DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(3)07882 and NOP14

DIOPT Version :9

Sequence 1:	NP_001303435.1	Gene:	l(3)07882 / 46201	FlyBaseID:	FBgn0010926	Length:	852	Species:	Drosophila melanogaster
Sequence 2:	NP_010133.1	Gene:	NOP14 / 851407	SGDID:	S000002307	Length:	810	Species:	Saccharomyces cerevisiae

Alignment Length:	884	Identity:	210/884 - (23%)
Similarity:	369/884 - (41%)	Gaps:	160/884 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 KKTTRSANPFD-----NSTAQSSKRGNPFDVHVNKEK------FKILGRICKHDRGMPGVSRAKA 69
            |.:.|.|..:|     .:.|:..:..|||::...:.|      .|...||..   |.||:|:...
Yeast    30 KNSKRQAKEYDREEKKKAIAEIREEFNPFEIKAARNKRRDGLPSKTADRIAV---GKPGISKQIG 91

  Fly    70 LQKRAQTLGQQFAVKHKTNRFKDNRIGKHLSGDQL--TESVMNARYLAEKMSQVRSNQKAEKFNL 132
            .::|.:....:..:|:|.....|.|.|:.   |:|  .|..|..|:..|:.||  |.:.|..|||
Yeast    92 EEQRKRAFEARKMMKNKRGGVIDKRFGER---DKLLTEEEKMLERFTRERQSQ--SKRNANLFNL 151

  Fly   133 NDDE--------LLTHRGQTLEEIEQYRDERSDDEELDDEALDADFTAAAHFGGEGDSAQDRQ-- 187
            .|||        .|||.||:|    ...||.::|||        ||.|:..|..:....|..|
Yeast   152 EDDEDDGDMFGDGLTHLGQSL----SLEDELANDEE--------DFLASKRFNEDDAELQQPQRK 204

  Fly   188 ----AAIDEMIVEQKRRKNEIAKEKDEVYDLTEKLDANYKLLLPLVAKVTKDEQDAKPPPD---A 245
                ..:.|:|.:.|..|.|..|.:..:.|..:.||.|::.::..:......:...:|..|   .
Yeast   205 KTKAEVMKEVIAKSKFYKQERQKAQGIMEDQIDNLDDNFEDVMSELMMTQPKKNPMEPKTDLDKE 269

  Fly   246 YDKLLKEMIFEPRGSVADKLINPDELAKQEAARLEKLENERLRRMRA--DGEEDEEASVAKPKHR 308
            ||..:||:..:.|.:.:|:....:|...:...:..:||.:||.||..  :.||.||        |
Yeast   270 YDIKVKELQLDKRAAPSDRTKTEEEKNAEAEEKKRELEQQRLDRMNGMIELEEGEE--------R 326

  Fly   309 SADDLDDGYFLAGEDDEGDDTLAYDLDGNLGTHLNGKKEAVLKGDENEDDDDKEGEEEEEEDSDE 373
            ..:|||||::                                           |.||:.|:|:|.
Yeast   327 GVEDLDDGFW-------------------------------------------ENEEDYEDDNDG 348

  Fly   374 ESDSEVDNLSDLKESESESEPEEAPKASKKKAKKSADTIPASLDTSIPFTIKMPKTYEDFTELLS 438
            .:||:    .|:| .|.:...|...:..|||                ..:|..|:|::...:.:.
Yeast   349 IADSD----DDIK-FEDQGRDEGFSQILKKK----------------NISISCPRTHDALLDQVK 392

  Fly   439 KHATAQKAIIIERIIKCNHPKLEGVNRENVVKLYSFLLQYLKDLFEDASEQDIREHFQLLSKLMP 503
            |........|::.|||...|||...|:|.:.|..:.||:::..|......::::...:..:.|:.
Yeast   393 KLDLDDHPKIVKNIIKAYQPKLAEGNKEKLGKFTAVLLRHIIFLSNQNYLKNVQSFKRTQNALIS 457

  Fly   504 YLYELTQLNPERMSNTLLEVIKEKYEEFRKNHKMYPSLDTLVYFKLVANLYSTSDFRHPVVTPCF 568
            .|..|::.....:|....:.|.|....::|||....|...||:|.::..|:||||..|.|:||..
Yeast   458 ILKSLSEKYNRELSEECRDYINEMQARYKKNHFDALSNGDLVFFSIIGILFSTSDQYHLVITPAL 522

  Fly   569 IFIQHVLSRSRVRTRQEISMGLFLVTVVLEFVSQSKRLVPAVFNFLQGIVHMSIPKRD------- 626
            |.:...|.:.:..:.:.|:.|..||.:|.::...|||.:|.|..|.|.|:...|.:::
Yeast   523 ILMSQFLEQIKFNSLKRIAFGAVLVRIVSQYQRISKRYIPEVVYFFQKILLTFIVEKENQEKPLD 587

  Fly   627 -----VEQLEITPPFERDGPLSKLLALPANTESTKLEPQQLQPTDLVTQTITPDFKV-RALDTSL 685
                 ::..|:..|.:.|....:...:|.:|.||.  ..:..|.|   |.::....| .:||.::
Yeast   588 FENIRLDSYELGLPLDVDFTKKRSTIIPLHTLSTM--DTEAHPVD---QCVSVLLNVMESLDATI 647

  Fly   686 LLIKEALQLVEEHVGACYLAQPFLALLSRLPLE----SYPEHVHQHHKDATELAEKLAAQKMKPL 746
            ..:.::|....|      :..|...|||....:    ..|.::....:..|:..|.:      ||
Yeast   648 STVWKSLPAFNE------IILPIQQLLSAYTSKYSDFEKPRNILNKVEKLTKFTEHI------PL 700

  Fly   747 APAEKKPKALRLLEPRFEAVYD-DKRRPKMSKAKEERAKLLHKIKREKKGAIREIRRDTSFVQML 810
            |....||.::....|::|..:: ||:.....:.:.|..|:..::|:|:|..::|||:|..|....
Yeast   701 ALQNHKPVSIPTHAPKYEENFNPDKKSYDPDRTRSEINKMKAQLKKERKFTMKEIRKDAKFEARQ 765

  Fly   811 RLKQTLQSDKERHEKVKRIYQEASVQQG-ELNELSRAKK 848
            |:::..:...:.|.|:..|....:.::| |.|:..|.:|
Yeast   766 RIEEKNKESSDYHAKMAHIVNTINTEEGAEKNKYERERK 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)07882	NP_001303435.1	Nop14	30..839	CDD:282059	202/854 (24%)
NOP14	NP_010133.1	Nop14	48..794	CDD:398014	201/854 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341671
Domainoid	1	1.000	123	1.000	Domainoid score	I1224
eggNOG	1	0.900	-	-		E1_KOG2147
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	189	1.000	Inparanoid score	I921
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55312
OrthoFinder	1	1.000	-	-		FOG0004332
OrthoInspector	1	1.000	-	-		oto99773
orthoMCL	1	0.900	-	-		OOG6_103518
Panther	1	1.100	-	-	LDO	PTHR23183
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R828
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.790