DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MYH3 and didum

DIOPT Version :9

Sequence 1:NP_002461.2 Gene:MYH3 / 4621 HGNCID:7573 Length:1940 Species:Homo sapiens
Sequence 2:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster


Alignment Length:2017 Identity:531/2017 - (26%)
Similarity:908/2017 - (45%) Gaps:449/2017 - (22%)


- Green bases have known domain annotations that are detailed below.


Human    44 KEEYAKGKIKSSQDGKVTVETEDNRTLVVK----PEDVYAM-NPPKFDRIEDMAMLTHLNEPAVL 103
            :|.|.||.      |.:.:.|:..:...||    ..|:..: ||.......|:..|::|:||.||
  Fly    29 EESYRKGA------GFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTTLSYLHEPGVL 87

Human   104 YNLKDRYTS-WMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFML 167
            :||:.|:.. .:||||.|:..|.:|||..:|:|.|.::..|||....:..||||::::.||..:.
  Fly    88 HNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFALAEEAYTKLE 152

Human   168 TDRENQSILITGESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFG 232
            .:..|.||:::|||||||||:.|..::|||.:..         |:.:..:|.::::::|::||||
  Fly   153 RENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGG---------SESETQVERKVLASSPIMEAFG 208

Human   233 NAKTVRNDNSSRFGKFIRIHF-GTTGK--LASADIETYLLEKSRVTFQLKAERSYHIFYQILS-- 292
            ||||.|||||||||||.::.| ...|.  |..|.:.|||||||||.:|.:.||:||||||:.:  
  Fly   209 NAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQLCAAR 273

Human   293 NKKPELIELLLITTNPYDYPFISQG---EILVASIDDAEELLATDSAIDILGFTPEEKSGLYKLT 354
            :|.||     |:..:...:.|::.|   ||  ..:.|||:...|..|:.:|||:.::.:.:.|:.
  Fly   274 SKYPE-----LVLDHQDKFQFLNMGGAPEI--ERVSDAEQFNETVQAMTVLGFSIQQIADIVKIL 331

Human   355 GAVMHYGNMKFKQKQRE--EQAEPDGTEVADK------TAYLMGLNSSDLLKALCFPRVKVGNEY 411
            ..::|.||::..:|..|  |:.:.|..::...      ||.|:.:::.||.:.|...:::..|||
  Fly   332 AGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIESVNEY 396

Human   412 VTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQ 476
            |....:::....|.:||:|.:|.|||.::|..:|:.|:....:..|||||||.|||.||.||.||
  Fly   397 VLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETFEVNSFEQ 461

Human   477 LCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMF 541
            .|||:.||||||.||.|:|.||||||.||||.||.||| .|...||:|||..:|:..:|:|||..
  Fly   462 FCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCIDLIESRLGVLDLLDEECRM 525

Human   542 PKATDTSFKNKLYDQHLGKSN---NFQKPKVVKGRAEAHFSLIHYAGTVDYSVSGWLEKNKDPLN 603
            ||.:|.|:..||    :||.|   :|:||:.    ....|.:.|::.||:|.|:|:||||:|.::
  Fly   526 PKGSDESWAGKL----IGKCNKFPHFEKPRF----GTTSFFIKHFSDTVEYDVNGFLEKNRDTVS 582

Human   604 ETVVGLYQKSSNRLLAHLYATFATAD---ADSGKKKV----------AKKKGSSF---------- 645
            :.:..:..: ||..||....|....|   .||.|...          .|::|:..          
  Fly   583 KELTQVLSE-SNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQH 646

Human   646 -QTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKG 709
             :||.:.|:|:|..|:|.|..|.||:||||.||:.|.....|.:.::.|||..||||.:||...|
  Fly   647 RKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAG 711

Human   710 FPNRILYGDFKQRYRVL-NASAIPEGQFIDSKKACEKLLASIDIDHTQYKFGHTKVFFKAGLLGT 773
            ||:|.||.||..||::| ..|.:.:.   |.|.:|..::.....|..:|:||:|::||:||.:..
  Fly   712 FPSRWLYPDFYMRYQLLVYRSKLDKN---DMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAF 773

Human   774 LEEMRDDRLAKLITRTQAV-----------------------CRGFLMRVEFQKMVQRRESIFCI 815
            ||::|.:...|.||..|:|                       .||:|.|...|||.:.|..:...
  Fly   774 LEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILS 838

Human   816 QYNIRSFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDE----------------- 863
            :|       .:.|...:.:.:::..:...:|.......:.:|...:|.                 
  Fly   839 KY-------ARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARR 896

Human   864 -------------------LAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQL 909
                               ||:.:.||.:.|.|.::.::.|      .......::..::|.|:|
  Fly   897 AYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENK------YMGLENKIISMQQRIDEL 955

Human   910 IKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN 974
            .:....|:.|              .:|::..|.||     ||||.::      |:.:..|.|.::
  Fly   956 NRDNSNLKHK--------------TSEISVLKMKL-----ELKKTLE------AEFKNVKAACQD 995

Human   975 KVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDL-QAEEDKVNSLNKTKSKLEQQVEDLESS 1038
            |           |:.|..|.::.:|.::...|.|::. .|:|:.::.    |....|:.|:|...
  Fly   996 K-----------DKLIEALNKQLEAERDEKMQLLEENGHAQEEWISQ----KQTWRQENEELRRQ 1045

Human  1039 LEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKK--KDFEYCQLQSKVEDEQTL 1101
            :::...:..:.|.|:|..| |..||       |.|.::|:|..::  ||.|.      :|:|..:
  Fly  1046 IDEIIDMAKNAEVNQRNQE-DRMLA-------EIDNRELNEAYQRAIKDKEV------IENENFM 1096

