DRSC/TRiP Functional Genomics Resources

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Protein Alignment MYH4 and ck

DIOPT Version :9

Sequence 1:NP_060003.2 Gene:MYH4 / 4622 HGNCID:7574 Length:1939 Species:Homo sapiens
Sequence 2:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster


Alignment Length:2244 Identity:553/2244 - (24%)
Similarity:898/2244 - (40%) Gaps:574/2244 - (25%)


- Green bases have known domain annotations that are detailed below.


Human    27 AQNKPFDAKTSVFVVDPKESYVKAIVQSREGGKVTAKTEAGATV-TVKEDQVFSMNPPKYDKIED 90
            |..:.||..            :.|.|.|.||.::..:.:.|..| ...|.::.:|:......:||
  Fly    15 ASGREFDVA------------IGARVVSAEGRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVED 67

Human    91 MAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVTAYRGKKRQEAPPHI 155
            |..:..|||..:|.||..||...:||||:|...|.||||:.||:|..:.:..|:.:|..|.||||
  Fly    68 MISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHI 132

Human   156 FSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEKKKEEPASGKMQGTLE 220
            |:|.||||..|...|::|.|:|:||||||||.:||.::||.|.|            ||| ...:|
  Fly   133 FAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAI------------SGK-HSWIE 184

Human   221 DQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVTFQLKAERS 285
            .||:.|||:|||||||||:||||||||||:|.|||.|.|.:..|.||.|||||||:..|..:||:
  Fly   185 QQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERN 249

Human   286 YHIFYQIL----SNKKPEL-IEMLLITTNPYDFAFVSQG-EITVPSIDDQEELMATDSAVDILGF 344
            ||:||.||    :::|..| :.|..      |:.:::.| .||....||..|.....||:.:|.|
  Fly   250 YHVFYCILAGLSADEKSRLDLGMAA------DYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLF 308

Human   345 TADEKVAIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEV-----ADKAAYLTSLNSADLLKSLCY 404
            :..|...|.||..|::|.||:|:|....:..   |.||:     .::.|.|..|....|:.:|..
  Fly   309 SDQEIWEIIKLLAALLHCGNIKYKATVVDNL---DATEIPEHINVERVAGLLGLPIQPLIDALTR 370

Human   405 PRVKVGNEFVTKGQTVQQVYNAVGALAKAIYEKMFLWMVTRINQQLDTKQPR---QYFIGVLDIA 466
            ..:....|.|....:..|..:...|..|.||.:||:.:|.:||..:  .:||   :..||||||.
  Fly   371 RTLFAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAI--FKPRGTSRNAIGVLDIF 433

Human   467 GFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIE-KP 530
            |||.||.||.||.|||:.||.|||||..|:|.||||||..|.|.|:.|:| :|....::||. |.
  Fly   434 GFENFDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDALDLIAIKQ 497

Human   531 MGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKPEAHFSLVHYAGTVDYNIAG 595
            :.|.::::||..|||.||.:...||::.| |...|:.||   |......|.|.|:||.|.|:..|
  Fly   498 LNIMALIDEEARFPKGTDQTMLAKLHKTH-GSHKNYLKP---KSDINTSFGLNHFAGVVFYDTRG 558

Human   596 WLDKNKDPLNETVVGLYQKSAMKTLAFLFSGAQTAEAEGGGGKKGGKKKGSSFQTVSALFRENLN 660
            :||||:|..:..::.|..:|..|.|..:|  ||..|.        |.:......|:|..||::|:
  Fly   559 FLDKNRDTFSPDLLHLVSQSTNKFLRQIF--AQDIEM--------GAETRKRTPTLSTQFRKSLD 613

Human   661 KLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQR 725
            .||..|.|..|.|:|||.|||.|.|...:..|...|||.:|::|.|||.|.|:|.|..:.:|.:|
  Fly   614 ALMKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVER 678

Human   726 YKVLNASAIPEGQFIDSKKASEKLLGSIEIDHTQYKFGHTKVFFKAGLLGTLEEMRDEKLAQLIT 790
            |:.| ...:|.....|.:.|:.::. ::.:..:.|:.||||||.|......||:.||..|.:.|.
  Fly   679 YRFL-IPGVPPAHRTDCQAATSRIC-AVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKIL 741

Human   791 RTQAICRGFLMRVEFRKMMERRESIFCIQYNIRAFMNVKHWPWMKL-YFKIKPLLKSAETEKEMA 854
            ..|...||::.|   |:.:..|.:...:|...:.:...|.:..|:: |.:::.|::|..      
  Fly   742 ILQRSIRGWVYR---RRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRV------ 797

