DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYH3 and myhz1.3

DIOPT Version :9

Sequence 1:	NP_002461.2	Gene:	MYH3 / 4621	HGNCID:	7573	Length:	1940	Species:	Homo sapiens
Sequence 2:	XP_001924014.2	Gene:	myhz1.3 / 100008070	ZFINID:	ZDB-GENE-070705-74	Length:	1937	Species:	Danio rerio

Alignment Length:	1930	Identity:	1542/1930 - (79%)
Similarity:	1747/1930 - (90%)	Gaps:	5/1930 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSSDTEMEVFGIAAPFLRKSEKERIEAQNQPFDAKTYCFVVDSKEEYAKGKIKSSQDGKVTVETE 65
            ||:|.||.|:|.||.:|||.|||||||||:||||||.|:|||.||.|.||.|||...|||||.|.
Zfish     1 MSTDAEMAVYGKAAIYLRKPEKERIEAQNKPFDAKTACYVVDDKELYVKGTIKSRDGGKVTVITL 65

Human    66 DNR-TLVVKPEDVYAMNPPKFDRIEDMAMLTHLNEPAVLYNLKDRYTSWMIYTYSGLFCVTVNPY 129
            |.: ..|.|.:||:.|||||||:||||||:||||||:||||||:||.:|||||||||||.|||||
Zfish    66 DTKEERVAKEDDVHPMNPPKFDKIEDMAMMTHLNEPSVLYNLKERYAAWMIYTYSGLFCATVNPY 130

Human   130 KWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQ 194
            ||||||:.|||..||||||.||||||||:||||||||||||||||:|||||||||||||||||||
Zfish   131 KWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITGESGAGKTVNTKRVIQ 195

Human   195 YFATIAATGDLAKKKDS--KMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 257
            ||||:|..|...||:.:  ||:|:||||||:|||||||:||||||||||||||||||||||||:|
Zfish   196 YFATVAVQGPEKKKEQAAGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSG 260

Human   258 KLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVA 322
            |||||||||||||||||||||..||.||||||:::|.||||||:.||||||||:|..|||:|.||
Zfish   261 KLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEMTLITTNPYDFPMCSQGQITVA 325

Human   323 SIDDAEELLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAY 387
            ||||.|||:|||:|||||||..|||.|:||.||||:|:||||||||||||||||||||.|||.||
Zfish   326 SIDDKEELVATDTAIDILGFNAEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDGTEEADKIAY 390

Human   388 LMGLNSSDLLKALCFPRVKVGNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKL 452
            |:||||:|:|||||:||||||||:|||||||.||:::|:|||||:||::|||||.||||.||||.
Zfish   391 LLGLNSADMLKALCYPRVKVGNEFVTKGQTVPQVYNSVSALSKSIYERMFLWMVIRINQMLDTKQ 455

Human   453 PRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMD 517
            .|..|||||||||||||::||:|||||||||||||||||||||||||||||||||.|.|||||||
Zfish   456 QRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFGMD 520

Human   518 LAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVKGRAEAHFSLIH 582
            |||||||||||:|||||||||||||||||||||||||||||||.|.|||||..||:|||||||:|
Zfish   521 LAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKCNAFQKPKPAKGKAEAHFSLVH 585

Human   583 YAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATADADSGKKKVAKKKGSSFQT 647
            |||||||::||||:||||||||:||.||||||.:|||.||.  ...:...|.||..||||.|.||
Zfish   586 YAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYP--PVVEETGGGKKGGKKKGGSMQT 648

Human   648 VSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPN 712
            ||:.|||||.|||:|||:||||||||:||||:||||.||:.||:||||||||||||||||||||:
Zfish   649 VSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPS 713

Human   713 RILYGDFKQRYRVLNASAIPEGQFIDSKKACEKLLASIDIDHTQYKFGHTKVFFKAGLLGTLEEM 777
            |||||||||||:|||||.||||||||:|||.||||.|||::|.:|:|||||||||||||||||||
Zfish   714 RILYGDFKQRYKVLNASVIPEGQFIDNKKASEKLLGSIDVNHDEYRFGHTKVFFKAGLLGTLEEM 778

Human   778 RDDRLAKLITRTQAVCRGFLMRVEFQKMVQRRESIFCIQYNIRSFMNVKHWPWMKLFFKIKPLLK 842
            ||::||.|:|.|||:||.:|||.||.||::|||||:.||||||||||||||||||:::|||||||
Zfish   779 RDEKLASLVTMTQALCRAYLMRREFVKMMERRESIYTIQYNIRSFMNVKHWPWMKVYYKIKPLLK 843

Human   843 SAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCD 907
            |||||||:|||||:|.|.|:.|||:|||:||||||:|.|:||||||||.|.:|||||.||||||:
Zfish   844 SAETEKELATMKEDFVKCKEALAKAEAKKKELEEKMVALLQEKNDLQLAVASESENLSDAEERCE 908

Human   908 QLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 972
            .|||:|.|||||:||.|||.|||||||||||||||||||||||||||||||||||||||||||||
Zfish   909 GLIKSKIQLEAKLKETTERLEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 973

Human   973 ENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLES 1037
            ||||||||||::..||:|.|||:|||||||||||.||||||||||||:|.|:|:||||||:|||.
Zfish   974 ENKVKNLTEEMAAQDESIGKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEG 1038

