679		8/21 (38%)
		Actin-binding	759..773		6/14 (43%)
		Myosin_tail_1	848..1925	CDD:460256	55/285 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1826..1849
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1909..1939
Myo31DF	NP_523538.1	MYSc_Myo1	21..677	CDD:276829	239/681 (35%)
		Myosin_TH1	801..977	CDD:461801	38/193 (20%)