Human   855 NMKEEFEKTKEELAKTEAK------RKELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLI 913
             :...|...:..:...:|.      |:|...||..:::.::.::..:         |..|     
  Fly   798 -LSHRFRHLRGHIVGLQAHARGYLVRREYGHKMWAVIKIQSHVRRMI---------AMRR----- 847

Human   914 KTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK 978
            ..|::||.|     :.||         ..:.||||::  ||..            ...|||.|..
  Fly   848 YRKLRLEHK-----QFAE---------VLQLRKLEEQ--ELLH------------RGNKHAREIA 884

Human   979 VKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDD---LEG 1040
            .::..:.:..|         |::.:||    .|::.:..|..:|.:..|..|.|:.|||   :|.
  Fly   885 EQHYRDRLHEL---------ERREIQE----QLENRRRVEVNMNIINDAARKQEEPVDDGKLVEA 936

Human  1041 SLE---------------QEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFE 1090
            ..:               :|..:..||..|:...:.|:    .:.:....|::.|:| .|.::|.
  Fly   937 MFDFLPDSSSDAPTPHGGRETSVFNDLPHAQNVNQDDI----IAPIHISEDEEDLSE-FKFQKFA 996

Human  1091 MSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLE 1155
            .:..||.:..:.|     :|.:|.....:....:::.|: |......:...|:........:|::
  Fly   997 ATYFQGNVNHQYA-----KKALKHPLLPLHTQGDQLAAQ-ALWITILRFTGDMPEPKYHTMDRMD 1055

Human  1156 EAG--GATSAQIEMNKKREAEFQK---MRRD----LEES--TLQHEATAAALRKKHADSVAELGE 1209
            ...  ...:|.:..|..|..|||:   |..|    |::.  :::|:..:..|::|:     :|||
  Fly  1056 TTSVMSKVTATLGRNFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKN-----KLGE 1115

Human  1210 QI-----------DSLQ-----RVKQKLEK---------EKSELKMEI-----NDLASNMETVSK 1244
            .:           ||.|     |....|||         .::||:.||     ..|.:|....|.
  Fly  1116 DVRRRLQDDEYTADSYQSWLQSRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNNPLKSSH 1180

Human  1245 AK------------ANFEKMCRTLEDQLSE-----IKTKEEEQQRLIN-----------ELSAQK 1281
            |:            |..||....|...:.|     ....||..:|..|           ||.|.|
  Fly  1181 ARGWILLSLCVGCFAPSEKFVNYLRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLELQATK 1245

Human  1282 AR--------------------LHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEE 1326
            ::                    ..|.:.|...||.:|.::..|.     .|:..|     .|.::
  Fly  1246 SKKPIMLPITFMDGNTKTLLADSATTARELCNQLSDKISLKDQF-----GFSLYI-----ALFDK 1300

Human  1327 TKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEE-- 1389
            ..:..:....:..|...|    |||.:||        |..:.|   |.||..:..:......|  
  Fly  1301 VSSLGSGGDHVMDAISQC----EQYAKEQ--------GAQERN---APWRLFFRKEIFAPWHEPT 1350

Human  1390 ---------LEEAKK--KLAQRLQDAEEHVEAV--------NSKCASLEKTKQRLQNEVEDLMID 1435
                     .::..:  |..:...|.||.:..:        .|...|:|:....|.|.:.|..:.
  Fly  1351 HDQVATNLIYQQVVRGVKFGEYRCDKEEDLAMIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLS 1415

Human  1436 -----VERSNAACIALDKKQ-----------------------------------RNF------- 1453
                 :||..|..:...||.                                   ||.       
  Fly  1416 GVDKAIERWAALVLQAYKKSYYVKDKIAPLKIKEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPKN 1480

Human  1454 DKVLA-EWKQKY---EETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQ---- 1510
            |.::| .|...|   ::.|..||.|..|..::|::  |....:.::.. |.|::.|....|    
  Fly  1481 DVIIAVNWTGVYVVDDQEQVLLELSFPEITAVSSQ--KTNKVFTQTFS-LSTVRGEEFTFQSPNA 1542

Human  1511 QEISDLTEQIAEG----GKHIHELEKVKKQLD--------------------------------- 1538
            ::|.||.....:|    .|::..|:..:...|                                 
  Fly  1543 EDIRDLVVYFLDGLKKRSKYVIALQDYRAPSDGTSFLSFFKGDLIILEDESCGESVLNNGWCIGR 1607

