Protein Alignment MYH6 and ninaC

DIOPT Version :10

• Sequence 1: NP_002462.2
• Gene: MYH6 / 4624
• HGNCID: 7576
• Length: 1939
• Species: Homo sapiens
• Sequence 2: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Alignment Length: 1081
• Identity: 266/1081 - (24%)
• Similarity: 453/1081 - (41%)
• Gaps: 214/1081 - (19%)

Human     5 QMADFGAAAQYLRKSEKER---LEAQTRPFDIRTECFVPDD--KEEFVKAKILSREGGKVIAETE 64
            |:.||  .::.|.|:.:.|   :|....||  .||....:|  :.:..:...|||:...:..|.|
  Fly   254 QINDF--ISESLEKNAENRPMMVEMVEHPF--LTELIENEDEMRSDIAEMLELSRDVKTLYKEPE 314

Human    65 NGKTVTVKEDQV--LQQNPPKFDKIEDMAMLTFLHEPAVLFNLKERYAAWMIYTYSGLFCVTVNP 127
                :.|....|  ..:.|.|... ||:|.|....:..::.:|:.|......|::.|...:::|.
  Fly   315 ----LFVDRGYVKRFDEKPEKMYP-EDLAALENPVDENIIESLRHRILMGESYSFIGDILLSLNS 374

Human   128 YKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVI 192
            .:....:..|..|.||.|.|||..|||||::|.|||.||..:|.|.|:::|||.:||:.|.:.:|
  Fly   375 NEIKQEFPQEFHAKYRFKSRSENQPHIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLI 439

Human   193 QYFASIAAIGDRGKKDNANANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATG 257
            ::...:.. |:||.       .|.:|..|    .|:....||.|..|::|:|......:.||.||
  Fly   440 KHLCYLGD-GNRGA-------TGRVESSI----KAILMLVNAGTPVNNDSTRCVLQYCLTFGKTG 492

Human   258 KLASADIETYLLEKSRVIFQLKAERNYHIFYQILS--NKKPELLDMLLVTNNPYDYAFVSQGEVS 320
            |::.|....|:|||.||......:.|:||||....  |::.:|.:..|..:..|.|..|.. ||.
  Fly   493 KMSGAVFNMYMLEKLRVATTDGTQHNFHIFYYFYDFINQQNQLKEYNLKADRNYRYLRVPP-EVP 556

Human   321 VASI----DDSEELMATDSAFD----VLGFTSEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPD 377
            .:.:    ||.|..:.....|:    .:.|..::...|.|:..||::.||::|:|..:  .||.:
  Fly   557 PSKLKYRRDDPEGNVERYREFENILRDIDFNHKQLETVRKVLAAILNIGNIRFRQNGK--YAEVE 619

Human   378 GTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSVQQVYYSI-------GALAKAVYEK 435
            .|:...:.|.|:.::....:..|.       |..:.||...::..|:.       .|:|..:|.:
  Fly   620 NTDIVSRIAELLRVDEKKFMWSLT-------NFIMVKGGIAERRQYTTEEARDARDAVASTLYSR 677

Human   436 MFNWMVTRINATLETKQPRQYF-----IGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMF 495
            :.::::.|||..:..  ||..|     |.:.|:.|||.|:.|..|||.||..||::|..:|..:|
  Fly   678 LVDFIINRINMNMSF--PRAVFGDTNAIIIHDMFGFECFNRNGLEQLMINTLNEQMQYHYNQRIF 740

Human   496 VLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGK 560
            :.|..|.:.|.|:...::|..:..|..:|:.||.|:..|:::.....:..|:     :.|....|
  Fly   741 ISEMLEMEAEDIDTINLNFYDNKTALDNLLTKPDGLFYIIDDASRSCQDQDL-----IMDRVSEK 800

Human   561 SNNFQKPRNIKGKQEAHFSLIHYAGTVDYNILGWLEKNKDPLNETVVALYQKSSLKLMATLFSSY 625
            .:.|     :|.......|:.||.|.:.|:...:.:.|:|.:...::..::.|..:.:..:|::.
  Fly   801 HSQF-----VKKHTATEISVAHYTGRIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTNQ 860

Human   626 ATADTGDSGKSKGG---------------KKKGSSFQTVSA---LHRENLNKLMTNLRTT----- 667
            .|         |.|               ::|..:..|:||   ....||..|..|.|.|
  Fly   861 LT---------KAGNLTMPFEAVQHKDESERKSYALNTLSAGCISQVNNLRTLAANFRFTCLTLL 916

Human   668 ---------HPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQR 723
                     ..||||||..:....|....:.:|..|::..|||:.:...:|||.:|:.:.:|.:|
  Fly   917 KMLSQNANLGVHFVRCIRADLEYKPRSFHSDVVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRR 981

Human   724 YRILNPVAIPEGQFIDSRKGTEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRI-- 786
            |:.|   |....:.::..|...:|| .|.:....:..|.||||        |....||.|:|:
  Fly   982 YQFL---AFDFDEPVEMTKDNCRLL-FLRLKMEGWALGKTKVF--------LRYYNDEFLARLYE 1034

Human   787 -----ITRMQAQARGQLMRIEF---------KKIVERRD-ALLVIQWNIRAFMGVKNWPWMKLYF 836
                 :.::|:..|..|.|...         ||..|..| |...||   :||.|.::      ..
  Fly  1035 LQVKKVIKVQSMMRALLARKRVKGGKVFKLGKKGPEHHDVAASKIQ---KAFRGFRD------RV 1090

Human   837 KIKPLL--KSAETEKEMATMKEEFGRIKETLEKS---------EARRKEL----------EEKMV 880
            ::.||:  ||.:..:..|.....|.  |:..|||         .||.::.          .::||
  Fly  1091 RLPPLVNEKSGQLNENTADFIRPFA--KKWREKSIFQVLLHYRAARFQDFVNLSQQVHIYNQRMV 1153

Human   881 SLLQEKNDLQLQVQAEQDNLNDAEE---------------RCDQL----------IKNKIQLEAK 920
            :.|   |.....|..|:.|:.:...               |.||:          ..|.|..:|.
  Fly  1154 AGL---NKCTRAVPFERINMREVNSSQLGPLPVPIKKMPFRLDQIPFYDTQYMVDPANSISRQAF 1215

Human   921 VKE-MNERLEDEEEMNA-----------ELTAKKRKLEDEC 949
            ..: :.:.:||:|..::           .||....|.|..|
  Fly  1216 PNQLLTQHMEDDEPWDSPLQRNPSMTSCALTYNAYKKEQAC 1256

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH6	NP_002462.2	Myosin_N	32..76	CDD:460670	9/45 (20%)
		MYSc_class_II	99..768	CDD:276951	189/722 (26%)
		Actin-binding	657..679		11/35 (31%)
		Actin-binding	759..773		5/13 (38%)
		Myosin_tail_1	848..1925	CDD:460256	29/158 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1826..1849
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1909..1939
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785	9/31 (29%)
		MYSc_Myo21	346..1022	CDD:276848	189/730 (26%)