|
Human 39 FVVDSKEEYAKGKIKSS---------QDGKVTV-----ETEDNRTLVVKPEDVYAMNPPKFDRIE 89
::.|.||.:.||::.|: |:.::.: .||.:..:.|:..||:.:||..||::|
Yeast 14 WIPDEKEVFVKGELMSTDINKNKFTGQEEQIGIVHPLDSTEVSNLVQVRISDVFPVNPSTFDKVE 78
Human 90 DMAMLTHLNEPAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGK-------- 146
:|:.|||||||:|||||:.||...:||||||||.|.:|||..|.:|:.:.:..|..|
Yeast 79 NMSELTHLNEPSVLYNLEKRYDCDLIYTYSGLFLVAINPYHNLNLYSEDHINLYHNKHNRLSKSR 143
Human 147 ----KRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATI--AATGDL 205
..::.|||||:|::.||:.:|::.::||||:|||||||||.|||:::||.|:| .:..::
Yeast 144 LDENSHEKLPPHIFAIAEEAYENLLSEGKDQSILVTGESGAGKTENTKKILQYLASITSGSPSNI 208
Human 206 AKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLE 270
|....|.:..:.|.:|:.:||:||:||||:||||:|||||||||:|.|...|.:..|.||.||||
Yeast 209 APVSGSSIVESFEMKILQSNPILESFGNAQTVRNNNSSRFGKFIKIEFNEHGMINGAHIEWYLLE 273
Human 271 KSRVTFQLKAERSYHIFYQILSN-KKPELIELLLITTNPYDYPFIS-QGEILVASIDDAEELLAT 333
|||:..|...||:||||||:||. ...||..|.|.:.|..||..:| ..:.::..|:|.|.....
Yeast 274 KSRIVHQNSKERNYHIFYQLLSGLDDSELKNLRLKSRNVKDYKILSNSNQDIIPGINDVENFKEL 338
Human 334 DSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQA--EPDGTEVADKTAYLMGLNSSDL 396
.||::|:||:.::...::::...::..||::| ...|.||| :.|.:.:... :|::..|.
Yeast 339 LSALNIIGFSKDQIRWIFQVVAIILLIGNIEF-VSDRAEQASFKNDVSAICSN----LGVDEKDF 398
Human 397 LKALCFPRVKVGNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVL 461
..|:..||.|.|.|:|::.:...|....:||||:::||:||.::|..||:.||......::||:|
Yeast 399 QTAILRPRSKAGKEWVSQSKNSQQAKFILNALSRNLYERLFGYIVDMINKNLDHGSATLNYIGLL 463
Human 462 DIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIE 526
|||||||||.||.||||||:||||||||||:|||||||.||.||.|:|.:||:|.||...|:|||
Yeast 464 DIAGFEIFENNSFEQLCINYTNEKLQQFFNNHMFVLEQSEYLKENIQWDYIDYGKDLQLTIDLIE 528
Human 527 K---PMGIFSILEEECMFPKATDTSFKNKL---YDQHLGKSNNFQKPKVVKGRAEAHFSLIHYAG 585
. |.|:..:|:||.:.||:||.||.:|| :||: |:.|::.::..| |.|.||||
Yeast 529 SKGPPTGVLPLLDEEAVLPKSTDESFYSKLISTWDQN---SSKFKRSRLKNG-----FILKHYAG 585
Human 586 TVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLY------ATFATADADSGKKKVAKK-KGS 643
.|:|:|.|||.|||||||:.::.|...|.|.:::.|: ::.|..:|:...::|.|. :.|
Yeast 586 DVEYTVEGWLSKNKDPLNDNLLSLLSSSQNDIISKLFQPEGEKSSSAGVEANISNQEVKKSARTS 650
Human 644 SFQTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRK 708
:|:|.|:..||....|::.|.:||||||||||||..|........|:|.||||||||||||:.|:
Yeast 651 TFKTTSSRHREQQITLLNQLASTHPHFVRCIIPNNVKKVKTFNRRLILDQLRCNGVLEGIRLARE 715
Human 709 GFPNRILYGDFKQRYRVLNASAIPEGQF---------IDSKKACEKLLASIDIDHTQYKFGHTKV 764
|:||||.:.:|.||||:| .||... ..:|:.||.||.|:.:|...||.|:||:
Yeast 716 GYPNRIAFQEFFQRYRIL----YPENSTTTTFSSKLKASTKQNCEFLLTSLQLDTKVYKIGNTKL 776
Human 765 FFKAGLLGTLEEMRDDRLAKLITRTQAVCRGFLMRVEFQKMVQRRESIFCIQYNIRSFMN-VKHW 828
|||||:|..||:.:|.:|..::.:..|..||:.:|.|....:|:.:....|....|.:.. ||..
Yeast 777 FFKAGVLADLEKQKDVKLNNIMIKLTATIRGYTVRKEITYHLQKLKKTRVIGNTFRLYNRLVKED 841
Human 829 PWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQ 893
||..||.:|||||.|:..........|:..|.|::|.:.|:|:|.||||....|.|..:.|..:.
