DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fbl and Pank4

DIOPT Version :9

Sequence 1:	NP_524870.1	Gene:	fbl / 46234	FlyBaseID:	FBgn0011205	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_598215.1	Gene:	Pank4 / 171053	RGDID:	628857	Length:	773	Species:	Rattus norvegicus

Alignment Length:	402	Identity:	141/402 - (35%)
Similarity:	213/402 - (52%)	Gaps:	45/402 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 FGMDIGGTLTKLVYFEPKDITPDEQDREAGILRNIRRYLTKNSAY---GKTGHRDTHLQMDNVEI 176
            |.:||||:||||.|:.                 .::..:.|..::   ||...:| |.....:.:
  Rat    37 FAIDIGGSLTKLAYYS-----------------TVQHKVAKVRSFDHPGKDAEQD-HEPPYEISV 83

  Fly   177 RKR-RGSLHFIRFQTTDMGNFLSLAKQKGMAELVTT----VCATGGGAFKFEQDFRDQVNMKLAK 236
            ::. ...||||:|:.|.|...|...:.    .||.|    :.||||||:||:....:::.:|:.|
  Rat    84 QEEITARLHFIKFENTYMEACLDFIRD----HLVNTETKVIQATGGGAYKFKDLIEEKLRLKVDK 144

  Fly   237 FDELDTLIKGILFADLHNRTECYYYENARDILKSEKQQFNFSQPFPFILVNVGSGVSILAVYGPD 301
            .|.:..||||..|...:...|.:.|:...|  ...:.|.|....||::|||:||||||:.|...|
  Rat   145 EDVMTCLIKGCNFVLKNIPHEAFMYQKDSD--PEFRFQTNHPNIFPYLLVNIGSGVSIVKVETED 207

  Fly   302 NYKRISGTSLGGGTFLGLCCLLTGCTSFEEAIQLATKGDNRKVDKLVKDIYGGDYNRFGLPGDLV 366
            .::.|.|:|:|||||.||..|||....|:|.:|||::|.:..||.||:|||||.:...||.|:|:
  Rat   208 RFEWIGGSSIGGGTFWGLGALLTKTKKFDELLQLASRGRHANVDMLVQDIYGGAHQTLGLSGNLI 272

  Fly   367 ASSFGQMHLNDKRVSVSREDLANATLVTITNNIGSIARMCALNEKIDRVVFVGNFLRVNPISMKL 431
            |||||:....|:  ..|:||:|.:.|..|:|:||.:|.:.|....:|||.|.|.|:|.:|::|:.
  Rat   273 ASSFGKSATADR--EFSKEDMAKSLLHMISNDIGQLACLYAKLHGLDRVYFGGFFIRGHPVTMRT 335

  Fly   432 LAYAMEFWSNGTMKGLFLEHEGYFGALGCLLQFNGELAAALNDGVEHSIHTESDSASEAAQTSST 496
            :.|::.|:|.|.::.|||.||||.||:|..|:           |.|.....:.......|.:|..
  Rat   336 ITYSINFFSKGEVQALFLRHEGYLGAIGAFLK-----------GAEQDNPNQYSWGENYAASSGL 389

  Fly   497 ADEPPEKAPTSK 508
            ....||..||.:
  Rat   390 MSTAPELCPTQR 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fbl	NP_524870.1	Fumble	115..460	CDD:281610	131/352 (37%)
Pank4	NP_598215.1	Pantothenate kinase. /evidence=ECO:0000250\|UniProtKB:Q9NVE7	2..402		141/402 (35%)
		PLN02902	17..771	CDD:215489	141/402 (35%)
		4'-phosphopantetheine phosphatase. /evidence=ECO:0000250\|UniProtKB:Q9NVE7	403..773
		Subfamily II EGMGR motif. /evidence=ECO:0000250\|UniProtKB:Q9NVE7	724..728
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5146
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D865329at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100565
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720