Protein Alignment MYH3 and zip

DIOPT Version :10

• Sequence 1: NP_002461.2
• Gene: MYH3 / 4621
• HGNCID: 7573
• Length: 1940
• Species: Homo sapiens
• Sequence 2: NP_523860.2
• Gene: zip / 38001
• FlyBaseID: FBgn0287873
• Length: 2056
• Species: Drosophila melanogaster
• Alignment Length: 1998
• Identity: 776/1998 - (38%)
• Similarity: 1195/1998 - (59%)
• Gaps: 107/1998 - (5%)

Human    15 PFLRKSEKERIE----AQNQPFDAKTYCFVVDSKEEYAKGKIKSSQDGKVTVE-TEDNRTLVVKP 74
            |.|:....||.:    |....:..|...:|....:.:....||.....:|.|| .|..:.:::..
  Fly    55 PELKYLSVERNQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMILR 119

Human    75 EDVYAMNPPKFDRIEDMAMLTHLNEPAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEV 139
            :|:..|||||||::||||.||.|||.:||:|:||||.|.:||||||||||.|||||.||:|..::
  Fly   120 DDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKI 184

Human   140 VEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAATGD 204
            :|.|:|.||.|.|||:|:|:|:||:.||.|||:||||.|||||||||.|||:|||:.|.:||
  Fly   185 MERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAA--- 246

Human   205 LAKKKDS---------------------------------------KM--------KGTLEDQII 222
             :|.|.|                                       ||        :|.||.|::
  Fly   247 -SKPKGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLL 310

Human   223 SANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIF 287
            .|||:||||||||||:|||||||||||||:|..:|.::.|:||||||||||...|.|.||::|||
  Fly   311 QANPILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIF 375

Human   288 YQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSAIDILGFTPEEKSGLYK 352
            ||:|:...||..|..:: .:...|.|:|.|.:.|..:||..|..||..:::|:|.|.|:.:.:::
  Fly   376 YQLLAGATPEQREKFIL-DDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFR 439

Human   353 LTGAVMHYGNMKFKQKQREEQAE-PDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQ 416
            :..||:.:|:|||:|::..:||. ||.| ||.|.|:|:||:.:|:.:|...||:|||.::|||.|
  Fly   440 IVSAVLLFGSMKFRQERNNDQATLPDNT-VAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQ 503

Human   417 TVDQVHHAVNALSKSVYEKLFLWMVTRINQQLD-TKLPRQHFIGVLDIAGFEIFEYNSLEQLCIN 480
            |.:||..||.|::|:.||::|.|:|.|||:.|| ||.....|||:||:|||||||.||.||||||
  Fly   504 TKEQVEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCIN 568

Human   481 FTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKAT 545
            :|||||||.|||.||:||||||::|||||.|||||:||...|:||:||.||.::|:|||.|||||
  Fly   569 YTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKAT 633

Human   546 DTSFKNKLYDQHLGKSNNFQKPKVVKG--RAEAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVG 608
            |.:|.:||...|      ...||.:|.  |..|.|:::||||.||||.:.||.||.|||||.:|.
  Fly   634 DKTFVDKLVSAH------SMHPKFMKTDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVS 692

Human   609 LYQKSSNRLLAHLY--------ATFATADADSGKKKVAKKKGSSFQTVSALFRENLNKLMSNLRT 665
            |.|.|.:..:.:::        |..|..|...|    |:.:...|:|||.|::|.|.|||..||.
  Fly   693 LLQGSQDPFVVNIWKDAEIVGMAQQALTDTQFG----ARTRKGMFRTVSHLYKEQLAKLMDTLRN 753

Human   666 THPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASA 730
            |:|:||||||||..|..|.::..|||.|||||||||||||||:||||||.:.:|:|||.:|..:.
  Fly   754 TNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNV 818

Human   731 IPEGQFIDSKKACEKLLASIDIDHTQYKFGHTKVFFKAGLLGTLEEMRDDRLAKLITRTQAVCRG 795
            ||:| |:|.||||||::.::::|...|:.|.:|:||:||:|..|||.||.:::.||...||.|||
  Fly   819 IPKG-FMDGKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRG 882

Human   796 FLMRVEFQKMVQRRESIFCIQYNIRSFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKT 860
            ||.|..:||.:|:..:|..||.|..:::.:::|.|.:|:.|:||||:..:.|:::...::|.::.
  Fly   883 FLARRNYQKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQV 947

Human   861 KDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTE 925
            :::|.......:|.|.|....:.||..|..|:|||.|...:|||...:|:..|.:||..::|:..
  Fly   948 REKLDTLAKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELET 1012

