DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(3)07882 and Nop14

DIOPT Version :9

Sequence 1:	NP_001303435.1	Gene:	l(3)07882 / 46201	FlyBaseID:	FBgn0010926	Length:	852	Species:	Drosophila melanogaster
Sequence 2:	NP_083554.2	Gene:	Nop14 / 75416	MGIID:	1922666	Length:	860	Species:	Mus musculus

Alignment Length:	899	Identity:	314/899 - (34%)
Similarity:	491/899 - (54%)	Gaps:	89/899 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VAKGKKASADAVYAKKTTRSANPFDNSTAQSSKRGNPFDVHVNKEKFKILGRICKHDRGMPGVSR 66
            :.|.|:..     |::....| |...|...:....|||:|.||::||:||||..:||.|:|||||
Mouse     1 MGKAKRTG-----ARRQVHKA-PAGASGGPAKTNPNPFEVKVNRQKFQILGRKTRHDVGLPGVSR 59

  Fly    67 AKALQKRAQTLGQQFAVKHKTNRFKDNRIGKHLSGDQLTESVMNARYLAEKMSQVRSNQKAEKFN 131
            |:|::||.|||.:::..::|:|.|.|.|.|::.|.....|.:|. |:..|   |.|.::|...:|
Mouse    60 ARAIRKRTQTLLKEYKERNKSNVFADKRFGEYNSNISPEEKMMK-RFALE---QQRYHEKKNIYN 120

  Fly   132 LNDDELLTHRGQTLEEIEQYRDERSDDEELDDE-ALDADFTAAAHFGG------------EGDSA 183
            ||:||.|||.||:|.:||::.|....|.:.:|. ||.|:.| |:||||            :||..
Mouse   121 LNEDEELTHYGQSLADIEKHNDIVDSDSDTEDRGALSAELT-ASHFGGGVHKNSSQKEGEDGDKP 184

  Fly   184 QDRQAAIDEMIVEQKRRKNEIAKEKDEVYDLTEKLDANYKLLLPLVAKVTKDEQD----AKPPPD 244
            :.|:..|:|:|.:.|:.|.|...::::..:||||||.::|.:..|:::..|..:|    .||.||
Mouse   185 KTRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQILMSRKPKKSEDKEKKEKPQPD 249

  Fly   245 AYDKLLKEMIFEPRGSVADKLINPDELAKQEAARLEKLENERLRRMRADGEEDEEASVAKPKHRS 309
            .||.:::|:.||.:...::::...:||||:|..||:|||.||||||..   :||..:..||||.|
Mouse   250 EYDMMVRELGFEMKAQPSNRMKTEEELAKEEQERLKKLEAERLRRMLG---KDEHENKKKPKHTS 311

  Fly   310 ADDLDDGYFLAGEDDEGDDTLAYDLDGNLGTHLNGKKEAVLKGDENEDDDDKEGEEEEEEDSDEE 374
            ||||:||:.|    |:.|..|....||.:  ::...:|...|..:.:::|.||||::.||:.:..
Mouse   312 ADDLNDGFIL----DKDDRRLLSYKDGKM--NIEDVQEEQSKEADGQENDQKEGEDDSEEEDESH 370

  Fly   375 SDSE----VDNLSDLKESESESEPE-EAPKASKK-----KAKKSADTIPASLDTSIPFTIKMPKT 429
            .|||    .|:.||| ||..|||.| |.||..::     |..|.......::...:|:....|::
Mouse   371 EDSEESEDPDSHSDL-ESNIESEEENETPKKEQRQTPGGKLPKDDQKAQKAVAAELPYVFAAPES 434

  Fly   430 YEDFTELLSKHATAQKAIIIERIIKCNHPKLEGVNRENVVKLYSFLLQYLKDLFEDASEQDIREH 494
            :|:...|||..:..::.:::|||.|||||.|...|:..:.||:.|||||:.||..| |..|::
Mouse   435 FEELKFLLSGRSMEEQLLVVERIQKCNHPSLAVGNKAKLEKLFGFLLQYIGDLATD-STPDLK-- 496

  Fly   495 FQLLSKLMPYLYELTQLNPERMSNTLLEVIKEKYEEFR-----KNHKMYPSLDTLVYFKLVANLY 554
              .:.||:.:||.|.|:.||..|:::..|:::...|..     |....:|.||.|:|.|:...|:
Mouse   497 --TIDKLVVHLYSLCQMFPESASDSIRFVLRDAMHEMEEMIETKGRAAFPGLDVLIYLKITGLLF 559

  Fly   555 STSDFRHPVVTPCFIFIQHVLSRSRVRTRQEISMGLFLVTVVLEFVSQSKRLVPAVFNFLQGIVH 619
            .||||.||||||..:.:..:|::..|.:.|::..|||:..:.||:||.|:|.:|.:||||.||::
Mouse   560 PTSDFWHPVVTPALLCMSQMLTKCPVMSLQDVIKGLFVCCLFLEYVSLSRRFIPELFNFLLGILY 624

  Fly   620 MSIPKRDVEQLEITPPFERDGPLSKLLALPANTESTKLEPQQLQ---PTDLVTQTITPDFKVRAL 681
            ::.|....:...:..||...|..|:||.:....:.|..:...|.   ...|.|.|.|     .|.
Mouse   625 IATPNTKSQGSTLVHPFRALGKNSELLVVSDKADVTTWQRGSLPLHWANRLSTLTAT-----EAN 684

  Fly   682 DTSLLLIKEALQLVEEHVGACYLA--------QPFLALLSR-LPLESYPEHVHQHHKDATELAEK 737
            .|.|..:...|.|: :|....|.|        :|..||||: |...|.|:.:.       |||:.
Mouse   685 HTRLSCVASCLSLM-KHCVLMYQALPSFHAIFRPHQALLSKHLADCSLPQELQ-------ELAQS 741

  Fly   738 LAA------QKMKPLAPAEKKPKALRLLEPRFEAVYDDKRRPKMSKAKEERAKLLHKIKREKKGA 796
            :.:      |..:||...:.||..|:...||...|.:..|:...||.::||.:|:||.|||.|||
Mouse   742 ILSAMEGQKQHCRPLVCEKSKPVPLKQFTPRLVKVLEFGRKQGSSKEEQERKRLIHKHKREFKGA 806

  Fly   797 IREIRRDTSFVQMLRLKQTLQSDKERHEKVKRIYQEASVQQGELNELSRAKKKK 850
            :||||:|..|:..::|.:.::.|.||..|||:::...:.|:||...|.|.|.||
Mouse   807 VREIRKDNQFLARMQLSEIMERDAERKRKVKQLFNSLATQEGEWKALKRKKFKK 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)07882	NP_001303435.1	Nop14	30..839	CDD:282059	301/858 (35%)
Nop14	NP_083554.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33		8/37 (22%)
		Nop14	24..849	CDD:282059	301/857 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..417		96/266 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831941
Domainoid	1	1.000	469	1.000	Domainoid score	I457
eggNOG	1	0.900	-	-		E1_KOG2147
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41773
Inparanoid	1	1.050	476	1.000	Inparanoid score	I1473
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55312
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004332
OrthoInspector	1	1.000	-	-		oto93915
orthoMCL	1	0.900	-	-		OOG6_103518
Panther	1	1.100	-	-	LDO	PTHR23183
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R828
SonicParanoid	1	1.000	-	-		X5420
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790