DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MYH4 and zip

DIOPT Version :9

Sequence 1:NP_060003.2 Gene:MYH4 / 4622 HGNCID:7574 Length:1939 Species:Homo sapiens
Sequence 2:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster


Alignment Length:1971 Identity:757/1971 - (38%)
Similarity:1194/1971 - (60%) Gaps:69/1971 - (3%)


- Green bases have known domain annotations that are detailed below.


Human    15 PFLRKSEKERIE----AQNKPFDAKTSVFVVDPKESYVKAIVQSREGGKVTAK-TEAGATVTVKE 74
            |.|:....||.:    |....:..|..|:|....:.:|.|.::...|.:|..: .|.|..|.:..
  Fly    55 PELKYLSVERNQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMILR 119

Human    75 DQVFSMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEV 139
            |.:..|||||:||:||||.:|.|:|.:||:|:|:||.:.:||||||||||.|||||.||:|..::
  Fly   120 DDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKI 184

Human   140 VTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFA------- 197
            :..|:|.||.|.|||:|:|:|:||:.||.|||:||||.|||||||||.|||:|||:.|       
  Fly   185 MERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKP 249

Human   198 ----------------------------------TIAVTGEKKKEEPASGKMQGTLEDQIISANP 228
                                              ||.|....|..|..|...:|.||.|::.|||
  Fly   250 KGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANP 314

Human   229 LLEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVTFQLKAERSYHIFYQIL 293
            :||||||||||:|||||||||||||:|.|:|.::.|:||||||||||...|.|.||::|||||:|
  Fly   315 ILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLL 379

Human   294 SNKKPELIEMLLITTNPYDFAFVSQGEITVPSIDDQEELMATDSAVDILGFTADEKVAIYKLTGA 358
            :...||..|..:: .:...:||:|.|.:.||.:||..|..||..:::|:|.|:::..:|:::..|
  Fly   380 AGATPEQREKFIL-DDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSA 443

Human   359 VMHYGNMKFKQKQREEQAE-PDGTEVADKAAYLTSLNSADLLKSLCYPRVKVGNEFVTKGQTVQQ 422
            |:.:|:|||:|::..:||. ||.| ||.|.|:|..|:..|:.::...||:|||.:||||.||.:|
  Fly   444 VLLFGSMKFRQERNNDQATLPDNT-VAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQ 507

Human   423 VYNAVGALAKAIYEKMFLWMVTRINQQLD-TKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNE 486
            |..||.|:|||.||:||.|:|.|||:.|| ||:....|||:||:||||||:.||.||||||:|||
  Fly   508 VEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNE 572

Human   487 KLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSF 551
            ||||.|||.||:||||||::|||||:|||||:||...|:||:||.||.::|:|||.||||||.:|
  Fly   573 KLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTF 637

Human   552 KNKLYEQHLGKSNNFQKPKPAKG--KPEAHFSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQK 614
            .:||...|      ...||..|.  :..|.|::|||||.|||:.|.||.||.|||||.:|.|.|.
  Fly   638 VDKLVSAH------SMHPKFMKTDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQG 696

Human   615 SAMKTLAFLFSGAQ---TAEAEGGGGKKGGKKKGSSFQTVSALFRENLNKLMTNLRSTHPHFVRC 676
            |....:..::..|:   .|:......:.|.:.:...|:|||.|::|.|.|||..||:|:|:||||
  Fly   697 SQDPFVVNIWKDAEIVGMAQQALTDTQFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRC 761

Human   677 IIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQFID 741
            ||||..|..|.::..|||.|||||||||||||||:|||:||.:.:|:|||::|..:.||:| |:|
  Fly   762 IIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKG-FMD 825

Human   742 SKKASEKLLGSIEIDHTQYKFGHTKVFFKAGLLGTLEEMRDEKLAQLITRTQAICRGFLMRVEFR 806
            .|||.||::.::|:|...|:.|.:|:||:||:|..|||.||.|::.||...||.|||||.|..::
  Fly   826 GKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQ 890

Human   807 KMMERRESIFCIQYNIRAFMNVKHWPWMKLYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTE 871
            |.:::..:|..||.|..|::.:::|.|.:||.|:||||:..:.|:::...::|.::.:|:|....
  Fly   891 KRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTLA 955

Human   872 AKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEI 936
            ...:|.|.|....:.||..|..|:|||.:..|:|||...:|:..|.:||..::|:..|.|:|||.
  Fly   956 KNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEER 1020

Human   937 NAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKK 1001
            ...|..:|:|||....:|::.:::.|....|::.||...:.|:|...|::|..|:...||.||||
  Fly  1021 VLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEKK 1085

