Protein Alignment MYH3 and Myo61F

DIOPT Version :10

• Sequence 1: NP_002461.2
• Gene: MYH3 / 4621
• HGNCID: 7573
• Length: 1940
• Species: Homo sapiens
• Sequence 2: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Alignment Length: 1097
• Identity: 326/1097 - (29%)
• Similarity: 526/1097 - (47%)
• Gaps: 181/1097 - (16%)

Human    86 DR--IEDMAML-THLNEPAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKK 147
            ||  ::|..:| .:.:|.|.:.|||.|:...:||||.|...::|||||.||:|..:.|:.||.|.
  Fly    35 DRAGVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKH 99

Human   148 RQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAATGDLAKKKDSK 212
            ..|.|||||:::|||::.::.:...|.:||:||||:|||..:|:|:|:.|  |.:|:     .:.
  Fly   100 FYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIA--ACSGN-----QTT 157

Human   213 MKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQ 277
            ::| ::|:::.:||:|||||||||.||||||||||::.|.|...|.....:|..||||||||..|
  Fly   158 VEG-VKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQ 221

Human   278 LKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQG-EILVASIDDAEELLATDSAIDILG 341
            :..||::|||||:|:.....|::.|.:......|.:::.| ...|..|:||:.......|:.::.
  Fly   222 MGGERNFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVID 286

Human   342 FTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVK 406
            ||.||:..::.:..:::|.||:.|.:.  |..|:.:..::....|.|:|:|:|:|..||....:.
  Fly   287 FTKEEQREIFGIVASILHLGNVGFTEV--EGNAKVNSRDLVVTAARLLGVNASELEAALTHRTID 349

Human   407 VGNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRIN---QQLDTKLPRQHFIGVLDIAGFEI 468
            ...:.||.....:...:|.:||:|:||::||.|:|.|:|   |..:|:..|.:.:|:|||.||||
  Fly   350 ARGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEI 414

Human   469 FEYNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFS 533
            |:.||.||.||||.||||||.|.......||:||::|||||..:::..:...|..:.||..||.|
  Fly   415 FQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIIS 479

Human   534 ILEEECMFP-KATDTSFKNKLYDQHLGKSNNFQKPKVVKGRAEAH---------FSLIHYAGTVD 588
            ||:|||:.| :.||.:|..|| .|.|.:.:::    |...:|.||         |.|:||||.|.
  Fly   480 ILDEECLRPGEPTDKTFLEKL-TQKLAQHHHY----VCHEKAPAHIKKIMLRDEFRLVHYAGEVT 539

Human   589 YSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATADADSGKKKVAKKKGSSFQTVSALFR 653
            |||:|:|:||.|.|...:.....|:.|.::.:.:.          :|::...|..  :|....||
  Fly   540 YSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFP----------EKELRSLKRP--ETAITQFR 592

Human   654 ENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGD 718
            .:||.||..|....|.::|||.||:.:|.......|||||::..|::|.:|:.|.||..|..|..
  Fly   593 ASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYEL 657

Human   719 FKQRYRVLNASAIPEGQFIDSKKA-CEKLLASIDIDHTQYKFGHTKVFFK-AGLLGTLEEMRDDR 781
            |.:||:.|:.|..|..:.....|| .::|:..:..|..:|:.|.||:|.: ...|...|:...::
  Fly   658 FLERYKSLSKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEK 722

Human   782 LAKLITRTQAVCRGFLMRVEFQKMVQRRESIFCIQYNIRSFMNVKHWPWMKLFFKIKPLLKSAET 846
            ..::....||..:|.:.|.::.|:  |.:.|....|..|...........:...||:..:|...|
  Fly   723 KHEIAAIIQAHWKGLMQRRKYLKL--RAQVIIMQSYCRRKLAQQAAKKRREAADKIRAFIKGFIT 785

Human   847 EKEMAT-MKEEFQKTKDELAKSEAKR-------KELEEK-------------------------- 877
            ..:... ..|||        .:.|||       |||..|
  Fly   786 RNDAPNGFNEEF--------IANAKRMWLLRLAKELPTKVLDKSWPHAPGHCEEASGILHRLHRL 842

Human   878 -------LVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAK-----------FQLEAKIKEVT 924
                   |....|:|...:|:|.||            ::.|.|           ||.:...||..
  Fly   843 HLARIYRLKLTPQQKRQFELKVLAE------------KVFKGKKNNYASSVSTWFQEDRIPKEHI 895

Human   925 ERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDET 989
            :|..|  .:.:...:::.|.:..|::.                ::|..:::.:.:      |...
  Fly   896 QRVND--FVASTFGSEQLKYQSFCTKF----------------DRHGYKSRDRFI------LLSN 936

Human   990 IAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKR 1054
            .|....:.|..::.|:..||             |....|....:||       ..:|:.|:..|.
  Fly   937 KAIYVLDGKTYKQKHRLPLD-------------KIDFTLTNHNDDL-------MVIRIPLDLKKD 981

Human  1055 KLEGDLKLAQESILDLEN---------------DKQQLDERLKKKDFEYCQLQSKVE 1096
            |  |||.|....|::...               |:..|:..:.|.......:|:..|
  Fly   982 K--GDLILIIPRIIEFSTYIIDTVGTASIVSIVDRNSLEHNVVKGKGGVIDIQTGAE 1036

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH3	NP_002461.2	Myosin_N	33..77	CDD:460670
		MYSc_Myh3	100..767	CDD:276878	254/681 (37%)
		Actin-binding	656..678		10/21 (48%)
		Actin-binding	758..772		4/14 (29%)
		Myosin_tail_1	847..1924	CDD:460256	52/317 (16%)
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	254/681 (37%)
		Myosin_TH1	863..1049	CDD:461801	38/232 (16%)