Human  1102 GLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNK 1166
                   :||..:|:                |....|.:||:....|.:.|:..|..|.:..|:.
  Fly  1097 -------LKEELSRL----------------TAGSFSLHARKASNASSQNEDDVGYASAKNTLDI 1138

Human  1167 KREAEFL--------------KLRRDLEEATLQHEAM------VAALRKKHADSVAELGEQIDNL 1211
            .|..:.|              |||..|||...:|:.:      :::..|...||.          
  Fly  1139 NRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKVLQEQYIKLSSRHKPTEDSF---------- 1193

Human  1212 QRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTT 1276
             ||.: ||.|..:.:.|.|.|.:|:      |..:|                       ::||..
  Fly  1194 -RVSE-LEVENEKLRSEYDQLRTSI------KHGVE-----------------------INELNA 1227

Human  1277 QKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDC 1341
            |.:.||.   |:.|:.||    ..||   |....||::.: |.||.|         :||...:|.
  Fly  1228 QHAALQE---EVRRRREE----CIQL---KAVLLQQSQSM-RSLEPE---------SLQMRGNDV 1272

Human  1342 DLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVE 1406
            :.|.|.:..::....:|:..| ||.:|      ::.:..::.|:|:|        ||.:.:::::
  Fly  1273 NELMEAFHSQKLINRQLESEL-KAITE------EHNSKLVEMTQEIE--------RLNNEKDELQ 1322

Human  1407 AVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDK-KQRNFDKVLAEWKTKCEE---SQAE 1467
            .|..:  |::        |.||..||..|.|      |: .:|...|.:|::....||   :.|:
  Fly  1323 KVMFE--SID--------EFEDSNVDTLRQN------DRYLRRELQKAVAQFLLVQEELKLANAK 1371

Human  1468 LEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEI-ADLTEQIAENGKTIHELEKSR 1531
            |:|..::..       :|::..||     |.::.::.....:: |::|:|.::|.:.:.:...|.
  Fly  1372 LKAYRQDGG-------QLEHKIEE-----EMIRNKSNGTSADVGANVTKQKSQNPQGLMKFHSSD 1424

Human  1532 KQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEID--RKIAEKDEEIEQLKRNYQRT 1594
            ....|::....|........|....|.::.:.:..|.:.:..|  |::..|  .:.|:|:.: ||
  Fly  1425 LDKILQRLLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSK--FVIQIKKMH-RT 1486

Human  1595 VETMQSALDAEVRSRNEAIRLKKKME--GDLNE-IEIQLSHANRQAAETLKHLRSVQGQLKDTQL 1656
            ...:::.:...|.|    |.|...|:  ||::| ::......|:|..:.. :|...:..:.|..:
  Fly  1487 PHPIENRVIWLVNS----ITLLNLMKQYGDVDEYVKFNTEKQNQQQLKNF-NLFEYRRVILDLIV 1546

Human  1657 HLDDAL----RGQEDLKEQLAIVE-------RRANLLQAEVEELRAT--------------LEQT 1696
            :|..||    :|..|.|...||:.       |:|:.:::....:.|:              :.|.
  Fly  1547 NLYQALIMQIQGLLDPKIVPAILNNDEIQRGRQAHGMRSRATSIGASSSPEHGGGPAWKQLIGQL 1611

Human  1697 ERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSE----------------VEDA 1745
            |...|..:...||:....|:.|    .|::....:..:.:.|:.:                :||.
  Fly  1612 EHFYKQFQHFGLDNCYAEQIFH----QLLYFICAVALNCLMLRGDICMWETGMIIRYNIGCIEDW 1672

Human  1746 SRDARNAEE--KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKG 1808
            .|..:.:.:  .|...:...:.:.:..|.|||.            ||:.||...|..|:.|.:..
  Fly  1673 VRSKKMSNDVLTALAPLNQVSQLLQSRKSEQDV------------QTICDLCTSLSTAQVLKVMK 1725

Human  1809 GKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSE--EDRKNVLRLQDLVDK 1871
            ..| :...|:.|..:..|      |.||.:...:..:....|.|...:  :..|.|.|..|:  |
  Fly  1726 SYK-LDDYESEITNVFLE------KLTEKLNARQMQKSNSDEFTIDQKFIQPFKVVFRYSDI--K 1781

Human  1872 LQ 1873
            |:
  Fly  1782 LE 1783

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYH3NP_002461.2 Myosin_N 36..73 CDD:280832 6/28 (21%)
Myosin_head 88..767 CDD:278492 275/723 (38%)
MYSc_Myh3 100..767 CDD:276878 271/711 (38%)
Actin-binding 656..678 12/21 (57%)
Actin-binding 758..772 7/13 (54%)
GrpE 843..>962 CDD:295646 23/154 (15%)
Myosin_tail_1 847..1924 CDD:279860 223/1141 (20%)
BAR <956..1063 CDD:299863 21/107 (20%)
MIT_CorA-like <1296..>1408 CDD:294313 24/111 (22%)
COG6 1373..>1506 CDD:303003 27/136 (20%)
TMPIT 1739..>1850 CDD:285135 22/128 (17%)
didumNP_724569.1 MYSc 65..778 CDD:214580 282/741 (38%)
MYSc_Myo5 84..767 CDD:276831 271/711 (38%)
IQ 900..922 CDD:197470 2/21 (10%)
GBP_C <971..1086 CDD:303769 34/148 (23%)
coiled coil 1049..1068 CDD:293879 5/19 (26%)
coiled coil 1077..1086 CDD:293879 1/8 (13%)
JAKMIP_CC3 <1190..1299 CDD:292653 41/176 (23%)
Myo5_CBD 1424..1792 CDD:271254 74/393 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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