Protein Alignment MYH6 and Myo95E

DIOPT Version :10

• Sequence 1: NP_002462.2
• Gene: MYH6 / 4624
• HGNCID: 7576
• Length: 1939
• Species: Homo sapiens
• Sequence 2: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Alignment Length: 1062
• Identity: 238/1062 - (22%)
• Similarity: 385/1062 - (36%)
• Gaps: 351/1062 - (33%)

Human    89 DMAMLTFLHEPAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPH 153
            |..:|..|.|.:.:.|:.:||....||||.|...|.:|||..:..::.:.|..|..|...:.|||
  Fly     9 DSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDKGIFQLPPH 73

Human   154 IFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFASI-------------------- 198
            |:.:::.|||.:....|:|.:|:|||||||||...|.::.:...|
  Fly    74 IYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLRKQSSTS 138

Human   199 ----------------------------------------------------------------- 198
                                                                             
  Fly   139 SASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIERQSRRH 203

Human   199 ----------------------------------------------------AAIG--------- 202
                                                                ||.|
  Fly   204 MREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPKYAVPTV 268

Human   203 ------------------DRGKKDN------------------ANANKGTLEDQIIQ-------- 223
                              ::.::|:                  |:.::|:..:.:.|
  Fly   269 YGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHSTESQPE 333

Human   224 ----------------------------------------------------------------- 223
                                                                             
  Fly   334 RERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRMRECVTC 398

Human   224 ANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERNYHIFY 288
            |:..|||.|||.|::|:||||:||...|.....|......|..|:|||:|:...:..|||:||||
  Fly   399 ADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGERNFHIFY 463

Human   289 QILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELMATDSAFDVLGFTSEEKAGVYKL 353
            |:|.....:||..|.:..|...|..:..   :.|..:|......|..:.||||.:.||...::::
  Fly   464 QLLLGADLQLLKSLKLYRNVEKYELLRN---TTAMEEDRMNFHYTKRSLDVLGLSCEESNSIFRV 525

Human   354 TGAIMHYGNMKFKQKQREEQAEP----DGTE--------DADKSAYLMGLNSADLLKGLCHPRVK 406
            ...::..||..|         .|    ||||        :..::|.|:.:.:..|:.  |..|..
  Fly   526 IAVVLKLGNFIF---------VPITNIDGTEGCQVSNVYEVQETAQLLNMEAQILIN--CLTRAN 579

Human   407 VGN---EYVTKGQSVQQVYYSIGALAKAVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEI 468
            ..|   |.|......:|...:...|.:.:|.::|.|:|.:||.:|::.| |:..:.:||..|||.
  Fly   580 STNSAQEDVGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESLKSTQ-REKNLALLDFYGFEA 643

Human   469 FDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKP-MGIM 532
            .|.|||||..||::.||:.|.|..|:...|||.|.:||:||:.||: .|.::..:||:|| .||:
  Fly   644 LDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDY-FDNESICELIDKPSYGIL 707

Human   533 SILEEECMFPKATDMTFKAKLYDNHLGKSN--------------NFQKPRNIKGKQEAHFSLIHY 583
            |::.|.                  ||..::              ||.    ..|.....|.:.||
  Fly   708 SLINEP------------------HLNSNDALLLRVQQCCAGHPNFM----TTGSNSMCFQIRHY 750

Human   584 AGTVDYNILGWLEKNKDPLNETVVALYQKSSLKLMATLFSSYATADTGDSGKSKGGKKKGSSFQT 648
            |..|:|:|..:||||.|.|.:.:.|.:.:|.|.|:.:||.        :....:...||.|   |
  Fly   751 ASVVNYSIHRFLEKNSDMLPKYISAAFYQSKLSLVQSLFP--------EGNPRRQVTKKPS---T 804

Human   649 VSALHRENLNKLMTNLRTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPN 713
            :|:..|..|..|:..::....|:|.||.|||.|.|...|..||.||:|...::..:.:||.|...
  Fly   805 LSSNIRTQLQTLLAIVKHRRSHYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCY 869

Human   714 RILYGDFRQRYRILNPVAIPEGQFIDSRKGTEKLLSSLDIDHNQYKFGHTKVFFKA-GLLGLLEE 777
            .:|:..|..||::||.:..|........:|...::.:|.:...::..|...||.:: ..:..||:
  Fly   870 HLLHVKFFHRYKLLNSLTWPHFHGGSQVEGIALIIRNLPLPSAEFTIGTKNVFVRSPRTVYELEQ 934

Human   778 MRDERLSRIITRMQAQARGQLMRIEFKKIVERRDALLVIQ--WNIRAFMGVKNWPWMKLYFKIKP 840
            .|..|:|.:...:|...|....|..|:::   |.:.::|.  |.          .|.:..|.| |
  Fly   935 FRRLRISELAVLIQTMFRMYHARKRFQRM---RHSQMIISSAWR----------TWRECRFGI-P 985

Human   841 LLKSAETEKEMATMKEEFGRIK 862
            ..............:||:..:|
  Fly   986 FTGRRHLWSLYRVAREEYRSLK 1007

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH6	NP_002462.2	Myosin_N	32..76	CDD:460670
		MYSc_class_II	99..768	CDD:276951	215/953 (23%)
		Actin-binding	657..679		7/21 (33%)
		Actin-binding	759..773		3/14 (21%)
		Myosin_tail_1	848..1925	CDD:460256	3/15 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1826..1849
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1909..1939
Myo95E	NP_001027208.1	Motor_domain	3..>123	CDD:473979	40/113 (35%)
		Motor_domain	<403..937	CDD:473979	173/582 (30%)
		Myosin_TH1	1092..1288	CDD:461801