DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fbl and Pank2

DIOPT Version :9

Sequence 1:	NP_524870.1	Gene:	fbl / 46234	FlyBaseID:	FBgn0011205	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	XP_038960511.1	Gene:	Pank2 / 296167	RGDID:	1305169	Length:	482	Species:	Rattus norvegicus

Alignment Length:	367	Identity:	224/367 - (61%)
Similarity:	281/367 - (76%)	Gaps:	12/367 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 LMSMPWFGMDIGGTLTKLVYFEPKDITPDEQDREAGILRNIRRYLTKNSAYGKTGHRDTHLQMDN 173
            |...||||:||||||.|||||||||||.:|:..|...|::||:|||.|.|||.||.||.||::.:
  Rat   111 LCIFPWFGLDIGGTLVKLVYFEPKDITAEEEKEEVESLKSIRKYLTSNVAYGSTGIRDVHLELKD 175

  Fly   174 VEIRKRRGSLHFIRFQTTDMGNFLSLAKQKGMAELVTTVCATGGGAFKFEQDFRDQVNMKLAKFD 238
            :.:..|:|:||||||.|.||..|:.:.:.|..:.|.|..||||||::||||||....:::|.|.|
  Rat   176 LTLCGRKGNLHFIRFPTHDMPAFIQMGRDKNFSSLHTVFCATGGGSYKFEQDFLTIGDLQLRKLD 240

  Fly   239 ELDTLIKGILFAD---LHNRTECYYYENARDILKSEKQQFNFSQPFPFILVNVGSGVSILAVYGP 300
            |||.||||||:.|   .:.|::|||:||..|..|.:|..|:...|:|.:|||:||||||||||..
  Rat   241 ELDCLIKGILYIDSVGFNGRSQCYYFENPADSEKCQKLPFDLKNPYPLLLVNIGSGVSILAVYSK 305

  Fly   301 DNYKRISGTSLGGGTFLGLCCLLTGCTSFEEAIQLATKGDNRKVDKLVKDIYGGDYNRFGLPGDL 365
            |||||::|||||||||.|||||||||::||||:::|::||:.||||||:|||||||.||||||..
  Rat   306 DNYKRVTGTSLGGGTFFGLCCLLTGCSTFEEALEMASRGDSTKVDKLVRDIYGGDYERFGLPGWA 370

  Fly   366 VAS---------SFGQMHLNDKRVSVSREDLANATLVTITNNIGSIARMCALNEKIDRVVFVGNF 421
            |||         |||.|...:||.:.|:||||.|||:|||||||||||||||||.|::|||||||
  Rat   371 VASSSEMSFFHHSFGNMMSKEKREAASKEDLARATLITITNNIGSIARMCALNENINQVVFVGNF 435

  Fly   422 LRVNPISMKLLAYAMEFWSNGTMKGLFLEHEGYFGALGCLLQ 463
            ||||.|:|:|||||:::||.|.:|.||.||||||||:|.||:
  Rat   436 LRVNTIAMRLLAYALDYWSKGQLKALFSEHEGYFGAVGALLE 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fbl	NP_524870.1	Fumble	115..460	CDD:281610	218/356 (61%)
Pank2	XP_038960511.1	Fumble	117..474	CDD:397611	218/356 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339776
Domainoid	1	1.000	476	1.000	Domainoid score	I409
eggNOG	1	0.900	-	-		E1_COG5146
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	480	1.000	Inparanoid score	I1409
OMA	1	1.010	-	-		QHG52384
OrthoDB	1	1.010	-	-		D326140at33208
OrthoFinder	1	1.000	-	-		FOG0001277
OrthoInspector	1	1.000	-	-		otm45149
orthoMCL	1	0.900	-	-		OOG6_100565
Panther	1	1.100	-	-	O	PTHR12280
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X986
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770