DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fbl and Pank1

DIOPT Version :9

Sequence 1:	NP_524870.1	Gene:	fbl / 46234	FlyBaseID:	FBgn0011205	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_001107811.1	Gene:	Pank1 / 75735	MGIID:	1922985	Length:	548	Species:	Mus musculus

Alignment Length:	466	Identity:	252/466 - (54%)
Similarity:	312/466 - (66%)	Gaps:	42/466 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 SPSPPTSPVISAKRNSWRASWRSALGSKSKSIAMA--------------SDSSSD--------PI 69
            |.||.|:|.:....:......|:||.|.......|              :.||.|        |.
Mouse    88 SRSPRTAPPVPGMGDRGAQHERAALQSPGAPEGAAAAVNGLLHNGFHPSAASSRDPPAPRFQLPS 152

  Fly    70 DLEAEPVFFEH----SRCNSYCSSSSAFTELPHPAIQIPQGDELMSMPWFGMDIGGTLTKLVYFE 130
            :|:.:|:|.:|    .:|.......|.....|             ..|||||||||||.||||||
Mouse   153 ELQPQPLFAQHDSPAKKCRLRRRMDSGRKNRP-------------PFPWFGMDIGGTLVKLVYFE 204

  Fly   131 PKDITPDEQDREAGILRNIRRYLTKNSAYGKTGHRDTHLQMDNVEIRKRRGSLHFIRFQTTDMGN 195
            |||||.:|:..|...|::||:|||.|:||||||.||.||::.|:.:..|:|:||||||.|..|..
Mouse   205 PKDITAEEEQEEVENLKSIRKYLTSNTAYGKTGIRDVHLELKNLTMCGRKGNLHFIRFPTCAMHL 269

  Fly   196 FLSLAKQKGMAELVTTVCATGGGAFKFEQDFRDQVNMKLAKFDELDTLIKGILFAD---LHNRTE 257
            |:.:..:|..:.|.||:|||||||||||:|||...:::|.|.||||.||:|:|:.|   .:.:.|
Mouse   270 FIQMGSEKNFSSLHTTLCATGGGAFKFEEDFRMIADLQLHKLDELDCLIQGLLYVDSVGFNGKPE 334

  Fly   258 CYYYENARDILKSEKQQFNFSQPFPFILVNVGSGVSILAVYGPDNYKRISGTSLGGGTFLGLCCL 322
            |||:||..:....:|:.:....|:|.:|||:||||||||||..|||||::|||||||||||||||
Mouse   335 CYYFENPTNPELCQKKPYCLDNPYPMLLVNMGSGVSILAVYSKDNYKRVTGTSLGGGTFLGLCCL 399

  Fly   323 LTGCTSFEEAIQLATKGDNRKVDKLVKDIYGGDYNRFGLPGDLVASSFGQMHLNDKRVSVSREDL 387
            ||||.:||||:.:|.|||:..|||||||||||||.||||.|..||||||.|...:||.|:|:|||
Mouse   400 LTGCETFEEALDMAAKGDSTNVDKLVKDIYGGDYERFGLQGSAVASSFGNMMSKEKRESISKEDL 464

  Fly   388 ANATLVTITNNIGSIARMCALNEKIDRVVFVGNFLRVNPISMKLLAYAMEFWSNGTMKGLFLEHE 452
            |.|||||||||||||||||||||.||||||||||||:|.:|||||||||:|||.|.:|.||||||
Mouse   465 ARATLVTITNNIGSIARMCALNENIDRVVFVGNFLRINMVSMKLLAYAMDFWSKGQLKALFLEHE 529

  Fly   453 GYFGALGCLLQ 463
            |||||:|.||:
Mouse   530 GYFGAVGALLE 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fbl	NP_524870.1	Fumble	115..460	CDD:281610	226/347 (65%)
Pank1	NP_001107811.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..120		9/31 (29%)
		Nucleolar localization signal. /evidence=ECO:0000269\|PubMed:23152917	1..8
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	132..167		8/34 (24%)
		Nucleolar localization signal. /evidence=ECO:0000269\|PubMed:23152917	168..185		3/29 (10%)
		Fumble	189..537	CDD:281610	226/347 (65%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836112
Domainoid	1	1.000	476	1.000	Domainoid score	I430
eggNOG	1	0.900	-	-		E1_COG5146
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56979
Inparanoid	1	1.050	480	1.000	Inparanoid score	I1446
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52384
OrthoDB	1	1.010	-	-		D326140at33208
OrthoFinder	1	1.000	-	-		FOG0001277
OrthoInspector	1	1.000	-	-		otm43084
orthoMCL	1	0.900	-	-		OOG6_100565
Panther	1	1.100	-	-	LDO	PTHR12280
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R888
SonicParanoid	1	1.000	-	-		X986
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800