Protein Alignment MYH3 and Mhc

DIOPT Version :10

• Sequence 1: NP_002461.2
• Gene: MYH3 / 4621
• HGNCID: 7573
• Length: 1940
• Species: Homo sapiens
• Sequence 2: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Alignment Length: 1921
• Identity: 1068/1921 - (55%)
• Similarity: 1426/1921 - (74%)
• Gaps: 20/1921 - (1%)

Human    15 PFLRKSEKERIEAQNQPFDAKTYCFVVDSKEEYAKGKIKSSQDGKVTVETEDNRTLVVKPEDVYA 79
            |:|..|.::|...|::|:|:|..|::.|.||.|..|:||:::...|:|..:...|..:|.:.:..
  Fly    15 PYLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGETRDLKKDLLQQ 79

Human    80 MNPPKFDRIEDMAMLTHLNEPAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYR 144
            :||||:::.|||:.||:||:.:||:||:.||.:.:||||||||||.:||||..|||.....:.||
  Fly    80 VNPPKYEKAEDMSNLTYLNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYR 144

Human   145 GKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAATGDLAKKK 209
            ||:|.|.|||||:|||.||..|||:..|||:|||||||||||.|||:||.||||:.|    :||.
  Fly   145 GKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGA----SKKT 205

Human   210 D--SKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKS 272
            |  :|.||:||||::..||:|||||||||||||||||||||||||||.|||||.||||||||||:
  Fly   206 DEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKA 270

Human   273 RVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSAI 337
            ||..|...||||||||||:|...|.:.::.|:|.|.|||..:|||::.|||||||||...||.|.
  Fly   271 RVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAF 335

Human   338 DILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCF 402
            ||||||.:||..:|::|.||||.|.|||||:.||||||.||.|...:.:.|.|.::::|.|.|..
  Fly   336 DILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLK 400

Human   403 PRVKVGNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFE 467
            ||:|||||:||:|:.|.||.:::.||.|.|:::||.|:|.:.|:.|||:..||||||||||||||
  Fly   401 PRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFE 465

Human   468 IFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIF 532
            |||||..||||||||||||||||||||||||||||::||||||||||||||..||:||||||||.
  Fly   466 IFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLIEKPMGIL 530

Human   533 SILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVK-GRAEAHFSLIHYAGTVDYSVSGWLE 596
            ||||||.|||||||.:|..||.:.|||||..|||||..| |:..|||::.||||.|.|:::||||
  Fly   531 SILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLE 595

Human   597 KNKDPLNETVVGLYQKSSNRLLAHLYATFATADADSGKKKVAK----KKGSSFQTVSALFRENLN 657
            |||||||:|||..::||.|:||..::|..|   ..||..:.||    |||..|.|||:.::|.||
  Fly   596 KNKDPLNDTVVDQFKKSQNKLLIEIFADHA---GQSGGGEQAKGGRGKKGGGFATVSSAYKEQLN 657

Human   658 KLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQR 722
            .||:.||:|.|||||||||||.|.||.::..||:|||.||||||||||||||||||::|.|||.|
  Fly   658 SLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMR 722

Human   723 YRVLNASAIPEGQFID-SKKACEKLLASIDIDHTQYKFGHTKVFFKAGLLGTLEEMRDDRLAKLI 786
            |:::....:   |.:: .|||.|.::..||:...||:.|:|||||:||:||.:||.||:||.|::
  Fly   723 YKIMCPKLL---QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIM 784

Human   787 TRTQAVCRGFLMRVEFQKMVQRRESIFCIQYNIRSFMNVKHWPWMKLFFKIKPLLKSAETEKEMA 851
            :..||..||:|.|..|:|:.::|.::..:|.|:|.::.::.|||.||:.|:||||..:..|.|:|
  Fly   785 SWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIA 849

