Protein Alignment MYH6 and Myo10A

DIOPT Version :10

• Sequence 1: NP_002462.2
• Gene: MYH6 / 4624
• HGNCID: 7576
• Length: 1939
• Species: Homo sapiens
• Sequence 2: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Alignment Length: 2015
• Identity: 497/2015 - (24%)
• Similarity: 823/2015 - (40%)
• Gaps: 422/2015 - (20%)

Human    87 IEDMAMLTFLHEPAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLP-VYNAEVVAAYRGKKRSEA 150
            :|||.:|..|||.::|:||:.||...:|||::|...:.|||||..| .|..||...|.|:.....
  Fly   157 VEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSL 221

Human   151 PPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFASIAAIGDRGKKDNANANKG 215
            |||:|:|...|:..:.:.   |.::|:||||:|||.:||.|:||.|::...|     .:|:|
  Fly   222 PPHLFAIGAAAHAALPSP---QVVVISGESGSGKTESTKLVMQYLAAVVPGG-----GSASA--- 275

Human   216 TLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKA 280
            .:.:||::|.|.|||||||:|.||||||||||::.::| .:|.:..|.|..|||||||::.|...
  Fly   276 VITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPG 339

Human   281 ERNYHIFYQIL------SNKKPELLDMLLVTNNPYDYAFVSQGEVSVAS-IDDSEELMATDSAFD 338
            |||||:||::|      ...|..||:       ...|.:::||....|| ..|.|.|   ..|..
  Fly   340 ERNYHVFYELLGGLSETERSKYGLLE-------ADKYFYLNQGATDCASGRVDWESL---QGAMQ 394

Human   339 VLGFTSEEKAGVYKLTGAIMHYGNMKFKQKQ---REEQAEPDGTEDADKSAYLMGLNSADLLKGL 400
            |||.:..|:.|:.::..|::|.||:.|.::|   .:|..|.....:...:|:|:.:::..|.:.|
  Fly   395 VLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRAL 459

Human   401 CHPRVKVGNEYVTKGQSVQQVYYSIGALAKAVYEKMFNWMVTRINATLETKQPRQ-YFIGVLDIA 464
            .....:...|.:.....:.|...:..|.|||:|..:|||:|:|||:.::...... :.|.:|||.
  Fly   460 TSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIF 524

Human   465 GFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPM 529
            |||....|||||||||:.||.||.:||.|:|.|||.||.:|.:|||.:.:..:|.....|.:||:
  Fly   525 GFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPV 589

Human   530 GIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNIKGKQEAHFSLIHYAGTVDYNILGW 594
            ||..:|::|..||:|||::|..|.:.|| ..|..:.:||  .|.||  |.:.||||.|.|.:.|:
  Fly   590 GICHLLDDESNFPRATDLSFLEKCHYNH-ALSELYARPR--IGAQE--FGVTHYAGQVWYCVDGF 649

Human   595 LEKNKDPLNETVVALYQKSSLKLMATLFSSYATADTGDSGKS--KGGKKKGSSFQ----TVSALH 653
            |:||:|.|...|:.|...|.|.|:..|......  ..|:||:  ||...:..:.:    ||:|..
  Fly   650 LDKNRDALRGDVLELLASSRLPLVGELTKQLRA--QRDAGKTLPKGSNGRFVTMKPRTPTVAARF 712

Human   654 RENLNKLMTNLRTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYG 718
            .::|.:|:.::...||.|||||.||:.|....||.|.|:.|||..|:|:.|:|.::|:|.|:.:.
  Fly   713 ADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQ 777

Human   719 DFRQRYRILNPVAIPEGQFIDSRKGTEKLLSSL---DIDHNQYKFGHTKVFFKAGLLGLLEEMRD 780
            .|.:|||.|.|..:..|  ...|:....||.::   .::...|:.|.|:||.:..|...||..|.
  Fly   778 HFVERYRHLLPSPLARG--TPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRT 840

Human   781 ERLSRIITRMQAQARGQLMRIEFKKIVERRDALLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSA 845
            |||.|....:|...||.|:|   :::..|:.|...:|         ..|...:...:.:.|.|.|
  Fly   841 ERLRRAAVSVQRHVRGMLVR---RQLARRQAAATRLQ---------ARWRGQRAQQRYERLRKGA 893

Human   846 ETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQL 910
            .|.:.:...::...|:::.  :|:.||::
  Fly   894 LTAQRLWRGRQARRRVQQL--RSDHRRRQ------------------------------------ 920

Human   911 IKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLE-DECSELKKDID-DLELTLAKVE--KEKH 971
                     :.:|..:|..:..|      ||:..|| .:.|.|  ||. :|....:|::  ...|
  Fly   921 ---------EAREAAQRAREARE------AKQAVLERSQLSYL--DIPAELAFIYSKLQGWSPPH 968

Human   972 ATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDL-QVEEDKVNSLSKSKVKLEQQVDD 1035
            ...:.||.|..........:               |..:|| |....|.:|:..:.::|:.:.:.
  Fly   969 GDRHLVKVLGTVPGPPSSAV---------------QLPEDLGQFSFGKFSSVYCNGLRLQPRREP 1018

