Protein Alignment MYH6 and myo2

DIOPT Version :10

• Sequence 1: NP_002462.2
• Gene: MYH6 / 4624
• HGNCID: 7576
• Length: 1939
• Species: Homo sapiens
• Sequence 2: NP_588114.1
• Gene: myo2 / 2539513
• PomBaseID: SPCC645.05C
• Length: 1526
• Species: Schizosaccharomyces pombe
• Alignment Length: 1627
• Identity: 569/1627 - (34%)
• Similarity: 854/1627 - (52%)
• Gaps: 212/1627 - (13%)

Human    29 RPFDIRTECFVPDDKEEFVKAKILSREGGK--VIAETENGKTVTVKEDQVLQQNPPKFDKIEDMA 91
            :..|.:...::.|.:..|.||.|......|  |:....:.....|.||::...||.|||::.|||
pombe    19 KDIDDKRWVWISDPETAFTKAWIKEDLPDKKYVVRYNNSRDEKIVGEDEIDPVNPAKFDRVNDMA 83

Human    92 MLTFLHEPAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFS 156
            .||:|:||||.:||::||.:..||||||||.|.||||..||:|..:::..|:.|.:....||:|:
pombe    84 ELTYLNEPAVTYNLEQRYLSDQIYTYSGLFLVAVNPYCGLPIYTKDIIQLYKDKTQERKLPHVFA 148

Human   157 ISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFASIAAIGDRGKKDNANANKGTLEDQI 221
            |:|.||..:|.::||||||:|||||||||.||||:|||.|:||:        :.......:|:||
pombe   149 IADLAYNNLLENKENQSILVTGESGAGKTENTKRIIQYLAAIAS--------STTVGSSQVEEQI 205

Human   222 IQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERNYHI 286
            |:.||.||:||||:||||:|||||||||::.|..:|::::|.||.||||||||:.|.:.|||||:
pombe   206 IKTNPVLESFGNARTVRNNNSSRFGKFIKVEFSLSGEISNAAIEWYLLEKSRVVHQNEFERNYHV 270

Human   287 FYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELMATDSAFDVLGFTSEEKAGVY 351
            |||:||.....|.:.||:|:|..||.::......:..:||.||.....:||..|||..:|...::
pombe   271 FYQLLSGADTALKNKLLLTDNCNDYRYLKDSVHIIDGVDDKEEFKTLLAAFKTLGFDDKENFDLF 335

Human   352 KLTGAIMHYGNMKFKQKQREEQAEPDG------TEDADKSAYLMGLNSADLLKGLCHPRVKVGNE 410
            .:...|:|.||:       :..|:..|      .::.||..:|:|::.....:.|..||:|.|:|
pombe   336 NILSIILHMGNI-------DVGADRSGIARLLNPDEIDKLCHLLGVSPELFSQNLVRPRIKAGHE 393

Human   411 YVTKGQSVQQVYYSIGALAKAVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFE 475
            :|...:|..||..||.|||||:||:.|.|:|.|:|.:|.....:.||||:|||||||||:.||||
pombe   394 WVISARSQTQVISSIEALAKAIYERNFGWLVKRLNTSLNHSNAQSYFIGILDIAGFEIFEKNSFE 458

Human   476 QLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEK--PMGIMSILEEE 538
            |||||:|||||||||||||||||||||.||.|.|.|||||.|||..||||||  |:||:|.|:||
pombe   459 QLCINYTNEKLQQFFNHHMFVLEQEEYMKEEIVWDFIDFGHDLQPTIDLIEKANPIGILSCLDEE 523

Human   539 CMFPKATDMTFKAKLYDNHLGKSNNFQKPRNIKGKQEAHFSLIHYAGTVDYNILGWLEKNKDPLN 603
            |:.|||||.||.:||......||..: ||...   .:..|.|.|||..|.|:..||||||.||||
pombe   524 CVMPKATDATFTSKLDALWRNKSLKY-KPFKF---ADQGFILTHYAADVPYSTEGWLEKNTDPLN 584

Human   604 ETVVALYQKSSLKLMATLFSSYATADTGDSGKSKGGKKKGSSFQTVSALHRENLNKLMTNLRTTH 668
            |.|..|..:|:.|.:|||||.|...:|    |:..|:.|...|:||:..|:|.||:||....:|.
pombe   585 ENVAKLLAQSTNKHVATLFSDYQETET----KTVRGRTKKGLFRTVAQRHKEQLNQLMNQFNSTQ 645

Human   669 PHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPVAIP 733
            |||:|||:|||.|.....:.|||:.|||||||||||||.|.|||||:.:.|||.||.|:  ..:|
pombe   646 PHFIRCIVPNEEKKMHTFNRPLVLGQLRCNGVLEGIRITRAGFPNRLPFNDFRVRYEIM--AHLP 708

Human   734 EGQFIDSRKGTEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRMQAQARGQL 798
            .|.:::||:.:..:|..|.||...|:.|.:|:|||||:|..|||.|...|.|::|.:|.:.||.|
pombe   709 TGTYVESRRASVMILEELKIDEASYRIGVSKIFFKAGVLAELEERRVATLQRLMTMLQTRIRGFL 773

Human   799 MRIEFKKIVERRDALLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAETEKEMATMKEEFGRIKE 863
            .|..|:|.::...|:.::|.|::.:...:.:||.||:|.::|||.|.:.:|::.....|...:|.
pombe   774 QRKIFQKRLKDIQAIKLLQANLQVYNEFRTFPWAKLFFNLRPLLSSTQNDKQLKKRDAEIIELKY 838

Human   864 TLEKSEARRKELEEKMV-----------------SLLQEKNDLQLQVQAEQDNLNDAEERCDQLI 911
            .|:|.:..:.|:|..:|                 ::..:|.::..:.|....|:.|:.....|..
pombe   839 ELKKQQNSKSEVERDLVETNNSLTAVENLLTTERAIALDKEEILRRTQERLANIEDSFSETKQQN 903

Human   912 KNKIQLEAKVKEMNERLEDE--------EEMNAELTAKKRKL---EDECSELKKDIDDLELTLAK 965
            :|..:..|.:|::|..||.|        |.:.:|....|.||   |.:..:.|.:::.|....|.
pombe   904 ENLQRESASLKQINNELESELLEKTSKVETLLSEQNELKEKLSLEEKDLLDTKGELESLRENNAT 968

Human   966 VEKEKHATENKVKNLTEEMAGLDEIIAKLTK----EKKALQEAH--QQALDDLQVEEDKVNSLSK 1024
            |..||.....:.|:|.|.:...|..:.||||    .|..:||..  .|.:::..::::...|.|.
pombe   969 VLSEKAEFNEQCKSLQETIVTKDAELDKLTKYISDYKTEIQEMRLTNQKMNEKSIQQEGSLSESL 1033

Human  1025 SKV-KLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFD 1088
            .:| |||::...|...:...|:.:.:|...|...|..:...:|.:..||.|..|| .||||:...
pombe  1034 KRVKKLERENSTLISDVSILKQQKEELSVLKGVQELTINNLEEKVNYLEADVKQL-PKLKKELES 1097

Human  1089 INQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLE 1153
            :|      :.:|:..||..|. ||.:|:::|....:::              |::|||...|:.:
pombe  1098 LN------DKDQLYQLQATKN-KELEAKVKECLNNIKS--------------LTKELENKEEKCQ 1141

Human  1154 EAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQK 1218
            ....|:...||:.:..|....|: .|||....::|                 |.|:|
pombe  1142 NLSDASLKYIELQEIHENLLLKV-SDLENYKKKYE-----------------GLQLD-------- 1180

Human  1219 LEKEKSEFKLE-LDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKL 1282
                     || |.||.:|.:::.|...:|.....:|..|:..|:.||..|.....|.:.:.:.|
pombe  1181 ---------LEGLKDVDTNFQELSKKHRDLTFNHESLLRQSASYKEKLSLASSENKDLSNKVSSL 1236

Human  1283 QTENGEL---ARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDL 1344
            ..:..||   |.::.|.|..|:.|........:..||.||:             ||.::|.:.:|
pombe  1237 TKQVNELSPKASKVPELERKITNLMHEYSQLGKTFEDEKRK-------------ALIASRDNEEL 1288

Human  1345 --LREQYEEETEAKAELQRVLSKA------NSEVAQWRTKY-ETDAIQRTEELEEAKKKLAQRLQ 1400
              |:.:.|.:.:.:.|.|:||.:.      .|||...|.|. :.::|:  .:|.|.:.||....:
pombe  1289 RSLKSELESKRKLEVEYQKVLEEVKTTRSLRSEVTLLRNKVADHESIR--SKLSEVEMKLVDTRK 1351

Human  1401 DAEEAVEAVNAKCSSLEKTKHRL--------QNEI---------------EDLMVDVERSNAAAA 1442
            :...|:::    |...|...|||        :|.|               ...:.|:::.||..|
pombe  1352 ELNSALDS----CKKREAEIHRLKEHRPSGKENNIPAVKTTEPVLKNIPQRKTIFDLQQRNANQA 1412

Human  1443 ALDKKQRNFDKILAEWKQKYEESQSELE----SSQKEARSL-------STELFKLKNAYEESLEH 1496
            ..:..:|::|::..| |...|:..:||:    |.|...:||       :.||..||:........
pombe  1413 LYENLKRDYDRLNLE-KHNLEKQVNELKGAEVSPQPTGQSLQHVNLAHAIELKALKDQINSEKAK 1476

Human  1497 LETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKIL 1561
            :.:.:.:.:..::|:.          |.:..||||.|...::    ..||.:..||||.|    |
pombe  1477 MFSVQVQYEKREQELQ----------KRIASLEKVNKDSLID----VRALRDRIASLEDE----L 1523

Human  1562 RA 1563
            ||
pombe  1524 RA 1525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH6	NP_002462.2	Myosin_N	32..76	CDD:460670	11/45 (24%)
		MYSc_class_II	99..768	CDD:276951	333/676 (49%)
		Actin-binding	657..679		12/21 (57%)
		Actin-binding	759..773		7/13 (54%)
		Myosin_tail_1	848..1925	CDD:460256	182/798 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1826..1849
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1909..1939
myo2	NP_588114.1	COG5022	6..1516	CDD:227355	561/1612 (35%)