Human   852 TMKEEFQKTKDELAKSEAK-RKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQ 915
            .::|:.:|. :||..:|.| |||||.....|:.||..|...:..|...|.|.:||..:|...|..
  Fly   850 RLEEKAKKA-EELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKND 913

Human   916 LEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLT 980
            ||.:::::.||...||:...:|..:|:|.:.|.|.|||||:||||.:.|.|::|...:::::||.
  Fly   914 LENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLN 978

Human   981 EELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKL 1045
            :|::..||.|.||.:|||...|.:|:..::|||.|||:|.|||.|:||||.:::||.|||:|||:
  Fly   979 DEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKV 1043

Human  1046 RVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIK 1110
            |.|:|::|||:||||||.||::.|||.:|::|::.:::||.|...:.:|:||||.:.|:.|::||
  Fly  1044 RGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIK 1108

Human  1111 ELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKL 1175
            ||||||||||||:||||..|||.||||:|.|||||||.||||||||.||.|||||||||||..||
  Fly  1109 ELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKL 1173

Human  1176 RRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVS 1240
            |||||||.:|||:.:|.|||||.|:|||:.||:|.|.::|.|.||||:|:..:::||.:.::.::
  Fly  1174 RRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHIT 1238

Human  1241 KSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRS 1305
            ..||..|||.:.|:..|:|.:.|.:|..|:|::....|.:|..|..:|.|||||.||.|||||:.
  Fly  1239 NEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKI 1303

Human  1306 KQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVA 1370
            |.:.|.|.|:.||..:||::.:..|....::..||.|.||||.|||.||||:|||.|||||:|..
  Fly  1304 KISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQ 1368

Human  1371 QWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVER 1435
            .||:|||:|.:.|:|||||||:||..||.::||.:|::|.||..||||||||..|||||.::|:|
  Fly  1369 VWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDR 1433

Human  1436 ANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVK 1500
            ||::|.|.:|||:.|||::.|||.|.::..|||:||.||.|:.|||||:||.||||..:|||.|:
  Fly  1434 ANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVR 1498

Human  1501 RENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLE 1565
            ||||||..|:.||.:||.|.|:.|||:||:||::|.||.::|.||||||||||.||.|:||.|||
  Fly  1499 RENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLE 1563

Human  1566 LTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQL 1630
            |:||:.||||:|.||:||.|..::|:||.:::||::|:||.:.:.||:|:|||:|.|:||:||.|
  Fly  1564 LSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIAL 1628

Human  1631 SHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQ 1695
            .|||:..||..|:::..|.||||.|..|::..|.::|.:|||.|.|||||.||.|:||.|..|||
  Fly  1629 DHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQ 1693

Human  1696 TERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAI 1760
            .:|.|:.|||||.|::|::..:..||.|:...|:|||::|..|.|::::...:|:|:|||||||:
  Fly  1694 ADRGRRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAM 1758

Human  1761 TDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEF 1825
            .|||.:|:||:.|||.:...|:::|.|||.:|:||.||||||..|||||||.|||||.|:||||.
  Fly  1759 VDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELEN 1823

Human  1826 ELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQA 1890
            ||:|||:::.::.|.|||.|||||||::||||||||..|:||||||||.|:|:||||.|||:|.|
  Fly  1824 ELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIA 1888

Human  1891 NAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTR 1926
            ..:|.||||||.||||||||||:||..::|.|||.|
  Fly  1889 ALNLAKFRKAQQELEEAEERADLAEQAISKFRAKGR 1924

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH3	NP_002461.2	Myosin_N	33..77	CDD:460670	14/43 (33%)
		MYSc_Myh3	100..767	CDD:276878	420/674 (62%)
		Actin-binding	656..678		16/21 (76%)
		Actin-binding	758..772		8/13 (62%)
		Myosin_tail_1	847..1924	CDD:460256	580/1077 (54%)
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670	14/41 (34%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	420/674 (62%)
		Myosin_tail_1	842..1922	CDD:460256	580/1080 (54%)