Protein Alignment MYH6 and Myo81F

DIOPT Version :10

• Sequence 1: NP_002462.2
• Gene: MYH6 / 4624
• HGNCID: 7576
• Length: 1939
• Species: Homo sapiens
• Sequence 2: NP_001303492.1
• Gene: Myo81F / 26067052
• FlyBaseID: FBgn0267431
• Length: 2082
• Species: Drosophila melanogaster
• Alignment Length: 2137
• Identity: 503/2137 - (23%)
• Similarity: 850/2137 - (39%)
• Gaps: 523/2137 - (24%)

Human    89 DMAMLTFLHEPAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPH 153
            ||..::.:.|..:..||..||.:.:||||:|...:.|||||.:.::|.:.::.|...|..:..||
  Fly    12 DMTEMSEIDEIGINQNLNVRYNSDIIYTYTGSILLAVNPYKTINIFNKQTISEYHTCKLGDLSPH 76

Human   154 IFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFASIAAIGDRGKKDNANANKGTLE 218
            :|::::.||..::.|..||:.:|:||||||||.:||.::||..:|.:        |.::   .::
  Fly    77 VFAVAEAAYTSIVDDNINQACVISGESGAGKTESTKFILQYLCTITS--------NVSS---WVQ 130

Human   219 DQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERN 283
            .||::||..|||||||||.|||||||||||:::.|.....:....|..||||:||:.||.:.|||
  Fly   131 QQILEANTILEAFGNAKTTRNDNSSRFGKFMQVCFDDNNCIKGCVILDYLLEQSRITFQSEGERN 195

Human   284 YHIFYQILSNKKPELLDMLLVTNNP---YDYAFVSQGEVSVASIDDSEELMATDSAFDVLGFTSE 345
            |||.||:::..:..:.........|   |.|...|..|....:: :|::..|...||.||.....
  Fly   196 YHIMYQLVAQGQKNIGIANTFHLRPAEFYKYLNTSNSEKINMNL-ESKKFDAVTMAFTVLQIPQF 259

Human   346 EKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDG-TEDADKS--------AYLMGLNSADLLKGLC 401
            ...||:|:..:|:..||::|        .:.|| ..|..:|        :.|:||:..|..|.|.
  Fly   260 VIDGVFKVISSILWLGNIEF--------IDVDGEVTDLTRSDQEAISIISMLLGLSRCDFKKVLL 316

Human   402 HPRVKVGNEYVTKGQSVQQVYYSIGALAKAVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGF 466
            ..::.|..........:::...:..|||||:|.|||.|:|::||......|....|:|||||.||
  Fly   317 IRQINVRGNITEIPLKIKEALENRHALAKALYSKMFTWLVSKINNCTNPGQDDAKFLGVLDIFGF 381

Human   467 EIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEK-PMG 530
            |.|..|||||||||:|||||.:||||::|.|||..|:.|||.:..::| .|...|::::|| |..
  Fly   382 ENFSHNSFEQLCINYTNEKLHKFFNHYVFALEQSIYEHEGIYFNHVEF-TDNTPCLEILEKPPRC 445

Human   531 IMSILEEECMFPKATDMTFKAKL---YDNHLGKSNNFQKPRNIKGKQEAH----FSLIHYAGTVD 588
            :..:|.|:|..|:.:|:.|.:.:   :::|         |..|||....|    |.:.||||.|.
  Fly   446 VFKLLTEQCHMPQGSDLAFLSNMHTEFESH---------PNYIKGSDRRHWETEFGIKHYAGLVI 501

Human   589 YNILGWLEKNKDPLNETVVALYQKSSLKLMATLFSSYATADTGDSGKSKGGKKKGSSFQTVSALH 653
            |.:.|::|||:| :.:.|:..|...|..:.....|:|......:|...:|..|   |..|||...
  Fly   502 YAVGGFVEKNRD-VQQDVMFEYMSYSKDVFIKDLSTYQDIQFINSSYPRGSSK---SKCTVSDNF 562

Human   654 RENLNKLMTNLRTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYG 718
            |..|..|:..|:.|.|.:||||.||.:|.|...::.||:.||:..||::.|||.|:|||..:.:.
  Fly   563 RNQLQSLIDVLQNTKPWYVRCIKPNLQKRPNNYNSSLVLDQLKYLGVVDIIRIRREGFPIHLSHK 627

Human   719 DFRQRYRILNPVAIPEGQFIDSRKGTEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERL 783
            ||..||:.|    |....|...:|....:|....:...:::.|.:|:|.:.....|||..|.:.|
  Fly   628 DFIVRYKCL----IKNKSFEYPQKYLTNILEKNGMPTTEWQIGKSKIFLRNAAYELLETNRKDTL 688

