Protein Alignment MYH3 and Myo31DF

DIOPT Version :10

• Sequence 1: NP_002461.2
• Gene: MYH3 / 4621
• HGNCID: 7573
• Length: 1940
• Species: Homo sapiens
• Sequence 2: NP_523538.1
• Gene: Myo31DF / 34445
• FlyBaseID: FBgn0086347
• Length: 1011
• Species: Drosophila melanogaster
• Alignment Length: 1072
• Identity: 307/1072 - (28%)
• Similarity: 511/1072 - (47%)
• Gaps: 178/1072 - (16%)

Human    88 IEDMAMLTHLNEPAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAP 152
            ::|..:|..::....:.||:.|:.:..||||.|..||::|||:.:.:|.||.:..|:|::..|..
  Fly     9 VQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRELFENA 73

Human   153 PHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTL 217
            ||:|:|:|:||:.:...:::..|||:||||||||..:|.:::|.|  |.|....:.:..::|..|
  Fly    74 PHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIA--AVTNAQGQNEIERVKNVL 136

Human   218 EDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAER 282
                |.:|.:||.||||||.||||||||||::.|.|..........|..||||||||..|...||
  Fly   137 ----IQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGER 197

Human   283 SYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSAIDILGFTPEEK 347
            ::|.|||:|.......:....:......|.:::||.:.:  :.:..:...|.:|...|||:.:|.
  Fly   198 NFHSFYQLLRGANDNELRQYELQKETGKYHYLNQGSMDI--LTEKSDYKGTCNAFKTLGFSTDEV 260

Human   348 SGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADK-----TAYLMGLNSSDLLKALCFPRVKV 407
            ..:::...||:|.||::|       |...|...:::|     ||.|:.:..::|..||....:..
  Fly   261 QTIWRTIAAVLHLGNVEF-------QTIEDELVISNKQHLKSTAKLLQVTETELSTALTKRVIAA 318

Human   408 GNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQL-----DTKLPRQHFIGVLDIAGFE 467
            |...:.|.....|..:..:||:|::|::||.|:::|||:.:     .|:......||||||.|||
  Fly   319 GGNVMQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIYGFE 383

Human   468 IFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKP-MGI 531
            ||:.||.||.|||:.||||||.|...:...|||||::||||||.|::..:...| :|:|:| .||
  Fly   384 IFDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIIC-DLVEQPHKGI 447

Human   532 FSILEEECM-FPKATDTSFKNKLYDQHLGKSNNFQ----KP--KVVKGRAEAHFSLIHYAGTVDY 589
            .:|::|.|: ..|.||.:....: |::|.|..::.    ||  |.:|.|.:  |.:.||||.|.|
  Fly   448 IAIMDEACLSVGKVTDDTLLGAM-DKNLSKHPHYTSRQLKPTDKELKHRED--FRITHYAGDVIY 509

Human   590 SVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATADADSGKKKVAKKKGSSFQTVSALFRE 654
            :::|::|||||.|.:....|...|.:..|:.::     .:.....||..|:.    .|...||:.
  Fly   510 NINGFIEKNKDTLYQDFKRLLHNSKDANLSEMW-----PEGAQDIKKTTKRP----LTAGTLFQR 565

Human   655 NLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDF 719
            ::..|:..|....|.:||||.||:.|:....:...|.||:|..|:||.:|:.|.||.:|..|..|
  Fly   566 SMADLVVTLLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKF 630

Human   720 KQRYRVLNASAIPEGQ----------FIDSKKACEKLLASIDIDHTQYKFGHTKVFFKA-GLLGT 773
            ..||::::....|..:          .|:.||..:.:           |:||||:|.:: ..|..
  Fly   631 LLRYKMISQYTWPNFRAGSDRDGVRVLIEEKKFAQDV-----------KYGHTKIFIRSPRTLFA 684

Human   774 LEEMRDDRLAKLITRTQAVCRGFLMRVEFQKMVQRRESIFCIQ----YNIRSFMNVKHWPWMKLF 834
            ||..|::.:..::|..|...||:::|..|:||   :.:|..::    |.:||:
  Fly   685 LEHQRNEMIPHIVTLLQKRVRGWIVRRNFKKM---KAAITIVRAYKAYKLRSY------------ 734

Human   835 FKIKPLLKSAETEKEMATMKEEFQKTKDELA--KSEAK-RKELEEKLVTLVQEK------NDLQL 890
              ::.|.......|:|....:..|..:..||  |.||| .:..:.....::..|      ..|:|
  Fly   735 --VQELANRLRKAKQMRDYGKSIQWPQPPLAGRKVEAKLHRMFDFWRANMILHKYPRSEWPQLRL 797

Human   891 QVQAES-----------------ENLLDAEERCDQLIKAKFQLEA---KIKEVTERAEDEEEINA 935
            |:.|.:                 :.|.:::|...        .||   .||.:.....|.|....
  Fly   798 QIIAATALAGRRPYWGQARRWVGDYLANSQENSG--------YEAYNGSIKNIRNHPADGETFQQ 854

Human   936 ELTA-------------------------KKRKLEDECSELKKDIDDLELTLAKVEKEK------ 969
            .|.:                         |...::::..::|:.|...|||...|...:
  Fly   855 VLFSSFVKKFNHFNKQANRAFIVSDSTIHKLDGIKNKFKDMKRTIKIRELTSISVSPGRDQLIVF 919

Human   970 HATENK--VKNLTEELSGLDE----TIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKL 1028
            |:::||  |.:|..|.:.|.|    .:..:..:|          ..||...|.:||.......:|
  Fly   920 HSSKNKDLVFSLESEYTPLKEDRIGEVVGIVCKK----------YHDLTGTELRVNVTTNISCRL 974

Human  1029 EQQVEDLESSLEQEKKLRVDLERNKRKLEGDL 1060
            :.:...:  ::|....:.|.   |.|..||::
  Fly   975 DGKARII--TVEAASNVEVP---NFRPKEGNI 1001

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH3	NP_002461.2	Myosin_N	33..77	CDD:460670
		MYSc_Myh3	100..767	CDD:276878	237/694 (34%)
		Actin-binding	656..678		8/21 (38%)
		Actin-binding	758..772		6/14 (43%)
		Myosin_tail_1	847..1924	CDD:460256	51/280 (18%)
Myo31DF	NP_523538.1	MYSc_Myo1	21..677	CDD:276829	237/694 (34%)
		Myosin_TH1	801..977	CDD:461801	32/193 (17%)