Human   926 RAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETI 990
            |.|:|||....|..:|:|||....:|::.:::.|....|::.||...:.|:|...|:|:..|:..
  Fly  1013 RIEEEEERVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQN 1077

Human   991 AKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRK 1055
            .||.:|||.|:|........|..||:|...|.|.|:|.|..:.:||..|.::::.|.:.:|:|||
  Fly  1078 QKLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRK 1142

Human  1056 LEGDLKLAQESILDLENDKQQLDER----------LKKKDFEYCQLQSKVEDEQTLGLQFQKKIK 1110
            :|.:       :.||   |:||:||          |.|::.|..|...::::|.......||..:
  Fly  1143 IETE-------VADL---KEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQKAQR 1197

Human  1111 ELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKL 1175
            ||::::.|::|::|||:|.|||.||.|.|.:.|||.|...|.::...|:.|.||..|||.|...|
  Fly  1198 ELESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATL 1262

Human  1176 RRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVS 1240
            ::.|||.|:.||.::|.:|.||:..:..:.:|::||::.|..|||.|...:.|..||::.:.||:
  Fly  1263 KKSLEEETVNHEGVLADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVN 1327

Human  1241 KSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRS 1305
            .|:...::..:..|.|::|.:.|..||:|:.|||..:.::||.||..::.||||.|...|...:|
  Fly  1328 SSRQENDRRRKQAESQIAELQVKLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKS 1392

Human  1306 KQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVA 1370
            ......|..|.::.||||.:.|..|:..|:....:.:.|:||.||:.|.|...:|.|::..:::.
  Fly  1393 ASNMESQLTEAQQLLEEETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQ 1457

Human  1371 QWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVER 1435
            :.:.|.|.|| ...:||||.||:|.:.::..|.||:.:.|:...|:|:|:::|.|:||..:::|.
  Fly  1458 EIKKKAEEDA-DLAKELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEA 1521

Human  1436 ANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVK 1500
            ..:....|:|||:||||:|||.|...|:...|.:.:.:|:|...|::..:....:||.|::|.::
  Fly  1522 QRTKVLELEKKQKNFDKILAEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDLE 1586

Human  1501 RENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLE 1565
            .:.|.|:.|:.||........|.:|||||:::.:|.:.|:::...||.|..|:..|...||:::.
  Fly  1587 NKRKTLQNELDDLANTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVN 1651

Human  1566 LTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQL 1630
            :..::|:.:|.:..|:|..|:.:|...:.:..:::.||.|.:.|..|:..|||:||||.|||..:
  Fly  1652 MQALRSQFERDLLAKEEGAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTM 1716

Human  1631 SHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQ 1695
            ...|:...:.|||.:.:|.|:||.....::|...:|:|:......||:...|:|||.:|...|..
  Fly  1717 EMHNKVKEDALKHAKKLQAQVKDALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQLTEDLAS 1781

Human  1696 TERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAI 1760
            :||||:.||.|..:..|.:.....:.:.:|..|::||..:..|:.|:|:...::....::::||.
  Fly  1782 SERARRAAETERDELAEEIANNANKGSLMIDEKRRLEARIATLEEELEEEQSNSEVLLDRSRKAQ 1846

Human  1761 TDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEF 1825
            .....:..||..|:..|...|..:..||:..|:|:.:|.|.|.......|..|..||.:|..||.
  Fly  1847 LQIEQLTTELANEKSNSQKNENGRALLERQNKELKAKLAEIETAQRTKVKATIATLEAKIANLEE 1911

Human  1826 ELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQA 1890
            :||.|.|:.....|..||.::::||||...|::|::|.:.::.:|||..::|..||..:|.:|:.
  Fly  1912 QLENEGKERLLQQKANRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEEL 1976

Human  1891 NAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTR-----DFTSSRM 1933
            ....|:.||.|.|.|:..|..:....::|.|:.|.|     ..:|||:
  Fly  1977 QKEKTQKRKYQRECEDMIESQEAMNREINSLKTKLRRTGGIGLSSSRL 2024

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH3	NP_002461.2	Myosin_N	33..77	CDD:460670	8/44 (18%)
		MYSc_Myh3	100..767	CDD:276878	363/725 (50%)
		Actin-binding	656..678		15/21 (71%)
		Actin-binding	758..772		6/13 (46%)
		Myosin_tail_1	847..1924	CDD:460256	344/1086 (32%)
zip	NP_523860.2	Myosin_N	79..122	CDD:460670	8/42 (19%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	363/725 (50%)
		Myosin_tail_1	931..2011	CDD:460256	344/1090 (32%)