Protein Alignment MYH3 and jar

DIOPT Version :10

• Sequence 1: NP_002461.2
• Gene: MYH3 / 4621
• HGNCID: 7573
• Length: 1940
• Species: Homo sapiens
• Sequence 2: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Alignment Length: 1454
• Identity: 404/1454 - (27%)
• Similarity: 645/1454 - (44%)
• Gaps: 322/1454 - (22%)

Human    39 FVVDSKEEYAKGKIKSSQDGKVTVETEDNRTLVVKPED-VYAMNPPKFDRI----------EDMA 92
            :|.|:.|.|.:|:|  ::.|....|        |.|.| .|......||.|          :|..
  Fly     9 WVRDAAEGYIQGRI--TEIGAKEFE--------VTPTDRKYPKRTCHFDDIHSSCDGPQDHDDNC 63

Human    93 MLTHLNEPAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWL-PVYNPEVVEGYRGKKRQEAPPHIF 156
            .|..|||...|.|||.||....||||.....:.||||:.: .:|.|:.::.|.|:...|.|||:|
  Fly    64 ELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELPPHVF 128

Human   157 SISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQI 221
            :|:|.|.:.|...:.:|||:::||||||||.:||.:::|         |....||  .|.:|.:|
  Fly   129 AIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKY---------LCYSHDS--AGPIETKI 182

Human   222 ISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHI 286
            :.|||:|||||||||.||:|||||||||.:|:....::....|..|||||||:..|...||:||:
  Fly   183 LDANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHV 247

Human   287 FYQILSNKKPELIELLLITTNPYDYPFIS--------------------------QGEILVASID 325
            ||.:|:....:|.:.|.: ..|.||.::|                          :|.:....||
  Fly   248 FYMLLAGAPQQLRDKLSL-GKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIID 311

Human   326 DAEELLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADK----TA 386
            |.:.....|.|:..||.:..||.|:|.|..||:|.||:.|::...:.:.....:|.:::    |:
  Fly   312 DYQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQSLTITS 376

Human   387 YLMGLNSSDLLKALCFPRVKVGNEYVTKGQTVD---QVHHAVN---ALSKSVYEKLFLWMVTRIN 445
            .|:|::.::|..|| ..||........||..:.   :::.|.|   ||:|::|.:||..:|..||
  Fly   377 GLLGVDQTELRTAL-VSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLIN 440

Human   446 QQLDTKLPRQ---HFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGI 507
            |    .:|.|   .:||||||||||.|..||.||.|||:.|||||:|||.::...|||.||:||:
  Fly   441 Q----SIPFQASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGL 501

Human   508 ---EWTFIDFGMDLAACIELIE-KPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPK 568
               |.||.| ..|:   ||||| |..|||::|:||...||.:.:.|..::   |...:|:::...
  Fly   502 NVPEITFTD-NQDI---IELIEAKSNGIFTLLDEESKLPKPSYSHFTAEV---HKSWANHYRLGL 559

Human   569 VVKGRAEAH--------FSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATF 625
            ....|.:||        |.:.|:||.|.|:...::|||.|.|:.::.||.|:..|.||..|   |
  Fly   560 PRSSRLKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTL---F 621

Human   626 ATADADSGKKKVAKKKGSSFQTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLV 690
            .:..:.|.:.|:      :|.:|.:.|:..|.:||..|.....:|:|||.||........|.||.
  Fly   622 PSGSSTSVRGKL------NFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLA 680

Human   691 LHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAI-PEGQFIDSKKACEKLLASIDIDH 754
            |.||:|:|.:..:.:...|:|:|:|:.|....|:    |.: ||...:.::..||.:..|:::..
  Fly   681 LAQLKCSGTISVLELMEHGYPSRVLFADLYSMYK----SVLPPELVSLPARTFCEAMFQSLNLSA 741

Human   755 TQYKFGHTKVFFKAGLLGTLEE-MRDD---------RLAKLITRTQAV--CRGFLMRVEFQ-KMV 806
            ..:|||.|||||:.|.....:. ||.|         ::.|.:.|::.|  ..|.|..::.: :::
  Fly   742 KDFKFGITKVFFRPGKFVEFDRIMRSDPENMLAIVAKVKKWLIRSRWVKSALGALCVIKLRNRII 806