Human  1036 LEGSLEQEKKVRMDLERAKRKLEG--DLKLTQESIMDLENDKLQLEEKLKKK---EFDINQQNSK 1095
            :...|         |.||..:.:.  |.....:.|:...|||..  |..|:|   ::.:::..|.
  Fly  1019 ITAPL---------LTRAASRDQDFQDALAVFKLILRWSNDKAL--EGAKEKLLADYIVHKALSS 1072

Human  1096 --IEDEQVLALQLQ-KKLKENQARIEELEEELE------AERTARAKV----------EKLRSDL 1141
              :.||.::.|..| ..|..|......|.:.|.      ....|.:|.          |.||..|
  Fly  1073 RGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLL 1137

Human  1142 SRELEEISERLEEAGGATSVQIEMNKKRE-----AEFQKMRRDLEEA---TLQHEAT-------- 1190
            .|:|..     ::.||.:|..:.....|.     .|::...|..:.|   ||..||:
  Fly  1138 LRQLLR-----QQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSW 1197

Human  1191 -----AAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDD---VTSN--MEQIIKAKA 1245
                 ||||      :|:.||              .....:.|.|||   :|.:  ::.::...|
  Fly  1198 TSCEEAAAL------AVSSLG--------------VASRGWTLVLDDGQQLTDSCGLDYVMDLIA 1242

Human  1246 NLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRA----KLQTENG--ELARQLEEKEALISQLT 1304
            ..|........:::..|...:.|:.:|.|...:.|    ...|.:|  ::.|:......|:|:.:
  Fly  1243 EKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRSS 1307

Human  1305 R--------------GKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEA 1355
            .              |:.|.|.|.:...:.|::      .||..:.....|||
  Fly  1308 ALNERYFEREPSPGPGQGSSTGQAKSRSKSLDD------LLAGDIVPVPTDCD------------ 1354

Human  1356 KAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTK 1420
            ..|....|..:.|.:        .|.....|.|....|....|.|.::.|....:|.......:|
  Fly  1355 SQEPLHTLGLSESRL--------NDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSK 1411

Human  1421 HRLQNEI---EDLMVDVERSNAAAA-----ALDKKQRNFDKILAE-WKQKYEESQSELESSQKEA 1476
            :..:.|.   ...|.|...:.:.|:     .:..:..:.|:.|.: :....:.|..||..::..|
  Fly  1412 YADKAEYATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLA 1476

Human  1477 RSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLE 1541
            .|:....::.:|..|..::.|:.:          |:|:.:.:    ..|..|||:..:
  Fly  1477 ASIRGGSYEQENEAESEIDDLDDY----------INDIFQPI----PLVQNLEKLTSK------- 1520

Human  1542 LQSALEEAEASLEHEEGKILRAQLEFNQIKAEIE-----RKLAEKDEEMEQAKRNHQRVVDSLQ- 1600
                                      :|:.|.|:     .|..|:|||.|         ::.|.
  Fly  1521 --------------------------DQLAAIIKGGGVASKPEERDEESE---------IEDLDD 1550

Human  1601 ------------TSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLK 1653
                        ..||..|...:..:.::.....|.|..:..|....::..|.:.     ...|.
  Fly  1551 YINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETES-----GPALY 1610

Human  1654 DTQIQ---LDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERV 1715
            ..|:|   |..|:..|..:::.:.   .:|..||..|.:..|..         |...........
  Fly  1611 QQQVQRAFLQSAMAQNLQIQQQLL---AQNQALQTLLSQQAAAA---------AANNSTSPPPAP 1663

Human  1716 QLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQ--------------ECRNAEE---------KA 1757
            .:|.|.:.|....:..|....|:....|.|::|              ||::..|         :|
  Fly  1664 PILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGRA 1728

Human  1758 K-----KAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQ---- 1813
            |     |..........:.:.|:|..|.  :|:::..:|....||     .|:...||..:
  Fly  1729 KTVRIGKWRWPPPQDEPQFQTEEDFFAF--KMRQHQRKTTPQAQH-----HQMTSNGGMMESGPG 1786

Human  1814 LQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLR---LQDLVDKLQ- 1874
            .:...|...|.| |.|.|..........:.:|..|::..|..|.....|..|   .||:...:|
  Fly  1787 ARGASATAIEWE-EFEIESPTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDRDRETQDVGQPMQS 1850

Human  1875 -LKVKAYKRQAE-EAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGAKQKMHD 1937
             :..|..|:..| .|:.....::.|. |:..|:.:..|:.....|..:.:..||.. .|..|:.|
  Fly  1851 VVTTKLAKKSFEIGADRPPPGSVGKL-KLSSEMRQRLEQVTAGHSVRSTVSTKSEQ-RAPAKLED 1913

Human  1938  1937
              Fly  1914  1913

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH6	NP_002462.2	Myosin_N	32..76	CDD:460670
		MYSc_class_II	99..768	CDD:276951	253/689 (37%)
		Actin-binding	657..679		10/21 (48%)
		Actin-binding	759..773		5/13 (38%)
		Myosin_tail_1	848..1925	CDD:460256	211/1219 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1826..1849		4/22 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1909..1939		7/29 (24%)
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	253/689 (37%)
		PTZ00121	<828..>943	CDD:173412	32/179 (18%)
		MyTH4	1014..1171	CDD:470587	34/172 (20%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	18/86 (21%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022