Yeast 842 PWFNLFIRIKPLLTSSNDMTRTKKFNEQINKLKNDLQEMESKKKFLEEKNQKTVNELENTQDLLN 906
Human 894 AESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL 958
.|.||| .::|..:| :::.....|:|..|||
Yeast 907 QEKENL---------------------------RKNESLLN--------RVKTSSETLQKQFDDL 936
Human 959 ELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNK 1023
.....::.:||......::...:::.||.||| ||::|..| |::|.|
Yeast 937 VSEKDEISREKLEVAQNLEEAHQKIQGLQETI----REREATLE--------------KLHSKN- 982
Human 1024 TKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEY 1088
::|.:|:.||...:.:|:..:..::.:|.|||.::|..::.|...|.:.:..:::
Yeast 983 --NELIKQISDLNCDISKEQSSQSLIKESKLKLENEIKRLKDVINSKEEEIKSFNDK-------- 1037
Human 1089 CQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEE 1153
|.|..||.....:..:|......:|::.|..| ....|:|.| ::.:|...|:.:|
Yeast 1038 --LSSSEEDLDIKLVTLEKNCNIAMSRLQSLVTE---NSDLRSKNE----NFKKEKAALNNQL-- 1091
Human 1154 AGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVK--- 1215
|.:|:|.||::..:: .|:..:|...|:..|:|:|.|:....|:..:
Yeast 1092 ------------KNKESELLKMKEKID----NHKKELATFSKQRDDAVSEHGKITAELKETRIQL 1140
Human 1216 -------QKLEKEKSEFKLEIDD-----LSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQ 1268
||:::|.|.|:.|..: .:|.:||::.|| .:.||.:||:....|:.:.
Yeast 1141 TEYKSNYQKIKEEYSNFQRETKEQEQKKRNSLVESLNDSK------IKELEARLSQEISLNQYLN 1199
Human 1269 RSLS----ELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNA 1329
:.:| |.....:|..| ..|....:||.|:.:....:.|||:.|..|:.::||: ||.
Yeast 1200 KRISGNSVETNISSTRRST---SYSDDPLDKEDIIKKYYDLQLAFTEITRNLENEIEEK---KNL 1258
Human 1330 LAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKL 1394
::.. |.....|.....|:|:.||:: |||
Yeast 1259 ISRL----RFTETRLASSSFEDQKIKAQM---------------------------------KKL 1286
Human 1395 AQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQR---NFDKVLAE 1456
.:.:||.:..:...:.....|:....: :.::..||::|: .|...||.:.| :.:..::.
Yeast 1287 KKLIQDMDPSIPLDSILNEPLDNCPDK-ESDINKLMLEVD---YLKRQLDIETRAHYDAENAISA 1347
Human 1457 WKTKCEESQAELEASLKESRSLSTELFKLK-NAYEEAL----DQLETVK-RENKNLEQEIADLTE 1515
..:|..:.|.|...| |::::||| .|.||.: |:|:|:. |:..|| .:.|
Yeast 1348 LHSKFRKIQGESSLS-------SSDIYKLKFEASEERVKSLEDKLKTMPLRDRTNL--PVGD--- 1400
Human 1516 QIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKS-------EI 1573
|.:|..:|.:.|:..:..:||...:|..|.|: ..|:.::.|:|.|.|| ::
Yeast 1401 -IIKNRDSISKYEEEIRYYKLENYKLQEILNES-------NGKLSQLTLDLRQSKSKEALLSEQL 1457
Human 1574 DR-----KIAEKDEE-----IEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLN---- 1624
|| :..|:.:| |:|.|:.::..::.:|. .|:|.| |.|...|:.|.|:.
Yeast 1458 DRLQKDLESTERQKELLSSTIKQQKQQFENCMDDLQG---NELRLR-EHIHALKQAEEDVKNMAS 1518
Human 1625 -----------------EIEIQLSHANRQAAETLKHLRSVQGQ---LKDTQLHLDDALRGQED-- 1667
|.|::.:.::.|..|||..|:.||.. |.|...||.:.|...||
Yeast 1519 IIEKLKTQNKQKEKLIWEREMERNDSDMQLQETLLELKRVQDVKKILSDDLAHLKERLSAVEDRS 1583
Human 1668 --------LKEQLAI------------------VERRANLLQAEVEELRATLEQTER-------- 1698
|||:|.. :|...|..:|::.:|...|:...:
Yeast 1584 QYTDEINRLKEELNCSLKAETNLKKEFATLKYKLETSTNDSEAKISDLLKQLDHYTKVVEMLNNE 1648
Human 1699 --ARKLAEQELLDS----NERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAK 1757
|..|||:||... |...:.|..:..||...|::||:||.| :::....|..|.::..:..
Yeast 1649 KDAISLAEKELYQKYEALNTECESLKGKIVSLTKIKQELESDLNQ-KTDALQISNAALSSSTQKN 1712
Human 1758 KAITDAAMMAEE-LKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQ--LALKGGKKQIQKLET- 1818
|.||:.....|| |:.:.:.::....:.|.|:.:....:.:.|:.:| :.|....:.:|||.|
Yeast 1713 KEITEKIKYLEETLQLQMEQNSRNGELVKTLQASCNGYKDKFDDEKQKNIDLYEENQTLQKLNTD 1777
Human 1819 ---RIRELEFELEGEQKKNTESVKGLRKYERRVK-ELTYQSEEDRKNVLRLQDLVDKLQVKVKSY 1879
:::.|...|....:||....| :.:.|..|. |...:.||.:|| ..|:..|::||.|
Yeast 1778 LQLQLKNLHERLSDTTEKNAWLSK-IHELENMVSLETDLKYEEMKKN-KSLERAVEELQTK---- 1836
Human 1880 KRQAEEADEQANAHLTKFRKA--QHELEEAEERADIAESQVNKLRAKTRDFTSSRMVVHE 1937
..|..:..|.||.:.::|.:| ::|.:.::....|::.:: :::...||.:|.|..|.|
Yeast 1837 NSQQTDVIELANKNRSEFEEATLKYEAQISDLEKYISQQEL-EMKKSIRDNSSYRDKVQE 1895
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