Protein Alignment MYH3 and ninaC

DIOPT Version :10

• Sequence 1: NP_002461.2
• Gene: MYH3 / 4621
• HGNCID: 7573
• Length: 1940
• Species: Homo sapiens
• Sequence 2: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Alignment Length: 1162
• Identity: 260/1162 - (22%)
• Similarity: 484/1162 - (41%)
• Gaps: 244/1162 - (20%)

Human    17 LRKSEKER---IEAQNQPFDAKTYCFVVDSKEEYAKG---KIKSSQDGKVTVETED---NRTLV- 71
            |.|:.:.|   :|....||..:    ::::::|....   .::.|:|.|...:..:   :|..|
  Fly   263 LEKNAENRPMMVEMVEHPFLTE----LIENEDEMRSDIAEMLELSRDVKTLYKEPELFVDRGYVK 323

Human    72 ---VKPEDVYAMNPPKFDRIEDMAMLTHLNEPAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLP 133
               .|||.:|.         ||:|.|.:..:..::.:|:.|......|::.|...:::|..:...
  Fly   324 RFDEKPEKMYP---------EDLAALENPVDENIIESLRHRILMGESYSFIGDILLSLNSNEIKQ 379

Human   134 VYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFAT 198
            .:..|....||.|.|.|..|||||::|.|||.||..:|.|.|:::|||.:||:.|.:.:|::...
  Fly   380 EFPQEFHAKYRFKSRSENQPHIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIKHLCY 444

Human   199 I-----AATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGK 258
            :     .|||    :.:|.:|..|            ...||.|..|::|:|......:.||.|||
  Fly   445 LGDGNRGATG----RVESSIKAIL------------MLVNAGTPVNNDSTRCVLQYCLTFGKTGK 493

Human   259 LASADIETYLLEKSRVTFQLKAERSYHIFYQILS--NKKPELIELLLITTNPYDY----PFISQG 317
            ::.|....|:|||.||......:.::||||....  |::.:|.|..|.....|.|    |.:...
  Fly   494 MSGAVFNMYMLEKLRVATTDGTQHNFHIFYYFYDFINQQNQLKEYNLKADRNYRYLRVPPEVPPS 558

Human   318 EILVASID---DAEELLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGT 379
            ::.....|   :.|.....::.:..:.|..::...:.|:..|:::.||::|:|..:  .||.:.|
  Fly   559 KLKYRRDDPEGNVERYREFENILRDIDFNHKQLETVRKVLAAILNIGNIRFRQNGK--YAEVENT 621

Human   380 EVADKTAYLMGLNSSDLLKALC-FPRVKVG----NEYVTKGQTVDQVHHAVNALSKSVYEKLFLW 439
            ::..:.|.|:.::....:.:|. |..||.|    .:|     |.::...|.:|::.::|.:|..:
  Fly   622 DIVSRIAELLRVDEKKFMWSLTNFIMVKGGIAERRQY-----TTEEARDARDAVASTLYSRLVDF 681

Human   440 MVTRINQQLDTKLPRQHF-----IGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQ 499
            ::.|||  ::...||..|     |.:.|:.|||.|..|.||||.||..||::|..:|..:|:.|.
  Fly   682 IINRIN--MNMSFPRAVFGDTNAIIIHDMFGFECFNRNGLEQLMINTLNEQMQYHYNQRIFISEM 744

Human   500 EEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNF 564
            .|.:.|.|:...::|..:..|...|:.||.|:|.|:::     .:.....::.:.|:...|.:.|
  Fly   745 LEMEAEDIDTINLNFYDNKTALDNLLTKPDGLFYIIDD-----ASRSCQDQDLIMDRVSEKHSQF 804

Human   565 QKPKVVKGRAEAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATAD 629
                 ||.......|:.||.|.:.|....:.:.|:|.:...::..::.|.:..:..::....|
  Fly   805 -----VKKHTATEISVAHYTGRIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTNQLT-- 862

Human   630 ADSGK----------KKVAKKKGSSFQTVSA---LFRENLNKLMSNLRTT--------------H 667
             .:|.          |..:::|..:..|:||   ....||..|.:|.|.|              .
  Fly   863 -KAGNLTMPFEAVQHKDESERKSYALNTLSAGCISQVNNLRTLAANFRFTCLTLLKMLSQNANLG 926

Human   668 PHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIP 732
            .||||||..:....|.:....:|..|::..|||:.:...:|||.:|:.:.:|.:||:.|   |..
  Fly   927 VHFVRCIRADLEYKPRSFHSDVVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQFL---AFD 988

Human   733 EGQFID-SKKACEKLLASIDIDHTQYKFGHTKVFFKAGLLGTLEEMRDDRLAKLITRTQAVCRGF 796
            ..:.:: :|..|..|...:.::  .:..|.||||        |....|:.||:
  Fly   989 FDEPVEMTKDNCRLLFLRLKME--GWALGKTKVF--------LRYYNDEFLAR------------ 1031

Human   797 LMRVEFQKMVQRRESIFCIQYNIRSFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMK--EEFQK 859
            |..::.:|:::       :|..:|:.:..|.....|:|    .|.|......::|..|  :.|:.
  Fly  1032 LYELQVKKVIK-------VQSMMRALLARKRVKGGKVF----KLGKKGPEHHDVAASKIQKAFRG 1085

Human   860 TKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVT 924
            .:|.:            :|..||.||:. ||     :||..|.                 |:...
  Fly  1086 FRDRV------------RLPPLVNEKSG-QL-----NENTADF-----------------IRPFA 1115

Human   925 ERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDET 989
            ::..::......|..:..:.:|               ...:.::.|....::      ::||::.
  Fly  1116 KKWREKSIFQVLLHYRAARFQD---------------FVNLSQQVHIYNQRM------VAGLNKC 1159

Human   990 IAKLTREKKALQEAHQQALD-------------------DLQAEEDKVNSLNK---TKSKLEQQV 1032
            ...:..|:..::|.:...|.                   |.|...|..||:::   ....|.|.:
  Fly  1160 TRAVPFERINMREVNSSQLGPLPVPIKKMPFRLDQIPFYDTQYMVDPANSISRQAFPNQLLTQHM 1224

Human  1033 EDLE---SSLEQEKKL-RVDLERNKRKLEGDLKLAQESILDLEN--------DKQQL 1077
            ||.|   |.|::...: ...|..|..|.|...:...:.:.:.:|        |.|||
  Fly  1225 EDDEPWDSPLQRNPSMTSCALTYNAYKKEQACQTNWDRMGESDNIYNQGYFRDPQQL 1281

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH3	NP_002461.2	Myosin_N	33..77	CDD:460670	9/53 (17%)
		MYSc_Myh3	100..767	CDD:276878	183/718 (25%)
		Actin-binding	656..678		11/35 (31%)
		Actin-binding	758..772		5/13 (38%)
		Myosin_tail_1	847..1924	CDD:460256	44/267 (16%)
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785	5/18 (28%)
		MYSc_Myo21	346..1022	CDD:276848	183/726 (25%)