Human  1038 SLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLG 1102
            |||||||||:||||.|||||||||||||||:||||||||.:|:|||||||..||.||:||||:||
Zfish  1039 SLEQEKKLRMDLERAKRKLEGDLKLAQESIMDLENDKQQSEEKLKKKDFETSQLLSKIEDEQSLG 1103

Human  1103 LQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKK 1167
            .|.|||||||||||||||||||||||.|||.||||:|.:|||||:|||||||||.|:.|||:|||
Zfish  1104 AQLQKKIKELQARIEELEEEIEAERAARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNKK 1168

Human  1168 REAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDL 1232
            |||||.||||||||:||||||..||||||.|||||||||||||||||||||||||||:|:|||||
Zfish  1169 REAEFQKLRRDLEESTLQHEATAAALRKKQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDDL 1233

Human  1233 SSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKES 1297
            ||:||:|:|:||||||:||||||||||.:.||:|..|.:::|:.|::|||||.||..|||||||:
Zfish  1234 SSNMEAVAKAKANLEKMCRTLEDQLSEIKSKNDENIRQINDLSAQRARLQTENGEFGRQLEEKEA 1298

Human  1298 IVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRAL 1362
            :||||:|.|||||||.||||||:|||.|||||||||:||:||||||||||:|||||.||||||.:
Zfish  1299 LVSQLTRGKQAFTQQIEELKRQIEEEVKAKNALAHAVQSARHDCDLLREQFEEEQEAKAELQRGM 1363

Human  1363 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVE 1427
            |||||||||||||||||||||||||||:|||||||||::|||:||||:|||||||||||||||||
Zfish  1364 SKANSEVAQWRTKYETDAIQRTEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVE 1428

Human  1428 DLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEA 1492
            |||:||||||:|||.||||||||||||||||.|.||.|||||.:.||:|||||||||:||:|||.
Zfish  1429 DLMIDVERANALAANLDKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEET 1493

Human  1493 LDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEA 1557
            ||||||:|||||||:|||:|||||:.|.||:|||||||:|.:|.|||:||.||||||..|||||:
Zfish  1494 LDQLETLKRENKNLQQEISDLTEQLGETGKSIHELEKSKKAVETEKAEIQTALEEAEGTLEHEES 1558

Human  1558 KILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGD 1622
            ||||:||||.|||||||||:|||||||||:|||.||..|:|||.||:||||||:|:|:|||||||
Zfish  1559 KILRVQLELNQVKSEIDRKLAEKDEEIEQIKRNSQRVTESMQSTLDSEVRSRNDALRIKKKMEGD 1623

Human  1623 LNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVE 1687
            |||:|||||||||||||..|.||:||.||||.|||||||:|||||:|||:|:||||..|:|:|:|
Zfish  1624 LNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVAMVERRNTLMQSEIE 1688

Human  1688 ELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNA 1752
            ||||.||||||.||:|||||:|::|||.|||:|||||::||||||.||:|:||||||..::||||
Zfish  1689 ELRAALEQTERGRKVAEQELVDASERVGLLHSQNTSLLNTKKKLEADLVQIQSEVEDTVQEARNA 1753

Human  1753 EEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLE 1817
            ||||||||||||||||||||||||||||||||||||.|||||||||||||.||:||||||:||||
Zfish  1754 EEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEITVKDLQHRLDEAENLAMKGGKKQLQKLE 1818

Human  1818 TRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQ 1882
            :|:||||.|:|.||::..::|||:|||||||||||||:|||:|||.||||||||||:|||:||||
Zfish  1819 SRVRELETEIEAEQRRGADAVKGVRKYERRVKELTYQTEEDKKNVNRLQDLVDKLQLKVKAYKRQ 1883

Human  1883 AEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRD 1927
            :|||:||||:||:|.||.||||||||||||||||||||||||:||
Zfish  1884 SEEAEEQANSHLSKLRKVQHELEEAEERADIAESQVNKLRAKSRD 1928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYH3	NP_002461.2	Myosin_N	36..73	CDD:280832	21/37 (57%)
		Myosin_head	88..767	CDD:278492	549/680 (81%)
		MYSc_Myh3	100..767	CDD:276878	538/668 (81%)
		Actin-binding	656..678		17/21 (81%)
		Actin-binding	758..772		12/13 (92%)
		GrpE	843..>962	CDD:295646	96/118 (81%)
		Myosin_tail_1	847..1924	CDD:279860	868/1076 (81%)
		BAR	<956..1063	CDD:299863	90/106 (85%)
		MIT_CorA-like	<1296..>1408	CDD:294313	94/111 (85%)
		COG6	1373..>1506	CDD:303003	113/132 (86%)
		TMPIT	1739..>1850	CDD:285135	90/110 (82%)
myhz1.3	XP_001924014.2	Myosin_N	36..74	CDD:280832	21/37 (57%)
		Myosin_head	89..768	CDD:278492	549/680 (81%)
		MYSc_class_II	101..768	CDD:276951	538/668 (81%)
		SPEC	881..1043	CDD:295325	134/161 (83%)
		Myosin_tail_1	882..1925	CDD:279860	844/1042 (81%)
		MIT_CorA-like	<1297..>1409	CDD:294313	94/111 (85%)
		TMPIT	1473..>1583	CDD:285135	85/109 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1198	1.000	Domainoid score	I239
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D12270at7742
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.820