Human   807 QRRESIFCIQYNIRSFMNVK-HWPWMKLFFKIKPL----LKSAETEKEMATMKEE--------FQ 858
            .|.:.:...|...|.|:..| |.|..:...||..:    ||:.|....:...:||        ::
  Fly   807 YRNKCVLIAQRIARGFLARKQHRPRYQGIGKINKIRTNTLKTIEIASGLKMGREEIISGVNDIYR 871

Human   859 KTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEV 923
            :..|.:.|.:...:        :.|.:.|....|...:.|.|..:            |..|:||
  Fly   872 QIDDAIKKIKMNPR--------ITQREMDSMYTVVMANMNKLTVD------------LNTKLKE- 915

Human   924 TERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDE 988
            .::||::|.:        ||:::..        :.|....:.|:::...|.:.|.|..|:.
  Fly   916 QQQAEEQERL--------RKIQEAL--------EAERAAKEAEEQRQREEIENKRLKAEME---- 960

Human   989 TIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNK 1053
                 ||.|.|  ||.:..    |.|||:       ::.|..| |.||...:.:.|.|..||:.:
  Fly   961 -----TRRKAA--EAQRLR----QEEEDR-------RAALALQ-EQLEKEAKDDAKYRQQLEQER 1006

Human  1054 RKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLG----LQFQKKIKELQA 1114
            |..|..|:||.||...:|:...              .:::.|.|...:|    :.|.:.:..:.:
  Fly  1007 RDHELALRLANESNGQVEDSPP--------------VIRNGVNDASPMGPNKLISFSQVVSNIAS 1057

Human  1115 RIEELEEEIEAERATRAKTEKQRSDYAR-ELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRD 1178
            |.....|.:   ||.:....||:.|.:: :..||.:.:.     ||..|||.:....||.:
  Fly  1058 RYLNKSENV---RAQQQALGKQKYDLSKWKYSELRDAIN-----TSCDIELLEACRQEFHR---- 1110

Human  1179 LEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSK 1243
                         .|:..||                    .|.|:..:..:|:...:..||
  Fly  1111 -------------RLKVYHA--------------------WKAKNRKRTTMDENERAPRSV---- 1138

Human  1244 ANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRL------------QTEAG---------E 1287
                          .||..|...:.:.:.|:.|.:.|.            .|:.|         .
  Fly  1139 --------------MEAAFKQPPLVQPIQEIVTAQHRYFRIPFMRANAPDNTKRGLWYAHFDGQW 1189

Human  1288 LSRQLE---EKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYE 1349
            ::||:|   :|..|:      ..|.|...:..:..|||....:          :...::|..::.
  Fly  1190 IARQMELHADKPPIL------LVAGTDDMQMCELSLEETGLTR----------KRGAEILEHEFN 1238

Human  1350 EEQE---GKAELQRALSKANSEVA 1370
            .|.|   |||......:|.|...|
  Fly  1239 REWERNGGKAYKNLGAAKPNGPAA 1262

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH3	NP_002461.2	Myosin_N	33..77	CDD:460670	11/38 (29%)
		MYSc_Myh3	100..767	CDD:276878	256/719 (36%)
		Actin-binding	656..678		9/21 (43%)
		Actin-binding	758..772		9/13 (69%)
		Myosin_tail_1	847..1924	CDD:460256	106/564 (19%)
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	14/49 (29%)
		MYSc_Myo6	71..754	CDD:276833	256/719 (36%)
		CBD_MYO6-like	765..913	CDD:409646	30/167 (18%)
		ERM_helical	<954..1020	CDD:466641	27/88 (31%)
		MYO6_MIU_linker	1002..1093	CDD:480843	23/107 (21%)
		MyUb_Myo6	1076..1116	CDD:439319	12/61 (20%)
		Myosin-VI_CBD	1160..1246	CDD:465157	16/101 (16%)