Human  1539 ----HEKSELQT--------------------SLEEA-------------------------EAS 1554
                .|:.:...                    ::|||                         |.:
  Fly  1608 CDRSQERGDFPAETVYVLPTLSKPPQDILALFNIEEAHHGRRLSMASNGGAVEPRDRPHTLMEYA 1672

Human  1555 LEHEEGKILRIQLELNQVKSEIDRKIAEKDEEL-----DQLKRNHLRVVESMQSTLD-------A 1607
            |:|       .:|...:..|:.....:::.|||     |.:|...||.::|.:...:       |
  Fly  1673 LDH-------FRLPPKRTMSKTLTLSSKRSEELWRYSRDPIKAPLLRKLQSKEEFAEEACFAFAA 1730

Human  1608 EIRSRNDALRIKKKMEGDLNE--------MEIQLNHANRQAAEALRNLRN--------------- 1649
            .::...|....:.:|..::.:        .||..:....|..:.|.:.||               
  Fly  1731 ILKYMGDLPSKRPRMGNEITDHIFDGPLKHEILRDEIYCQLMKQLTDNRNRMSEERGWELMWLAT 1795

Human  1650 -----TQGILKDTQLHLDDAIR--GQDD---LKEQLAMVERRANLMQAEVEELR----------- 1693
                 :||:||:..|.|.....  .||.   |::.:...:|:....|.|||.::           
  Fly  1796 GLFACSQGLLKELLLFLRTRRHPISQDSMHRLQKTIRHGQRKYPPHQVEVEAIQHKTTQIFHKVY 1860

Human  1694 --------ASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGE------ 1744
                    ..::.:.|.:....    :.|:|:.|..::..||.  .|..:..||..:|:      
  Fly  1861 FPDDTDEAFEVDSSTRAKDFCN----NISQRLSLRTSEGFSLF--VKIADKVISVPEGDFFFDFV 1919

Human  1745 --MEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTV------KDLQLRL 1801
              :.|.:::||...:.|....|.....                |||....||      .||....
  Fly  1920 RHLTDWIKKARPIRDGANPQFTYQVFF----------------MKKLWTNTVPGKDRNADLIFHY 1968

Human  1802 DEAEQLALKGGKKQIQKLEARVRELESEVE-SEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNI 1865
            .:.....|:|..|..::..|::..|...|. .|.|..::|:      .:.::||.      ..:|
  Fly  1969 HQELPKLLRGYHKCSREEAAKLAALVFRVRFGENKQELQAI------PQMLRELI------PSDI 2021

Human  1866 LRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAK 1899
            :::|...:..::.|.:|.:......|.:.|...|
  Fly  2022 MKIQSTSEWKRSIVASYNQDGGMTSEDAKVAFLK 2055

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYH4NP_060003.2 Myosin_N 36..73 CDD:280832 7/37 (19%)
Myosin_head 88..770 CDD:278492 281/696 (40%)
MYSc_Myh4 100..770 CDD:276879 275/684 (40%)
Actin-binding. /evidence=ECO:0000250 659..681 11/21 (52%)
Actin-binding. /evidence=ECO:0000250 761..775 7/13 (54%)
Myosin_tail_1 850..1927 CDD:279860 241/1404 (17%)
RILP-like 965..1098 CDD:304877 30/150 (20%)
MIT_CorA-like <1299..>1411 CDD:294313 21/124 (17%)
COG6 1376..>1511 CDD:303003 34/210 (16%)
DUF342 <1670..1767 CDD:302792 21/126 (17%)
ckNP_001285949.1 MYSc 64..733 CDD:214580 284/709 (40%)
MYSc_Myo7 77..721 CDD:276832 275/684 (40%)
MyTH4 <1138..1245 CDD:214535 24/106 (23%)
B41 1251..1467 CDD:214604 37/240 (15%)
FERM_B-lobe 1355..1439 CDD:271216 15/83 (18%)
FERM_C1_MyoVII 1461..1559 CDD:270019 21/100 (21%)
SH3 1560..1624 CDD:302595 4/63 (6%)
MyTH4 1701..1849 CDD:214535 28/147 (19%)
B41 1856..2068 CDD:214604 40/234 (17%)
FERM_M 1966..2068 CDD:278785 18/102 (18%)
FERM_C2_MyoVII 2064..2159 CDD:270020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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