DRSC/TRiP Functional Genomics Resources

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Protein Alignment MYH3 and Myo10A

DIOPT Version :10

Sequence 1:NP_002461.2 Gene:MYH3 / 4621 HGNCID:7573 Length:1940 Species:Homo sapiens
Sequence 2:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster


Alignment Length:1828 Identity:458/1828 - (25%)
Similarity:731/1828 - (39%) Gaps:423/1828 - (23%)


- Green bases have known domain annotations that are detailed below.


Human    76 DVYAMNPPKF-----------------DRIEDMAMLTHLNEPAVLYNLKDRYTSWMIYTYSGLFC 123
            ||.|.:|..|                 ..:|||.:|..|:|.::|:||:.||...:|||::|...
  Fly   128 DVIARHPQTFALQPGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSIL 192

Human   124 VTVNPYKWLP-VYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTV 187
            :.|||||..| .|..||.:.|.|:.....|||:|:|...|:..:.:.   |.::|:||||:|||.
  Fly   193 IAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAALPSP---QVVVISGESGSGKTE 254

Human   188 NTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIH 252
            :||.|:||.|.:...|..|       ...:.:||:.|.|||||||||:|.||||||||||::.::
  Fly   255 STKLVMQYLAAVVPGGGSA-------SAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVY 312

Human   253 FGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSN-KKPELIELLLITTNPYDYPFISQ 316
            | .:|.:..|.|..|||||||:..|...||:||:||::|.. .:.|..:..|:..:.|.|  ::|
  Fly   313 F-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFY--LNQ 374

Human   317 GEILVAS-IDDAEELLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTE 380
            |....|| ..|.|.|   ..|:.:||.:..|:.|:.::..||:|.||:.|.::|.....|  |.|
  Fly   375 GATDCASGRVDWESL---QGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQE--GVE 434

Human   381 VADK-----TAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWM 440
            |...     .|:|:.:::..|.:||.....:...|.:.....:||...|.:|.:|::|..||.|:
  Fly   435 VGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWL 499

Human   441 VTRIN---QQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQEEY 502
            |:|||   |:..|.  ..|.|.:|||.|||....||.||||||:.||.||.:||.|:|.|||.||
  Fly   500 VSRINSIVQKGGTH--DAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEY 562

Human   503 KKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKP 567
            .:|.:|||.:.:..:|.....|.:||:||..:|::|..||:|||.||..|.:..| ..|..:.:|
  Fly   563 ARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNH-ALSELYARP 626

Human   568 KVVKGRAEAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATADADS 632
            ::  |..|  |.:.||||.|.|.|.|:|:||:|.|...|:.|...|...|:..|.... .|..|:
  Fly   627 RI--GAQE--FGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQL-RAQRDA 686

Human   633 GKKKVAKKKGSSFQ---------TVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHS 688
            ||   ...|||:.:         ||:|.|.::|.:|:.::...||.|||||.||:.|....|:..
  Fly   687 GK---TLPKGSNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMP 748

Human   689 LVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEGQFIDSKKACEKLLASI--- 750
            .||.|||..|:|:.|:|.::|:|.|:.:..|.:|||.|..|.:..|  ...::.|..||.::   
  Fly   749 CVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARG--TPYRELCRALLEAMPRT 811

Human   751 DIDHTQYKFGHTKVFFKAGLLGTLEEMRDDRLAKLITRTQAVCRGFLMRVEFQKMVQRRESIFCI 815
            .::...|:.|.|:||.:..|...||..|.:||.:.....|...||.|:|   :::.:|:.:...:
  Fly   812 GVEGPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVR---RQLARRQAAATRL 873

Human   816 QYNIRSFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVT 880
            |         ..|...:...:.:.|.|.|.|.:.:...::                         
  Fly   874 Q---------ARWRGQRAQQRYERLRKGALTAQRLWRGRQ------------------------- 904

Human   881 LVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLE 945
                                 |..|..|| ::..:...:.:|..:||.:..|             
  Fly   905 ---------------------ARRRVQQL-RSDHRRRQEAREAAQRAREARE------------- 934

