DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fbl and PANK4

DIOPT Version :9

Sequence 1:	NP_524870.1	Gene:	fbl / 46234	FlyBaseID:	FBgn0011205	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_060686.3	Gene:	PANK4 / 55229	HGNCID:	19366	Length:	773	Species:	Homo sapiens

Alignment Length:	442	Identity:	146/442 - (33%)
Similarity:	226/442 - (51%)	Gaps:	56/442 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 SRCNSYCSSSSAFTELPHPAIQIPQGD---ELMSMPWFGMDIGGTLTKLVYFEPKDITPDEQDRE 142
            :.|.:..|.||.  :....:|.:|..:   .|.:...|.:||||:||||.|:.
Human     2 AECGASGSGSSG--DSLDKSITLPPDEIFRNLENAKRFAIDIGGSLTKLAYYS------------ 52

  Fly   143 AGILRNIRRYLTKNSAYGKTGHRDTHLQMD-------NVEIRKRRGSLHFIRFQTTDMGNFLSLA 200
                 .::..:.|..::..:| :||..:.:       ..||..|   ||||:|:.|.:...|...
Human    53 -----TVQHKVAKVRSFDHSG-KDTEREHEPPYEISVQEEITAR---LHFIKFENTYIEACLDFI 108

  Fly   201 KQKGMAELVTT----VCATGGGAFKFEQDFRDQVNMKLAKFDELDTLIKGILFADLHNRTECYYY 261
            |.    .||.|    :.||||||:||:....:::.:|:.|.|.:..||||..|...:...|.:.|
Human   109 KD----HLVNTETKVIQATGGGAYKFKDLIEEKLRLKVDKEDVMTCLIKGCNFVLKNIPHEAFVY 169

  Fly   262 ENARDILKSEKQQFNFSQPFPFILVNVGSGVSILAVYGPDNYKRISGTSLGGGTFLGLCCLLTGC 326
            :...|  ...:.|.|....||::|||:||||||:.|...|.::.:.|:|:|||||.||..|||..
Human   170 QKDSD--PEFRFQTNHPHIFPYLLVNIGSGVSIVKVETEDRFEWVGGSSIGGGTFWGLGALLTKT 232

  Fly   327 TSFEEAIQLATKGDNRKVDKLVKDIYGGDYNRFGLPGDLVASSFGQMHLNDKRVSVSREDLANAT 391
            ..|:|.:.||::|.:..||.||:|:|||.:...||.|:|:|||||:....|:  ..|:||:|.:.
Human   233 KKFDELLHLASRGQHSNVDMLVRDVYGGAHQTLGLSGNLIASSFGKSATADQ--EFSKEDMAKSL 295

  Fly   392 LVTITNNIGSIARMCALNEKIDRVVFVGNFLRVNPISMKLLAYAMEFWSNGTMKGLFLEHEGYFG 456
            |..|:|:||.:|.:.|....:|||.|.|.|:|.:|::|:.:.|::.|:|.|.::.|||.||||.|
Human   296 LHMISNDIGQLACLHARLHSLDRVYFGGFFIRGHPVTMRTITYSINFFSKGEVQALFLRHEGYLG 360

  Fly   457 ALGCLLQFNGELAAALNDGVEHSIHTESDSASEAAQTSSTADEPPEKAPTSK 508
            |:|..|:           |.|.....:.......|.:|......||..|..:
Human   361 AIGAFLK-----------GAEQDNPNQYSWGENYAGSSGLMSASPELGPAQR 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fbl	NP_524870.1	Fumble	115..460	CDD:281610	130/355 (37%)
PANK4	NP_060686.3	Pantothenate kinase. /evidence=ECO:0000305\|PubMed:27322068	2..402		146/442 (33%)
		PLN02902	17..771	CDD:215489	142/425 (33%)
		4'-phosphopantetheine phosphatase. /evidence=ECO:0000305\|PubMed:27322068	403..773
		Subfamily II EGMGR motif. /evidence=ECO:0000305\|PubMed:27322068	724..728
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5146
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D865329at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100565
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R888
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750