Human  1002 ALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLA 1066
            .|:|........|..||:|...|.|.|.|.|..:.:||..|.::::...:.:|:|||:|.::...
  Fly  1086 LLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRKIETEVADL 1150

Human  1067 QESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERA 1131
            :|...:......::..:|.|:|.|::....:|::|.|.....||..:||::::.|::|::|||:|
  Fly  1151 KEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEKA 1215

Human  1132 SRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAAL 1196
            :||||||.|.|||.|||.:...|.::...|:||.|:..|||.|...:::.|||.|:.||...|.:
  Fly  1216 ARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVLADM 1280

Human  1197 RKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLS 1261
            |.||:..:..:.:|:::|::.|..|||.|..|:.|..|||:.:.:|:.::...::..:..|.|::
  Fly  1281 RHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQIA 1345

Human  1262 EIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEE 1326
            |::.|..|.:|..:||..:..:|..|:...:.||:|.:...|...:.......|:.|.::.||||
  Fly  1346 ELQVKLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEE 1410

Human  1327 TKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELE 1391
            |:.|..|:..|:....:.:.|:||.||:.|||...:|.:::..:::.:.:.|.|.|| ...:|||
  Fly  1411 TRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDA-DLAKELE 1474

Human  1392 EAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKV 1456
            |.||:|.:.::..|..|:.:.::...|:|:|:::|:|:||..|::|......:.|:|||:||||:
  Fly  1475 EGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNFDKI 1539

Human  1457 LAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIA 1521
            |||.|...|:...|.:.:::|:|...|::..|....:|:.|.:|.|:.:.|.||.|:.||.....
  Fly  1540 LAEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLANTQG 1604

Human  1522 EGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEE 1586
            ...|::|||||.|:.|:.:.:||:...||.|..|:..|...||:::.:..::|:.:|.:..|:|.
  Fly  1605 TADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAKEEG 1669

Human  1587 LDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQ 1651
            .::.:|..::.:..:::.||.|.:.|..|:..|||:||||.|:|..:...|:...:||::.:..|
  Fly  1670 AEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAKKLQ 1734

Human  1652 GILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASER 1716
            ..:||.....::|...:::|:......||:...::|||.:|...|..:||.|:.||.|..:.:|.
  Fly  1735 AQVKDALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQLTEDLASSERARRAAETERDELAEE 1799

Human  1717 VQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAE---EKAKKAITDAAMMAEELKKEQD 1778
            :.....:.:.:|:.|::||..|:.::.|:|   :|..|:|   ::::||......:..||..|:.
  Fly  1800 IANNANKGSLMIDEKRRLEARIATLEEELE---EEQSNSEVLLDRSRKAQLQIEQLTTELANEKS 1861

Human  1779 TSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKG 1843
            .|...|..:..:|:..|:|:.:|.|.|.......|..|..|||::..||.::|:|.|..:...|.
  Fly  1862 NSQKNENGRALLERQNKELKAKLAEIETAQRTKVKATIATLEAKIANLEEQLENEGKERLLQQKA 1926

Human  1844 LRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELE 1908
            .||.::::||||...|::|:::.:.::.:|||.:::|..||..:|.||:......:.||.|.|.|
  Fly  1927 NRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQRECE 1991

Human  1909 EAKERADIAESQVNKLRVKSR 1929
            :..|..:....::|.|:.|.|
  Fly  1992 DMIESQEAMNREINSLKTKLR 2012

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYH4NP_060003.2 Myosin_N 36..73 CDD:280832 9/37 (24%)
Myosin_head 88..770 CDD:278492 366/729 (50%)
MYSc_Myh4 100..770 CDD:276879 359/717 (50%)
Actin-binding. /evidence=ECO:0000250 659..681 15/21 (71%)
Actin-binding. /evidence=ECO:0000250 761..775 6/13 (46%)
Myosin_tail_1 850..1927 CDD:279860 331/1079 (31%)
RILP-like 965..1098 CDD:304877 38/132 (29%)
MIT_CorA-like <1299..>1411 CDD:294313 33/111 (30%)
COG6 1376..>1511 CDD:303003 46/134 (34%)
DUF342 <1670..1767 CDD:302792 27/99 (27%)
zipNP_523860.2 Myosin_N 80..117 CDD:280832 9/36 (25%)
Myosin_head 133..854 CDD:278492 366/729 (50%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 359/717 (50%)
Myosin_tail_1 931..2011 CDD:279860 331/1083 (31%)
Prefoldin 1431..1515 CDD:298833 28/84 (33%)
FAM76 <1847..1926 CDD:292665 21/78 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D47111at2759
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100110
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X58
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.720

Return to query results.
Submit another query.