DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fbl and Pank2

DIOPT Version :9

Sequence 1:	NP_524870.1	Gene:	fbl / 46234	FlyBaseID:	FBgn0011205	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_705721.3	Gene:	Pank2 / 74450	MGIID:	1921700	Length:	456	Species:	Mus musculus

Alignment Length:	439	Identity:	244/439 - (55%)
Similarity:	310/439 - (70%)	Gaps:	25/439 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 KRNSWRASWRSALGSKSKSIAMASD------SSSDPIDL-EAEPVFFEHSRCNSYCSSSSAFTEL 96
            :|....|:..:|:|..:.|.|...|      ||:.|... |||.|  ...|..|...|:||..
Mouse    24 ERQGRAAATSAAVGESADSEARRRDPLRRRASSAAPSGSGEAESV--RRERPGSLGGSTSAGR-- 84

  Fly    97 PHPAIQIPQGDELMS----MPWFGMDIGGTLTKLVYFEPKDITPDEQDREAGILRNIRRYLTKNS 157
                   |:.:.|..    .||||:||||||.|||||||||||.:|:..|...|::||:|||.|.
Mouse    85 -------PRAEGLRKRRPLFPWFGLDIGGTLVKLVYFEPKDITAEEEKEEVESLKSIRKYLTSNV 142

  Fly   158 AYGKTGHRDTHLQMDNVEIRKRRGSLHFIRFQTTDMGNFLSLAKQKGMAELVTTVCATGGGAFKF 222
            |||.||.||.||::.::.:..|:|:||||||.|.||..|:.:.:.|..:.|.|..||||||::||
Mouse   143 AYGSTGIRDVHLELKDLTLCGRKGNLHFIRFPTHDMPAFIQMGRDKNFSSLHTVFCATGGGSYKF 207

  Fly   223 EQDFRDQVNMKLAKFDELDTLIKGILFAD---LHNRTECYYYENARDILKSEKQQFNFSQPFPFI 284
            ||||....:::|.|.||||.||||||:.|   .:.|::|||:||..|..|.:|..|:...|:|.:
Mouse   208 EQDFLTIGDLQLRKLDELDCLIKGILYIDSVGFNGRSQCYYFENPADSEKCQKLPFDLKNPYPLL 272

  Fly   285 LVNVGSGVSILAVYGPDNYKRISGTSLGGGTFLGLCCLLTGCTSFEEAIQLATKGDNRKVDKLVK 349
            |||:||||||||||..|||||::|||||||||.|||||||||::||||:::|::||:.||||||:
Mouse   273 LVNIGSGVSILAVYSKDNYKRVTGTSLGGGTFFGLCCLLTGCSTFEEALEMASRGDSTKVDKLVR 337

  Fly   350 DIYGGDYNRFGLPGDLVASSFGQMHLNDKRVSVSREDLANATLVTITNNIGSIARMCALNEKIDR 414
            |||||||.||||||..||||||.|...:||.:.|:||||.|||:|||||||||||||||||.|::
Mouse   338 DIYGGDYERFGLPGWAVASSFGNMMSKEKREAASKEDLARATLITITNNIGSIARMCALNENINQ 402

  Fly   415 VVFVGNFLRVNPISMKLLAYAMEFWSNGTMKGLFLEHEGYFGALGCLLQ 463
            |||||||||||.|:|:|||||:::||.|.:|.||.||||||||:|.||:
Mouse   403 VVFVGNFLRVNTIAMRLLAYALDYWSKGQLKALFSEHEGYFGAVGALLE 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fbl	NP_524870.1	Fumble	115..460	CDD:281610	218/347 (63%)
Pank2	NP_705721.3	Fumble	100..448	CDD:397611	218/347 (63%)
Pank2	NP_705721.3	Nuclear export signal. /evidence=ECO:0000250\|UniProtKB:Q9BZ23	154..161		1/6 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836111
Domainoid	1	1.000	476	1.000	Domainoid score	I430
eggNOG	1	0.900	-	-		E1_COG5146
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	480	1.000	Inparanoid score	I1446
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52384
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001277
OrthoInspector	1	1.000	-	-		otm43084
orthoMCL	1	0.900	-	-		OOG6_100565
Panther	1	1.100	-	-	O	PTHR12280
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R888
SonicParanoid	1	1.000	-	-		X986
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.790