Human   946 DECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDD 1010
                                                              .|:|:.|..|.:..|
  Fly   935 --------------------------------------------------AKQAVLERSQLSYLD 949

Human  1011 LQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQ 1075
            :.||                 :..:.|.|:.......|  |:..|:.|.:.....|.:.|..|..
  Fly   950 IPAE-----------------LAFIYSKLQGWSPPHGD--RHLVKVLGTVPGPPSSAVQLPEDLG 995

Human  1076 QLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDY 1140
            |..  ..|....||.           ||:.|.:           .|.|.|...|||.:..|....
  Fly   996 QFS--FGKFSSVYCN-----------GLRLQPR-----------REPITAPLLTRAASRDQDFQD 1036

Human  1141 ARELEEL------SERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHAD 1199
            |..:.:|      .:.||.|          .:|..|::: :.:.|....|:.|.:|....:.|. 
  Fly  1037 ALAVFKLILRWSNDKALEGA----------KEKLLADYI-VHKALSSRGLRDEILVQLCNQVHG- 1089

Human  1200 SVAELGEQIDNLQRVKQKL-------------------EKEKSEFKLEIDDLSSSMESVSKSKAN 1245
            .....||.....|.:.|.|                   |..:|...|.:..|.......:.|.|.
  Fly  1090 LPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAV 1154

Human  1246 LEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESI-VSQLSRSKQAF 1309
            ....||:......|.|........:| .||......||.|.:.....||..:: ||.|..:.:.:
  Fly  1155 GAGACRSFVPAWLEWRAWTRGCDMAL-PLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASRGW 1218

Human  1310 TQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRT 1374
            |...:: .:||.:                 .|.|   .|..:...:.||..|.....|::.:...
  Fly  1219 TLVLDD-GQQLTD-----------------SCGL---DYVMDLIAEKELCPAFPAPRSDLLRSGA 1262

Human  1375 KYE----TDAIQR------TEELEEAKKKLAQRLQDSEE---QVEAVNAKCASLEKTKQRLQGEV 1426
            |:.    .||::|      .......|:.:.:..:.|.|   :..|:|.:....|.:....||  
  Fly  1263 KFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRSSALNERYFEREPSPGPGQG-- 1325

Human  1427 EDLMVDVERANSLAAALDKKQRNFDKVLA----EWKTKCEESQAELEASLKESRSLSTELFKLKN 1487
                       |.......:.::.|.:||    ...|.|:..:......|.|||        |.:
  Fly  1326 -----------SSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESR--------LND 1371

Human  1488 AYEEALDQLETVKREN--KNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEA 1550
            .|..| ::|..|.::.  :..:.:.|......|.:|        |......:||:.   ...:.|
  Fly  1372 RYHSA-ERLAPVGKDTGPRYQKSQHAGRRSHAASHG--------SHSSKYADKAEY---ATRSSA 1424

Human  1551 ALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRL 1615
            ..:..||..|...:...:|.|:    .::.|:.::.|          ....||..:...::|..|
  Fly  1425 MSDTSEAPSLASHVRRVRVPSQ----ASDVDQFLDDL----------FSPVLDGSLDELSDARSL 1475

Human  1616 KKKMEG----DLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVE 1676
            ...:.|    ..||.|.::...:....:..:.:..||...|.|.             |:|||.:.
  Fly  1476 AASIRGGSYEQENEAESEIDDLDDYINDIFQPIPLVQNLEKLTS-------------KDQLAAII 1527

Human  1677 RRANLL--------QAEVEELRATLEQ-------TERARKLAEQELL----------DSNERVQL 1716
            :...:.        ::|:|:|...:.:       .|...||..:|.|          |||....|
  Fly  1528 KGGGVASKPEERDEESEIEDLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPL 1592

Human  1717 LHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1781
            ||               .||||..|.|..   ....:::.::|...:| ||:.|:.:|...|..:
  Fly  1593 LH---------------QLMQLPGETESG---PALYQQQVQRAFLQSA-MAQNLQIQQQLLAQNQ 1638

Human  1782 RMKKNLEQ 1789
            .::..|.|
  Fly  1639 ALQTLLSQ 1646

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity