Protein Alignment fbl and PANK2

DIOPT Version :9

• Sequence 1: NP_524870.1
• Gene: fbl / 46234
• FlyBaseID: FBgn0011205
• Length: 512
• Species: Drosophila melanogaster
• Sequence 2: NP_705902.2
• Gene: PANK2 / 80025
• HGNCID: 15894
• Length: 570
• Species: Homo sapiens
• Alignment Length: 521
• Identity: 252/521 - (48%)
• Similarity: 328/521 - (62%)
• Gaps: 96/521 - (18%)

  Fly    23 KKPT-----SPSPPTSPVISAKRNSWR------------ASWRSA-------------------- 50
            ::||     .|||.:|..:.|:   ||            :.|.:|
Human    61 REPTGREAFGPSPASSDWLPAR---WRNGRGGRPRARLCSGWTAAEEARRNPTLGGLLGRQRLLL 122

  Fly    51 ------LG--------SKSKSIAMASD-SSSDPIDLEAEPVFFEHSRCNSYCSSSSAFTELPHPA 100
                  ||        :.:.|::.|.: ::.||.....||:       ....||:|.      ||
Human   123 RMGGGRLGAPMERHGRASATSVSSAGEQAAGDPEGRRQEPL-------RRRASSASV------PA 174

  Fly   101 I----QIPQGDELMS---------------------MPWFGMDIGGTLTKLVYFEPKDITPDEQD 140
            :    :..:.|.|.|                     .||||:||||||.|||||||||||.:|::
Human   175 VGASAEGTRRDRLGSYSGPTSVSRQRVESLRKKRPLFPWFGLDIGGTLVKLVYFEPKDITAEEEE 239

  Fly   141 REAGILRNIRRYLTKNSAYGKTGHRDTHLQMDNVEIRKRRGSLHFIRFQTTDMGNFLSLAKQKGM 205
            .|...|::||:|||.|.|||.||.||.||::.::.:..|:|:||||||.|.||..|:.:.:.|..
Human   240 EEVESLKSIRKYLTSNVAYGSTGIRDVHLELKDLTLCGRKGNLHFIRFPTHDMPAFIQMGRDKNF 304

  Fly   206 AELVTTVCATGGGAFKFEQDFRDQVNMKLAKFDELDTLIKGILFAD---LHNRTECYYYENARDI 267
            :.|.|..|||||||:||||||....:::|.|.||||.||||||:.|   .:.|::|||:||..|.
Human   305 SSLHTVFCATGGGAYKFEQDFLTIGDLQLCKLDELDCLIKGILYIDSVGFNGRSQCYYFENPADS 369

  Fly   268 LKSEKQQFNFSQPFPFILVNVGSGVSILAVYGPDNYKRISGTSLGGGTFLGLCCLLTGCTSFEEA 332
            .|.:|..|:...|:|.:|||:||||||||||..|||||::|||||||||.||||||||||:||||
Human   370 EKCQKLPFDLKNPYPLLLVNIGSGVSILAVYSKDNYKRVTGTSLGGGTFFGLCCLLTGCTTFEEA 434

  Fly   333 IQLATKGDNRKVDKLVKDIYGGDYNRFGLPGDLVASSFGQMHLNDKRVSVSREDLANATLVTITN 397
            :::|::||:.||||||:|||||||.||||||..||||||.|...:||.:||:||||.|||:||||
Human   435 LEMASRGDSTKVDKLVRDIYGGDYERFGLPGWAVASSFGNMMSKEKREAVSKEDLARATLITITN 499

  Fly   398 NIGSIARMCALNEKIDRVVFVGNFLRVNPISMKLLAYAMEFWSNGTMKGLFLEHEGYFGALGCLL 462
            |||||||||||||.|::|||||||||:|.|:|:|||||:::||.|.:|.||.||||||||:|.||
Human   500 NIGSIARMCALNENINQVVFVGNFLRINTIAMRLLAYALDYWSKGQLKALFSEHEGYFGAVGALL 564

  Fly   463 Q 463
            :
Human   565 E 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fbl	NP_524870.1	Fumble	115..460	CDD:281610	220/347 (63%)
PANK2	NP_705902.2	Fumble	214..562	CDD:281610	220/347 (63%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146037
Domainoid	1	1.000	476	1.000	Domainoid score	I437
eggNOG	1	0.900	-	-		E1_COG5146
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	479	1.000	Inparanoid score	I1480
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52384
OrthoDB	1	1.010	-	-		D326140at33208
OrthoFinder	1	1.000	-	-		FOG0001277
OrthoInspector	1	1.000	-	-		otm41014
orthoMCL	1	0.900	-	-		OOG6_100565
Panther	1	1.100	-	-	O	PTHR12280
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R888
SonicParanoid	1	1.000	-	-		X986
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800