DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fbl and PANK3

DIOPT Version :9

Sequence 1:	NP_524870.1	Gene:	fbl / 46234	FlyBaseID:	FBgn0011205	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_078870.1	Gene:	PANK3 / 79646	HGNCID:	19365	Length:	370	Species:	Homo sapiens

Alignment Length:	355	Identity:	225/355 - (63%)
Similarity:	279/355 - (78%)	Gaps:	3/355 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 SMPWFGMDIGGTLTKLVYFEPKDITPDEQDREAGILRNIRRYLTKNSAYGKTGHRDTHLQMDNVE 175
            |.|||||||||||.||.||||.|||.:|:..|...|::||:|||.|.|||.||.||.||::.::.
Human    10 SFPWFGMDIGGTLVKLSYFEPIDITAEEEQEEVESLKSIRKYLTSNVAYGSTGIRDVHLELKDLT 74

  Fly   176 IRKRRGSLHFIRFQTTDMGNFLSLAKQKGMAELVTTVCATGGGAFKFEQDFRDQVNMKLAKFDEL 240
            :..|||:||||||.|.|:..|:.:.:.|..:.|.|.:|||||||:|||:|||...|:.|.|.|||
Human    75 LFGRRGNLHFIRFPTQDLPTFIQMGRDKNFSTLQTVLCATGGGAYKFEKDFRTIGNLHLHKLDEL 139

  Fly   241 DTLIKGILFAD---LHNRTECYYYENARDILKSEKQQFNFSQPFPFILVNVGSGVSILAVYGPDN 302
            |.|:||:|:.|   .:.:.||||:.||.:..:.:|..||...|:|.::||:|||||||||:..||
Human   140 DCLVKGLLYIDSVSFNGQAECYYFANASEPERCQKMPFNLDDPYPLLVVNIGSGVSILAVHSKDN 204

  Fly   303 YKRISGTSLGGGTFLGLCCLLTGCTSFEEAIQLATKGDNRKVDKLVKDIYGGDYNRFGLPGDLVA 367
            |||::|||||||||||||.|||||.|||||:::|:|||:.:.||||:|||||||.||||||..||
Human   205 YKRVTGTSLGGGTFLGLCSLLTGCESFEEALEMASKGDSTQADKLVRDIYGGDYERFGLPGWAVA 269

  Fly   368 SSFGQMHLNDKRVSVSREDLANATLVTITNNIGSIARMCALNEKIDRVVFVGNFLRVNPISMKLL 432
            ||||.|...:||.|||:||||.||||||||||||:|||||:||||:||||||||||||.:|||||
Human   270 SSFGNMIYKEKRESVSKEDLARATLVTITNNIGSVARMCAVNEKINRVVFVGNFLRVNTLSMKLL 334

  Fly   433 AYAMEFWSNGTMKGLFLEHEGYFGALGCLL 462
            |||:::||.|.:|.|||||||||||:|.||
Human   335 AYALDYWSKGQLKALFLEHEGYFGAVGALL 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fbl	NP_524870.1	Fumble	115..460	CDD:281610	219/347 (63%)
PANK3	NP_078870.1	Fumble	14..362	CDD:397611	219/347 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146039
Domainoid	1	1.000	476	1.000	Domainoid score	I437
eggNOG	1	0.900	-	-		E1_COG5146
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	479	1.000	Inparanoid score	I1480
Isobase	1	0.950	-	0	Normalized mean entropy	S1674
OMA	1	1.010	-	-		QHG52384
OrthoDB	1	1.010	-	-		D326140at33208
OrthoFinder	1	1.000	-	-		FOG0001277
OrthoInspector	1	1.000	-	-		otm41014
orthoMCL	1	0.900	-	-		OOG6_100565
Panther	1	1.100	-	-	O	PTHR12280
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R888
SonicParanoid	1	1.000	-	-		X986
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.750