Human   784 -----------------------SRIITRMQAQARGQLMRIEFKKIVERRDALLVIQWNIRAFMG 825
                                   .:.:.|:|...||..:||.|.::  ||.| :|||..:|....
  Fly   689 YKNAVIIQKNWKKYYIQKSFLRNKQAVLRIQHAYRGWRLRIRFMRM--RRSA-IVIQSRLRGVFA 750

Human   826 VKNWPWMKLYFKIKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEK-NDL 889
                                   :|:|....|..|:.|.|:|    |..:.|::.|:..:. .|.
  Fly   751 -----------------------REVAAALREMKRVDEELKK----RDGIYEQLTSITTKTLADC 788

Human   890 QLQVQAE-------QDNLN-DAEERCDQLIKNKIQLEAKVKEMNERLEDE-----EEMNAELTAK 941
            :..:|.|       .||:. .|:...|:...:.....:.:|:....|::.     |...|...|.
  Fly   789 ERSIQEELSVLAHISDNIRASAKPLSDKNDSDSNTARSSIKQNTVNLDNMFDFLCESKGAFENAL 853

Human   942 KRKLEDECSELKKDIDD-------LELTLAKVEKEKHATENKVKNLTEE-----------MAGLD 988
            .:::.|..:.|.|::|:       .|.:....:..|..|...|:.|.|.           .|.|:
  Fly   854 IKEINDNWNNLVKNLDEEIGLCIHTEDSFDSQKTGKLFTTKTVRTLPEPTVPPPPPPVSISANLN 918

Human   989 E-------IIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQ--EK 1044
            .       .:.|||..|:..:|.:.  |.|.:..:|.....|.|.|.::.|:|:.|...:|  ||
  Fly   919 SEPIYEAINLYKLTTTKEIKKEKYM--LLDYKSIKDNSKKPSTSSVFVKYQIDERENRRKQRVEK 981

Human  1045 KVR----MDLERAKRKLEGDLKLTQE------------SIMDLEND---------KLQLEEKLKK 1084
            |:.    :|:.:       |:.:...            :..||.:|         |.:..:|..|
  Fly   982 KIHELTLIDIHK-------DIHIDNSFYNILEFAENYFNTHDLSSDCNFISTPTQKGKSSDKTAK 1039

Human  1085 KEFDINQQNSKI---------EDEQVLALQLQKKL---------KENQARI-----------EEL 1120
            .|..:..::.||         .:..||:..:.::|         .|.:.:|           |||
  Fly  1040 HEMTMFSKSDKIPTSHIHMYDPENVVLSCSMFRELCKYMRGELNAERELQIIQYIVGLGIEREEL 1104

Human  1121 EEE--LEAERTAR---------------------------------AKVEKLRSDLSRELEEISE 1150
            .:|  ::..|.:|                                 :.::|...:|..:|.:.|:
  Fly  1105 RDEIFIQCIRQSRNNPNIDWTDRIWIILCLSIVAFQPSKLLFRYFVSFIKKSMIELDGKLRQYSQ 1169

Human  1151 RLEEAGGATSVQIEMNKKREAEFQKMRR-----------DLEEATLQHEATAAALRKKHADSVAE 1204
            ...:...:|.|...|......|...|||           |.....:....|..|     .|:|.:
  Fly  1170 WCFDNCKSTKVSTRMYPPSSVEVAAMRRLGTIVCRFFFLDARTKAIDVHPTDTA-----GDAVQK 1229

Human  1205 LGEQI------------------------DNLQRVKQKLEKEKSEF---KLELDDVTSNMEQIIK 1242
            |.|::                        |.|..|....|.:::.:   |...:..:|...|.:
  Fly  1230 LAEKLNLTTTDGWAIYQNRPDGEEHIKSYDYLYDVISSWEMKQATYAGTKKTTNGSSSGENQFV- 1293

Human  1243 AKANLEKVSRTLEDQANEYRVKLEEAQRSL---NDF------TTQRAKLQTE--NGELARQLE-E 1295
            .|..|.|.:..|.....|..:...:|..|:   ::|      ..|.|.||.:  .|:.:.|.: |
  Fly  1294 FKKRLFKSTHELSQDPVEVSMLYSQAVHSVVKKDEFPVSEKVALQLAGLQAQVALGDPSNQPKPE 1358

Human  1296 KEALISQLTRGKLSYTQQME----DLKRQLEEEGKAKNA-------LAHALQSARHDCDLLREQY 1349
            ..:.|:.....::|.|::.:    .|.:...:.|.::||       |:..:|...:...:.:..|
  Fly  1359 YYSDINSFLPIRISKTREQQFWIPILAQAHRQYGSSRNALTAKVLYLSCVMQYPLYGTTMFKVNY 1423

Human  1350 EEETEAKAE---------LQRVLSKANSEVAQWR------------TKYETDAIQRTEELEEAKK 1393
            :......:.         :..:..:..|.|.|::            ..:.|.::.|:.:|  .|.
  Fly  1424 KGYWNLASNIILGIHYDGIMFINPEDKSVVFQFKYVDIESILLDPSDSFITISLNRSAQL--LKT 1486

Human  1394 KLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEW 1458
            .|.     ....:|  :.||...|..:   :|:|..|::                 ::...|:.|
  Fly  1487 SLY-----GSSLIE--SQKCFVFETPQ---KNDIGSLII-----------------SYYPALSNW 1524

Human  1459 KQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHL-----------------ETFKRENKN 1506
                  ..:.||.|:|...:...:..:|.........||                 .|.:|.:|:
  Fly  1525 ------ILNNLECSKKYKGTTKEDRLRLYQNVVLCRRHLVDMNIVKKPHDFGGFLRNTLRRLSKH 1583

Human  1507 ----LQEEISDLTEQLGEGGKNV-HELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLE 1566
                |:.|:...|::.||..|.. |......||.....:...|..|||           |..|:
  Fly  1584 RLEKLRSEVGSNTQEHGETYKGFSHTFWAFSKQQIPFCISTISDQEEA-----------LMIQV- 1636

Human  1567 FNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQL 1631
            |:.|..  ...|....|.:.:|:..|.|::.|:....              .|.|..|||:.:||
  Fly  1637 FDSILT--YSGLGSSGESISRAEDEHIRIIQSIMDKC--------------MKKESLLNELYLQL 1685

Human  1632 SHANRMAAEAQKQVK----SLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRA 1692
            ........:|..:|.    :|.|:|....:....|||     |..||.::|.::...:|..:...
  Fly  1686 IKQTTDHPDANSRVNLKNWALLSVLCSVILPSMKAVR-----KYLIAHLKRCSSDFLSEEGKYAR 1745

Human  1693 VVE----QTERSRKL----AEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQE 1749
            ..|    :|:.:|:.    :.:|::.|:.|                                 :.
  Fly  1746 YAENCFFRTQGTRRRQWTPSREEILCTTNR---------------------------------RP 1777

Human  1750 CRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALK---GGK 1811
            |     .:|....|....:.|.:.....:..||.:||.:        ..||.|:..::.   |..
  Fly  1778 C-----YSKFYFMDGQYYSIEFQPSSTANDVLEIIKKKI--------GLLDNAKGYSIYEVIGNS 1829

Human  1812 KQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKK-----NLLRLQDLVD 1871
            ::....|.:|.::..:.|   |....|.:|.:|:...|.:........||     |.:.|:|:|:
  Fly  1830 ERSLSSEEKVCDVMAKWE---KYQITSQQGFQKNTTLISQQNQYMFLFKKHLFFDNYINLEDIVE 1891

Human  1872 KLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAE-----------ERADIAES 1917
            |            |....|...||   |..::.:.|.|           ||.|..||
  Fly  1892 K------------ELLYHQILHNL---RSERYPITEMEAIMLTALQSQLERGDCCES 1933

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH6	NP_002462.2	Myosin_N	32..76	CDD:460670
		MYSc_class_II	99..768	CDD:276951	242/688 (35%)
		Actin-binding	657..679		10/21 (48%)
		Actin-binding	759..773		3/13 (23%)
		Myosin_tail_1	848..1925	CDD:460256	239/1335 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1826..1849		5/22 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1909..1939		6/20 (30%)
Myo81F	NP_001303492.1	Motor_domain	23..673	CDD:473979	242/687 (35%)
		MyTH4	1091..1194	CDD:459939	14/102 (14%)
		FERM_F1_DdMyo7_like	1198..1299	CDD:340728	15/106 (14%)
		B41	1202..1419	CDD:214604	38/222 (17%)
		PH-like	1415..1523	CDD:473070	17/136 (13%)
		MyTH4	1664..1771	CDD:459939	25/125 (20%)
		FERM_F1_DdMyo7_like	1775..1880	CDD:340728	23/153 (15%)
		B41	1781..1992	CDD:214604	38/179 (21%)
		PH-like	1988..2076	CDD:473070